Ocean and Earth Science, National Oceanography Centre Southampton

Jörg Wiedenmann

Primary position:
Professor of Biological Oceanography
Other positions:
Head of the Coral Reef Laboratory


The University of Southampton

Jörg Wiedenmann is a Professor at the University of Southampton and head of the Marine Biotechnology Laboratory and the Coral Laboratory at the National Oceanography Centre Southampton (http://www.noc.ac.uk/corals/).

He discovered green and red fluorescent GFP-like proteins in sea anemones in 1997, and proposed their application as their application as in vivo markers (Patent DE19718640A1, DPMA). His research focused on the ecology of cnidarian pigments, the biochemistry of fluorescent proteins and chromoproteins and their application as markers in biomedical research. He cloned the coding DNAs of over 40 novel GFP-like proteins from marine invertebrates and conducted detailed biochemical and spectral characterization of the proteins. He was involved in the X-ray crystallography of several fluorescent proteins. Various aspects of the impact of GFP-like proteins on the coloration of reef corals were studied in the Great Barrier Reef, the Mediterranean Sea and under controlled laboratory conditions. Research of Jörg also elucidated the origin of the invasive alga Caulerpa taxifolia, the molecular phylogeny of zooxanthellae in temperate waters and their loss in bleaching of sea anemones and the regulation of heat shock proteins in cnidarians under stress. He is peer reviewer for several international journals and a member of the NERC Peer Review College and steering committee member of the NERC-funded Coral Aquarist Researcher Network (CARN, http://carnuk.org/about.aspx). He secured funding >£1 million. His work received several prestigious awards including the Merckle Research Award, the Award Cooperation University & Industry, and the Vice Chancellor Teaching Award.

Professor Jörg Wiedenmann's photo


The University of Southampton's electronic library (e-prints)


