Dr Diego Gomez-Nicola is Career Track Lecturer and MRC NIRG Fellow within the Centre for Biological Sciences at the University of Southampton. As a neuroscientist, Dr Gomez-Nicola is interested in unveiling the roles of glial cells in the healthy and diseased brain, as a way to understand the fascinating complexity of our brain.
Understanding how our brain works and reacts to disease is the most exciting and challenging task of biomedical science
2013-2016: MRC NIRG Fellow. University of Southampton, UK. 2011-2013: Marie Curie Fellow (IEF FP7, European Union). CNS Inflammation Group, Centre for Biological Sciences, University of Southampton, UK. 2010-2011: Postdoctoral Fellow of the Spanish Ministry of Education. CNS Inflammation Group, School of Biological Sciences, University of Southampton, UK. 2008-2010: Postdoctoral researcher. Neural Plasticity Group, National Hospital of Paraplegics, Toledo, Spain. 2003-2008: PhD student. Neural Plasticity Group, Cajal Institute (CSIC), Madrid, Spain.
2008: PhD in Molecular biology (Neurosciences). Autonoma University of Madrid , Spain. 2005: MSci in Molecular biology (Neurosciences). Autonoma University of Madrid, Spain. 2003: BSci in Biological Sciences (Neurobiology). Complutense University of Madrid, Spain.
My research is focused in the understanding of the multicellular response of the CNS to injury or neurodegeneration, aiming at providing an integrative and detailed study of the functions and cross-regulation of the different cell components during neuropathology. In the past I studied the role of proinflammatory cytokines in the regulation of the activation state of glial cells, in the context of brain inflammation, spinal cord injury, neuropathic pain or multiple sclerosis. The goal of my current research is to study the regulation of microglial proliferation during chronic neurodegenerative diseases such as prion or Alzheimer's. The expansion of the microglial population is a hallmark of neurodegeneration and contributes to the development of the pathology. A detailed understanding of the molecules and mechanisms orchestrating microglial proliferation could open a window to elaborate therapeutic approaches to control the neuroinflammatory component of the disease. Also, I am interested in the study of the dynamics and regulation of adult neurogenesis during neurodegeneration. Understanding of the basic mechanisms regulating the generation of new functional neurons could provide useful ways to improve functional recovery during chronic neurodegenerative diseases.
Ahmed Salman (Faculty of Medicine) Project Title: A study of the first transgenic model of infantile nystagmus (knockout-first, reporter driven Frmd7tm1a(KOMP)Wtsi mouse) Funding Provider: Wessex Medical Research & Fight for Sight
Katharine Askew (CfBS) Project Title: Understanding microglial dynamics in the healthy and diseased brain Funding Provider: Vice-chancellor studentship
Natascha Vana (CfBS) Project Title: Modulation of Alzheimer’s disease protein networks: Minimising neuronal toxicity while preserving synaptic plasticity Funding Provider: Gerald Kerkut Trust
MRC New Investigator Grant ARUK Pilot Grant Wessex Medical Research Innovation Grant Dementia Consortium Grant
An important aspect of chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's and prion disease, is the generation of an innate inflammatory response within the central nervous system (CNS).
Microglial cells are the resident immune cells of the brain and play crucial roles in the regulation of normal and pathological neural functions. This PhD project aims at studying the balance of the numbers of microglial cells from development to ageing, to better understand the roles of these cells in the brain, through a multidisciplinary approach using in vivo models, genetic molecular tools and behavioural analysis of brain function.
SGH Lab Representative at Research Strategy Group, CfBS SGH Lab Representative at Core Equipment and Service Contracts Group, CfBS
Reviewer for the Spanish National Agency for Evaluation of Projects (ANEP), the European Union, MS Society, Alzheimer’s Society and MRC. Charter member of the Spanish Young Neuroscientists Club (CJN) of the SENC. 2009. Spanish Glial Network: Member of the Board since 2011. STEM Ambassador Member of the Editorial Board of Scientific Reports
Dr Diego Gomez-Nicola CNS Inflammation Group Centre for Biological Sciences University of Southampton Mail Point 840, LD80C South Lab and Path Block Southampton General Hospital Tremona Road Southampton SO166YD Tel: +44(0)238120 5358