Medicine

Martin Feelisch

MSc, PhD

Primary position:
Professor of Experimental Medicine and Integrative Biology

Background

The University of Southampton

After the study of pharmacy Martin earned his PhD in pharmacology from the Heinrich-Heine University in Dusseldorf in 1988. He was appointed to the Personal Chair of Experimental Medicine & Integrative Biology at Southampton University in April 2012, following a number of other senior research positions in both academia and industry in the USA and Europe.

Qualifications
  • BSc/MSc (Diploma), Pharmacy, Heinrich-Heine University, Dusseldorf, 1985
  • PhD (summa cum laude), Pharmacology, Heinrich-Heine University, 1988
  • Specialist for Drug Information, Apothekerkammer Nordrhein, 1992
  • Expert in Pharmacology, German Society for Experimental & Clinical Pharmacology and Toxicology (DGPT), 1992
  • Habilitation (venia legendi), Pharmacology and Toxicology, University of Cologne, 1997
Appointments held
  • Professor of Experimental Medicine & Integrative Biology, University of Southampton, Faculty of Medicine, 2012-present
  • Professor of Experimental Medicine and Biology, University of Warwick Medical School (MRC Strategic Appointment), 2007-2012
  • Professor of Medicine and Biochemistry, Adjunct Professor of Pharmacology, Boston University School of Medicine (Boston, USA), 2003-2007
  • Professor of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center (Shreveport, USA), 1999-2003
  • Senior Lecturer & Scientific Coordinator, The Wolfson Institute for Biomedical Research, University College London, 1997-1999
  • Director of Pharmacology, Schwarz Pharma (Monheim, Germany), 1991-1997
  • Department Head, Pharmacology, Schwarz Pharma, 1990-1991
  • Visiting Research Scientist, The Wellcome Research Laboratories, Beckenham, 1989/90
  • Postdoctoral Research Fellow, Pharmacology, Heinrich Heine University (Germany), 1988-1989

 

Professor Martin Feelisch's photo

Publications

The University of Southampton's electronic library (e-prints)

