Medicine

Anthony Williams

BSc, MBBS, MRCP, FRCPath, PhD

Primary position:
Reader in Clinical Immunology and Allergy

Background

The University of Southampton

Dr Williams was appointed as Reader in Clinical Immunology and Allergy in 2009. He graduated in Medicine from University College London and undertook general medicine training in Cardiff. He then specialised in Clinical Immunology and Allergy at Oxford and completed his PhD in the MHC class I antigen presentation at the Weatherall Institute of Molecular Medicine, University of Oxford. He moved to Southampton to undertake a Wellcome Clinician Scientist Fellowship and develop a Translational Clinical Immunology programme through the Faculty of Medicine.

Dr Williams leads a Translational Immunology group within the Experimental Cancer Medicine Centre (ECMC), CRUK Clinical Centre, Southampton that applies cutting edge immunological monitoring analyses (immunometry) to clinical trials that are evaluating immunological modifiers in haematological and solid organ malignancies (i.e. DNA vaccines, monoclonal antibodies and adoptive cellular therapies). He also has translational research programmes in Paediatric Infectious diseases, particularly primary immunodeficiency, and allergic disease. Commercial partnerships with GSK Bio and Merck Serono have been established for the application of immunometry to multi centre vaccine trials.

He is a Clinical Consultant in Immunology and Allergy and Head of the Regional Clinical Immunology Laboratory at Southampton University Hospital Trust.

Qualifications

BSc, Pharmacology, University College London, 1989
MBBS, Medicine, University College London, 1992
MRCP, Royal College of Physicians, London, 1996
MSc, Medical Immunology, St Georges Medical School, 1999
PhD, Molecular immunology, Oxford University, 2003
FRCPath, Royal College of Pathologists, London 2003

Appointments held

Wellcome Trust Clinical Training Fellow, Weatherall Institute of Molecular Medicine, University of Oxford, 1999-2003.

Wellcome Trust Clinician Scientist, Cancer Sciences Division, University of Southampton, 2003-2007.

Senior Lecturer in Clinical Immunology and Allergy, University of Southampton, 2007-2009.

Reader in Clinical Immunology and Allergy, University of Southampton, 2009- present.

Dr Anthony Williams's photo

Publications

The University of Southampton's electronic library (e-prints)