D’Angelo, Cecilia and Wiedenmann, Jörg (2014) Impacts of nutrient enrichment on coral reefs: new perspectives and implications for coastal management and reef survival. [in special issue: Environmental Change Issues] Current Opinion in Environmental Sustainability, 7, 82-93. (doi:10.1016/j.cosust.2013.11.029).
Hume, Benjamin C.C., D’Angelo, Cecilia, Cunnington, Anna, Smith, Edward G. and Wiedenmann, Jörg (2014) The corallivorous flatworm Amakusaplana acroporae: an invasive species threat to coral reefs? Coral Reefs, 33, (1), 267-272. (doi:10.1007/s00338-013-1101-6).
Feary, David A., Burt, John A., Bauman, Andrew G., Al Hazeem, Shaker, Abdel-Moati, Mohamed A., Al-Khalifa, Khalifa A., Anderson, Donald M., Amos, Carl, Baker, Andrew, Bartholomew, Aaron, Bento, Rita, Cavalcante, Geórgenes H., Chen, Chaolun Allen, Coles, Steve L., Dab, Koosha, Fowler, Ashley M., George, David, Grandcourt, Edwin, Hill, Ross, John, David M., Jones, David A., Keshavmurthy, Shashank, Mahmoud, Huda, Moradi Och Tapeh, Mahdi, Mostafavi, Pargol Ghavam, Naser, Humood, Pichon, Michel, Purkis, Sam, Riegl, Bernhard, Samimi-Namin, Kaveh, Sheppard, Charles, Vajed Samiei, Jahangir, Voolstra, Christian R. and Wiedenmann, Joerg (2013) Critical research needs for identifying future changes in Gulf coral reef ecosystems. Marine Pollution Bulletin, 72, (2), 406-416. (doi:10.1016/j.marpolbul.2013.02.038).
Hume, B., D'Angelo, C., Burt, J., Baker, A.C., Riegl, B. and Wiedenmann, J. (2013) Corals from the Persian/Arabian Gulf as models for thermotolerant reef-builders: prevalence of clade C3 Symbiodinium, host fluorescence and ex situ temperature tolerance. [in special issue: Coral Reefs of the Gulf: Past, Present and the Future of a Unique Ecosystem] Marine Pollution Bulletin, 72, (2), 313-322. (doi:10.1016/j.marpolbul.2012.11.032).
Wiedenmann, Jörg, D'Angelo, Cecilia, Smith, Edward G., Hunt, Alan N., Legiret, François-Eric, Postle, Anthony D. and Achterberg, Eric P. (2013) Letter. Nutrient enrichment can increase the susceptibility of reef corals to bleaching. Nature Climate Change, 3, (5), 160-164. (doi:10.1038/nclimate1661).
Hartle-Mougiou, Katherine, D'Angelo, Cecilia, Smith, Edward G., Burt, John, West, Paul and Wiedenmann, Jörg (2012) Diversity of zooxanthellae from corals and sea anemones after long-term aquarium culture. Journal of the Marine Biological Association of the United Kingdom, 92, (04), 687-691. (doi:10.1017/S0025315411001159).
D'Angelo, Cecilia and Wiedenmann, Jörg (2012) An experimental mesocosm for long-term studies of reef corals. Journal of the Marine Biological Association of the United Kingdom, 92, (04), 769-775. (doi:10.1017/S0025315411001883).
Lam, Amy J., St-Pierre, François, Gong, Yiyang, Marshall, Jesse D., Cranfill, Paula J., Baird, Michelle A., McKeown, Michael R., Wiedenmann, Jörg, Davidson, Michael W., Schnitzer, Mark J., Tsien, Roger Y. and Lin, Michael Z. (2012) Improving FRET dynamic range with bright green and red fluorescent proteins. Nature Methods, 9, (10), 1005-1012. (doi:10.1038/nmeth.2171).
Kenkel, C.D., Traylor, M.R., Wiedenmann, J., Salih, A. and Matz, M.V. (2011) Fluorescence of coral larvae predicts their settlement response to crustose coralline algae and reflects stress. Proceedings of The Royal Society B Biological Sciences, 278, (1718), 2691-2697. (doi:10.1098/rspb.2010.2344).
Wiedenmann, Jörg, Gayda, Susan, Adam, Virgile, Oswald, Franz, Nienhaus, Karin, Bourgeois, Dominique and Nienhaus, G. Ulrich (2011) From EosFP to mIrisFP: structure-based development of advanced photoactivatable marker proteins of the GFP-family. Journal of Biophotonics, 4, (6), 377-390. (doi:10.1002/jbio.201000122).
Wacker, Stephan Armin, Alvarado, Cristobal, von Wichert, Götz, Knippschild, Uwe, Wiedenmann, Jörg, Clauß, Karen, Nienhaus, Gerd Ulrich, Hameister, Horst, Baumann, Bernd, Borggrefe, Tilman, Knöchel, Walter and Oswald, Franz (2011) RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. The EMBO Journal, 30, 43-56. (doi:10.1038/emboj.2010.289).
Hvasanov, David, Wiedenmann, Jörg, Braet, Filip and Thordarson, Pall (2011) Induced polymersome formation from a diblock PS-b-PAA polymer via encapsulation of positively charged proteins and peptides. Chemical Communications, 47, (22), 6314-6316. (doi:10.1039/c1cc11662b).