Article

Feelisch, Martin, Gorman, Shelley and Weller, Richard B (2014) Vitamin D status and ill health. The Lancet Diabetes & Endocrinology, 2, (4), e8. (doi:10.1016/S2213-8587(14)70043-9). (PMID:24703057).
Siddiqi, Nishat, Neil, Christopher, Bruce, Margaret, Maclennan, Graeme, Cotton, Seonaidh, Papadopoulou, Sofia, Feelisch, Martin, Bunce, Nicholas, Lim, Pitt O., Hildick-Smith, David, Horowitz, John, Madhani, Melanie, Boon, Nicholas, Dawson, Dana, Kaski, Juan Carlos and Frenneaux, Michael (2014) Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI). European Heart Journal, 1-9. (doi:10.1093/eurheartj/ehu096). (PMID:24639423).
Liu, Donald, Fernandez, Bernadette O., Hamilton, Alistair, Lang, Ninian N., Gallagher, Julie M.C., Newby, David E., Feelisch, Martin and Weller, Richard B (2014) UVA irradiation of human skin vasodilates arterial vasculature and lowers blood pressure independently of nitric oxide synthase. Journal of Investigative Dermatology, 1-38. (doi:10.1038/jid.2014.27). (PMID:24445737).
Cortese-Krott, Miriam M., Fernandez, Bernadette O., Santos, José L.T., Mergia, Evanthia, Grman, Marian, Nagy, Péter, Kelm, Malte, Butler, Anthony and Feelisch, Martin (2014) Nitrosopersulfide (SSNO-) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide. Redox Biology, 2, 234-244. (doi:10.1016/j.redox.2013.12.031). (PMID:24494198).
Umbrello, Michele, Dyson, Alex, Bollen Pinto, Bernardo, Fernandez, Bernadette O., Simon, Verena, Feelisch, Martin and Singer, Mervyn (2014) Short-term hypoxic vasodilation in vivo is mediated by bioactive nitric oxide metabolites, rather than free nitric oxide derived from haemoglobin-mediated nitrite reduction. The Journal of Physiology, 592, (5), 1061-1075. (doi:10.1113/jphysiol.2014.255687). (PMID:24396056).
Siervo, Mario, Riley, Heather L., Fernandez, Bernadette O, Leckstrom, Carl A., Martin, Daniel S., Mitchell, Kay, Levett, Denny Z.H., Montgomery, Hugh E., Mythen, Monty G., Grocott, Michael P. W. and Feelisch, Martin (2014) Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation. PLoS ONE, 9, (4), e94915. (doi:10.1371/journal.pone.0094915). (PMID:15134560).
Martin, Daniel S., Gilbert-Kawai, Edward T., Meale, Paula M., Fernandez, Bernadette O., Cobb, Alexandra, Khosravi, Maryam, Mitchell, Kay, Grocott, Michael P.W., Levett, Denny Z.H., Mythen, Michael G. and Feelisch, Martin (2013) Design and conduct of 'Xtreme Alps': a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude. Contemporary Clinical Trials, 36, (2), 450-459. (doi:10.1016/j.cct.2013.09.002). (PMID:24028941).
Feelisch, Martin and Olson, Kenneth R. (2013) Embracing sulfide and CO to understand nitric oxide biology. Nitric Oxide, 2-4. (doi:10.1016/j.niox.2013.06.004). (PMID:23769946).
Maher, Abdul R., Arif, Sayqa, Madhani, Melanie, Abozguia, Khalid, Ahmed, Ibrar, Fernandez, Bernadette O., Feelisch, Martin, O'Sullivan, A.G., Christopoulos, Arthur, Sverdlov, Aaron L., Ngo, Doan, Dautov, Rustem, James, Philip E., Horowitz, John D. and Frenneaux, Michael P. (2013) Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite. British Journal of Pharmacology, 169, (3), 659-670. (doi:10.1111/bph.12152). (PMID:23472879).
Umbrello, Michele, Dyson, Alex, Feelisch, Martin and Singer, Mervyn (2013) The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching. Antioxidants & Redox Signaling, 19, (14), 1690-710. (doi:10.1089/ars.2012.4979). (PMID:23311950).
Cortese-Krott, Miriam M., Rodriguez-Mateos, Ana, Kuhnle, Gunter, Brown, Geoff, Feelisch, Martin and Kelm, Malte (2013) A multi-level analytical approach for detection and visualization of intracellular NO production and nitrosation events using diaminofluoresceins. Free Radical Biology and Medicine, 53, 2146-2158. (doi:10.1016/j.freeradbiomed.2012.09.008). (PMID:23026413).