Article

Coelho, Tracy, Andreoletti, Gaia, Ashton, James J., Pengelly, Reuben J., Gao, Yifang, RamaKrishnan, Ananth, Batra, Akshay, Beattie, Robert M., Williams, Anthony P. and Ennis, Sarah (2014) Immuno-genomic profiling of patients with inflammatory bowel disease. Inflammatory Bowel Diseases, 20, (10), 1813-1819. (doi:10.1097/MIB.0000000000000174).
Van Hateren, A., Carter, R., Bailey, A., Kontouli, N., Williams, A.P., Kaufman, J. and Elliott, T.J. (2013) A mechanistic basis for the co-evolution of chicken tapasin and major histocompatibility complex class I (MHC I) proteins. Journal of Biological Chemistry, n/a, n/a. (doi:10.1074/jbc.M113.474031). (PMID:24078633).
Wilkens , J., Male, V., Ghazal, P., Forster, T., Gibson, D., Williams, A.R.W., Brito-Mutunayagam, S.L., Craigon, M., Lourenco, P., Cameron, I.T., Chwalisz, K., Moffett, A. and Critchley, H.O.D. (2013) Uterine Natural Killer cells regulate endometrial bleeding in women and are suppressed by the progesterone receptor modulator asoprisnil. The Journal of Immunology, 191, (5), 2226-2235. (doi:10.4049/jimmunol.1300958).
Bolze, A., Mahlaoui, N., Byun, M., Turner, B., Trede, N., Ellis, S.R., Abhyankar, A., Itan, Y., Patin, E., Brebner, S., Sackstein, P., Puel, A., Pickard, c., Abel, L., Quintana-Murci, L., Faust, S.N., Williams, A.P., Baretto, R., Duddridge, M., Kini, U., Pollard, A.J., Gaud, C., Frange, P., Orbach, D., Emile, J.F., Stephan, J.L., Sorensen, R., Plebani, A., Hammarstrom, L., Conley, M.E., Selleri, L. and Casanova, J.L. (2013) Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia. Science, 340, (6135), 976-978. (doi:10.1126/science.1234864). (PMID:23579497).
Mant, Alexandra, Chinnery, Fay, Elliott, Tim and Williams, Anthony P. (2012) The pathway of cross-presentation is influenced by the particle size of phagocytosed antigen. Immunology, 136, (2), 163-175. (doi:10.1111/j.1365-2567.2012.03558.x). (PMID:22260486).
Noakes, P.S., Vlachava, M., Kremmyda, L.S., Diaper, N.D., Miles, E.A., Erlewyn-Lajeunesse, M., Williams, A.P., Godfrey, K.M. and Calder, P.C. (2012) Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 months. American Journal Clinical Nutrition, 95, (2), 395-404. (doi:10.3945/​ajcn.111.022954 ). (PMID:22218160).
Chowdhury, Ferdousi, Johnson, Peter and Williams, Antony Peter (2010) Enumeration and phenotypic assessment of human plasmacytoid and myeloid dendritic cells in whole blood. Cytometry Part A (doi:10.1002/cyto.a.20872).
Boulanger, Denise S.M., Oliveira, Roberta, Ayres, Lisa, Prior, Stephen H., James, Edward, Williams, Anthony P. and Elliott, Tim (2010) Absence of tapasin alters immunodominance against a lymphocytic choriomeningitis virus polytope. Journal of Immunology, 184, (1), 73-83. (doi:10.4049/jimmunol.0803489).
Howe, Christopher, Garstka, Malgorzata, Al-Balushi, Mohammed, Ghanem, Esther, Antoniou, Antony N., Fritzsche, Susanne, Jankevicius, Gytis, Kontouli, Nasia, Schneeweiss, Clemens, Williams, Anthony, Springer, Sebastian and Elliott, Tim (2009) Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules. EMBO Journal, 28, (23), 3730-3744. (doi:10.1038/emboj.2009.296).
Wilkens, J., Williams, A.R.W., Chwalisz, K., Han, C., Cameron, I.T. and Critchley, H.O.D. (2009) Effect of asoprisnil on uterine proliferation markers and endometrial expression of the tumour suppressor gene, PTEN. Human Reproduction, 24, (5), 1036-1044. (doi:10.1093/humrep/den494 ).
Chowdhury, Ferdousi and Williams, Anthony P. (2009) From research to regulated: challenges in transferring methods. Bioanalysis, 1, (2), 285-291. (doi:10.4155/bio.09.51).
Leung, Leo, Tomassi, Cyrille, Van Beneden, Katrien, Decruy, Tine, Trappeniers, Matthias, Elewaut, Dirk, Gao, Yifang, Elliott, Tim, Al-Shamkhani, Aymen, Ottensmeier, Christian, Werner, Jörn M., Williams, Anthony, Van Calenbergh, Serge and Linclau, Bruno (2009) The synthesis and in vivo evaluation of 2,2-difluoro KRN7000. ChemMedChem, 4, (3), 329 -334. (doi:10.1002/cmdc.200800348 ).
Chowdhury, Ferdousi, Williams, Anthiny and Johnson, Peter (2009) Validation and comparison of two multiplex technologies, Luminex® and Mesoscale Discovery, for human cytokine profiling. Journal of Immunological Methods, 340, (1), 55-64. (doi:10.1016/j.jim.2008.10.002).
Doffinger, R., Barcenas-Morales, G., Mant, A., Carter, R., Kumararatne, D., Faust, S.N. and Williams, A. (2008) Immunodeficiency in a child with high affinity auto-antibodies to Interleukin 12p40 and Interferon alpha. 13th Meeting, European Society for Paediatric Infectious Diseases. Clinical and Experimental Immunology, 154, (Supplement 1), 22. (doi:10.1111/j.1365-2249.2008.03767.x).
Leung, Leo, Tomassi, Cyrille, Van Beneden, Katrien, Decruy, Tine, Elewaut, Dirk, Elliott, Tim, Al-Shamkhani, Aymen, Ottensmeier, Christian, Van Calenbergh, Serge, Werner, Joern, Williams, Tony and Linclau, Bruno (2008) Synthesis and in vivo evaluation of 4-deoxy-4,4-difluoro-KRN7000. Organic Letters, 10, (20), 4433-4436. (doi:10.1021/ol801663m).
Williams, A.R.W., Critchley, H.O.D., Osei, J., Ingamells, S., Cameron, I.T., Han, C. and Chwalisz, K. (2007) The effects of the selective progesterone receptor modulator asoprisnil on the morphology of uterine tissues after 3 months treatment in patients with symptomatic uterine leiomyomata. Human Reproduction, 22, (6), 1696-1704. (doi:10.1093/humrep/dem026).
Mant, Alexandra, Tourniaire, Guilhem, Diaz-Mochon, Juan J., Elliott, Tim J., Williams, Anthony P. and Bradley, Mark (2006) Polymer microarrays: identification of substrates for phagocytosis assays. Biomaterials, 27, (30), 5299-5306. (doi:10.1016/j.biomaterials.2006.04.040). (PMID:16808972).
Gennery, Andrew R., Hodges, Elizabeth, Williams, Anthony P., Harris, Susan, Villa, Anna, Angus, Brian, Cant, Andrew J. and Smith, John L. (2005) Omenn's syndrome occurring in patients without mutations in recombination activating genes. Clinical Immunology, 116, (3), 246-256. (doi:10.1016/j.clim.2005.04.014).
Krishna, Mamidipudi T., Goswami, Rajee, Frew, Anthony J., Smith, John L. and Williams, Anthony P. (2005) Laboratory diagnostics for hereditary angioedema: An economic, evidence-based standpoint. The Journal of Allergy and Clinical Immunology, 115, (4), 878-879. (doi:10.1016/j.jaci.2004.12.1126).
Gao, B., Williams, A., Sewell, A. and Elliott, T. (2004) Generation of a functional, soluble tapasin protein from an alternatively spliced mRNA. Genes & Immunity, 5, (2), 101-108. (doi:10.1038/sj.gene.6364043).
Howarth, Mark, Williams, Anthony, Tolstrup, Anne B. and Elliott, Tim (2004) Tapasin enhances MHC class I peptide presentation according to peptide half-life. Proceedings of the National Academy of Sciences of the United States of America, 101, (32), 11737-11742. (doi:10.1073/pnas.0306294101).
Williams, Anthony P., Peh, Chen Au, Purcell, Anthony W., McCluskey, James and Elliott, Tim (2002) Optimization of the MHC class I peptide cargo is dependent on tapasin. Immunity, 16, (4), 509-520. (doi:10.1016/S1074-7613(02)00304-7).
 

