Centre for Biological Sciences

Diego Gomez-Nicola

DPhil, MSc, BSc

Primary position:
Career Track Lecturer
Other positions:
MRC NIRG Research Fellow

Background

The University of Southampton
Dr Diego Gomez-Nicola's photo

Career history

2013-2016: MRC NIRG Fellow. University of Southampton, UK.
2011-2013: Marie Curie Fellow (IEF FP7, European Union). CNS Inflammation Group, Centre for Biological Sciences, University of Southampton, UK.
2010-2011: Postdoctoral Fellow of the Spanish Ministry of Education. CNS Inflammation Group, School of Biological Sciences, University of Southampton, UK.
2008-2010: Postdoctoral researcher. Neural Plasticity Group, National Hospital of Paraplegics, Toledo, Spain.
2003-2008: PhD student. Neural Plasticity Group, Cajal Institute (CSIC), Madrid, Spain.

Academic qualifications

2008: PhD in Molecular biology (Neurosciences). Autonoma University of Madrid , Spain.
2005: MSci in Molecular biology (Neurosciences). Autonoma University of Madrid, Spain. 
2003: BSci in Biological Sciences (Neurobiology). Complutense University of Madrid, Spain.

 

Publications

The University of Southampton's electronic library (e-prints)

Article

Gomez-Nicola, Diego and Boche, Delphine (2015) Post-mortem analysis of neuroinflammatory changes in human Alzheimer's disease. Alzheimer s Research & Therapy, 7, (42), 1-8. (doi:10.1186/s13195-015-0126-1). (PMID:25904988).
Gomez-Nicola, Diego, Riecken, K., Perry, V. Hugh and Fehse, B. (2015) Multicolor RGB marking allows morphometric and functional analysis of hippocampal granule neurons at the single-cell level. Human Gene Therapy (doi:10.1089/hum.2015.010). (PMID:25894663).
Gomez-Nicola, Diego and Perry, V. Hugh (2015) Microglial dynamics and role in the healthy and diseased brain: a paradigm of functional plasticity. The Neuroscientist, 169-184. (doi:10.1177/1073858414530512 ). (PMID:24722525).
Gomez-Nicola, Diego, Riecken, K., Fehse, B. and Perry, V. Hugh (2014) In-vivo RGB marking and multicolour single-cell tracking in the adult brain. Scientific Reports, 4, (7520), 1-10. (doi:10.1038/srep07520). (PMID:25531807).
Miller, Victoria and Gomez-Nicola, Diego (2014) How can we exploit the brain's ability to repair itself? Expert Review of Neurotherapeutics, 14, (12), 1345-1348. (doi:10.1586/14737175.2014.985659). (PMID:25427149).
Gomez-Nicola, Diego, Schetters, Sjoerd T.T. and Perry, V. Hugh (2014) Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease. Glia, 62, (7), 1041-1052. (doi:10.1002/glia.22660). (PMID:24648328).
Gómez-Nicola, Diego, Suzzi, Stefano, Vargas-Caballero, Mariana, Fransen, Nina L., Al-Malki, Hussain, Cebrian-silla, A., García-verdugo , Jm, Riecken, K., Fehse, B. and Perry, V. Hugh (2014) Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration. Brain, 1-17. (doi:10.1093/brain/awu155). (PMID: 24941947).
Gómez-Nicola, Diego, Fransen, Nina L., Suzzi, Stefano and Perry, V Hugh (2013) Regulation of microglial proliferation during chronic neurodegeneration. The Journal of Neuroscience, 33, (6), 2481-2493. (doi:10.1523/JNEUROSCI.4440-12.2013 ). (PMID:23392676).
Gomez-Nicola, Diego, Teeling, Jessica, Guaza, Carmen, Godbout, Jonathan P. and Taub, Dennis D. (2013) Editorial. The role of inflammatory mediators in immune-to-brain communication during health and disease. Mediators of Inflammation, 2013, (429231), 1-3. (doi:10.1155/2013/429231). (PMID:24109163).
Burgos, Elisa, Gomez-Nicola, Diego, Pascual, David, Martín, María Isabel, Nieto-Sampedro, Manuel and Goicoechea, Carlos (2012) Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells. European Journal of Pharmacology (doi:10.1016/j.ejphar.2012.02.008). (PMID:22374260).
Gomez-Nicola, Diego, Valle-Argos, Beatriz, Pallas-Bazarra, Noemí and Nieto-Sampedro, Manuel (2011) Interleukin-15 regulates proliferation and self-renewal of adult neural stem cells. Molecular Biology of the Cell, 22, (12), 1960-1970. (doi:10.1091/mbc.E11-01-0053). (PMID:21508317).
Valle-Argos, Beatriz, Gomez-Nicola, Diego and Nieto-Sampedro, Manuel (2011) Neurostatin blocks glioma cell cycle progression by inhibiting EGFR activation. Molecular and Cellular Neuroscience, 46, (1), 89-100. (doi:10.1016/j.mcn.2010.08.009). (PMID:20801220).
Nieto-Sampedro, Manuel, Valle-Argos, Beatriz, Gómez-Nicola, Diego, Fernández-Mayoralas, Alfonso and Nieto-Díaz, Manuel (2011) Inhibitors of glioma growth that reveal the tumour to the immune system. Clinical Medicine Insights Oncology, 5, 265-314. (doi:10.4137/CMO.S7685). (PMID:22084619).
Valle-Argos, Beatriz, Gomez-Nicola, Diego and Nieto-Sampedro, Manuel (2010) Glioma growth inhibition by neurostatin and O-But GD1b. Neuro-Oncology, 12, (11), 1135-1146. (doi:10.1093/neuonc/noq073). (PMID:20615925).
Gomez-Nicola, Diego, Pallas-Bazarra, Noemí, Valle-Argos, Beatriz and Nieto-Sampedro, Manuel (2010) CCR7 is expressed in astrocytes and upregulated after an inflammatory injury. Journal of Neuroimmunology, 227, (1-2), 87-92. (doi:10.1016/j.jneuroim.2010.06.018). (PMID:20638137).
Valle-Argos, Beatriz, Gomez-Nicola, Diego and Nieto-Sampedro, Manuel (2010) Synthesis and characterization of neurostatin-related compounds with high inhibitory activity of glioma growth. European Journal of Medicinal Chemistry, 45, (5), 2034-2043. (doi:10.1016/j.ejmech.2010.01.015). (PMID:20153569).
Gomez-Nicola, Diego, Spagnolo, Alessandra, Guaza, Carmen and Nieto-Sampedro, Manuel (2010) Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice. Experimental Neurology, 222, (2), 235-242. (doi:10.1016/j.expneurol.2009.12.034). (PMID:20070942).
Gomez-Nicola, Diego, Valle-Argos, Beatriz and Nieto-Sampedro, Manuel (2010) Blockade of IL-15 activity inhibits microglial activation through the NFkappaB, p38, and ERK1/2 pathways, reducing cytokine and chemokine release. Glia, 58, (3), 264-276. (doi:10.1002/glia.20920). (PMID:19610094).
Gomez-Nicola, D., Valle-Argos, B., Suardíaz, M., Taylor, J.S. and Nieto-Sampedro, M. (2008) Role of IL-15 in spinal cord and sciatic nerve after chronic constriction injury: regulation of macrophage and T-cell infiltration. Journal of Neurochemistry, 107, (6), 1741-1752. (doi:10.1111/j.1471-4159.2008.05746.x). (PMID:19014377).
Gomez-Nicola, Diego, Valle-Argos, Beatriz, Pita-Thomas, D Wolfgang and Nieto-Sampedro, Manuel (2008) Interleukin 15 expression in the CNS: blockade of its activity prevents glial activation after an inflammatory injury. Glia, 56, (5), 494-505. (doi:10.1002/glia.20628). (PMID:18240307).
Gomez-Nicola, Diego, Doncel-Pérez, Ernesto and Nieto-Sampedro, Manuel (2006) Regulation by GD3 of the proinflammatory response of microglia mediated by interleukin-15. Journal of Neuroscience Research, 83, (5), 754-762. (doi:10.1002/jnr.20777). (PMID:16477650).