Wolff, Michael, Kredel, Simone, Haasen, Dorothea, Wiedenmann, Jörg, Nienhaus, G. Ulrich, Kistler, Barbara, Oswald, Franz and Heilker, Ralf (2010) High Content Screening of CXCR2-Dependent Signalling Pathways. Combinatorial Chemistry & High Throughput Screening, 13, (1), 3-15.
Fuchs, Jochen, Böhme, Susan, Oswald, Franz, Hedde, Per Niklas, Krause, Maike, Wiedenmann, Jörg and Nienhaus, G. Ulrich (2010) A photoactivatable marker protein for pulse-chase imaging with superresolution. Nature Methods, 7, (8), 627-630. (doi:10.1038/nmeth.1477).
Nienhaus, G. Ulrich and Wiedenmann, Jörg (2009) Structure, Dynamics and Optical Properties of Fluorescent Proteins: Perspectives for Marker Development. Chemphyschem, 10, (9-10), 1369-1379. (doi:10.1002/cphc.200800839).
Kredel, Simone, Oswald, Franz, Nienhaus, Karin, Deuschle, Karen, Röcke, Carlheinz, Wolff, Michael, Heilker, Ralf, Nienhaus, G. Ulrich and Wiedenmann, Jörg (2009) mRuby, a bright monomeric red fluorescent protein for labeling of subcellular structures. PLoS ONE, 4, (2), e4391. (doi:10.1371/journal.pone.0004391).
Kredel, Simone, Wolff, Michael, Wiedenmann, Jörg, Nienhaus, G. Ulrich, Gierschik, Peter, Kistler, Barbara and Heilker, Ralf (2009) CXCR2 Inverse Agonism Detected by Arrestin Redistribution. Journal of Biomolecular Screening, 14, (9), 1076-1091. (doi:10.1177/1087057109344616).
Wiedenmann, Joerg, Oswald, Franz and Nienhaus, Gerd Ulrich (2009) Fluorescent proteins for live cell imaging: Opportunities, limitations, and challenges. IUMBM Life, 61, (11), 1029-1042. (doi:10.1002/iub.256).
Hedde, Per Niklas, Fuchs, Jochen, Oswald, Franz, Wiedenmann, Jörg and Nienhaus, Gerd Ulrich (2009) Online image analysis software for photoactivation localization microscopy. Nature Methods, 6, 689-690. (doi:10.1038/nmeth1009-689).
Adam, Virgile, Lelimousin, Mickaël, Boehme, Susan, Desfonds, Guillaume, Nienhaus, Karin, Field, Martin J., Wiedenmann, Joerg, McSweeney, Sean, Nienhaus, G. Ulrich and Bourgeois, Dominique (2008) Structural characterization of IrisFP, an optical highlighter undergoing multiple photo-induced transformations. Proceedings of the National Academy of Sciences of the United States of America, 105, (47), 18343-18348. (doi:10.1073/pnas.0805949105).
Vogt, Alexander, D'Angelo, Cecilia, Oswald, Franz, Denzel, Andrea, Mazel, Charles H., Matz, Mikhail V., Invanchenko, Sergey, Nienhaus, G. Ulrich and Wiedenmann, Jörg (2008) A green fluorescent protein with photoswitchable emission from the deep sea. PLoS ONE, 3, (11), e3766. (doi:10.1371/journal.pone.0003766).
Wolff, Michael, Kredel, Simone, Wiedenmann, Jorg, Nienhaus, G.U. and Heilker, Ralf (2008) Cell-based assays in practice: cell markers from naturally fluorescent proteins. Combinatorial Chemistry & High Throughput Screening, 11, (8), 602-609. (doi:10.2174/138620708785739880).
Nienhaus, Karin, Nar, Herbert, Heilker, Ralf, Wiedenmann, Jörg and Nienhaus, G. Ulrich (2008) Trans−Cis Isomerization is Responsible for the Red-Shifted Fluorescence in Variants of the Red Fluorescent Protein eqFP611. Journal of the American Chemical Society, 130, (38), 12578-12579. (doi:10.1021/ja8046443).
Salat, D., Liefke, R., Wiedenmann, J., Borggrefe, T. and Oswald, F. (2008) ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of Notch target genes. Molecular and Cellular Biology, 28, (10), 3502-3512. (doi:10.1128/MCB.01966-07).
Kredel, S., Nienhaus, K., Wolff, M., Oswald, F., Ivanchenko, S., Cymer, F., Jeromin, A., Michel, F.J., Spindler, K.D., Heilker, R., Nienhaus, G.U. and Wiedenmann, J. (2008) Optimized and far-red emitting variants of fluorescent protein eqFP611. Chemistry & Biology, 15, (3), 224-233. (doi:10.1016/j.chembiol.2008.02.008).
Glaschick, Sylvia, Röcker, Carlheinz, Deuschle, Karen, Wiedenmann, Jörg, Oswald, Franz, Mailänder, Volker and Nienhaus, G. Ulrich (2008) Axial resolution enhancement by 4Pi confocal fluorescence microscopy with two-photon excitation. Journal of Biological Physics, 33, (5-6), 433-443. (doi:10.1007/s10867-008-9084-1).
