Medicine

Tracey Newman

BSc, PhD

Primary position:
Senior Lecturer in Clinical Neurosciences

Background

The University of Southampton



Dr Newman leads a multidisciplinary group that investigates immune mediated mechanisms that lead to neuronal injury, and its consequences, in the central nervous system.  Members of the group are developing the use of biocompatible nanoparticle delivery and reporter systems. 

The group is based in the Life Sciences Building on the Highfield Campus.

Qualifications

Postgraduate Certificate in Academic Practice (FHEA)

PhD, University of Southampton
BSc, Biochemistry and Physiology

Appointments held

Senior Lecturer, University of Southampton 2014 - present

Lecturer, University of Southampton 2010 – 2014

 

Dr Tracey Newman's photo

Publications

The University of Southampton's electronic library (e-prints)

Article

Verschuur, C.A., Agyemang-Prempeh, A. and Newman, Tracey A. (2014) Inflammation is associated with a worsening of presbycusis: evidence from the MRC national study of hearing. International Journal of Audiology, 53, (7), 469-475. (doi:10.3109/14992027.2014.891057). (PMID:24679110).
Wright, G., Sharifi, Y., Newman, Tracey A., Davies, N.A., Vairappan, B., Perry, V.H. and Jalan, R. (2014) Characterization of temporal microglia and astrocyte immune responses in bile-duct ligated rat models of cirrhosis. Liver International, 1-22. (doi:10.1111/liv.12481). (Submitted).
Carrillo-de Sauvage, M.A., Maatouk, L., Arnoux, I., Pasco, M., Sanz Diez, A., Delahaye, M., Herrero, M.T., Newman , T.A., Calvo, C.F., Audinat, E., Tronche, F. and Vyas, S. (2013) Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation. Cell Death and Differentiation, 20, 1546-1557. (doi:10.1038/cdd.2013.108). (PMID:24013726).
Fairbairn, N., Christofidou, A., Kanaras, Antonios G., Newman, T.A. and Muskens, Otto L. (2013) Hyperspectral darkfield microscopy of single hollow gold nanoparticles for biomedical applications. Physical Chemistry Chemical Physics, 15, 4163-4168. (doi:10.1039/C2CP43162A ). (PMID:23183927).
Causon, Andrew, Verschuur, Carl and Newman, Tracey A. (2013) Trends in cochlear implant complications: implications for improving long term outcomes. Otology & Neurotology, 34, (2), 259-265. (doi:10.1097/MAO.0b013e31827d0943). (PMID:23303172).
Newman, T.A., Bailey, J.L., Stocker, L., Macklon, N.S. and Cheong, Y. (2013) Expression of neuronal markers in the endometrium of women with and without endometriosis. Human Reproduction (In Press).
Garland, Patrick, Broom, Lucy J., Quraishe, Shmma, Dalton, P.D., Skipp, Paul, Newman, T.A. and Perry, V.H. (2012) Soluble axoplasm enriched from injured CNS axons reveals the early modulation of the actin cytoskeleton. PLoS ONE, 7, (10), e47552-[8pp]. (doi:10.1371/journal.pone.0047552). (PMID:23115653).
Buckiova, Daniela, Ranjan, Sanjeev, Newman, Tracey A., Johnston, Alexander H., Sood, Rohit, Kinnunen, Paavo K.J., Popelář, Jiří, Chumak, Tetyana and Syka, Josef (2012) Minimally invasive drug delivery to the cochlea through application of nanoparticles to the round window membrane. Nanomedicine, 7, (9), 1339-1354. (doi:10.2217/nnm.12.5). (PMID:22475648).
Roy, S., Johnston, A.H., Moin, S.T., Dudas, J., Newman, T.A., Hausott, B., Schrott-Fischer, A. and Glueckert, R. (2012) Activation of TrkB receptors by NGFβ mimetic peptide conjugated polymersome nanoparticles. Nanomedicine Nanotechnology Biology and Medicine (PMID:22206946).
