Medicine

Mike Grocott

BSc MBBS MD FRCA FRCP FFICM

Primary position:
Professor of Anaesthesia and Critical Care Medicine
Other positions:
Head, Integrative Physiology and Critical Illness Group, CES Lead, Critical Care Research Area, Southampton NIHR Respiratory BRU

Background

The University of Southampton

Mike Grocott is the Professor of Anaesthesia and Critical Care at the University of Southampton and Consultant in Critical Care Medicine at University Hospital Southampton NHS Foundation Trust.

He leads the Critical Care Research Area within the Southampton NIHR Respiratory Biomedical Research Unit and is Head of the Integrative Physiology and Critical Illness Group at the University of Southampton. He also leads the Anaesthesia and Critical Care Research Unit within University Hospitals Southampton NHS Foundation Trust (UHS).

TRAINING
Mike graduated in medicine from St George’s Hospital Medical School, University of London having also completed an intercalated degree in “Biomedical Sciences and Immunology” (BSc, 1989; MBBS, 1992). He has completed general professional training in internal medicine (MRCP, 1996) and UK anaesthesia fellowship (FRCA, 1999) before undertaking research training with Professor Michael (Monty) Mythen within the UCL Centre for Anaesthesia (MD, 2010).

CLINICAL ACADEMIC
He was appointed Senior Lecturer in Critical Care Medicine within the Division of Medicine at UCL in 2005.
In 2008 he moved to UHS as a Consultant in Critical Care Medicine. Mike was appointed Honorary Reader at the University of Southampton in 2010 and to the Chair of Anaesthesia and Critical Care Medicine in 2011. In 2011 he was also awarded the British Oxygen Company Chair of the Royal College of Anaesthetists. He has been elected as a Fellow of the Royal College of Physicians (FRCP, 2010) and a founding fellow of the Faculty of Intensive Care Medicine (FFICM, 2011)

INTEGRATIVE PHYSIOLOGY
With Dr Kevin Fong, Mike co-founded the UCL Centre for Altitude Space and Extreme Environment Medicine (CASE) in 2000 and was co-director (2000-2007) and then director (2007-2011). Since 2006, he has been Director of the Caudwell Xtreme Everest Hypoxia Research Consortium and chairs the executive board.
(www.xtreme-everest.co.uk ) Mike led the 2003 CASE Baruntse, 2006 Xtreme Everest Cho Oyu and the 2007 Caudwell Xtreme Everest medical research expeditions and was one of the team who obtained blood gases near to the summit of Everest in 2007. He also leads the Fit-4-Surgery research consortium.

HEALTH SERVICES RESEARCH
Mike is the Founding Director of the National Institute of Academic Anaesthesia (NIAA) Health Services Research Centre at the Royal College of Anaesthetists and chairs the HQIP funded National Emergency Laparotomy Audit (2012-). He was previously the director of the UCL/UCLH Surgical Outcomes Research Centre (SOuRCe; 2008-2010) which he confounded in 2000.

RESEARCH MANAGEMENT AND GOVERNANCE
Mike is the Division A (Cancer, Surgery and Critical Care) lead for R&D. He is the Hampshire and Isle of Wight CLRN specialty group lead for Anaesthesia and Critical Care and serves on the UKCRN Specialty Groups in this role. He also serves on the Board and Research Council of the National institute of Academic Anaesthesia.

Professor  Mike Grocott's photo
Web links

Publications

The University of Southampton's electronic library (e-prints)