Alieva, N.O., Konzen, K.A., Field, S.F., Meleshkevitch, E.A., Hunt, M., Beltran-Ramirez, V., Nienhaus, G-U., Miller, D.J., Wiedenmann, J., Salih, A. and Matz, M.V. (2008) Diversity and evolution of coral fluorescent proteins. PLoS ONE, 3, (7), e2680. (doi:10.1371/journal.pone.0002680).
D'Angelo, Cecilia, Denzel, Andrea, Vogt, Alexander, Matz, Mikhail V., Oswald, Franz, Salih, Anya, Nienhaus, G. Ulrich and Wiedenmann, Jörg (2008) Blue light regulation of host pigment in reef-building corals. Marine Ecology Progress Series, 364, 97-106. (doi:10.3354/meps07588).
Leutenegger, A., Kredel, S., Gundel, S., D'Angelo, C., Salih, A. and Wiedenmann, J. (2007) Analysis of fluorescent and non-fluorescent sea anemones from the Mediterranean Sea during a bleaching event. Journal of Experimental Marine Biology and Ecology, 353, (2), 221-234. (doi:10.1016/j.jembe.2007.09.013).
Wiedenmann, J., Leutenegger, A., Gundel, S., Schmitt, F., D'Angelo, C. and Funke, W. (2007) Long-term monitoring of space competition among fluorescent and nonfluorescent sea anemones in the Mediterranean Sea. Journal of the Marine Biological Association of the United Kingdom, 87, (4), 851-852. (doi:10.1017/S0025315407057050).
Leutenegger, Alexandra, D'Angelo, Cecilia, Matz, Mikhail V., Denzel, Andrea, Oswald, Franz, Salih, Anya, Ulrich Nienhaus, G. and Wiedenmann, Jörg (2007) It's cheap to be colorful: anthozoans show a slow turnover of GFP-like proteins. FEBS Journal, 274, (10), 2496-2505. (doi:10.1111/j.1742-4658.2007.05785.x). (PMID:17419724).
Ivanchenko, S., Glaschick, S., Röcker, C., Oswald, F., Wiedenmann, J. and Nienhaus, G.U. (2007) Two-photon excitation and photoconversion of EosFP in dual-color 4Pi confocal microscopy. Biophysical Journal, 92, (12), 4451-4457. (doi:10.1529/biophysj.106.103408).
Cronauer, M.V., Ince, Y., Engers, R., Rinnab, L., Weidemann, W., Suschek, C.V., Burchardt, M., Kleinert, H., Wiedenmann, J., Sies, H., Ackermann, R. and Kröncke, K.D. (2007) Nitric oxide-mediated inhibition of androgen receptor activity: possible implications for prostate cancer progression. Oncogene, 26, (13), 1875-1884. (doi:10.1038/sj.onc.1209984).
Oswald, F., Schmitt, F.M., Leutenegger, A., Ivanchenko, S., D'Angelo, C., Salih, A., Maslakova, S., Bulina, M., Schirmbeck, R., Nienhaus, G.U., Matz, M.V. and Wiedenmann, J. (2007) Contributions of host and symbiont pigments to the coloration of reef corals. FEBS Journal, 274, (4), 1102-1122. (doi:10.1111/j.1742-4658.2007.05661.x).
Visram, S., Wiedenmann, J. and Douglas, A.E. (2007) Molecular diversity of symbiotic algae Symbiodinium (Zooxanthellae) in Cnidarians of the Mediterranean Sea. Journal of the Marine Biological Association of the United Kingdom, 86, 1281-1283.
Wacker, S.A., Oswald, F., Wiedenmann, J. and Knochel, W. (2007) A green to red photoconvertible protein as analyzing tool for early vertebrate development. Developmental Dynamics, 236, (2), 473-480. (doi:10.1002/dvdy.20955).
Nienhaus, K., Renzi, F., Vallone, B., Wiedenmann, J. and Nienhaus, G.U. (2006) Chromophore-Protein Interactions in the Anthozoan Green Fluorescent Protein asFP499. Biophysical Journal, 91, (11), 4210-4220. (doi:10.1529/biophysj.106.087411).
Wolff, M., Wiedenmann, J., Nienhaus, G.U., Valler, M. and Heilker, R. (2006) Novel fluorescent proteins for high-content screening. Drug Discovery Today, 11, (23-24), 1054-1060. (doi:10.1016/j.drudis.2006.09.005).
Wolff, M., Haasen, D., Merk, S., Kroner, M., Maier, U., Bordel, S., Wiedenmann, J., Nienhaus, G.U., Valler, M. and Heilker, R. (2006) Automated high content screening for phosphoinositide kinase 3 inhibition using an AKT1 redistribution assay. Combinatorial Chemistry & High Throughput Screening, 9, (5), 339-350.
Nienhaus, G. Ulrich, Nienhaus, Karin, Hölzle, Angela, Ivanchenko, Sergey, Renzi, Fabiana, Oswald, Franz, Wolff, Michael, Schmitt, Florian, Röcker, Carlheinz, Vallone, Beatrice, Weidemann, Wolfgang, Heilker, Ralf, Nar, Herbert and Wiedenmann, Jörg (2006) Photoconvertible fluorescent protein EosFP: biophysical properties and cell biology applications. Photochemistry and Photobiology, 82, (2), 351-358. (doi:10.1562/2005-05-19-RA-533).