Book Section

Gomez-Nicola, Diego and Perry, V. Hugh (2014) Neurodegenerative diseases. In, Tremblay, Marie-Eve and Sierra, Amanda (eds.) Microglia in Health and Disease. New York, US, Springer , 437-453.

Conference or Workshop Item

Liang, Y., Riecken , K., Maslyukov, A., Gomez-Nicola, Diego, Kovalchuk, Y., Perry, V.H., Fehse, B. and Garaschuk, O. (2014) Multicolor in vivo single cell tracking reveals the dynamic behavior of olfactory adult-born neurons during the pre-integration phase. At 44th Meeting of the Society for Neuroscience (SfN), Washington, US, 15 - 19 Nov 2014.
Martinez-Muriana , A., Mancuso , R., Francos-Quijorna, I., Olmos-Alonso, Adrian, Navarro, X., Perry, V.H., Gomez-Nicola, Diego and Lopez-Vales, R. (2014) CSF1R contributes to microgliosis and disease progression in amyotrophic lateral sclerosis. At 9th FENS Forum of Neuroscience, Milano, IT, 05 - 09 Jul 2014.
Gomez-Nicola, Diego, Riecken, Kristoffer, Fehse, Boris and Perry, V. Hugh (2013) In vivo RGB marking and multicolour cell tracking in the adult brain. In, Neuroscience 2013. Meeting of the Society for Neuroscience (SfN), San Diego, US, 09 - 13 Nov 2013.
Gomez-Nicola, Diego, Fransen, Nina L., Suzzi, Stefano and Perry, V.H. (2013) Regulation of microglial proliferation during chronic neurodegneration. At XI European Meeting on Glial Cells in Health and Disease, Berlin, DE, 03 - 06 Jul 2013.
Gomez-Nicola, Diego, Suzzi, Stefano, Fransen, Nina L. and Perry, V.H. (2013) Regulation of neurogenesis in prion disease. At BNA 22nd Annual Meeting, London, GB, 25 - 30 Jun 2013.
Gomez-Nicola, Diego, Fransen, Nina L., Suzzi, Stefano and Perry, V. Hugh (2012) Dynamics and regulation of microglial proliferation in prion disease. At 8th Federation of European Neuroscience Societies (FENS) Forum of Neuroscience, Barcelona, ES, 14 - 18 Jul 2012. (Submitted).
Suzzi, Stefano, Weber, K, Fehse, B, Perry, V. Hugh and Gomez-Nicola, Diego (2012) Regulation of neurogenesis in prion disease. At 8th Federation of European Neuroscience Societies (FENS) Forum of Neuroscience, Barcelona, ES, 14 - 18 Jul 2012. (Submitted).
Gomez-Nicola, Diego, Fransen, Nina L., Suzzi, Stefano and Perry, V. Hugh (2012) Dynamics and regulation of microglial proliferation in prion disease. 10th European Congress of Neuropathology, Edinburgh, GB, 06 - 09 Jun 2012.
Gomez-Nicola, Diego and Perry, V. Hugh (2011) Regulation of neurogenesis in prion disease. At The Cambridge Neural Stem Cell Symposium, Cambridge, GB, 05 - 06 Sep 2011.
Gomez-Nicola, Diego and Perry, V. Hugh (2011) Dynamics of microglial proliferation in prion disease. At British Neuroscience Association 21st Biennial Meeting, Harrogate, GB, 17 - 20 Apr 2011.
 