Article

Hennis, Philip J., Gilbert-Kawai, Edward and Grocott, Michael P.W. (2014) Isolated generalized tonic-clonic seizure at high altitude in a young male trekker with a positive family history of seizure. High Altitude Medicine & Biology, 15, (1), 93-94. (doi:10.1089/ham.2013.1102). (PMID:24559380).
Jack, S., West, M.A., Raw, D., Marwood, S., Ambler, G., Cope, T.M., Shrotri, M., Sturgess, R.P., Calverley, P.M.A., Ottensmeier, C.H. and Grocott, M.P.W. (2014) The effect of neoadjuvant chemotherapy on physical fitness and survival in patients undergoing oesophagogastric cancer surgery. European Journal of Surgical Oncology (doi:10.1016/j.ejso.2014.03.010). (PMID:24731268).
Holloway, Cameron J., Murray, Andrew J., Mitchell, Kay, Martin, Daniel S., Johnson, Andrew W., Cochlin, Lowri E., Codreanu, Ion, Dhillon, Sundeep, Rodway, George W., Ashmore, Tom, Levett, Denny Z.H., Neubauer, Stefan, Montgomery, Hugh E, Grocott, Michael P.W. and Clarke, Kieran (2014) Oral coenzyme Q10 supplementation does not prevent cardiac alterations during a high altitude trek to Everest base camp. High Altitude Medicine & Biology (doi:10.1089/ham.2013.1053). (PMID:24661196).
Dushianthan, Ahilanandan, Goss, Victoria, Cusack, Rebecca, Grocott, Michael P.W. and Postle, Anthony D. (2014) Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers. BMC Pulmonary Medicine, 14, 10. (doi:10.1186/1471-2466-14-10).
Siervo, Mario, Riley, Heather L., Fernandez, Bernadette O, Leckstrom, Carl A., Martin, Daniel S., Mitchell, Kay, Levett, Denny Z.H., Montgomery, Hugh E., Mythen, Monty G., Grocott, Michael P. W. and Feelisch, Martin (2014) Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation. PLoS ONE, 9, (4), e94915. (doi:10.1371/journal.pone.0094915). (PMID:15134560).
West, M.A., Lythgoe, D., Barben, C.P., Noble, L., Kemp, G.J., Jack, S. and Grocott, M.P.W. (2013) Cardiopulmonary exercise variables are associated with postoperative morbidity after major colonic surgery: a prospective blinded observational study. BJA British Journal of Anaesthesia (doi:10.1093/bja/aet408). (PMID:24322573).
Martin, D.S. and Grocott, M.P.W. (2013) III. Oxygen therapy in anaesthesia: the yin and yang of O2. BJA British Journal of Anaesthesia, 111, (6), 867-871. (doi:10.1093/bja/aet291). (PMID:24233308).
Burke, Shaunna M., Brunet, Jennifer, Sabiston, Catherine M., Jack, Sandy, Grocott, Michael P.W. and West, Malcolm A. (2013) Patients' perceptions of quality of life during active treatment for locally advanced rectal cancer: the importance of preoperative exercise. Supportive Care in Cancer, 21, (12), 3345-3353. (doi:10.1007/s00520-013-1908-2). (PMID:23912669).
Moonesinghe, Suneetha Ramani, Mythen, Michael G., Das, Priya, Rowan, Kathryn M. and Grocott, Michael P.W. (2013) Risk stratification tools for predicting morbidity and mortality in adult patients undergoing major surgery: qualitative systematic review. Anesthesiology, 119, (4), 959-981. (doi:10.1097/ALN.0b013e3182a4e94d). (PMID:24195875).
Grocott, M.P.W., Dushianthan, A., Hamilton, M.A., Mythen, M.G., Harrison, D., Rowan, K. and Optimisation Systematic Review: Steering Group (2013) Perioperative increase in global blood flow to explicit defined goals and outcomes after surgery: a Cochrane systematic review. British Journal of Anaesthesia, 111, (4), 535-548. (doi:10.1093/bja/aet155 ). (PMID:23661403).
Martin, Daniel S., Gilbert-Kawai, Edward T., Meale, Paula M., Fernandez, Bernadette O., Cobb, Alexandra, Khosravi, Maryam, Mitchell, Kay, Grocott, Michael P.W., Levett, Denny Z.H., Mythen, Michael G. and Feelisch, Martin (2013) Design and conduct of 'Xtreme Alps': a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude. Contemporary Clinical Trials, 36, (2), 450-459. (doi:10.1016/j.cct.2013.09.002). (PMID:24028941).
Grocott, Michael P.W. and Levett, Denny Z.H. (2013) Everest 60 years on: what next? Extreme Physiology & Medicine , 2, (20), 1-2. (doi:10.1186/2046-7648-2-20). (PMID:24398142).
O'Doherty, A.F., West, M., Jack, S. and Grocott, M.P.W. (2013) Preoperative aerobic exercise training in elective intra-cavity surgery: a systematic review. British Journal of Anaesthesia, 110, (5) (doi:10.1093/bja/aes514 ). (PMID:23393151).
Gavlak, Johanna C., Stocks, Janet, Laverty, Aidan, Fettes, Emma, Bucks, Romola, Sonnappa, Samatha, Cooper, Janine, Grocott, Michael P., Levett, Denny Z., Martin, Daniel S., Imray, Christopher H. and Kirkham, Fenella J. (2013) The Young Everest Study: preliminary report of changes in sleep and cerebral blood flow velocity during slow ascent to altitude in unacclimatised children. Archives of Disease in Childhood, 98, (5), 356-362. (doi:10.1136/archdischild-2012-302512 ). (PMID:23471157).
Grocott, Michael P.W. (2013) Editorial. Integrative physiology and systems biology: reductionism, emergence and causality. Extreme physiology & medicine, 2, (1), 9. (doi:10.1186/2046-7648-2-9). (PMID:23849742).
Colson, M., Baglin, J., Bolsin, S. and Grocott, M.P.W. (2013) Reply from the authors. BJA British Journal of Anaesthesia, 110, (3), 486. (doi:10.1093/bja/aes583 ). (PMID:23404975).
Colson, .M, Baglin, J., Bolsin, S. and Grocott, M.P.W. (2013) Reply from the authors. BJA British Journal of Anaesthesia, 110, (3), 484-485. (doi:10.1093/bja/aes582). (PMID:23404974).
Colson, M., Baglin, J., Bolsin, S. and Grocott, M.P.W. (2013) Reply from the authors. BJA British Journal of Anaesthesia, 110, (3), 483-484. (doi:10.1093/bja/aes591). (PMID:23404970).