Surovtesva, Elena V., Johnston, Alexander H., Zhang, Weikai, Zhang, Ya, Kim, Adele, Murakoshi, Michio, Wada, Hiroshi, Newman, Tracey A., Zou, Jing and Pyykko, Illmari (2012) Prestin binding peptides as ligands for targeted polymersome mediated drug delivery to outer hair cells in the inner ear. International Journal of Pharmaceutics (doi:10.1016/j.ijpharm.2011.12.042). (PMID:22227343).
Zhang, Ya, Zhang, Weikai, Johnston, Alexander H., Newman, Tracey .A., Pyykko, Ilmari and Zou, Jing (2012) Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve. International Journal of Nanomedicine (PMID:22403485).
Roy, Soumen, Glueckert, Rudolf, Johnston, Alex H., Perrier, Thomas, Newman, T.A., Saulnier, Patrick and Schrott-Fischer, Anneliese (2012) Strategies for drug delivery to the human inner ear by multifunctional nanoparticles. Nanomedicine, 7, (1), 55-63. (doi:10.2217/nnm.11.84). (PMID:22106854).
Moreno, Beatriz, Jukes, John-Paul, Vergara-Irigaray, Nuria, Errea, O., Villoslada, Pablo, Perry, V.H. and Newman, T.A. (2011) Systemic inflammation induces axon injury during brain inflammation. Annals of Neurology, 70, (6), 932-942. (doi:10.1002/ana.22550). (PMID:22190366).
Zhang, Y., Zhang, W., Johnston , A., Newman, T.A., Pyykko, I. and Zou, J. (2011) Comparison of the distribution pattern of PEG-b-PCL polymersomes delivered into the rat inner ear via different methods. Acta Oto-Laryngologica (PMID:21905960). (In Press).
Arundell, Martin, Perry, V. Hugh and Newman, Tracey A. (2011) Integration of a macro/micro architectured compartmentalised neuronal culture device using a rapid prototyping moulding process. Lab on a Chip, 11, (17), 3001-3005. (doi:10.1039/C1LC20120D). (PMID:21776485).
Newman, T.A., Sinadinos, Christopher, Johnston, Alexander H., Sealey, Megan and Mudher, A. (2011) Using Drosophila models of neurodegenerative diseases for drug discovery. Expert Opinion on Drug Discovery, 6, (2), 129-140. (doi:10.1517/17460441.2011.549124).
Zhang, Ya, Zhang, Weikai, Johnston, Alexander H., Newman, Tracey A., Pyykko, Iimari and Zou, Jing (2010) Improving the visualization of fluorescently tagged nanoparticles and fluorophore-labeled molecular probes by treatment with CuSO(4) to quench autofluorescence in the rat inner ear. Hearing Research, 269, (1-2), 1-11. (doi:10.1016/j.heares.2010.07.006). (PMID:20659540).
Zhang, Ya, Zhang , Weikai, Johnston , Alexander H., Newman , Tracey A, Pyykko , Iimari and Zou, Jing (2010) Improving the visualization of fluorescently tagged nanoparticles and fluorophore-labeled molecular probes by treatment with CuSO(4) to quench autofluorescence in the rat inner ear. Hearing Research, 269, (1-2), 1-11. (doi:10.1016/j.heares.2010.07.006). (PMID:20659540).
Johnston, Alexander H., Dalton, Paul D. and Newman, Tracey A. (2010) Polymersomes, smaller than you think: ferrocene as a TEM probe to determine core structure. Journal of Nanoparticle Research, 12, (6) (doi:10.1007/s11051-010-9886-5).
Roy, Soumen, Johnston, Alex H., Newman, Tracey A., Glueckert, Rudolf, Dudas, Jozsef, Bitsche, Mario, Corbacella, Elisa, Rieger, Gunde, Martini, Alessandro and Fischer, Anneliese Schrott (2010) Cell-specific targeting in the mouse inner ear using nanoparticles conjugated with a neurotrophin derived peptide ligand: potential tool for drug delivery. International Journal of Pharmaceutics, 390, (2), 214-224. (doi:10.1016/j.ijpharm.2010.02.003). (PMID:20153412).