Garcia-Saura, Maria-Francisca, Saijo, Fumito, Bryan, Nathan S., Bauer, Selena, Rodriguez, Juan and Feelisch, Martin (2012) Nitroso-redox status and vascular function in marginal and severe ascorbate deficiency. Antioxidants & Redox Signaling, 17, (7), 937-950. (doi:10.1089/ars.2011.4201). (PMID:22304648).
Cortese-Krott, Miriam M., Rodriguez-Mateos, Ana, Sansone, Roberto, Kuhnle, Gunter G.C., Thasian-Sivarajah, Sivatharsini, Krenz, Thomas, Horn, Patrick, Krisp, Christoph, Wolters, Dirk, Heiß, Christian, Kroncke, Klaus-Dietrich, Hogg, Neil, Feelisch, Martin and Kelm, Malte (2012) Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease. Blood, 120, 4229-4237. (doi:10.1182/blood-2012-07-442277). (PMID:23007404).
Siervo, Mario, Tomatis, Virginia, Blossom, C.M. Stephen, Feelisch, Martin and Bluck, Les C.J. (2012) VEGF is indirectly associated with NO production. European Journal of Clinical Investigation, 42, (9), 967-973. (doi:10.1111/j.1365-2362.2012.02684.x). (PMID:22568403).
Milsom, Alexandra B., Fernandez, Bernadette O., Garcia-Saura, Maria F., Rodriguez, Juan and Feelisch, Martin (2012) Contributions of nitric oxide synthases, dietary nitrite/nitrate, and other sources to the formation of NO signaling products. Antioxidants & Redox Signaling, 17, (3), 422-432. (doi:10.1089/ars.2011.4156). (PMID:22133018).
Berra, Lorenzo, Coppadoro, Andrea, Yu, Binglan, Lei, Chong, Spagnolli, Ester, Steinbicker, Andrea U., Bloch, Kenneth D., Lin, Tian, Sammy, Fatima Y., Shaw Warren, H., Fernandez, Bernadette O., Feelisch, Martin, Dzik, Walter H., Stowell, Christopher P. and Zapol, Warren M. (2012) Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers. Anesthesiology, 117, (1), 56-63. (doi:10.1097/ALN.0b013e31825575e6). (PMID:22531338).
Fago, Angela, Jensen, Frank B., Tota, Bruno, Feelisch, Martin, Olson, Kenneth R., Helbo, Signe, Lefevre, Sjannie, Mancardi, Daniele, Palumbo, Anna, Sandvik, Guro K. and Skovgaard, Nini (2012) Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: a comparative approach. Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology, 162, (1), 1-6. (doi:10.1016/j.cbpa.2012.01.011). (PMID:22314020).
Pacheco, Luis G.C., Castro, Thiago L.P., Carvalho, Rodrigo D., Moraes, Pablo M., Dorella, Fernanda A., Carvalho, Natália B., Slade, Susan E., Scrivens, James H., Feelisch, Martin, Meyer, Roberto, Miyoshi, Anderson, Oliveira, Sergio C., Dowson, Christopher G and Azevedo, Vasco (2012) A role for sigma factor σ(E) in Corynebacterium pseudotuberculosis resistance to nitric oxide/peroxide stress. Frontiers in Microbiology, 3, (126) (doi:10.3389/fmicb.2012.00126). (PMID:22514549).
Levett, Denny Z., Fernandez, Bernadette O., Riley, Heather L., Martin, Daniel S., Mitchell, Kay, Leckstrom, Carl A., Ince, Can, Whipp, Brian J., Mythen, Monty G., Montgomery, Hugh E., Grocott, Mike P. and Feelisch, Martin Caudwell Extreme Everest Group (2011) The role of nitrogen oxides in human adaptation to hypoxia. Scientific Reports, 1, (109) (doi:10.1038/srep00109). (PMID:22355626).
Levett, Denny Z., Fernandez, Bernadette O., Riley, Heather L., Martin, Daniel S., Mitchell, Kay, Leckstrom, Carl A., Ince, Can, Whipp, Brian J., Mythen, Monty G., Montgomery, Hugh E., Grocott, Mike P. and Feelisch, Martin (2011) The role of nitrogen oxides in human adaptation to hypoxia. Scientific Reports, 1, 109. (doi:10.1038/srep00109). (PMID:22355626).
Dyson, Alex, Bryan, Nathan S, Fernandez, Bernadette O, Garcia-Saura, Maria-Francisca, Saijo, Fumito, Mongardon, Nicolas, Rodriguez, Juan, Singer, Mervyn and Feelisch, Martin (2011) An integrated approach to assessing nitroso-redox balance in systemic inflammation. Free Radical Biology and Medicine, 51, (6), 1137-1145. (doi:10.1016/j.freeradbiomed.2011.06.012). (PMID:21718783).