Research

Research Interests

My research is focused in the understanding of the multicellular response of the CNS to injury or neurodegeneration, aiming at providing an integrative and detailed study of the functions and cross-regulation of the different cell components during neuropathology.
In the past I studied the role of proinflammatory cytokines in the regulation of the activation state of glial cells, in the context of brain inflammation, spinal cord injury, neuropathic pain or multiple sclerosis.
The goal of my current research is to study the regulation of microglial proliferation during chronic neurodegenerative diseases such as prion or Alzheimer's. The expansion of the microglial population is a hallmark of neurodegeneration and contributes to the development of the pathology. A detailed understanding of the molecules and mechanisms orchestrating microglial proliferation could open a window to elaborate therapeutic approaches to control the neuroinflammatory component of the disease.
Also, I am interested in the study of the dynamics and regulation of adult neurogenesis during neurodegeneration. Understanding of the basic mechanisms regulating the generation of new functional neurons could provide useful ways to improve functional recovery during chronic neurodegenerative diseases.

We thank the following funders for supporting our current projects:
Medical Research Council (MRC)
Alzheimer’s Research UK
Wessex Medical Research

Phd Supervision

Ahmed Salman (Faculty of Medicine)
Project Title: A study of the first transgenic model of infantile nystagmus (knockout-first, reporter driven Frmd7tm1a(KOMP)Wtsi mouse)
Funding Provider: Wessex Medical Research & Fight for Sight

Grants Awarded

MRC New Investigator Grant
ARUK Pilot Grant
Wessex Medical Research Innovation Grant

Overbooking in the Dentate Gyrus

Microglial cells (green) increase in number in the brain with chronic neurodegnerative diseases.

Overbooking in the Dentate Gyrus

Retroviral tracing-newborn neurons

Multicolour RGB marking of newborn neurons in the adult hippocampus

Retroviral tracing-newborn neurons

Primary research group:  Biomedical Sciences

Affiliate research group:  Southampton Neuroscience Group (SoNG)

Research projects

Control of adult neurogenesis during chronic neurodegeneration

Neurogenesis is increased during acute and chronic neurodegeneration, with the potential to replace damaged neurons at the sites of neuronal loss.

Inflammation in chronic neurodegeneration and the contribution of systemic inflammation

We are investigating the microglia activation in a model of prion disease, mouse scrapie.

Regulation of microglial proliferation during chronic neurodegeneration

An important aspect of chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's and prion disease, is the generation of an innate inflammatory response within the central nervous system (CNS).

Understanding oligodendrocyte progenitor dynamics and myelin loss in Alzheimer’s Disease

Oligodendrocyte progenitor cells (OPCs) may be altered in Alzheimer’s disease.

Teaching Responsibilities

Lecturer

BIOL3048 Neurodegenerative diseases

Tutor

BIOL2014 Neuroscience

Supervisor

BIOL3034 In-depth research project

Contributions

University of Southampton

SGH Lab Representative at Research Strategy Group, CfBS
SGH Lab Representative at Core Equipment and Service Contracts Group, CfBS

Professional Contributions

Reviewer for the Spanish National Agency for Evaluation of Projects (ANEP), the European Union, MS Society, Alzheimer’s Society and MRC.
Charter member of the Spanish Young Neuroscientists Club (CJN) of the SENC. 2009.
Spanish Glial Network: Member of the Board since 2011.
STEM Ambassador

Contact

Dr Diego Gomez-Nicola
CNS Inflammation Group
Centre for Biological Sciences
University of Southampton
Mail Point 840, LD80C
South Lab and Path Block
Southampton General Hospital
Tremona Road
Southampton
SO166YD
Tel: +44(0)23 8079 5358

Email: D.Gomez-Nicola@soton.ac.uk