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Centre for Biological Sciences

Research Group: Molecular and Cellular Biosciences

Currently Active: 

Our Molecular and Cellular Biosciences Research Group seeks to understand the fundamental cellular and molecular mechanisms that underpin basic biological processes. These include: the structures and interactions of biological molecules; the signals between and within cells; the mechanisms by which cells become specialised and respond to the environment; and understanding how cellular/molecular processes relate to health and disease.

Group Overview

The Cellular and Molecular Biosciences staff pursue a range of externally-funded projects within five broad research themes: the molecular organisation of proteins and nucleic acids; developmental biology and its influence on adult health and disease; cell signalling pathways controlling gene expression, cell growth and cell division; plant growth and environmental interactions; membrane proteins and cellular function.

We collaborate closely with researchers across the University and with investigators around the world. For example, we work with physical scientists and engineers to investigate biomolecules as substrates for the production of novel materials and our joint projects with staff in Medicine aim to understand the origins of disease.

Within the School of Biological Sciences, we have a wealth of modern facilities. We are well equipped for structural (X-ray and NMR) and biophysical studies of proteins and nucleic acids and have a superb Proteomics facility which includes a range of state-of-the-art mass spectrometers. The Bioimaging Facility comprises a range of modern microscopes including confocal and multiphoton instruments, allowing the use of Fluorescence Correlation Spectroscopy techniques.

We are housed within the new, purpose-built Life Sciences Building on the University's Highfield campus and at the Southampton General Hospital campus.

Molecular and Cellular Biosciences Principal Investigators (PI)

Dr Mark Coldwell: PI Cellular and molecular biosciences
Dr Katrin Deinhardt: PI Cellular Neurobiology
Professor Malcolm East: PI Membrane proteins
Professor Keith Fox: PI Nucleic Acids
Dr Haruko Okamoto: PI Plant Molecular Genetics & Biochemistry
Dr Paul Skipp: PI Proteomics
Dr Ivo Tews: PI Protein interactions & cell membranes
Dr Jeremy Webb: PI Microbial biofilms
Dr Joern Werner: PI Protein-ligand interactions
Dr Herman Wijnen Associate Professor: PI Biological timing
Dr Phil Williamson: PI Structural biology and biological membranes
Dr Lorraine Williams: PI Membrane transporters

Postgraduate opportunities

If you are interested in joining us either to study or to become part of our research team please select the relevant link below for further information.

Funded PhD Opportunities

Current job vacancies at the University of Southampton 

Research Staff

Staff MemberPrimary Position
Ilectra AdamResearch Fellow (post-doctoral research associate)
Muhammad AkhtarEmeritus Professor
Mohammed AlsulamiPostgraduate Research Student in Biochemistry
Chris AnthonyEmeritus Professor
Akanksha BafnaResearch Fellow in Biological Timing
Matthew BellamyTeaching Fellow
Mary BetonPostgraduate Research Student
Ahmad Zulhilmi Bin NazriPostgraduate Research Student In Plant Molecular Biology
Dominic BurgResearch Fellow
Dominic BurgResearch Fellow
John ButlerResearch Fellow in Molecular Biology
Yuming CaiPostgraduate research student in Centre for Biological Science, Faculty of Natural and Environmental Science
Alison CaldwellPostgraduate research student in biological sciences
Michael LJ CarterPostgraduate Research Student in Biochemistry
Mark J ColdwellAssociate Professor
Joanne CowanBBSRC Research Fellow in Molecular Cell Biology
Katrin DeinhardtLecturer in Neuroscience
James DillonTeaching Fellow
Nullin DivechaAssociate Professor
Adam DoreyPostgraduate Research Student in Biological Sciences
Declan A DoyleLecturer in Molecular mechanisms and molecular medicine
Malcolm EastProfessor in Biochemistry
Richard J EdwardsAssociate Professor in Biological Sciences
James A EdwardsPostgraduate Research Student - Detection of Modified Cytosine Residues in DNA
Luke S EvansPostgraduate Research Student
Nicholas EvensPostgraduate Research Student in Centre for Biological Sciences
Rob M EwingAssociate Professor in Proteomics and Systems Biology
Shulan FengResearch Technician: Centre for Proteomic Research
Keith R FoxProfessor of Biochemistry
Tania Garcia BecerraResearch Technician (Plant Biology)
Annalisa GastaldelloResearch Fellow in Immunoproteomics
Jane GibsonLecturer in Bioinformatics
Alexander HullPostgraduate Research Student In Biological Sciences
Andrew HutchinPostgraduate Research Student in Structural Biology
Sylwia KacprzakPostgraduate Research Student in Plant Biology
Anthony LeeEmeritus Professor of Biochemistry
Helen LewisResearch Fellow
Moritz MachelettPostgraduate Research Student in Biological Sciences
Halina MikolajekResearch Fellow in X-ray Crystallography and NMR
Karolina MirowskaPostgraduate Research Student in Biological Sciences
Amritpal MudherAssociate Professor in Neurosciences
Flora J.M O'BrienPostgraduate Research Student in Biological Sciences
Vincent O'ConnorProfessor of Neurochemistry
Haruko OkamotoLecturer
Mike PageResearch Fellow
Erika ParkinsonResearch Fellow in Proteomics
Helen PatrickPostgraduate Research Student in Molecular and Cellular Biosciences
Chrysia-Maria PegasiouPostgraduate Research Student in Biological Sciences
Curtis PhippenPostgraduate Research Student in Structural Biology
Chris G. ProudProfessor of Cellular Regulation
Miguel Ramírez MorenoPostgraduate Research Student in Biological Sciences
Matthew RodriguesPostgraduate research student in structural biology
David A RuslingLecturer in Pharmacology
David RuslingResearch Fellow
Ibrahim SayohPostgraduate Research Student in Biological Sciences
Thomas SeckerProject Technician Environmental Health
Zahid ShahResearch Fellow
Peter Shoolingin-Jordan Emeritus Professor
Ben SibbettPostgraduate Research Student in Plant Molecular Biology
Hannah V SiddleLecturer in Molecular Biology
Hazel Katherine Smith WATBIO Research Fellow
Roshan SoodBioinformatics
Yvette Stijf-BultsmaResearch Assistant
Rahul TareLecturer
Matthew J TerryProfessor of Molecular Plant Biology
Ivo TewsLecturer in Structural Biology
David TumbarelloLecturer in Biomedical Sciences
Billy M ValdesProject Technician: Plant Molecular Genetics
Mariana Vargas-CaballeroResearch Career Track Lecturer, Institute for Life Sciences
Jeremy S WebbProfessor of Microbiology
Joern WernerReader in Structural Biology
Herman WijnenAssociate Professor in Biological Sciences
Lorraine E WilliamsAssociate Professor in Plant Biology
Philip WilliamsonLecturer
David C WiltonEmeritus Professor
Nancy WongPostgraduate Research Student in Molecular and Cellular Biosciences
Noel WorthamResearch Fellow in Molecular Biology
Benjamin YarnallPostgraduate research student in structural biology

