Engineering and the Environment

Dyan Ankrett

PhD

Primary position:
Research Fellow

Background

The University of Southampton

Dyan Ankrett is research associate within Engineering Sciences at University of Southampton. Her current roll is multidisciplinary, combining cell biology with ultrasonic technology in microfluidic devices, with particular focus on drug delivery.

She obtained a BSc (Hons) degree in Biomedical Science (2003) and a PhD in Cancer Drug Discovery and Metabolism (2008), both wards were obtained from De Montfort University in Leicestershire, UK. Her first post-doctoral position was within the Cancer Drug Discovery Group at De Montfort University (2008-2010) involving in vitro screening of novel anticancer agents using state-of-the-art mass spectrometry.

Dyan combined her biological skills with ultrasonic technology and proposed research project that was awarded funding by Agilent Technologies. Dyan is continuing her collaboration with Agilent.

Dr Dyan Ankrett's photo

Publications

The University of Southampton's electronic library (e-prints)

Article

Ankrett, Dyan N., Carugo, Dario, Lei, Junjun, Glynne-Jones, Peter, Townsend, Paul A., Zhang, Xunli and Hill, Martyn (2013) The effect of ultrasound-related stimuli on cell viability in microfluidic channels. Journal of Nanobiotechnology, 11, (20), 1-5. (doi:10.1186/1477-3155-11-20).
Carugo, Dario, Ankrett, Dyan N., O'Byrne, Vincent, Willis, Sean, Wright, David, Lewis, Andrew, Hill, Martyn and Zhang, Xunli (2013) A novel biomimetic analysis system for quantitative characterisation of sclerosing foams used for the treatment of varicose veins. Journal of Materials Science Materials in Medicine, 24, (6), 1417-1423. (doi:10.1007/s10856-013-4913-6). (PMID:23512153).
Roumeliotis, Theodoros, Halabalaki, Maria, Alexi, Xanthippi, Ankrett, Dyan N., Giannopoulou, Eugenia G., Skaltsounis, Alexios-Leandros , Sayan, B.S., Alexis, Michael N., Townsend, Paul A. and Garbis, Spiros D. (2013) Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: the quantitative and temporal interrogation of chemically induced cell death at the protein level. Journal of Proteome Research, 12, (4), 1591-1603. (doi:10.1021/pr300968q). (PMID:23418717).
Rosser, Matthew D., Haris, Parves I., Ankrett, Dyan N. and Konje, Justin C. (2011) The emerging role of epigenetics and miRNAs in endometriosis. Expert Review of Obstetrics & Gynecology, 6, (4), 431-450. (doi:10.1586/eog.11.32).
Carugo, Dario, Ankrett, Dyan N., Glynne-Jones, Peter, Capretto, Lorenzo, Boltryk, Rosemary J., Zhang, Xunli, Townsend, Paul A. and Hill, Martyn (2011) Contrast agent-free sonoporation: the use of an ultrasonic standing wave microfluidic system for the delivery of pharmaceutical agents. Biomicrofluidics, 5, (4), 044108-[15pp]. (doi:10.1063/1.3660352).

Conference or Workshop Item

Carugo, Dario, Ankrett, Dyan N., Glynne-Jones, Peter, Capretto, Lorenzo, Boltryk, Rosemary J., Townsend, Paul A., Zhang, Xunli and Hill, Martyn (2011) Contrast agent-free cell sonoporation using a continuous-flow microfluidic device. In, The 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS ), Seattle, US, 02 Oct 2011 - 06 Oct 2012 .
Glynne-Jones, Peter, Mishra, Puja, Ankrett, Dyan, Boltryk, Rosemary J., Riehle, Mathis and Hill, Martyn (2011) Practical design of devices for cell sorting and characterisation. In, ICU 2011: International Congress on Ultrasonics , 05 - 08 Sep 2011.
 

Research

Research Interests

Dyan’s current research interests lie in utilising ultrasonic waves to create transient pores in biological membranes, a phenomenon known as sonoporation. Sonoporation is a very useful biophysical stimulus for facilitating the intracellular delivery of therapeutic agents. Dyan is particularly interested in exploiting sonoporation for facilitating the delivery of dietary flavonoids, which are widely known to possess many health benefits.

On-going research projects

Ultrasonic streaming
Ultrasonically generated high velocity fluid flow vortices around cardiac cells to controllably induce cell stress, mimicking myocardial infarction, ischaemia and cell death

Tissue engineering
Acoustic manipulation of biological cells to assemble multi-layered structures of heterogeneous cell types

Ultrasonic concentration of waterborne bacteria
Acoustic manipulation of bacteria in a microfluidic device

Primary research group:  Electro-Mechanical Engineering

Contact

Dr Dyan Ankrett
Engineering and the Environment
University of Southampton
Highfield
Southampton
SO17 1BJ
Tel: +44 (0) 2380592994 (Laboratory)
+44 (0) 2380592427 (Office)

Room Number: 13/4073