Grocott, Michael P. W. (2013) Integrative physiology and systems biology: reductionism, emergence and causality. Extreme Physiology & Medicine, 2, (1), 9. (doi:10.1186/2046-7648-2-9). (PMID:23849742).
Grocott, M.P.W., Galsworthy, M.J. and Moonesinghe, S.R. (2013) Health services research and anaesthesia. Anaesthesia, 68, (2), 121-135. (doi:10.1111/anae.12063). (PMID:23106155).
Otto, James M., O'Doherty, Alasdair F., Hennis, Philip J., Cooper, Jackie A., Grocott, Michael P.W., Snowdon, Chris, Carlisle, John B., Swart, Michael, Richards, Toby and Montgomery, Hugh E. (2013) Association between preoperative haemoglobin concentration and cardiopulmonary exercise variables: a multicentre study. Perioperative medicine, 2, (1), 18. (doi:10.1186/2047-0525-2-18). (PMID:24472426).
Martin, Daniel S., Gilbert-Kawai, Edward, Levett, Denny Z.H., Mitchell, Kay, Kumar Bc, Rajendra, Mythen, Michael G. and Grocott, Michael P.W. (2013) Xtreme Everest 2: unlocking the secrets of the Sherpa phenotype? Extreme Physiology and Medicine, 2, (1), 30-35. (doi:10.1186/2046-7648-2-30). (PMID:24229457).
Martin, Daniel Stuart and Grocott, Michael Patrick William (2012) Oxygen therapy in critical illness: precise control of arterial oxygenation and permissive hypoxemia. Critical Care Medicine (doi:10.1097/CCM.0b013e31826a44f6). (PMID:23263574).
Burdett, Edward, Dushianthan, Ahilanandan, Bennett-Guerrero, Elliott, Cro, Suzie, Gan, Tong J., Grocott, Michael P.W., James, Michael F.M., Mythen, Michael G., O'Malley, Catherine M.N., Roche, Anthony M. and Rowan, Kathy (2012) Perioperative buffered versus non-buffered fluid administration for surgery in adults. Cochrane Database of Systematic Reviews, 12, CD004089. (doi:10.1002/14651858.CD004089.pub2). (PMID:23235602).
Dushianthan, Ahilanandan, Cusack, Rebecca, Goss, Victoria, Postle, Anthony D. and Grocott, Mike P.W. (2012) Clinical review. Exogenous surfactant therapy for acute lung injury/acute respiratory distress syndrome - where do we go from here? Critical Care, 16, (6), 238. (PMID:23171712).
Dushianthan, Ahilanandan, Cusack, Rebecca, Goss, Victoria, Postle, Anthony D and Grocott, Mike P.W. (2012) Clinical review: Exogenous surfactant therapy for acute lung injury/acute respiratory distress syndrome - where do we go from here? Critical Care, 16, (6), 238. (doi:10.1186/cc11512). (PMID:23171712).
Grocott, Michael P.W., Dushianthan, Ahilanandan, Hamilton, Mark A., Mythen, Michael G., Harrison, David and Rowan, Kathy (2012) Perioperative increase in global blood flow to explicit defined goals and outcomes following surgery. Cochrane Database of Systematic Reviews , 11, CD004082. (doi:10.1002/14651858.CD004082.pub5). (PMID:23152223).
Colson, M., Baglin, J., Bolsin, S. and Grocott, M.P.W. (2012) Cardiopulmonary exercise testing predicts 5 yr survival after major surgery. British Journal of Anaesthesia, 109, (5), 735-741. (doi:10.1093/bja/aes263 ). (PMID:22910977).
Otto, J.M., O'Doherty, A.F., Hennis, P.J., Mitchell, K., Pate, J.S., Cooper, J.A., Grocott, M.P.W. and Montgomery, H.E. (2012) Preoperative exercise capacity in adult inflammatory bowel disease sufferers, determined by cardiopulmonary exercise testing. International Journal of Colorectal Disease, 27, (11), 1485-1491. (doi:10.1007/s00384-012-1533-4). (PMID:22842663).
Low, Emma V., Avery, Anthony J., Gupta, Vaibhav, Schedlbauer, Angela and Grocott, Michael P.W. (2012) Identifying the lowest effective dose of acetazolamide for the prophylaxis of acute mountain sickness: systematic review and meta-analysis. BMJ (Clinical research ed.), 345, e6779. (doi:10.1136/bmj.e6779). (PMID:23081689).
Hennis, P.J., Meale, P.M, Hurst, R.A., O'Doherty, A.F., Otto, J., Kuper, M., Harper, N., Sufi, P. A., Heath, D., Montgomery, H. E. and Grocott, M.P.W. (2012) Cardiopulmonary exercise testing predicts postoperative outcome in patients undergoing gastric bypass surgery. British Journal of Anaesthesia, 109, (4), 566-571. (doi:10.1093/bja/aes225 ). (PMID:22810563).
Dushianthan, Ahilanandan, Cusack, Rebecca, Grocott, Mike and Postle, Anthony (2012) Exogenous surfactant therapy in acute lung injury/acute respiratory distress syndrome: the need for a revised paradigm approach. Journal of Cardiothoracic and Vascular Anesthesia, 26, (5), p.e50. (doi:10.1053/j.jvca.2012.03.008). (PMID:22265270).
Grocott, Michael P.W. and Montgomery, Hugh E (2012) Editorial. Extreme Physiology & Medicine: a new journal focussed on integrative human physiology under stress. Extreme Physiology & Medicine, 1, (1), 1. (doi:10.1186/2046-7648-1-1). (PMID:23849731).
Grocott, Michael P.W., Martin, Daniel S. and Mythen, Michael G. (2012) Enhanced recovery pathways as a way to reduce surgical morbidity. Current Opinion in Critical Care, 18, (4), 385-392. (doi:10.1097/MCC.0b013e3283558968). (PMID:22710280).
McMorrow, R.C.N., Windsor, J.S., Hart, N.D., Richards, P., Rodway, G.W., Ahuja, V.Y., O'Dwyer, M.J., Mythen, M.G. and Grocott, M.P.W Caudwell Extreme Everest Research Group (2012) Closed and open breathing circuit function in healthy volunteers during exercise at Mount Everest base camp (5300 m). Anaesthesia, 67, (8), 875-880. (doi:10.1111/j.1365-2044.2012.07152.x). (PMID:22519895).
Martin, D.S., Pate, J.S., Vercueil, A., Doyle, P.W., Mythen, M.G. and Grocott, Michael P. W. The Caudwell Xtreme Everest Research Group (2012) Reduced coagulation at high altitude identified by thromboeslastography. Thrombosis and Haemostasis, 107, (6), 1066-1071. (doi:10.1160/TH12-01-0004). (PMID:22437051).