Siervo, M., Stephan, B.C.M., Feelisch, M. and Bluck, L.J.C (2011) Measurement of in vivo nitric oxide synthesis in humans using stable isotopic methods: a systematic review. Free Radical Biology & Medicine, 51, (4), 795-804. (doi:10.1016/j.freeradbiomed.2011.05.032). (PMID:21672626).
Ormerod, Julian O.M., Ashrafian, Houman, Maher, Abdul R., Arif, Sayqa, Born, Gustav V.R., Egginton, Stuart, Feelisch, Martin, Watkins, Hugh and Frenneaux, Michael P. (2011) The role of vascular myoglobin in nitrite-mediated blood vessel relaxation. Cardiovascular Research, 89, (3), 560-565. (doi:10.1093/cvr/cvq299). (PMID:20889759).
Jourd'heuil, Frances L., Lowery, Anthony M., Melton, Elaina M., Mnaimneh, Sanie, Bryan, Nathan S., Fernandez, Bernadette O., Park, Joo-Ho, Ha, Chung-Eun, Bhagavan, Nadhipuram V., Feelisch, Martin and Jourd'heuil, David (2010) Redox-sensitivity and site-specificity of S- and N- denitrosation in proteins. PLoS One, 5, (12), e14400-[10pp]. (doi:10.1371/journal.pone.0014400). (PMID:21203591).
Klings, Elizabeth S., Lowry, Matthew H, Li, Guihua, Jean, Jyh-Chang, Fernandez, Bernadette O., Garcia-Saura, Maria F., Feelisch, Martin and Joyce-Brady, Martin (2010) Hyperoxia-induced lung injury in gamma-glutamyl transferase deficiency is associated with alterations in nitrosative and nitrative stress. American Journal of Pathology, 175, (6), 2309-2318. (doi:10.2353/ajpath.2009.081017). (PMID:19850887).
Kulshrestha, Pankaj, McKinstry, Katherine C., Fernandez, Bernadette O., Feelisch, Martin and Mitch, William A. (2010) Application of an optimized total N-nitrosamine (TONO) assay to pools: placing N-nitrosodimethylamine (NDMA) determinations into perspective. Environmental Science & Technology, 44, (9), 3369-3375. (doi:10.1021/es100361f). (PMID:20355696).
Feelisch, Martin, Kolb-Bachofen, Victoria, Liu, Donald, Lundberg, Jon O., Revelo, Lucia P., Suschek, Christoph V. and Weller, Richard B. (2010) Is sunlight good for our heart? European Heart Journal, 31, (9), 1041-1045. (doi:10.1093/eurheartj/ehq069). (PMID:20215123).
Saijo, Fumito, Milsom, Alexandra B., Bryan, Nathan S., Bauer, Selena M., Vowinkel, Thorsten, Ivanovic, Marina, Andry, Chris, Granger, D. Neil, Rodriguez, Juan and Feelisch, Martin (2010) On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease. Nitric Oxide: Biology and Chemistry, 22, (2), 155-167. (doi:10.1016/j.niox.2009.11.009). (PMID:20005300).
Garcia-Saura, Maria Francisca, Fernandez, Bernadette O., McAllister, Brian P., Whitlock, David R., Cruikshank, William W. and Feelisch, Martin (2010) Dermal nitrite application enhances global nitric oxide availability: new therapeutic potential for immunomodulation? Journal of Investigative Dermatology, 130, (2), 608-611. (doi:10.1038/jid.2009.303). (PMID:19812594).
Lim, Chee Chew, Bryan, Nathan S., Jain, Mohit, Garcia-Saura, Maria F., Fernandez, Bernadette O., Sawyer, Douglas B., Handy, Diane E., Loscalzo, Joseph, Feelisch, Martin and Liao, Ronglih (2009) Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms. American Journal of Physiology: Heart and Circulatory Physiology, 297, (6), H2144-H2153. (doi:10.1152/ajpheart.00673.2009). (PMID:19801492).
Lundberg, Jon O., Gladwin, Mark T., Ahluwalia, Amrita, Benjamin, Nigel, Bryan, Nathan S., Butler, Anthony, Cabrales, Pedro, Fago, Angela, Feelisch, Martin, Ford, Peter C., Freeman, Bruce A., Frenneaux, Michael, Friedman, Joel, Kelm, Malte, Kevil, Christopher G., Kim-Shapiro, Daniel B., Kozlov, Andrey V., Lancaster Jr, Jack R., Lefer, David J., McColl, Kenneth, McCurry, Kenneth, Patel, Rakesh P., Petersson, Joel, Rassaf, Tienush, Reutov, Valentin P., Richter-Addo, George B., Schechter, Alan, Shiva, Sruti, Tsuchiya, Koichiro, van Faassen, Ernst E., Webb, Andrew J., Zuckerbraun, Brian S., Zweier, Jay L. and Weitzberg, Eddie (2009) Nitrate and nitrite in biology, nutrition and therapeutics. Nature Chemical Biology, 5, (12), 865-869. (doi:10.1038/nchembio.260). (PMID:19915529).
