- Primary position:
- Reader in Chemical Biology
Ali is a Reader in chemical biology, jointly appointed in Chemistry and the Cancer Sciences division of the Faculty of Medicine. He is the recipient of a Career Establishment Award from Cancer Research UK, and the European Association for Chemical and Molecular Sciences' medal for European Young Chemist.
Ali is currently Chair of the RSC's "Chemical Biology and Bioorganic Group", and an elected member of the RSC's "Chemistry and Biology Interface Division" council.
Prior to this, he was a postdoctoral fellow in Prof. Stephen Benkovic’s laboratory at Penn State University. Whilst in the States he worked on a variety of projects, developing several new technologies and methodologies.
Ali started his scientific career studying Chemistry at the University of Bristol. After obtaining his PhD from Professor Joe Sweeney’s group at Reading University, he joined Professor Douglas Young at the University of Sussex as a postdoctoral fellow, studying the mechanism of Homocitrate Synthase.
The University of Southampton's electronic library (e-prints)
We are interested in the study and selective modulation of medically relevant protein networks. Our aim is to combat diseases such as cancer and HIV on a genetic level with molecules that selectively disrupt protein-protein interactions that are vital for the disease state. Through our collaborative efforts with several groups here at the University of Southampton, and around the world, we are developing compounds that tackle diseases in a novel way.
We are also interested in the field of Synthetic Biology. There are several projects currently underway in our labs, aiming to reprogram cellular behaviour through introduction of non-native genes and reconfiguration of proteinnetworks. We are also active in developing new approaches to de novo construction of synthetic genomes and non-natural molecules that behave analogously to their counterparts in living systems.
Primary research group: Molecular Diagnostics and Therapeutics