Martin, Daniel S., Pate, Jim S., Vercueil, Andre, Doyle, Patrick W., Mythen, Michael G. and Grocott, Mike P.W. Caudwell Xtreme Everest Research Group (2012) Reduced coagulation at high altitude identified by thromboelastography. Thrombosis and Haemostasis, 107, (6), 1066-1071. (doi:10.1160/TH12-01-0004). (PMID:22437051).
Grocott, M.P.W. and Pearse, R.M. (2012) Perioperative medicine: the future of anaesthesia? British Journal of Anaesthesia, 108, (5), 723-726. (doi:10.1093/bja/aes124). (PMID:22499744).
Levett, Denny Z., Radford, Elizabeth J., Menassa, David A., Graber, E. Franziska, Morash, Andrea J., Hoppeler, Hans, Clarke, Kieran, Martin, Daniel S., Ferguson-Smith, Anne C., Montgomery, Hugh E., Grocott, Michael P.W. and Murray, Andrew J. (2012) Acclimatization of skeletal muscle mitochondria to high-altitude hypoxia during an ascent of Everest. FASEB Journal, 26, (4), 1431-1441. (doi:10.1096/fj.11-197772). (PMID:22186874).
Sevastru, Stefan, Wakatsuki, Mai, Fennell, Jonathan and Grocott, Michael P.W. (2012) Plasma exchange in the management of a case of hypertriglyceridaemic pancreatitis triggered by venlafaxine. BMJ Case Reports, 2012 (doi:10.1136/bcr.11.2011.5208). (PMID:22892234).
Howard, Luke, Grocott, Michael P.W., Naeije, Robert, Oudiz, Ron and Wensel, Roland (2012) Editorial. Cardiopulmonary exercise testing. Pulmonary Medicine, 2012, 564134-[3pp]. (doi:10.1155/2012/564134). (PMID:23365737).
Levett, Denny Z., Fernandez, Bernadette O., Riley, Heather L., Martin, Daniel S., Mitchell, Kay, Leckstrom, Carl A., Ince, Can, Whipp, Brian J., Mythen, Monty G., Montgomery, Hugh E., Grocott, Mike P. and Feelisch, Martin (2011) The role of nitrogen oxides in human adaptation to hypoxia. Scientific Reports, 1, 109. (doi:10.1038/srep00109). (PMID:22355626).
Pearse, Rupert M., Holt, Peter J.E. and Grocott, Michael P.W. (2011) Managing perioperative risk in patients undergoing elective non-cardiac surgery. British Medical Journal, 343, (d5759), d5759. (doi:10.1136/bmj.d5759). (PMID:22108268).
Wilson, Mark H., Edsell, Mark E.G., Davagnanam, Indran, Hirani, Shashivadan P., Martin, Dan S., Levett, Denny Z.H., Thornton, John S., Golay, Xavier, Strycharczuk, Lisa, Newman, Stanton P., Montgomery, Hugh E., Grocott, Mike P.W. and Imray, Christopher H.E. Caudwell Xtreme Everest Research Group (2011) Cerebral artery dilatation maintains cerebral oxygenation at extreme altitude and in acute hypoxia--an ultrasound and MRI study. Journal of Cerebral Blood Flow & Metabolism, 31, (10), 2019-2029. (doi:10.1038/jcbfm.2011.81). (PMID:21654697).
Pearse, Rupert M., Holt, Peter J.E. and Grocott, Michael P.W. (2011) Managing perioperative risk in patients undergoing elective non-cardiac surgery. BMJ, 343, d5759. (doi:10.1136/bmj.d5759 ). (PMID:21976704).
West, M., Jack, S. and Grocott, M.P.W. (2011) Perioperative cardiopulmonary exercise testing in the elderly. Best Practice & Research Clinical Anaesthesiology, 25, (3), 427-437. (doi:10.1016/j.bpa.2011.07.004). (PMID:21925407).
Dushianthan, A., Grocott, M.P.W., Postle, A.D. and Cusack, R. (2011) Acute respiratory distress syndrome and acute lung injury. Postgraduate Medical Journal, 87, (1031), 612-622. (doi:10.1136/pgmj.2011.118398). (PMID:21642654).
Jack, S., West, M. and Grocott, M.P.W. (2011) Perioperative exercise training in elderly subjects. [in special issue: Perioperative Morbidity and Mortality in the Elderly] Best Practice & Research Clinical Anaesthesiology, 25, (3), 461-72. (doi:10.1016/j.bpa.2011.07.003). (PMID:21925410).
Hennis, Philip J., Meale, Paula M. and Grocott, Michael P.W. (2011) Cardiopulmonary exercise testing for the evaluation of perioperative risk in non-cardiopulmonary surgery. Postgraduate Medical Journal, 87, (1030), 550-557. (doi:10.1136/pgmj.2010.107185 ). (PMID:21693573).
Grocott, M.P.W. and Gan, T.J. (2011) Fluid resuscitation 'post Boldt': throwing out the baby with the bathwater? British Journal of Hospital Medicine, 72, (6), 306-307. (PMID:21727807).
Dushianthan, A., Grocott, M.P.W., Postle, A.D. and Cusack, R. (2011) Acute respiratory distress syndrome and acute lung injury. Postgraduate Medical Journal (doi:10.1136/pgmj.2011.118398). (PMID:21642654).
Ackland, Gareth L., Moran, Noeleen, Cone, Steven, Grocott, Michael P.W. and Mythen, Michael G. (2011) Chronic kidney disease and postoperative morbidity after elective orthopedic surgery. Anesthesia and analgesia, 112, (6), 1375-1381. (doi:10.1213/​ANE.0b013e3181ee8456). (PMID:20807976).
McMorrow, R.C.N., Windsor, J.S., Mythen, M.G. and Grocott, M.P.W. Caudwell Xtreme Everest Research Group (2011) A novel ambulatory closed circuit breathing system for use during exercise. Anaesthesia, 66, (5), 348-353. (doi:10.1111/j.1365-2044.2011.06698.x). (PMID:21443642).
Moonesinghe, Suneetha Ramani, Mythen, Michael Gerard and Grocott, Michael Patrick William (2011) High-risk surgery: epidemiology and outcomes. Anesthesia and Analgesia, 112, (4), 891-901. (doi:10.1213/​ANE.0b013e3181e1655b ). (PMID:20495138).
Wilson, Mark H., Levett, Denny Z., Dhillon, Sundeep, Mitchell, Kay, Morgan, Jon, Grocott, Michael P.W. and Imray, Chris (2011) Stroke at high altitude diagnosed in the field using portable ultrasound. Wilderness and Environmental Medicine, 22, (1), 54-57. (doi:10.1016/j.wem.2010.10.007). (PMID:21377120).