van Faassen, Ernst E., Bahrami, Soheyl, Feelisch, Martin, Hogg, Neil, Kelm, Malte, Kim-Shapiro, Daniel B., Kozlov, Andrey V., Li, Haitao, Lundberg, Jon O., Mason, Ron, Nohl, Hans, Rassaf, Tienush, Samouilov, Alexandre, Slama-Schwok, Anny, Shiva, Sruti, Vanin, Anatoly F., Weitzberg, Eddie, Zweier, Jay and Gladwin, Mark T. (2009) Nitrite as regulator of hypoxic signaling in mammalian physiology. Medicinal Research Reviews, 29, (5), 683-741. (doi:10.1002/med.20151). (PMID:19219851).
Qin, Xuebin, Hu, Weiguo, Song, Wenping, Blair, Price, Wu, Gongxiong, Hu, Xuemei, Song, Yanli, Bauer, Selena, Feelisch, Martin, Leopold, Jane A., Loscalzo, Joseph and Halperin, Jose A. (2009) Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice. American Journal of Hematology, 84, (4), 221-227. (doi:10.1002/ajh.21363). (PMID:19229985).
Perlman, David H., Bauer, Selena M., Ashrafian, Houman, Bryan, Nathan S., Garcia-Saura, Maria F., Lim, Chee C., Fernandez, Bernadette O., Infusini, Giuseppe, McComb, Mark E., Costello, Catherine E. and Feelisch, Martin (2009) Mechanistic insights into nitrite-induced cardioprotection using an integrated metabolomic/proteomic approach. Circulation Research, 104, (6), 796-804. (doi:10.1161/CIRCRESAHA.108.187005). (PMID:19229060).
Cornelius, Julia, Tran, Tuan, Turner, Nicole, Piazza, Abigail, Mills, Lauren, Slack, Ryan, Hauser, Sean, Alexander, J. Steven, Grisham, Matthew B., Feelisch, Martin and Rodriguez, Juan (2009) Isotope tracing enhancement of chemiluminescence assays for nitric oxide research. Biological Chemistry, 390, (2), 181-189. (doi:10.1515/BC.2009.017). (PMID:19040352).
Feelisch, Martin, Fernandez, Bernadette O., Bryan, Nathan S., Garcia-Saura, Maria Francisca, Bauer, Selena, Whitlock, David R., Ford, Peter C., Janero, David R., Rodriguez, Juan and Ashrafian, Houman (2008) Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems. Journal of Biological Chemistry, 283, (49), 33927-33934. (doi:10.1074/jbc.M806654200). (PMID:18835812).
Nagasaka, Yasuko, Fernandez, Bernadette O., Garcia-Saura, Maria F., Petersen, Bodil, Ichinose, Fumito, Bloch, Kenneth D., Feelisch, Martin and Zapol, Warren M. (2008) Brief periods of nitric oxide inhalation protect against myocardial ischemia-reperfusion injury. Anesthesiology, 109, (4), 675-682. (doi:10.1097/ALN.0b013e318186316e). (PMID:18813047).
Feelisch, Martin (2008) The chemical biology of nitric oxide--an outsider's reflections about its role in osteoarthritis. Osteoarthritis and Cartilage, 16, supplement 2, S3-S13. (doi:10.1016/S1063-4584(08)60007-2). (PMID:18794015).
Butler, Anthony R. and Feelisch, Martin (2008) Therapeutic uses of inorganic nitrite and nitrate: from the past to the future. Circulation, 117, (16), 2151-2159. (doi:10.1161/CIRCULATIONAHA.107.753814). (PMID:18427145).
Lee, Ung, Wie, Chris, Fernandez, Bernadette O., Feelisch, Martin and Vierling, Elizabeth (2008) Modulation of nitrosative stress by S-nitrosoglutathione reductase is critical for thermotolerance and plant growth in Arabidopsis. The Plant Cell, 20, (3), 786-802. (doi:10.1105/tpc.107.052647). (PMID:18326829).
Erzurum, S. C., Ghosh, S., Janocha, A. J., Xu, W., Bauer, S., Bryan, N. S., Tejero, J., Hemann, C., Hille, R., Stuehr, D. J., Feelisch, M and Beall, C. M. (2007) Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans. Proceedings of the National Academy of Sciences of the United States of America, 104, (45), 17593-175988. (doi:10.1073/pnas.0707462104 ). (PMID:12614846).
Feelisch, Martin (2007) Nitrated cyclic GMP as a new cellular signal. Nature Chemical Biology, 3, (11), 687-688. (doi:10.1038/nchembio1107-687). (PMID:17948012).