Roy , Soumen, Johnston, Alex H., Newman , TA, Glueckert , Rudolf, Dudas , Jozsef, Bitsche , Mario, Corbacella , Elisa, Reiger , Gunde and Schrott-Fischer , Alessandro (2010) Cell-specific targeting in the mouse inner ear using nanoparticles conjugated with a neurotrophin-derived peptide ligand: potential tool for drug delivery. International Journal of Pharmaceutics, 390, (2), 214-224. (doi:10.1016/j.ijpharm.2010.02.003). (PMID:20153412).
Teeling, J.L., Cunningham, C., Newman, Tracey A. and Perry, V.H. (2010) The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: implications for a role of COX-1. Brain, Behavior and Immunity, 24, (3), 409-419. (doi:10.1016/j.bbi.2009.11.006). (PMID:19931610).
Folwell, James, Cowan, Catherine M., Ubhi, Kiren K., Shiabh, Hassan, Newman, Tracey A., Shepherd, David and Mudher, Amritpal (2009) Aβ exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease. Experimental Neurology, 223, (2), 1-9. (doi:10.1016/j.expneurol.2009.09.014).
Anderson, Malin, Johnston, A.H., Newman, T.A., Dalton, P.D. and Rask-Andersen, Helge (2009) Internalization of nanoparticles into spiral ganglion cells. Journal of Nanoneuroscience, 1, (1), 75-84. (doi:10.1166/jns.2009.008).
Galea, Ian, Felton, Leigh M., Waters, Sara, van Rooijen, Nico, Perry, V. Hugh and Newman, Tracey A. (2008) Immune-to-brain signalling: the role of cerebral CD163-positive macrophages. Neuroscience Letters, 448, (1), 41-46. (doi:10.1016/j.neulet.2008.09.081). (PMID:18852025).
Carare, R.O., Bernardes-Silva, M., Newman, T.A., Page, A.M., Nicoll, J.A.R., Perry, V.H. and Weller, R.O. (2008) Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology. Neuropathology & Applied Neurobiology, 34, (2), 131-144. (doi:10.1111/j.1365-2990.2007.00926.x).
Ubhi, Kiren K., Shaibah, Hassan, Newman, Tracey A., Shepherd, David and Mudher, Amritpal (2007) A comparison of the neuronal dysfunction caused by Drosophila tau and human tau in a Drosophila model of tauopathies. Invertebrate Neuroscience, 7, (3), 165-171. (doi:10.1007/s10158-007-0052-4).
Mudher, A., Folwell, J., Shepherd, D. and Newman, T. (2006) Consequences of co-expression of human tau and Abeta in Drosophila. Comparative Biochemisty and Physiology - Part A: Molecular & Intergrative Physiology, 143, (4, supplement 1), S113-S114. (doi:10.1016/j.cbpa.2006.01.046).
Shepherd, D., Newman, T., Chee, F., Cuttle, M. and Mudher, A. (2006) Modelling human neurodegenerative diseases in Drosophila. Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology, 143, (4, Suplement 1), p.S113. (doi:10.1016/j.cbpa.2006.01.046).
Newman, T., Shaibah, H. and Shepherd, D. (2006) Modelling axonal injury using Drosophila. Comparative Biochemistry and Physiology Part A, 143, (4, Supplement 1), p.S115. (doi:10.1016/j.cbpa.2006.01.046).
Chee, F., Mudher, A., Newman, T.A., Cuttle, M., Lovestone, S. and Shepherd, D. (2006) Overexpression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions. Biochemical Society Transactions, 34, (1), 88-90.
Chee, Francis C., Mudher, Amritpal, Cuttle, Matthew F., Newman, Tracey A., MacKay, Daniel, Lovestone, Simon and Shepherd, David (2005) Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions. Neurobiology of Disease, 20, (3), 918-928. (doi:10.1016/j.nbd.2005.05.029).
Newman, Tracey A., Galea, Ian, van Rooijen, Nico and Perry, V. Hugh (2005) Blood-derived dendritic cells in an acute brain injury. Journal of Neuroimmunology, 166, (1-2), 167-172. (doi:10.1016/j.jneuroim.2005.04.026).