Holloway, Cameron J., Montgomery, Hugh E., Murray, Andrew J., Cochlin, Lowri E., Codreanu, Ion, Hopwood, Naomi, Johnson, Andrew W., Rider, Oliver J., Levett, Denny Z.H., Tyler, Damian J., Francis, Jane M., Neubauer, Stefan, Grocott, Michael P.W. and Clarke, Kieran Caudwell, Xtreme Everest Research Group (2011) Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp. The FASEB Journal, 25, (2), 792-796. (doi:10.1096/fj.10-172999). (PMID:20978235).
Holloway, Cameron J., Montgomery, Hugh E., Murray, Andrew J., Cochlin, Lowri E., Codreanu, Ion, Hopwood, Naomi, Johnson, Andrew W., Rider, Oliver J., Levett, Denny Z.H., Tyler, Damian J., Francis, Jane M., Neubauer, Stefan, Grocott, Michael P.W., Clarke, Kieran and Caudwell Xtreme Everest Research Group (2011) Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest base camp. Federation of American Societies for Experimental Biology Journal, 25, (2), 792-796. (doi:10.1096/fj.10-172999). (PMID:20978235).
Ackland, G.L., Harris, S., Ziabari, Y., Grocott, M. and Mythen, M. SOuRCe Investigators (2010) Revised cardiac risk index and postoperative morbidity after elective orthopaedic surgery: a prospective cohort study. BJA British Journal of Anaesthesia, 105, (6), 744-752. (doi:10.1093/bja/aeq245). (PMID:20876700).
Levett, Denny Z.H., Martin, Daniel S., Wilson, Mark H., Mitchell, Kay, Dhillon, Sundeep, Rigat, Fabio, Montgomery, Hugh E., Mythen, Monty G. and Grocott, Michael P.W. Caduwell Xtreme Everest Research Group (2010) Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxia. BMC Medical Research Methodology, 10, 98. (doi:10.1186/1471-2288-10-98). (PMID:20964858).
Franck, Linda S., McQuillan, Annette, Wray, Jo, Grocott, Michael P.W. and Goldman, Allan (2010) Parent stress levels during children's hospital recovery after congenital heart surgery. Pediatric Cardiology, 31, (7), 961-968. (doi:10.1007/s00246-010-9726-5). (PMID:20495910).
Grocott, M.P.W. and Pearse, R.M. (2010) Prognostic studies of perioperative risk: robust methodology is needed. British Journal of Anaesthesia, 105, (3), 243-245. (doi:10.1093/bja/aeq207 ). (PMID:11385372).
Martin, Daniel S., Goedhart, Peter, Vercueil, Andre, Ince, Can, Levett, Denny Z.H. and Grocott, Mike P.W. Caudwell Xtreme Everest Research Group (2010) Changes in sublingual microcirculatory flow index and vessel density on ascent to altitude. Experimental Physiology, 95, (8), 880-891. (doi:10.1113/expphysiol.2009.051656). (PMID:20418348).
Martin, Daniel S., Khosravi, Maryam, Grocott, Mike P.W. and Mythen, Michael G. (2010) Concepts in hypoxia reborn. Critical Care, 14, (4), 315. (doi:10.1186/cc9078). (PMID:20727228).
Grocott, Michael P.W., Martin, Daniel S., Wilson, Mark H., Mitchell, Kay, Dhillon, Sundeep, Mythen, Monty G., Montgomery, Hugh E. and Levett, Denny Z.H. Caudwell Xtreme Everest Research Group (2010) Caudwell Xtreme Everest expedition. High Altitude Medicine & Biology, 11, (2), 133-137. (doi:10.1089/ham.2009.1093). (PMID:20586597).
Hollowell, Jennifer, Grocott, Mike P.W., Hardy, Rebecca, Haddad, Fares S., Mythen, Monty G. and Raine, Rosalind (2010) Major elective joint replacement surgery: socioeconomic variations in surgical risk, postoperative morbidity and length of stay. Journal of Evaluation in Clinical Practice, 16, (3), 529-538. (doi:10.1111/j.1365-2753.2009.01154.x). (PMID:20210822).
Edwards, Lindsay M., Murray, Andrew J., Tyler, Damian J., Kemp, Graham J., Holloway, Cameron J., Robbins, Peter A., Neubauer, Stefan, Levett, Denny, Montgomery, Hugh E., Grocott, Mike P, Clarke, Kieran and Caudwell Xtreme Everest Research Group (2010) The effect of high-altitude on human skeletal muscle energetics: P-MRS results from the Caudwell Xtreme Everest expedition. PLoS ONE, 5, (5), e10681. (doi:10.1371/journal.pone.0010681). (PMID:20502713).
Edwards, Lindsay M., Murray, Andrew J., Tyler, Damian J., Kemp, Graham J., Holloway, Cameron J., Robbins, Peter A., Neubauer, Stefan, Levett, Denny, Montgomery, Hugh E., Grocott, Mike P.W. and Clarke, Kieran (2010) The effect of high-altitude on human skeletal muscle energetics: P-MRS results from the Caudwell Xtreme Everest expedition. PLoS ONE, 5, (5), e10681. (doi:10.1371/journal.pone.0010681). (PMID:20502713).
Chapman, Susan M., Grocott, Michael P.W. and Franck, Linda S. (2010) Systematic review of paediatric alert criteria for identifying hospitalised children at risk of critical deterioration. Intensive Care Medicine, 36, (4), 600-611. (doi:10.1007/s00134-009-1715-x). (PMID:19940976).
Martin, Daniel S., Levett, Denny Z.H., Grocott, Mike P.W. and Montgomery, Hugh E. (2010) Variation in human performance in the hypoxic mountain environment. Experimental Physiology, 95, (3), 463-470. (doi:10.1113/expphysiol.2009.047589). (PMID:19946029).
Hooper, T.J., Levett, D.Z.H., Mellor, A.J. and Grocott, M.P.W. (2010) Resting and exercising cardiorespiratory variables and acute mountain sickness. Journal of the Royal Naval Medical Service, 96, (1), 6-12. (PMID:20608004).
Khosravi, Maryam and Grocott, Mike P.W. (2009) Mountainside to bedside: reality or fiction? Expert Review of Respiratory Medicine, 3, (6), 561-565. (doi:10.1586/ers.09.56 ). (PMID:20477346).
Grocott, Michael P.W. (2009) Improving outcomes after surgery. BMJ, 10, (339), b5173. (doi:10.1136/bmj.b5173). (PMID:20008005).
Allen, Samuel H., Moore, James and Grocott, Michael P.W. (2009) Expedition medicine in the tropics: through heat and sleet. Transactions of the Royal Society of Tropical Medicine and Hygiene, 103, (11), 1081-1084. (doi:10.1016/j.trstmh.2009.07.001). (PMID:19740504).