Loos, D.C., Habuchi, S., Flors, C., Hotta, J-I., Wiedenmann, J., Nienhaus, G.U. and Hofkens, J. (2006) Photoconversion in the red fluorescent protein from the sea anemone Entacmaea quadricolor: is cis-trans isomerization involved? Journal of the American Chemical Society, 128, (19), 6270-6271. (doi:10.1021/ja0545113 S0002-7863(05)04511-7).
Wiedenmann, J. and Nienhaus, G.U. (2006) Live-cell imaging with EosFP and other photoactivatable marker proteins of the GFP Family. Expert Review of Proteomics, 3, 361-374.
Ivanchenko, S., Röcker, C., Oswald, F., Wiedenmann, J. and Nienhaus, G.U. (2005) Targeted green-red photoconversion of EosFP, a fluorescent marker protein. Journal of Biological Physics, 31, (3-4), 249-259. (doi:10.1007/s10867-005-0174-z).
Nienhaus, K., Nienhaus, G.U., Wiedenmann, J. and Nar, H. (2005) Structural basis for photo-induced protein cleavage and green-to-red conversion of fluorescent protein EosFP. Proceedings of the National Academy of Sciences of the USA, 102, (26), 9156-9159. (doi:10.1073/pnas.0501874102).
Nieva, C., Gwoźdź, T., Dutko-Gwoźdź, J., Wiedenmann, J., Spindler-Barth, M., Wieczorek, E., Dobrucki, J., Duś, D., Henrich, V., Ożyhar, A. and Spindler, K.D. (2005) Ultraspiracle promotes the nuclear localization of ecdysteroid receptor in mammalian cells. Biological Chemistry, 386, (5), 463-470. (doi: 10.1515/BC.2005.055).
Wiedenmann, J., Vallone, B., Renzi, F., Nienhaus, K., Ivanchenko, S., Röcker, C. and Nienhaus, G.U. (2005) The red fluorescent protein eqFP611 and its genetically engineered dimeric variants. Journal of Biomedical Optics, 10, 014003. (doi:10.1117/1.1854680).
Anikin, K., Röcker, C., Wittemann, A., Wiedenmann, J., Ballauff, M. and Nienhaus, G.U. (2005) Polyelectrolyte-mediated protein adsorption: fluorescent protein binding to individual polyelectrolyte nanospheres. Journal of Physical Chemistry B, 109, (12), 5418-5420. (doi:10.1021/jp0506282 S1089-5647(05)00628-0).
Wiedenmann, J, Ivanchenko, S, Oswald, F, Schmitt, F, Rocker, C, Salih, A, Spindler, K.D. and Nienhaus, G.U. (2004) EosFP, a fluorescent marker protein with UV-inducible green-to-red fluorescence conversion. Proceedings of the National Academy of Sciences of the USA, 101, (45), 15905-15910. (doi:10.1073/pnas.0403668101).
Wiedenmann, J., Ivanchenko, S., Oswald, F. and Nienhaus, G.U. (2004) Identification of GFP-like proteins in non-bioluminescent, azooxanthellate Anthozoa opens new perspectives for bioprospecting. Marine Biotechnology, 6, (3), 270-277. (doi:10.1007/s10126-004-3006-4).
Choresh, O., Loya, Y., Müller, W.E.G., Wiedenmann, J. and Azem, A. (2004) The mitochondrial 60-kDa heat shock protein in marine invertebrates: biochemical purification and molecular characterization. Cell Stress & Chaperones, 9, (1), 38-48. (doi: 10.1379/469.1).
Schenk, A., Ivanchenko, S., Röcker, C., Wiedenmann, J. and Nienhaus, G.U. (2004) Photodynamics of red fluorescent proteins studied by fluorescence correlation spectroscopy. Biophysical Journal, 86, 384-394.
Nienhaus, K., Vallone, B., Renzi, F., Wiedenmann, J. and Nienhaus, G.U. (2003) Crystallization and preliminary X-ray diffraction analysis of the red fluorescent protein eqFP611. Acta Crystallographica D, 59, (7), 1253 -1255. (doi:10.1107/S0907444903008837).
Wiedenmann, J, Schenk, A, Rocker, C, Girod, A, Spindler, K-D and Nienhaus, G.U. (2002) A far-red fluorescent protein with fast maturation and reduced oligomerization tendency from Entacmaea quadricolor (Anthozoa, Actinaria). Proceedings of the National Academy of Sciences of the USA, 99, (18), 11646-11651. (doi:10.1073/pnas.182157199).
Savage, A.M., Goodson, M.S., Visram, S., Trapido-Rosenthal, H., Wiedenmann, J. and Douglas, A.E. (2002) Molecular diversity of symbiotic algae at the latitudinal margins of their distribution: dinoflagellates of the genus Symbiodinium in corals and sea anemones. Marine Ecology Progress Series, 244, 17-26. (doi:10.3354/meps244017).
Wiedenmann, J., Elke, C., Spindler, K-D. and Funke, W. (2000) Cracks in the -can: fluorescent proteins from Anemonia sulcata (Anthozoa, Actinaria). Proceedings of the National Academy of Sciences of the USA, 97, (26), 14091-14096.