Chee, F.C., Mudher, A., Cuttle, M.F., Newman, T.A., MacKay, D., Lovestone, S. and Shepherd, D. (2005) Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions. Neurobiology of Disease, 20, (3), 918-928. (doi:10.1016/j.nbd.2005.05.029).
Hendriks, J.J.A, van Meeteren, M.E., van der Pol, S.M.A., Newman, T.A., Dijkstra, C.D. and de Vries, H.E. (2005) Axonal damage and oxidative stress during chronic experimental allergic encephalomyelitis. Journal of Neuroprotection and Neuroregeneration, 1, (3), 171-176.
Galea, Ian, Palin, Karine, Newman, Tracey A., Van Rooijen, Nico, Perry, V. Hugh and Boche, Delphine (2005) Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain. Glia, 49, (3), 375-384. (doi:10.1002/glia.20124).
Sun, D., Newman, T.A., Perry, V.H. and Weller, R.O. (2004) Cytokine-induced enhancement of autoimmune inflammation in the brain and spinal cord: implications for multiple sclerosis. Neuropathology and Applied Neurobiology, 30, (4), 374-384. (doi:10.1111/j.1365-2990.2003.00546.x).
Mudher, A., Shepherd, D., Newman, T.A., Mildren, P., Jukes, J.P., Squire, A., Mears, A., Berg, S., MacKay, D., Asuni, A.A., Bhat, R. and Lovestone, S. (2004) GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila. Molecular Psychiatry, 9, (5), 522-530. (doi:10.1038/sj.mp.4001483). (PMID:14993907).
Galea, Ian, Newman, Tracey A. and Gidron, Yori (2004) Letter. Stress and exacerbations in multiple sclerosis: whether stress triggers relapses remains a conundrum. British Medical Journal, 328, (7434), p.287. (doi:10.1136/bmj.328.7434.287).
Newman, T., Carare-Nnadi, R., Bernardes-Silva, M., Weller, R. and Perry, V. H. (2004) Traffic of antigen presenting cells to and from the brain. Neuroimmunology, 154, (1-2), 1-230.
Mudher, A., Shepherd, D., Newman, T.A., Mildren, P., Jukes, J.P., Squire, A., Mears, A., Berg, S., Mackay, D., Asuni, A.A., Bhat, R. and Lovestone, S. (2004) GSK-3b inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila. Molecular Psychiatry, 9, (5), 1-9. (doi:10.1038/sj.mp.4001483).
Perry, V.H., Newman, T.A. and Cunningham, C. (2003) The impact of systemic infection on the progression of neurodegenerative disease. Nature Reviews Neuroscience, 4, (2), 103-112. (doi:10.1038/nrn1032).
Shepherd, D., Newman, T., Mudher, A. and Lovestone, S. (2002) Modelling tauopathies in Drosophila. Neurobiology of Aging, 23, (1, Supplement 1), p.S234. (doi:10.1016/S0197-4580(02)00052-0).
Newman, T.A., Woolley, S.T., Hughes, P.M., Sibson, N.R., Anthony, D.C. and Perry, V.H. (2001) T-cell- and macrophage-mediated axon damage in the absence of a CNS-specific immune response: involvement of metalloproteinases. Brain, 124, (11), 2203-2214. (doi:10.1093/brain/124.11.2203).
Sun, Dong, Tani, Marie, Newman, Tracey A., Krivacic, Kimberly, Phillips, Marian, Chernosky, Ann, Gill, Pelvender, Griswold, Katherine J., Ransohoff, Richard M., Weller, Roy O. and Tao, Wei (2000) Role of chemokines, neuronal projections, and the blood-brain barrier in the enhancement of cerebral EAE following focal brain damage. Journal of Neuropathology and Experimental Neurology, 59, (12), 1031-1043.
Weller, Roy O., Massey, Adrian, Newman, Tracey A., Hutchings, Margaret, Kuo, Yu-Min and Roher, Alex E. (1998) Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. American Journal of Pathology, 153, (3), 725-733.