Research

Research Interests

Dr Williams’ research encompasses basic science, translational assessment and clinical adoption of diagnostic and therapeutic interventions that stem from the adaptation of discovery science in Human Immunology.

Immunological end points for Clinical Trials

In collaboration with Professor Ottensmeier (ECMC Director) and the Experimental Cancer Medicine Centre, the translational research group have developed a portfolio of validated immunological end point assessments that are utilised in DNA vaccine, monoclonal antibody and small molecule studies. These assessments evaluate antigen specific CD4 and CD8 responses by tetramer, intracellular cytokine, secreted protein array and phenotypic enumeration. Figure 1 shows one such example where polyfunctional T cells against specific antigens maybe enumerated and utilised as biomarkers of vaccine responsiveness. These studies also extend to important rarer cell populations including functional assessments of regulatory T cells (Tregs), invariant NKT cells (iNKTs), inflammatory monocytes, myeloid dendritic cell (mDC), plasmacytoid dendritic cells (pDC) and Natural Killer cells (NK’s). These assessment platforms are currently being shared with commercial partners (e.g. MerckSerono and Geron Corp) for multi centre studies and first in man evaluations.

Host Defence, Infection and Immunodeficiency

In collaboration with Dr Saul Faust (Wellcome Trust Clinical Research Facility Director [WTCRF] and Senior Lecturer in Paediatric Infection and Immunity) a joint research team has been established to evaluate host defence in severe, persistent, unusual or recurrent paediatric sepsis. The programme has focused on evaluating the innate immune system of such children, partnering functional characterisations with genomic profiling through exome analysis of index cases. These studies have developed an array of new analysis tools that are currently being applied to other clinical infectious disease settings (Cystic Fibrosis and Adult onset Primary Immunodeficiency) and through commercial partnerships (GSK Bio) for the interrogation of new vaccine interventions.

Academic unit:  Cancer Sciences Academic Unit

Affiliate academic units:  Cancer Sciences Research group

Figure 1

one such example where polyfunctional T cells against specific antigens maybe enumerated and utilised as biomarkers of vaccine responsiveness

Figure 1

Responsibilities

Post graduate student Supervision

2004 Mark Howarth PhD
2005 Claire Stephens MSc
2006 Lucy Hedges MSc
2007 Emily White MSC
2008 Yifang Gao PhD
2009 Emily Keeble MSc
2010 Ananth Ramakrishnan PhD

Faculty of Medicine

Post graduate Education Management Committee- MSc Allergy Chair

National and International responsibilities

External Examiner for the University of Oxford MSc Immunology programme
Royal College of Pathology National Examiner

Teaching Responsibilities

BM4 BM5. Educational Lead for Clinical Immunology, 2009 to present. Deliver Year 1 and 2 core programme lectures in basic immunology and application to organ specific modules_GI/Rheumatology and Endocrinology.

MSc Allergy. Chair of the MSc Allergy programme curriculum development, assessments and examination group, 2006 to present.

MSc Allergy. Module leader and Lecturer on redesigned course (2009), delivering lectures on all 5 modules.

BSc Biomedical Sciences. Deliver lectures on immunity and infectious disease.

Integrated PhD Cancer Immunology Programme. Rotational project supervisor for each of the cohorts, 2007 to present

Contact

Dr Anthony Williams
Faculty of Medicine
University of Southampton
Southampton General Hospital
Mailpoint 801
South Academic Block
Tremona Road
Southampton
SO16 6YD
or
Faculty of Medicine
University of Southampton
Building 85
Life Sciences Building
Highfield Campus
Southampton
SO171BJ

Room Number: SGH/CS/C15/MP824

Telephone: (023) 8120 5162
Facsimile: (023) 8120 5152
Email: A.P.Williams@soton.ac.uk