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Professor Bruno J Linclau 

Professor of Organic Chemistry, Head of Organic Chemistry: Synthesis, Catalysis and Flow

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Professor Bruno Linclau was appointed into his current position in August 2015 as Professor of Organic Chemistry. He is Head of the Organic Chemistry: Synthesis, Catalysis and Flow Section.




Bruno Linclau graduated from the University of Ghent, Belgium in 1992. His undergraduate thesis was carried out at Leicester University as an ERASMUS exchange student with Dr P R Jenkins during his final year. Back in Ghent, he joined the group of Professor M Vandewalle for his PhD (1992 - 1996, funded by the Belgian "National Fund of Scientific Research"), where he completed the total synthesis of several Vitamin D analogues. This was followed by a postdoctoral stay with Professor D P Curran in Pittsburgh PA (USA) (1997 - 1999), with a fellowship from the "Belgian American Educational Foundation" and from the University of Pittsburgh. There he worked on fluorous chemistry applications in combinatorial chemistry and developed a fluorous scavenger approach illustrated with automated solution phase parallel synthesis of urea libraries. He joined the Chemistry at Southampton University as a lecturer in August 1999, followed by a promotion to Senior Lecturer in 2005, to Reader in 2013, and to Professor in 2015. He is Head of the Organic Chemistry Section.

Most current research projects involve organofluorine chemistry, with a focus on investigating how fluorination of organic compounds can modify their physical properties, such as hydrogen bonding, lipophilicity and conformation. We have a particular focus on fluorinated carbohydrates, but are also working with fluorinated glycolipids and steroids.

Another strand of research involves the development of synthetic methodology and its application in the total synthesis of natural products. Currently we are exploring methodology towards the synthesis of quaternary stereocentres, and its application in the synthesis of the angiogenesis inhibitor luminacin D.

He is a member of the Royal Society of Chemistry (RSC) Carbohydrate Subject Group Committee, and of the RSC Fluorine Subject Group Committee. He is also a regular member of the American Chemical Society (ACS), and of the Society of Chemistry and Industry (SCI).










Research interests

We are working in the field of synthetic organic chemistry. Projects often involve the development of new methodology with application in the total synthesis of natural products and analogues, or for the synthesis of compounds of biological interest. We are also interested in carbohydrate and organofluorine chemistry, and in the development of immobilised reagents for use in parallel synthesis.

Research group(s)

Organic Chemistry: Synthesis, Catalysis and Flow

Research project(s)

Linclau: Total synthesis of natural products and analogues

Innovative Synthesis, Culture and Entrepreneurship in Chemistry (ISCE-Chem)

Linclau: Synthesis of tetrafluorinated carbohydrates

Linclau: The synthesis HIV protease inhibitors

Linclau: The synthesis of carbasugars and carbanucleosides

Linclau: The synthesis of glycosylceramide analogues

Linclau: The development of solid-supported reagents

Key Publication(s)


Professor Bruno J Linclau
Chemistry University of Southampton Highfield Southampton SO17 1BJ

Room Number: 30/3036

Telephone: (023) 8059 3816

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