BSc, MSc, DPhil
- Primary position:
- MRC NIRG Research Fellow
2013-present: MRC NIRG Research Fellow, CNS Inflammation Group, University of Southampton, UK.
2011-2013: Marie Curie Fellow (EU). CNS Inflammation Group, University of Southampton, UK.
2010-2011: Postdoctoral Research Fellow. Spanish Ministry of Science, CNS Inflammation Group, University of Southampton, UK.
2008-2010: Postdoctoral Research Fellow. National Hospital of Paraplegics, Toledo, Spain.
2005-2008: PhD. Autonoma University and Cajal Institute, Madrid, Spain.
2003-2005: MSc. Autonoma University and Cajal Institute, Madrid, Spain.
1998-2003: BSc. Complutense University, Madrid, Spain.
The University of Southampton's electronic library (e-prints)
Conference or Workshop Item
My research is focused in the understanding of the multicellular response of the CNS to injury or neurodegeneration, aiming at providing an integrative and detailed study of the functions and cross-regulation of the different cell components during neuropathology.
In the past I studied the role of proinflammatory cytokines in the regulation of the activation state of glial cells, in the context of brain inflammation, spinal cord injury, neuropathic pain or multiple sclerosis.
The goal of my current research is to study the regulation of microglial proliferation during chronic neurodegenerative diseases such as prion or Alzheimer's. The expansion of the microglial population is a hallmark of neurodegeneration and contributes to the development of the pathology. A detailed understanding of the molecules and mechanisms orchestrating microglial proliferation could open a window to elaborate therapeutic approaches to control the neuroinflammatory component of the disease.
Also, I am interested in the study of the dynamics and regulation of adult neurogenesis during neurodegeneration. Understanding of the basic mechanisms regulating the generation of new functional neurons could provide useful ways to improve functional recovery during chronic neurodegenerative diseases.
Primary research group: Biomedical Sciences
Affiliate research group: Southampton Neuroscience Group (SoNG)
We are investigating the microglia activation in a model of prion disease, mouse scrapie.
An important aspect of chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's and prion disease, is the generation of an innate inflammatory response within the central nervous system (CNS).
Neurogenesis is increased during acute and chronic neurodegeneration, with the potential to replace damaged neurons at the sites of neuronal loss.
Oligodendrocyte progenitor cells (OPCs) may be altered in Alzheimer’s disease.
Reviewer for the Spanish National Agency for Evaluation of Projects (ANEP) and the European Union.
2009-present: Charter member of the Spanish Young Neuroscientists Club (CJN) of the SENC.
2011-present: Spanish Glial Network: Member of the Board.
Recently awarded grants
2013-2016: MRC New Investigator Research Grant (NIRG) "Regulation of microglial proliferation and its contribution to chronic neurodegeneration".
2012-2014: ARUK Pilot Grant "Regulation of microglial proliferation in Alzheimer Disease".