Book Section

Wiedenmann, J. (2008) Marine proteins. In, Walsh, P.J., Smith, S.L., Fleming, L.E., Solo-Gabriele, H. and Gerwick, W.H. (eds.) Oceans and Human Health: Risks and Remedies from the Seas. Burlington, USA, Elsevier, 469-496.
Wiedenmann, J., Vallone, B., Renzi, F., Nienhaus, K., Ivanchenko, S., Röcker, C. and Nienhaus, G.U. (2004) Dimeric variants of the red fluorescent protein eqFP611 generated by site-directed mutagenesis. In, Savitsky, A.P., Brovko, L.Y., Bornhop, D.J., Raghavachari, R. and Achilefu, S.I. (eds.) Genetically Engineered and Optical Probes for Biomedical Applications II. Bellingham, USA, International Society for Optical Engineering, 23-29. (Proceedings of SPIE 5329). (doi: 10.1117/12.529370).
Wiedenmann, J., Röcker, C. and Funke, W. (1999) The morphs of Anemonia aff. sulcata (Cnidaria, Anthozoa) in particular consideration of the ectodermal pigments. In, Pfadenhauer, J. (ed.) Verhandlungen der Gesellschaft für Ökologie. Heidelberg, Germany, Spektrum Akademischer Verlag, 497-503.


Research Interests

Specialism: Biological Oceanography

Marine Biotechnology
Novel marker proteins from marine invertebrates, life cell imaging, protein biochemistry, protein engineering.

Molecular analyses of marine organism:
Biological functions of host pigments in anthozoans, molecular responses of the coral holobiont to environmental stress, adaptation potential of reef corals to global warming and ocean acidification, coral proteomics, light-induced gene regulation in anthozoans.

Ecology of Anthozoans:
Host-symbiont interactions in hermatypic corals and see anemones, interspecific relations, aqua culture and propagation of corals.

The Coral Reef Laboratory

I head the Ocean and Earth Science Coral Reef Laboratory. This includes the Coral Reef Tank located in the reception area of NOCS.

I am also a member of the Coral Aquarist Research Network (CARN).

Primary research group:  Marine Biology and Ecology

Research projects

Influence of Nutrient Starvation on Corals' Susceptibility to Thermal Bleaching (INCORALS)

Understanding the exceptional heat tolerance of reef corals from the Persian/Arabian Gulf


Professor Jörg Wiedenmann
Ocean and Earth Science, National Oceanography Centre Southampton
University of Southampton Waterfront Campus
European Way
Southampton SO14 3ZH
United Kingdom

Room Number: NOCS/566/18

Telephone: (023) 8059 6497
Email: joerg.wiedenmann@noc.soton.ac.uk