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Medicine

Mr Ramsey Cutress BM BCh, MA, PhD, FRCS (Gen Surg)

Associate Professor in Breast Surgery

Mr Ramsey Cutress's photo
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Mr Ramsey Cutress is Associate Professor in Breast Surgery within Medicine at the University of Southampton.

As an academic breast cancer surgeon I work both within the University of Southampton, and the Breast Unit at University Hospital Southampton, in clinics and the operating theatre. Surgery is a key treatment for early stage breast cancer, and the focus of my research is to develop improvements in treatments and outcomes for our patients.

Ramsey Cutress is Associate Professor in Breast Surgery at the University of Southampton and an Honorary Consultant Surgeon at Southampton University Hospitals Trust. He completed his medical degree at Oxford University and during clinical surgical training he won a National Breast Reconstructive and Oncoplastic Fellowship. He wrote his Ph.D on the significance of BAG-1 isoform expression in breast cancer demonstrating that BAG-1 potentiates oestrogen dependent transcription within breast cancer cells and showing that BAG-1 expression predicts survival in breast cancer. This work was within Prof Graham Packham’s laboratory, and was funded by a Robertson Trust fellowship from Royal College of Surgeons of Edinburgh, and the ninth Guernsey Research Fellowship from Hope.

Ramsey leads a translational research laboratory and divides his time between the clinic and research. In the clinic he leads the development of breast reconstructive and oncoplastic surgery in Southampton. Research interests include clinical aspects breast cancer, breast cancer molecular biology, and breast cancer translational research and clinical trials.

Appointments held

October 2009 to date
Senior Lecturer in Breast Surgery and Consultant Breast Surgeon
University of Southampton and Southampton University Hospitals Trust

October 2007-2008
National Oncoplastic Fellowship in Breast Surgery
Portsmouth Hospitals Trust

2004-2007
Wessex Higher Surgical Training

February 2000 – 2003
Clinical Research Fellow (PhD)
University of Southampton

Research

Responsibilities

Publications

Teaching

Contact

Research interests

National Breast Cancer Clinical Trials

Local Investigator for National Institute of Health Research (NIHR) breast cancer clinical trials

Member of the research group for the POSH study

Translational Research

Translational research interests and collaborations include

Chief Investigator for “A study to develop a blood test for use in breast screening

Projects to understand how the immune system might be better harnessed to fight breast cancer as part of the Southampton Experimental Cancer Medicine Centre (ECMC)

The influence of Diet, Nutrition and Exercise on Breast Cancer in collaboration with the Southampton Biomedical Research Unit

Biomarker and Therapeutic Targets

Early work by Ramsey Cutress demonstrated that the expression pattern of a protein known as BAG-1 was associated with survival from breast cancer. This protein is one of 16 markers within the Oncotype DX® commercial breast cancer assay.

Current work within the Cutress laboratory is targeted at developing ways of blocking the function of BAG-1 in breast cancer.

Funding

We are grateful to the following who have kindly provided funding for our breast cancer research:

Cancer Research UK
Breast Cancer Campaign
Breast Cancer Research Trust
National Institute for Health Research
The Royal College of Surgeons of Edinburgh
Wessex Medical Research
Southampton Hospital Charity

Acknowledgements

We are extremely grateful to all who have taken part in our Research to fight Breast Cancer.

 

Nuclear and cytoplasmic BAG-1 positive
Figure A
Nuclear BAG-1 positive, cytoplasmic BAG-1 negative
Figure B
Nuclear and cytoplasmic BAG-1 negative with internal control
Figure C
BAG-1 expression predicts clinical outcome
BAG-1 expression

Academic unit(s)

Cancer Sciences Academic Unit

Affiliate academic unit(s)

Cancer Sciences Research group

Member of writing group for the Association of Breast Surgeons (ABS) “National Oncoplastic and Breast Reconstruction Guidelines” second edition

Chair: University Hospitals Southampton Breast Multidisciplinary Team (MDT)

Membership of the Trial Management and Steering Groups of National Clinical Research Trials

Supervision of Post-Doctoral scientists

Provision of Peer Review for Grant Funding Bodies and National and International Scientific Journals

Secretary of the Academic and Research Group of the Association of Breast Surgery

Article(s)

Book(s)

Book Section(s)

Conference(s)

For the Royal College of Surgeons of England

Course Director: Advanced Skills in Breast Disease Management Course

Serves as a co-opted member of the Education and Training Committee for the Association of Breast Surgery

For the Wessex Deanery (Surgical Training)

Clinical and Educational supervision for Junior Doctors attached to the Southampton Breast Unit
Examiner for FRCS revision course

For the University of Southampton

Supervisor for PhD students
Supervisor for Medical Student “Project in Depth”
Chair for scientific sessions at the Annual Medical School Fourth Year Scientific Conference
Examiner for the University of Southampton School of Medicine
Lecturer on Scientific Basis of Medicine course
Lecturer for student revision course on breast disease

Mr Ramsey Cutress
Phone: (023) 8120 6184 Fax: (023) 8120 5152 Email: R. I. Cutress@soton.ac.uk

Room Number: SGH/CSB/MP824

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