Book

Mudher, Amritpal and Newman, Tracey (eds.) (2007) Drosphile: A toolbox for the study of neurodegenerative disease, London, GB, Taylor and Francis, 220pp. (Society for Experimental Biology, 60).

Book Section

Löbler, Marian, Rohm, H.W., Schmitz, K.-P., Johnston, A.H., Newman, T.A., Ranjan, S., Sood, R. and Kinnunen, P.K.J. (2009) Drug delivery by nanoparticles - facing the obstacles. In, 4th European Conference of the International Federation for Medical and Biological Engineering. Antwerp, BE, Springer, 2335-2338. (IFMBE Proceedings, 22 19). (doi:10.1007/978-3-540-89208-3).
Mudher, A., Newman, T.A., Chee, F.C. and Shepherd, D.S. (2007) Using Drosophila models to unravel pathogenic mechanisms that underlie neurodegeneration in Tauopathies. In, Mudher, Amritpal and Newman, T.A. (eds.) Drosophila: A Toolbox for the Study of Neurodegenerative Disease. England, GB, .
 

Research

Research Interests

The contribution of inflammation to outcomes in hearing loss.

Age related hearing loss affects a significant number of older people. Despite this and in common with other conditions with a neurodegenerative component, we lack disease-modifying drugs to treat the condition. With collaborators in ISVR (Verschuur, Lineton) we are exploring the contribution of the innate immune system to the rate of progression of hearing loss. A better understanding of the relationship between inflammatory markers and hearing function may enable us to stratify individuals such that we are able to determine those individuals most at risk of deterioration. Our current work includes investigating hearing and inflammation in a longitudinal human study of older community dwelling individuals.

A percentage of people experiencing hearing loss due to changes within their cochleae are recipients of cochlear implants. These devices are designed to transduce sounds from the outside world to the auditory pathways within the cochlea and brain. A small subset of the cohort, those with partial hearing loss, receive shorter electroacoustic implants. These implants replace the missing function in part of the cochlea and allow the residual hearing to remain functional. In both implant groups a small number of patients do not do as well as anticipated, we have a multi-centre study underway to explore the contribution of inflammation to this variation in outcome.

Biocompatible nanoparticles for enhanced drug delivery

The growing burden of neurological disease is driving a need to develop new routes for selective drug delivery to the central nervous system. We have developed targeted engineered nanoparticles for drug delivery. We use organic nanoparticles capable of delivering several different cargo types (hydrophilic, hydrophobic, and protein). These are being tested in vitro, and in vivo.

Through a combination of approaches we are investigating the interaction of the nanoparticles with neurons, and stem cells (Evans, Oreffo, FoM), including the uptake mechanisms and the factors that influence this. We are working to identify neuron-specific ligands to use as targeting moieties. We have developed fluorescence-based approaches to resolve the delivery kinetics, including the temporal profile, of compounds. Our current focus is the fate and clearance of the nanoparticles after internalization.

In collaboration with colleagues at the University of Malaya (Woo, Ariffin), and HDH (Cheong), we are exploiting these nanoparticles for enhanced delivery of compounds to the female reproductive tract.

Nanotoxicology – airborne particulates

As nanoparticle usage becomes more mainstream, in both medicine and consumer products, there is a need to investigate the possible detrimental impact of nanoparticles on the health and integrity of the CNS. Anthropogenic airborne nanoparticles may also be a challenge to the nervous system. Together with colleagues in the Centre for Biological Sciences (Poppy, Girling) we are investigating the impact of airborne nanoparticulate pollutants on learning and memory in the honey bee, an insect of significant ecological and economic importance.


Academic unit:  Clinical and Experimental Sciences

Research project

Targeting stem cells with nanoparticles

Promoting tissue regeneration by carrying drugs and molecules directly to stem cells.

Responsibilities

Postgraduate student supervision

Year of entry 2010

Shilong Lu (FoM/FEE)

Year of entry 2011

Andrew Causon (FoM/FEE)
Christine Reitmayer (FoM/FNES)
Katerina Zisimopolou (FoM)

Year of entry 2012

Akosua Agyemang-Prempeh (FoM/FEE)

Year of entry 2013

Edoardo Scarpa (FoM)

Faculty of Medicine

Deputy Programme Lead of the Masters in Medical Science

 

Teaching Responsibilities

MMedSc Deputy Programme Lead and Module Co-ordinator for MEDI4015/4014/6056/6057. Lectures and small group teaching.

BM5/BM4 Lectures, BMedSc project supervision, Personal tutor.

Project supervision on the BSc/MBiol/MMedSc/BMedSc.

Contact

Dr Tracey Newman
Faculty of Medicine
University of Southampton
Building 85
Life Sciences Building
Highfield Campus
Southampton
SO171BJ

+44 2380 597642

Room Number: 85/3041

Telephone: (023) 8059 7642
Email: T.A.Newman@soton.ac.uk