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Research project

R Carare - Physiology of Perivascular drainage of the brain and how it is affected by advancing age

Staff

Lead researcher

Professor Roxi Carare

Head of School

Research interests

  • Causes and new therapeutic strategies for dementias and other neurodegenerative diseases
  • New early diagnostic measures in dementia based on biomarkers from the nose
  • Drug delivery to the brain
Connect with Roxi

Email: R.O.Carare@soton.ac.uk

Other researchers

Professor James Nicoll

Connect with James

Email: J.Nicoll@soton.ac.uk

Research outputs

The fine anatomy of the perivascular compartment in the human brain
Matthew MacGregor Sharp, Diederik Bulters, Sebastian Brandner, Janice Holton, Ajay Verma, David J. Werring & Roxana O. Carare, 2018, Neuropathology and Applied Neurobiology, 45(3), 305-308
DOI: 10.1111/nan.12480
Type: article
Loss of Clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways
Aleksandra Wojtas, Silvia Kang, Benjamin Olley, Maureen Gatherer, Mitsuru Shinohara, Patricia Lozano, Chia-Chen Liu, Aishe Kurti, Kelsey Baker, Dennis Dickson, Mei Yue, Leonard Petrucelli, Guojun Bu, Roxana Carare & John D. Fryer, 2017, Proceedings of National Academy of Sciences of the United States of America, 114(33), E6962-E6971
DOI: 10.1073/pnas.1701137114
Type: article
Vascular basement membranes as pathways for the passage of fluid into and out of the brain
Alan W.J. Morris, Matthew MacGregor Sharp, Nazira J. Albargothy, Rute Fernandes, Cheryl A Hawkes, Ajay Verma, Roy O Weller & Roxana O. Carare, 2016, Acta Neuropathologica, 131(5), 725-736
DOI: 10.1007/s00401-016-1555-z
Type: article
Pathophysiology of lymphatic drainage of the central nervous system: implications for the pathophysiology of multiple sclerosis
Roy O. Weller, Roxanna O. Carare, Cheryl A. Hawkes & Ian Galea, 2015
DOI: 10.1016/B978-0-12-800763-1.00019-1
Type: bookChapter
Quantification of molecular interactions between ApoE, amyloid-beta (A?) and laminin: relevance to accumulation of A? in Alzheimer's disease
Jurgita Zekonyte, Kenji Sakai, James A.R. Nicoll, Roy O. Weller & Roxana O. Carare, 2015, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1862(5), 1047-1053
DOI: 10.1016/j.bbadis.2015.08.025
Type: article