Sinha, Sidhartha, Sinha, Shrestha, Ashby, Elizabeth, Jayaram, Raja and Grocott, Michael P.W. (2009) Quality of reporting in randomized trials published in high-quality surgical journals. Journal of the American College of Surgeons, 209, (5), 565-571.e1. (doi:10.1016/j.jamcollsurg.2009.07.019).
Martin, Daniel S., Levett, Denny Z.H., Mythen, Michael and Grocott, Mike P.W. (2009) Changes in skeletal muscle oxygenation during exercise measured by near-infrared spectroscopy on ascent to altitude. Critical Care, 13, (Supp.5), S7. (doi:10.1186/cc8005).
Moonesinghe, S. Ramani, Mythen, Michael G. and Grocott, Michael P.W. (2009) Patient-related risk factors for postoperative adverse events. Current Opinion in Critical Care, 15, (4), 320-327. (doi:10.1097/MCC.0b013e32832e067c). (PMID:19512920).
Scrase, E., Laverty, A., Gavlak, J.C.D., Sonnappa, S., Levett, D.Z.H., Martin, D., Grocott, M.P.W. and Stocks, J. (2009) The Young Everest Study: effects of hypoxia at high altitude on cardiorespiratory function and general well-being in healthy children. Archives of Disease in Childhood, 94, (8), 621-626. (doi:10.1136/adc.2008.150516 ). (PMID:19395400).
Martin, Daniel S., Ince, Can, Goedhart, Peter, Levett, Denny Z.H. and Grocott, Mike P.W. Caudwell Xtreme Everest Research Group (2009) Abnormal blood flow in the sublingual microcirculation at high altitude. European Journal of Applied Physiology, 106, (3), 473-478. (doi:10.1007/s00421-009-1023-8). (PMID:15343008).
Windsor, J.S., Firth, P.G., Grocott, M.P., Rodway, G.W. and Montgomery, H.E. (2009) Mountain mortality: a review of deaths that occur during recreational activities in the mountains. Postgraduate Medical Journal, 85, (1004), 316-321. (doi:10.1136/pgmj.2009.078824 ). (PMID:19528307).
Windsor, Jeremy S., Currie, Rachael J., Grocott, Michael P., Chiocconi, Ramon and Hillebrandt, David (2009) Health screening on Aconcagua. Wilderness & Environmental Medicine, 20, (1), 90. (doi:10.1580/08-WEME-LE-221.1). (PMID:19364172).
Grocott, Michael P.W., Martin, Daniel S., Levett, Denny Z.H., McMorrow, Roger, Windsor, Jeremy and Montgomery, Hugh E. Caudwell Xtreme Everest Research Group (2009) Arterial blood gases and oxygen content in climbers on Mount Everest. New England Journal of Medicine, 360, (2), 140-149. (doi:10.1056/NEJMoa0801581). (PMID:19129527).
Martin, Daniel S., Levett, Denny Z.H., Mythen, Michael and Grocott, Mike P.W. Caudwell Xtreme Everest Research Group (2009) Changes in skeletal muscle oxygenation during exercise measured by near-infrared spectroscopy on ascent to altitude. Critical Care, 13, supplement 5, S7. (doi:10.1186/cc8005). (PMID:19951391).
Windsor, Jeremy S., Hamilton, Edwin, Grocott, Michael P.., O'Dwyer, Michael J. and Milledge, James S. (2009) The Snow Snorkel: a proof of concept study. Wilderness & Environmental Medicine, 20, (1), 61-65. (doi:10.1580/08-WEME-BR-183.1). (PMID:19364164).
Bezemer, Rick, Karemaker, John M., Klijn, Eva, Martin, Daniel, Mitchell, Kay, Grocott, Mike, Heger, Michal and Ince, Can (2009) Simultaneous multi-depth assessment of tissue oxygen saturation in thenar and forearm using near-infrared spectroscopy during a simple cardiovascular challenge. Critical Care, 13 , supplement 5, S5. (doi:10.1186/cc8003). (PMID:19951389).
Rodway, George W., Windsor, Jeremy S. and Grocott, Michael P.W. (2008) A short walk with Milledge. High Altitude Medicine & Biology, 9, (4), 335-339. (doi:10.1089/ham.2008.1032). (PMID:19115919).
Grocott, Mike and Montgomery, Hugh (2008) Genetophysiology: using genetic strategies to explore hypoxic adaptation. High Altitude Medicine & Biology, 9, (2), 123-129. (doi:10.1089/ham.2008.1012). (PMID:18578643).
Ashby, E., Grocott, M.P.W. and Haddad, F.S. (2008) Outcome measures for orthopaedic interventions on the hip. The Journal of Bone and Joint Surgery, 90, (5), 545-549. (doi:10.1302/0301-620X.90B5.19746). (PMID:18450615).
Grocott, Michael P.W. (2008) Human physiology in extreme environments: lessons from life at the limits? Postgraduate Medical Journal, 84, (987), 2-3. (doi:10.1136/pgmj.2007.066472 ). (PMID:18230743).
Thompson, Julian, Raitt, James, Hutchings, Lynn, Drenos, Fotios, Bjargo, Eirik, Loset, Are, Grocott, Mike, Montgomery, Hugh and Cauldwell Extreme Everest Research Group (2007) Angiotensin-converting enzyme genotype and successful ascent to extreme high altitude. High Altitude Medicine & Biology, 8, (4), 278-285. (doi:10.1089/ham.2007.1044). (PMID:18081503).
Grocott, M.P.W., Browne, J.P., Van der Meulen, J., Matejowsky, C., Mutch, M., Hamilton, M.A., Levett, D.Z.H., Emberton, M., Haddad, F.S. and Mythen, M.G. (2007) The Postoperative Morbidity Survey was validated and used to describe morbidity after major surgery. Journal of Clinical Epidemiology, 60, (9), 919-928. (doi:10.1016/j.jclinepi.2006.12.003). (PMID:17689808).
Grocott, M.P.W. and Johannson, L. (2007) Ketamine for emergency anaesthesia at very high altitude (4243 m above sea-level). Anaesthesia, 62, (9), 959-962. (doi:10.1111/j.1365-2044.2007.05074.x). (PMID:17697228).
Grocott, Mike, Richardson, Alan, Montgomery, Hugh and Mythen, Monty (2007) Caudwell Xtreme Everest: a field study of human adaptation to hypoxia. Critical Care, 11, (4), 151-152. (doi:10.1186/cc5921).
