DPhil, MSc, BSc
- Primary position:
- Career Track Lecturer
- Other positions:
- MRC NIRG Research Fellow
2013-2016: MRC NIRG Fellow. University of Southampton, UK.
2011-2013: Marie Curie Fellow (IEF FP7, European Union). CNS Inflammation Group, Centre for Biological Sciences, University of Southampton, UK.
2010-2011: Postdoctoral Fellow of the Spanish Ministry of Education. CNS Inflammation Group, School of Biological Sciences, University of Southampton, UK.
2008-2010: Postdoctoral researcher. Neural Plasticity Group, National Hospital of Paraplegics, Toledo, Spain.
2003-2008: PhD student. Neural Plasticity Group, Cajal Institute (CSIC), Madrid, Spain.
2008: PhD in Molecular biology (Neurosciences). Autonoma University of Madrid , Spain.
2005: MSci in Molecular biology (Neurosciences). Autonoma University of Madrid, Spain.
2003: BSci in Biological Sciences (Neurobiology). Complutense University of Madrid, Spain.
The University of Southampton's electronic library (e-prints)
Conference or Workshop Item
My research is focused in the understanding of the multicellular response of the CNS to injury or neurodegeneration, aiming at providing an integrative and detailed study of the functions and cross-regulation of the different cell components during neuropathology.
In the past I studied the role of proinflammatory cytokines in the regulation of the activation state of glial cells, in the context of brain inflammation, spinal cord injury, neuropathic pain or multiple sclerosis.
The goal of my current research is to study the regulation of microglial proliferation during chronic neurodegenerative diseases such as prion or Alzheimer's. The expansion of the microglial population is a hallmark of neurodegeneration and contributes to the development of the pathology. A detailed understanding of the molecules and mechanisms orchestrating microglial proliferation could open a window to elaborate therapeutic approaches to control the neuroinflammatory component of the disease.
Also, I am interested in the study of the dynamics and regulation of adult neurogenesis during neurodegeneration. Understanding of the basic mechanisms regulating the generation of new functional neurons could provide useful ways to improve functional recovery during chronic neurodegenerative diseases.
Ahmed Salman (Faculty of Medicine)
Project Title: A study of the first transgenic model of infantile nystagmus (knockout-first, reporter driven Frmd7tm1a(KOMP)Wtsi mouse)
Funding Provider: Wessex Medical Research & Fight for Sight
MRC New Investigator Grant
ARUK Pilot Grant
Wessex Medical Research Innovation Grant
Microglial cells (green) increase in number in the brain with chronic neurodegnerative diseases.
Multicolour RGB marking of newborn neurons in the adult hippocampus
Primary research group: Biomedical Sciences
Affiliate research group: Southampton Neuroscience Group (SoNG)
Neurogenesis is increased during acute and chronic neurodegeneration, with the potential to replace damaged neurons at the sites of neuronal loss.
We are investigating the microglia activation in a model of prion disease, mouse scrapie.
An important aspect of chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's and prion disease, is the generation of an innate inflammatory response within the central nervous system (CNS).
Oligodendrocyte progenitor cells (OPCs) may be altered in Alzheimer’s disease.
BIOL3048 Neurodegenerative diseases
BIOL3034 In-depth research project
University of Southampton
SGH Lab Representative at Research Strategy Group, CfBS
SGH Lab Representative at Core Equipment and Service Contracts Group, CfBS
Reviewer for the Spanish National Agency for Evaluation of Projects (ANEP), the European Union, MS Society, Alzheimer’s Society and MRC.
Charter member of the Spanish Young Neuroscientists Club (CJN) of the SENC. 2009.
Spanish Glial Network: Member of the Board since 2011.