CHEM6109 Advanced Bioorganic Chemistry
Aims and Objectives
1. Carbohydrates Aims: To understand: 1) What glycobiology is. 2) Why is carbohydrate chemistry important in the progress of glycobiology. 3) Tools of the trade in carbohydrate chemistry 2. Protein-protein interactions (PPI) Aims: To understand: 1) The role of of PPI in cell biology. 2) The potential of PPI as therapeutic targets. 3) The landscape of current PPI inhibitors. 4) Methods used to identify PPI inhibitors. 5) Methods used to verify and quantify the activity of PPI inhibitors.
Having successfully completed this module you will be able to:
- Tell the role of carbohydrate chemistry in glycobiology.
- Design the synthesis of a trisaccharide.
- Apply methodology to devise synthesis of other oligosaccharides.
- Explain the potential for targeting PPIs for therapy, with specific examples.
- Discuss the merits and disadvantages of the various methods for identifying PPI inhibitors.
- Explain what methods should be used to characterise a given PPI inhibitor.
The syllabus, which is described in outline below, is aligned with the following QAA benchmark statements for chemistry at FHEQ Level 7 (Masters). • to extend students' comprehension of key chemical concepts and so provide them with an in-depth understanding of specialised areas of chemistry; • to develop in students the ability to adapt and apply methodology to the solution of unfamiliar types of problems; • to instill a critical awareness of advances at the forefront of the chemical science discipline; • to prepare students effectively for professional employment or doctoral studies in the chemical sciences; • the ability to adapt and apply methodology to the solution of unfamiliar problems; • knowledge base extends to a systematic understanding and critical awareness of topics which are informed by the forefront of the discipline; • problems of an unfamiliar nature are tackled with appropriate methodology and taking into account the possible absence of complete data. The module will provide an overview two rapidly advancing areas of bioorganic chemistry. It will include a brief overview of key concepts and include in depth analysis of the most recent developments in carbohydrate chemistry and therapeutic applications of peptides. Content will be varied to include the most modern scientific developments, but typically will include: • Introduction to carbohydrate chemistry • Modern methods of carbohydrate synthesis • Glycobiology and biochemistry • Protein-protein interaction inhibitors
Learning and Teaching
Teaching and learning methods
Teaching methods: Lectures, workshops, directed reading, Bb online support. Learning methods: Independent study, student motivated peer group study, student driven tutor support
|Preparation for scheduled sessions||20|
|Practical classes and workshops||4|
|Total study time||75|
Resources & Reading list
B. G. Davies and A .J. Fairbanks. Carbohydrate Chemistry.
|Examination (1 hours)||100%|
|Examination (1 hours)||100%|
Pre-requisites: CHEM3038 or CHEM6095.