Grocott, Michael P.W., Levett, Denny Z.H., Matejowsky, Claire, Emberton, Mark and Mythen, Michael G. (2007) Letter to the editor. ASA scores in the preoperative patient: feedback to clinicians can improve data quality. Journal of Evaluation in Clinical Practice, 13, (2), 318-319. (doi:10.1111/j.1365-2753.2006.00736.x). (PMID:17378882).
Martin, Daniel, McCorkell, Stuart, Vercueil, Andre, Gunning, Paul, Cox, Mark, Dick, John, Mythen, Monty and Grocott, Mike (2007) Increased gastric-end tidal P(CO2) gap during exercise at high altitude measured by gastric tonometry. High Altitude Medicine & Biology, 8, (1), 50-55. (doi:10.1089/ham.2006.1022). (PMID:17394417).
Grocott, Michael, Montgomery, Hugh and Vercueil, Andre (2007) High-altitude physiology and pathophysiology: implications and relevance for intensive care medicine. Critical Care, 11, (1), 203. (doi:10.1186/cc5142). (PMID:17291330).
Roche, A.M., James, M.F.M., Grocott, M.P.W. and Mythen, M.G. (2006) Just scratching the surface: varied coagulation effects of polymer containers on TEG variables. European Journal of Anaesthesiology, 23, (1), 45-49. (PMID:16390565).
Vercueil, Andre, Grocott, Michael P.W. and Mythen, Michael G (2005) Physiology, pharmacology, and rationale for colloid administration for the maintenance of effective hemodynamic stability in critically ill patients. Transfusion Medicine Reviews, 19, (2), 93-109. (doi:10.1016/j.tmrv.2004.11.006). (PMID:15852239).
Grocott, Michael P.W., Mythen, Michael G. and Gan, Tong J. (2005) Perioperative fluid management and clinical outcomes in adults. Anesthesia & Analgesia, 100, (4), 1093-1106. (doi:10.1213/01.ANE.0000148691.33690.AC). (PMID:15781528).
Grocott, Michael P.W., McCorkell, Stuart and Cox, Mark L. (2005) Resuscitation from hemorrhagic shock using rectally administered fluids in a wilderness environment. Wilderness and Environmental Medicine, 16, (4), 209-211. (PMID:16366202).
Windsor, J., Dewdney, A., Crooks, R. and Grocott, Michael P.W. (2004) Postobstructive pulmonary oedema. Hospital Medicine, 65, (8), 508. (PMID:15330360).
Meeran, Hanif and Grocott, Michael P.W. (2004) Clinical review: evidence-based perioperative medicine? Critical Care, 9, (1), 81-85. (doi:10.1186/cc2932).
Down, J.F., Barclay, G.R., Bennett-Guerrero, E., Hamilton-Davies, C., Stephens, R., Grocott, M.P.W. and Mythen, M.G. (2004) A descriptive study of the variation in baseline levels of antiendotoxin core antibodies between US and UK populations. Journal of Endotoxin Research, 10, (3), 195-196. (doi:10.1177/09680519040100030601). (PMID:15198854).
Older, P., Grocott, M.P.W., Chaloner, E., Mythen, M.G. and Mackenzie, S.J. (2004) Should perioperative management target oxygen delivery? BJA British Journal of Anaesthesia, 92, (4), 597-598. (doi:10.1093/bja/aeh540). (PMID:14570780).
Bennett-Guerrero, E., Hyam, J.A., Shaefi, S., Prytherch, D.R., Sutton, G.L., Weaver, P.C., Mythen, M.G., Grocott, M.P. and Parides, M.K. (2003) Comparison of P-POSSUM risk-adjusted mortality rates after surgery between patients in the USA and the UK. British Journal of Surgery, 90, (12), 1593-1598. (doi:10.1002/bjs.4347). (PMID:14648741).
Grocott, Mike and Farrar, Daniel (2003) Intravenous artificial oxygen carriers. British Journal of Hospital Medicine, 64, (6), 352-356. (PMID:12833830).
Roche, A.M., James, M.F.M., Grocott, M.P.W. and Mythen, M.G. (2003) Citrated blood does not reliably reflect fresh whole blood coagulability in trials of in vitro hemodilution. Anesthesia & Analgesia, 96, (1), 58-61. (doi:10.1213/​01.ANE.0000040005.95838.57). (PMID:12505923).
Grocott, M.P.W, Stephens, R. and Hamilton, M.A. (2002) What are you going to do about the base deficit? British Journal of Hospital Medicine, 63, (11), 701. (PMID:12474622).
Grocott, Mike, Levett, Denny and Stephens, Robert (2002) Can we measure the quality of perioperative care? Hospital Medicine, 63, (3), 188. (PMID:11933829).
Stephens, Robert and Grocott, Mike (2002) Saline or Hartmann's solution: is it still a controversy? British Journal of Hospital Medicine, 63, (2), 124. (PMID:11902089).
Adams, Murray J., Cardigan, Rebecca A., Marchant, Warwick A., Grocott, Michael P.W., Mythen, Monty G., Mutch, Maj, Purdy, Gordon, Mackie, Ian J. and Machin, Samuel J. (2002) Tissue factor pathway inhibitor antigen and activity in 96 patients receiving heparin for cardiopulmonary bypass. Journal of Cardiothoracic and Vascular Anesthesia, 16, (1), 59-63. (doi:10.1053/jcan.2002.29677). (PMID:11854880).
Grocott, M.P.W. and Hamilton, M.A. (2002) Resuscitation fluids. Vox Sanguinis, 82, (1), 1-8. (doi:10.1046/j.1423-0410.2002.00123.x). (PMID:11856460).
Mythen, Monty, Grocott, Michael and Webb, Andrew R. (2001) The National Confidential Enquiry into Perioperative Deaths 2000: then and now. British Journal of Hospital Medicine, 62, (5), 262-263. (PMID:11385883).
Sivaloganathan, M., Stephens, R. and Grocott, Michael (2000) Management of flail chest. British Journal of Hospital Medicine, 61, (11), 811. (PMID:11198758).
Ackland, Gareth, Grocott, Michael P.W. and Mythen, Michael G. (2000) Understanding gastrointestinal perfusion in critical care: so near, and yet so far. Critical Care, 4, (5), 269-281. (doi:10.1186/cc709). (PMID:11094506).
Kennedy, Angus M., Grocott, Michael, Schwartz, Martin S., Modarres, Hamid, Scott, Mark and Schon, Fred (1997) Median nerve injury: an underrecognised complication of brachial artery cardiac catheterisation? Journal of Neurology, Neurosurgery & Psychiatry, 63, (4), 542-546. (doi:10.1136/jnnp.63.4.542). (PMID:9343143).
 