Lundberg, Jon O., Feelisch, Martin, Björne, Håkan, Jansson, Emmelie and Weitzberg, Eddie (2006) Cardioprotective effects of vegetables: is nitrate the answer? Nitric Oxide, 15, (4), 359-362. (doi:10.1016/j.niox.2006.01.013). (PMID:16563818).
Duranski, Mark R., Elrod, John W., Calvert, John W., Bryan, Nathan S., Feelisch, Martin and Lefer, David J. (2006) Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury. American Journal of Physiology: Heart and Circulatory Physiology, 291, (6), H2980-H2986. (doi:10.1152/ajpheart.01173.2005). (PMID:16877550).
Wang, Xunde, Bryan, Nathan S., MacArthur, Peter H., Rodriguez, Juan, Gladwin, Mark T. and Feelisch, Martin (2006) Measurement of nitric oxide levels in the red cell: validation of tri-iodide-based chemiluminescence with acid-sulfanilamide pretreatment. Journal of Biological Chemistry, 281, (37), 26994-27002. (doi:10.1074/jbc.M603953200). (PMID:16845122).
Donzelli, Sonia, Switzer, Christopher H., Thomas, Douglas D., Ridnour, Lisa A., Espey, Michael Graham, Isenberg, Jeffrey S., Tocchetti, Carlo G., King, S. Bruce, Lazzarino, Giuseppe, Miranda, Katrina M., Roberts, David D., Feelisch, Martin and Wink, David A. (2006) The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling. Antioxidants & Redox Signaling, 8, (7-8), 1363-1371. (doi:10.1089/ars.2006.8.1363). (PMID:16910783).
Elrod, John W., Greer, James J.M., Bryan, Nathan S., Langston, Will, Szot, Jeffrey F., Gebregzlabher, Henock, Janssens, Stefan, Feelisch, Martin and Lefer, David J. (2006) Cardiomyocyte-specific overexpression of NO synthase-3 protects against myocardial ischemia-reperfusion injury. Arteriosclerosis, Thrombosis, and Vascular Biology, 26, (7), 1517-1523. (doi:10.1161/01.ATV.0000224324.52466.e6). (PMID:16645153).
Heiss, Christian, Lauer, Thomas, Dejam, André, Kleinbongard, Petra, Hamada, Sandra, Rassaf, Tienush, Matern, Simone, Feelisch, Martin and Kelm, Malte (2006) Plasma nitroso compounds are decreased in patients with endothelial dysfunction. Journal of the American College of Cardiology, 47, (3), 573-579. (doi:10.1016/j.jacc.2005.06.089). (PMID:16458138).
Kleinbongard, Petra, Dejam, André, Lauer, Thomas, Jax, Thomas, Kerber, Stefan, Gharini, Putrika, Balzer, Jan, Zotz, Rainer B., Scharf, Rüdiger E., Willers, Reinhart, Schechter, Alan N., Feelisch, Martin and Kelm, Malte (2006) Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans. Advances in Free Radical Biology & Medicine, 40, (2), 295-302. (doi:10.1016/j.freeradbiomed.2005.08.025). (PMID:16413411).
Peyrot, Fabienne, Fernandez, Bernadette O., Bryan, Nathan S, Feelisch, Martin and Ducrocq, Claire (2006) N-Nitroso products from the reaction of indoles with Angeli's salt. Chemical Research in Toxicology, 19, (1), 58-67. (doi:10.1021/tx050253b). (PMID:16411657).
Zamora, Ruben, Bryan, Nathan S., Boyle, Patricia, Wong, Catarina, Milsom, Alexandra B., Jaffe, Ronald, Feelisch, Martin and Ford, Henri R. (2005) Nitrosative stress in an animal model of necrotizing enterocolitis. Free Radical Biology and Medicine, 39, (11), 1428-37. (doi:10.1016/j.freeradbiomed.2005.07.004). (PMID:16274878).
Gladwin, Mark T., Schechter, Alan N., Kim-Shapiro, Daniel B., Patel, Rakesh P., Hogg, Neil, Shiva, Sruti, Cannon, Richard O., Kelm, Malte, Wink, David A., Espey, Michael Graham, Oldfield, Edward H., Pluta, Ryszard M., Freeman, Bruce A., Lancaster, Jack R., Feelisch, Martin and Lundberg, Jon O. (2005) The emerging biology of the nitrite anion. Nature Chemical Biology, 1, (6), 308-314. (doi:10.1038/nchembio1105-308). (PMID:16408064).
Bryan, Nathan S., Fernandez, Bernadette O., Bauer, Selena M., Garcia-Saura, Maria Francisca, Milsom, Alexandra B., Rassaf, Tienush, Maloney, Ronald E., Bharti, Ajit, Rodriguez, Juan and Feelisch, Martin (2005) Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues. Nature Chemical Biology, 1, (5), 290-297. (doi:10.1038/nchembio734). (PMID:16408049).