Related Projects

Related ProjectsStatusType
DNA sequence recognition by triple helix formationActive
Calcium Pumps and ThermogenesisActive
Grant - Charting Intercellular SpaceActive
Integrated in silico prediction of protein-protein interaction motifsActive
Genetic diversification in a multi-species bacterial biofilm communityActive
Understanding the role of lipid-protein interactions in the intracellular localisation of proteins and its role in muscular dystrophy. Active
Extending the boundaries of nucleic acid chemistryActive
Antimicrobial copper: Biocidal efficacy and killing mechanism of copper and copper alloy dry surfaces against bacterial and viral pathogensActive
Plastid-to-nucleus signalling in plantsActive
Epigenetic mechanisms in metabolic bone disease: from pathology to biomarkerActive
Effect of folic acid supplementation during the life course on cancer susceptibilityActive
Structure and Function of Membrane ProteinsActive
Calcium Pump TargetingActive
Environmental Healthcare Unit ConsultancyActive
Development of novel methods to assess the viability and infectivity of pathogens in biofilms found in drinking water supply systems.Active
Role of membrane transporters in light-regulated seedling developmentActive
Improving solar conversion efficiency in marine microalgaeActive
Epigenetic mechanisms and the developmental origins of health and diseaseActive
Rapid assessment of surface contamination and decontamination efficacyActive
Development of endoscope decontamination proceduresActive
Circadian Developmental RequirementsActive
Identification of novel crustacean pathogen receptor proteinsActive
Differentiation therapy and cancerActive
Physiological role of sucrose and amino acid permeases in higher plants Active
Characterisation of glycosyltransferases functioning during the synthesis of the secondary cell wall hemicellulose glucuronoxylanActive
Biofouling control for in-situ lab-on-a-chip environmental sensorsActive
Roles of the Mnks (MAP kinase-activated protein kinases) in cell physiology Active
Anionic lipids in cell signalling: a mechanism for the modulation of ABC multidrug transportersActive
Light regulation of chloroplast development and tetrapyrrole synthesisActive
DNA quadruplexes and their interaction with ligandsActive
Dispersal of Biofilm in Cystic Fibrosis using Low Dose Nitric OxideActive
Structure, function and regulation of eukaryotic initiation factor eIF2B Active
Identification of perinatal epigenetic markers of later phenotypeActive
Temperature entrainment of the molecular circadian clock circuits in DrosophilaActive
Interactome-wide prediction of short linear protein interaction motifs in humansActive
Consequences of early embryo environmentActive
Role of Pax-3 in sensory neurogenesisActive
Calcium ATPases - role in calcium homeostasis and signallingActive
Understanding the role of serum amyloid-P component in the stabilization of amyloid depositsActive
Structure, function and regulation of eukaryotic elongation factor 2 kinase (eEF2K)Active
Modifying Uracil DNA GlycosylaseActive
Light regulation of amino acid uptake in marine cyanobacteriaActive
Transcriptome-wide prediction of eukaryotic translation initiationActive
BioliSME II: Demonstration, validation and preliminary promotion of a commercial prototype speedy system for sampling and detecting Listeria monocytogenesActive
Global transcriptomic responses to parasitismActive
Label-free spectroscopy for diagnosing and monitoring ADActive
Control of Drosophila circadian behaviour by the RHO1-signalling pathwayActive
Dissecting pathways involved in Manganese homeostasis and stress in higher plant cellsActive
Maternal mechanisms induced by diet regulating embryo developmental plasticity affecting life-long healthActive Other
DNA sequence recognition by small moleculesActive
Physiological role of sucrose and amino acid permeases in higher plantsActive
SecurEau – Security and decontamination of drinking water distribution systems following a deliberate contamination event.Active
Cold Atmospheric Plasma (CAP) for the decontamination of reusable surgical instrumentsActive
The role of nitric oxide in the control of biofilm and zoonotic pathogen colonisation of the salad phylloplaneActive
Structural basis of the elongation factor 2 kinase (EF2K) activation by Calcium/CalmodulinActive
Regulation of ribosome biogenesisActive
Molecular mechanisms controlling heart cells proteins synthesis and cardiac hypertrophyActive
Investigating the role of membranes on protein aggregation and neurotoxicity of the huntingtin protein.Active
Modifying nucleic acid nanostructures by triplex formationActive
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