Research

Research Interests

Human responses to hypoxia, oxygen transport and utilisation, measuring and improving outcome following surgery, acute lung injury, and fluid therapy.

Higher degree supervision

Dr Ahilanandan Dushianthan (PhD, primary supervisor) Dr Ramani Moonesinghe (MD Res, primary supervisor) Ms Elizabeth Ashby (MD Res, primary supervisor) Dr Roger McMorrow (MD, secondary supervisor) Ms Claire Black (PhD, secondary supervisor) Mr Malcolm West (PhD, secondary supervisor) Dr Edward Gilbert-Kawai (PhD, secondary supervisor) Dr Matthew Oliver (MD Res, secondary supervisor) Dr John-Oliver Dunn (PhD, primary supervisor) Ms. Lisa Loughney (PhD, secondary supervisor)

Higher degree completed supervisions
Dr Dan Martin (PhD, primary supervisor) - 2012

Primary research group:

Integrative Physiology and Critical Illness Group, Clinical and ExperimentalSciences 

http://www.southampton.ac.uk/medicine/academic_units/academic_units/clinical_experimental_sciences.page?


Affiliate research groups:

UoS Centre for Human Integrative Physiology, Human Development and Health http://www.southampton.ac.uk/medicine/academic_units/academic_units/human_development_health.page?,

NIAA Health Services Research Centre (Director)http://www.niaa-hsrc.org.uk/,

National Emergency Laparotomy Audit (Chair)http://www.nela.org.uk/,

Caudwell Xtreme Everest Hypoxia Research Consortium (Director) http://www.xtreme-everest.co.uk/,

Fit-4-Surgery Research Collaboration (Lead)

http://www.fit-4-surgery.org.uk/>

Primary research group:  Clinical and Experimental Sciences

Affiliate research group:  Human Development and Health

Responsibilities

Mike is Joint Editor-in-Chief of the BioMedCentral journal "Extreme Physiology and Medicine" (www.extremephysiolmed.com/ ) and serves on the editorial board of several other journals.

He is co-chair of the KnO2wledge series of meetings and of the National Perioperative CPET meeting. He is on the managing faculty of Evidence Based Perioperative Medicine (EBPOM) and the Current Controversies in Anaesthesia and Perioperative Medicine series of meetings.

Contact

Professor Mike Grocott
Faculty of Medicine
University of Southampton
Southampton General Hospital
Mailpoint 801
South Academic Block
Tremona Road
Southampton
SO16 6YD
or
Faculty of Medicine
University of Southampton
Building 85
Life Sciences Building
Highfield Campus
Southampton
SO171BJ

Room Number: SGH/CD93

Telephone: (023) 8120 8449
Email: mike.grocott@soton.ac.uk