Ridnour, Lisa A., Thomas, Douglas D., Mancardi, Daniele, Espey, Michael G., Miranda, Katrina M., Paolocci, Nazareno, Feelisch, Martin, Fukuto, Jon and Wink, David A. (2005) The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations. Biological Chemistry, 385, (1), 1-10. (doi:10.1515/BC.2004.001). (PMID:14977040).
Rodriguez, Juan, Specian, Victoria, Maloney, Ronald, Jourd'heuil, David and Feelisch, Martin (2005) Performance of diamino fluorophores for the localization of sources and targets of nitric oxide. Free Radical Biology and Medicine, 38, (3), 356-68. (doi:10.1016/j.freeradbiomed.2004.10.036). (PMID:15629864).
Janero, David R., Bryan, Nathan S., Saijo, Fumito, Dhawan, Vijay, Schwalb, David J., Warren, Michael C. and Feelisch, Martin (2004) Differential nitros(yl)ation of blood and tissue constituents during glyceryl trinitrate biotransformation in vivo. Proceedings of the National Academy of Sciences of the United States of America, 101, (48), 16958-16963. (doi:10.1073/pnas.0406075101 ). (PMID:8901678).
Reif, A., Shutenko, Z. V., Feelisch, M. and Schmidt, H. H. H. W. (2004) Superoxide dismutase and catalase are required to detect •NO from both coupled and uncoupled neuronal no synthase. Advances in Free Radical Biology & Medicine, 37, (7), 988-997. (doi:10.1016/j.freeradbiomed.2004.07.005). (PMID:15336315).
Tao, Ling, Gao, Erhe, Bryan, Nathan S., Qu, Yan, Liu, Hui-Rong, Hu, Aihua, Christopher, Theodore A., Lopez, Bernard L., Yodoi, Junji, Koch, Walter J, Feelisch, Martin and Ma, Xin L. (2004) Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected]. Proceedings of the National Academy of Sciences of the United States of America, 101, (31), 11471-11476. (doi:10.1073/pnas.0402941101). (PMID:15277664).
Bryan, Nathan S., Rassaf, Tienush, Rodriguez, Juan and Feelisch, Martin (2004) Bound NO in human red blood cells: fact or artifact? Nitric Oxide, 10, (4), 221-228. (doi:10.1016/j.niox.2004.04.008). (PMID:15275868).
Bryan, Nathan S., Rassaf, Tienush, Maloney, Ronald E., Rodriguez, Cynthia M., Saijo, Fumito, Rodriguez, Juan R. and Feelisch, Martin (2004) Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo. Proceedings of the National Academy of Sciences of the United States of America, 101, (12), 4308-4313. (doi:10.1073/pnas.0306706101). (PMID:15014175).
Rassaf, Tienush, Feelisch, Martin and Kelm, Malte (2004) Circulating NO pool: assessment of nitrite and nitroso species in blood and tissues. Free Radical Biology and Medicine, 36, (4), 413-422. (doi:10.1016/j.freeradbiomed.2003.11.011). (PMID:14975444).
Dejam, André, Kleinbongard, Petra, Rassaf, Tienush, Hamada, Sandra, Gharini, Putrika, Rodriguez, Juan, Feelisch, Martin and Kelm, Malte (2003) Thiols enhance NO formation from nitrate photolysis. Free Radical Biology and Medicine, 35, (12), 1551-1559. (doi:10.1016/j.freeradbiomed.2003.09.009). (PMID:14680678).
Wink, David A., Miranda, Katrina M., Katori, Tatsuo, Mancardi, Daniele, Thomas, Douglas D., Ridnour, Lisa, Espey, Michael G., Feelisch, Martin, Colton, Carol A., Fukuto, Jon M., Pagliaro, Pasquale, Kass, David A. and Paolocci, Nazareno (2003) Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm. American Journal of Physiology: Heart and Circulatory Physiology, 285, (6), H2264-H2276. (doi:10.1152/ajpheart.00531.2003). (PMID:12855429).
Kleinbongard, Petra, Dejam, André, Lauer, Thomas, Rassaf, Tienush, Schindler, Achim, Picker, Olaf, Scheeren, Thomas, Gödecke, Axel, Schrader, Jürgen, Schulz, Rainer, Heusch, Gerd, Schaub, Günter A., Bryan, Nathan S., Feelisch, Martin and Kelm, Malte (2003) Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radical Biology and Medicine, 35, (7), 790-796. (doi:10.1016/S0891-5849(03)00406-4). (PMID:14583343).
Miranda, Katrina M., Paolocci, Nazareno, Katori, Tatsuo, