Centre for Biological Sciences

Diego Gomez-Nicola

BSc, MSc, DPhil

Primary position:
MRC NIRG Research Fellow

Background

The University of Southampton

Academic qualifications

BSc, Complutense University (Madrid, Spain), 1998-2003
MSc, Autonoma University and Cajal Institute (Madrid, Spain), 2003-2005
PhD, Autonoma University and Cajal Institute (Madrid, Spain), 2005-2008

Work history

Postdoctoral Research Fellow, National Hospital of Paraplegics (Toledo, Spain), 2008-2010
Postdoctoral Research Fellow of the Spanish Ministry of Science, CNS Inflammation Group, University of Southampton, 2010-2011
Marie Curie Fellow (EU), CNS Inflammation Group, University of Southampton, 2011-2013
MRC NIRG Research Fellow, CNS Inflammation Group, University of Southampton, 2013-present

Dr Diego Gomez-Nicola's photo

Publications

The University of Southampton's electronic library (e-prints)

Article

Gómez-Nicola, Diego, Suzzi, Stefano, Vargas-Caballero, Mariana, Fransen, Nina L., Al-Malki, Hussain, Cebrian-silla, A., García-verdugo , Jm, Riecken, K., Fehse, B. and Perry, V. Hugh (2014) Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration. Brain (doi:10.1093/brain/awu155). (PMID: 24941947).
Gomez-Nicola, Diego, Schetters, Sjoerd and Perry, V.H. (2014) Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease. Glia (doi:10.1002/glia.22660). (PMID:24648328).
Gomez-Nicola, Diego, Teeling, Jessica L., Guaza, C., Godbout, J.P. and Taub, D.D. (2013) The role of inflammatory mediators in immune-to-brain communication during health and disease. Mediators of Inflammation, 2013, 1-3. (doi:10.1155/2013/429231). (PMID:24109163).
Gómez-Nicola, Diego, Fransen, Nina L., Suzzi, Stefano and Perry, V Hugh (2013) Regulation of microglial proliferation during chronic neurodegeneration. The Journal of Neuroscience, 33, (6), 2481-2493. (doi:10.1523/JNEUROSCI.4440-12.2013 ). (PMID:23392676).
Burgos, Elisa, Gomez-Nicola, Diego, Pascual, David, Martín, María Isabel, Nieto-Sampedro, Manuel and Goicoechea, Carlos (2012) Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells. European Journal of Pharmacology (doi:10.1016/j.ejphar.2012.02.008). (PMID:22374260).
Gomez-Nicola, Diego, Valle-Argos, Beatriz, Pallas-Bazarra, Noemí and Nieto-Sampedro, Manuel (2011) Interleukin-15 regulates proliferation and self-renewal of adult neural stem cells. Molecular Biology of the Cell, 22, (12), 1960-1970. (doi:10.1091/mbc.E11-01-0053). (PMID:21508317).
Valle-Argos, Beatriz, Gomez-Nicola, Diego and Nieto-Sampedro, Manuel (2011) Neurostatin blocks glioma cell cycle progression by inhibiting EGFR activation. Molecular and Cellular Neuroscience, 46, (1), 89-100. (doi:10.1016/j.mcn.2010.08.009). (PMID:20801220).
Nieto-Sampedro, Manuel, Valle-Argos, Beatriz, Gómez-Nicola, Diego, Fernández-Mayoralas, Alfonso and Nieto-Díaz, Manuel (2011) Inhibitors of glioma growth that reveal the tumour to the immune system. Clinical Medicine Insights Oncology, 5, 265-314. (doi:10.4137/CMO.S7685). (PMID:22084619).
Valle-Argos, Beatriz, Gomez-Nicola, Diego and Nieto-Sampedro, Manuel (2010) Glioma growth inhibition by neurostatin and O-But GD1b. Neuro-Oncology, 12, (11), 1135-1146. (doi:10.1093/neuonc/noq073). (PMID:20615925).
Gomez-Nicola, Diego, Pallas-Bazarra, Noemí, Valle-Argos, Beatriz and Nieto-Sampedro, Manuel (2010) CCR7 is expressed in astrocytes and upregulated after an inflammatory injury. Journal of Neuroimmunology, 227, (1-2), 87-92. (doi:10.1016/j.jneuroim.2010.06.018). (PMID:20638137).
Valle-Argos, Beatriz, Gomez-Nicola, Diego and Nieto-Sampedro, Manuel (2010) Synthesis and characterization of neurostatin-related compounds with high inhibitory activity of glioma growth. European Journal of Medicinal Chemistry, 45, (5), 2034-2043. (doi:10.1016/j.ejmech.2010.01.015). (PMID:20153569).
Gomez-Nicola, Diego, Spagnolo, Alessandra, Guaza, Carmen and Nieto-Sampedro, Manuel (2010) Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice. Experimental Neurology, 222, (2), 235-242. (doi:10.1016/j.expneurol.2009.12.034). (PMID:20070942).
Gomez-Nicola, Diego, Valle-Argos, Beatriz and Nieto-Sampedro, Manuel (2010) Blockade of IL-15 activity inhibits microglial activation through the NFkappaB, p38, and ERK1/2 pathways, reducing cytokine and chemokine release. Glia, 58, (3), 264-276. (doi:10.1002/glia.20920). (PMID:19610094).
Gomez-Nicola, D., Valle-Argos, B., Suardíaz, M., Taylor, J.S. and Nieto-Sampedro, M. (2008) Role of IL-15 in spinal cord and sciatic nerve after chronic constriction injury: regulation of macrophage and T-cell infiltration. Journal of Neurochemistry, 107, (6), 1741-1752. (doi:10.1111/j.1471-4159.2008.05746.x). (PMID:19014377).
Gomez-Nicola, Diego, Valle-Argos, Beatriz, Pita-Thomas, D Wolfgang and Nieto-Sampedro, Manuel (2008) Interleukin 15 expression in the CNS: blockade of its activity prevents glial activation after an inflammatory injury. Glia, 56, (5), 494-505. (doi:10.1002/glia.20628). (PMID:18240307).
Gomez-Nicola, Diego, Doncel-Pérez, Ernesto and Nieto-Sampedro, Manuel (2006) Regulation by GD3 of the proinflammatory response of microglia mediated by interleukin-15. Journal of Neuroscience Research, 83, (5), 754-762. (doi:10.1002/jnr.20777). (PMID:16477650).

Conference or Workshop Item

Gomez-Nicola, Diego, Riecken, Kristoffer, Fehse, Boris and Perry, V. Hugh (2013) In vivo RGB marking and multicolour cell tracking in the adult brain. In, Neuroscience 2013. Meeting of the Society for Neuroscience (SfN), San Diego, US, 09 - 13 Nov 2013.
Gomez-Nicola, Diego, Fransen, Nina L., Suzzi, Stefano and Perry, V.H. (2013) Regulation of microglial proliferation during chronic neurodegneration. At XI European Meeting on Glial Cells in Health and Disease, Berlin, DE, 03 - 06 Jul 2013.
Gomez-Nicola, Diego, Suzzi, Stefano, Fransen, Nina L. and Perry, V.H. (2013) Regulation of neurogenesis in prion disease. At BNA 22nd Annual Meeting, London, GB, 25 - 30 Jun 2013.
Gomez-Nicola, Diego, Fransen, Nina L., Suzzi, Stefano and Perry, V. Hugh (2012) Dynamics and regulation of microglial proliferation in prion disease. At 8th Federation of European Neuroscience Societies (FENS) Forum of Neuroscience, Barcelona, ES, 14 - 18 Jul 2012. (Submitted).
Suzzi, Stefano, Weber, K, Fehse, B, Perry, V. Hugh and Gomez-Nicola, Diego (2012) Regulation of neurogenesis in prion disease. At 8th Federation of European Neuroscience Societies (FENS) Forum of Neuroscience, Barcelona, ES, 14 - 18 Jul 2012. (Submitted).
Gomez-Nicola, Diego, Fransen, Nina L., Suzzi, Stefano and Perry, V. Hugh (2012) Dynamics and regulation of microglial proliferation in prion disease. 10th European Congress of Neuropathology, Edinburgh, GB, 06 - 09 Jun 2012.
Gomez-Nicola, Diego and Perry, V. Hugh (2011) Regulation of neurogenesis in prion disease. At The Cambridge Neural Stem Cell Symposium, Cambridge, GB, 05 - 06 Sep 2011.
Gomez-Nicola, Diego and Perry, V. Hugh (2011) Dynamics of microglial proliferation in prion disease. At British Neuroscience Association 21st Biennial Meeting, Harrogate, GB, 17 - 20 Apr 2011.
 

Research

Research Interests

My research is focused in the understanding of the multicellular response of the CNS to injury or neurodegeneration, aiming at providing an integrative and detailed study of the functions and cross-regulation of the different cell components during neuropathology.

In the past I studied the role of proinflammatory cytokines in the regulation of the activation state of glial cells, in the context of brain inflammation, spinal cord injury, neuropathic pain or multiple sclerosis.

The goal of my current research is to study the regulation of microglial proliferation during chronic neurodegenerative diseases such as prion or Alzheimer's. The expansion of the microglial population is a hallmark of neurodegeneration and contributes to the development of the pathology. A detailed understanding of the molecules and mechanisms orchestrating microglial proliferation could open a window to elaborate therapeutic approaches to control the neuroinflammatory component of the disease.

Also, I am interested in the study of the dynamics and regulation of adult neurogenesis during neurodegeneration. Understanding of the basic mechanisms regulating the generation of new functional neurons could provide useful ways to improve functional recovery during chronic neurodegenerative diseases.

Member of: Spanish Glial Network (RGE),  Spanish Society for Neuroscience (SENC).

Primary research group:  Biomedical Sciences

Affiliate research group:  Southampton Neuroscience Group (SoNG)

Research projects

Inflammation in chronic neurodegeneration and the contribution of systemic inflammation

We are investigating the microglia activation in a model of prion disease, mouse scrapie.

Regulation of microglial proliferation during chronic neurodegeneration

An important aspect of chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's and prion disease, is the generation of an innate inflammatory response within the central nervous system (CNS).

Control of adult neurogenesis during chronic neurodegeneration

Neurogenesis is increased during acute and chronic neurodegeneration, with the potential to replace damaged neurons at the sites of neuronal loss.

Responsibilities

  • Reviewer for the Spanish National Agency for Evaluation of Projects (ANEP) and the European Union.
  • Charter member of the Spanish Young Neuroscientists Club (CJN) of the SENC. 2009.
  • Spanish Glial Network: Member of the Board since 2011.
  • STEM Ambassador
  • Recently awarded grants:
    • MRC New Investigator Research Grant (NIRG) 2013-2016 "Regulation of microglial proliferation and its contribution to chronic neurodegeneration"
    • ARUK Pilot Grant 2012-2014 "Regulation of microglial proliferation in Alzheimer Disease"

Contributions

  • Charter member of the Spanish Young Neuroscientists Club (CJN) of the SENC. 2009
  • Spanish Glial Network: Member of the Board since 2011

Contact

Dr Diego Gomez-Nicola
CNS Inflammation Group
Centre for Biological Sciences
University of Southampton
Mail Point 840, LD80C
South Lab and Path Block
Southampton General Hospital
Tremona Road
Southampton
SO166YD
Tel: +44(0)23 8079 5358

Email: D.Gomez-Nicola@soton.ac.uk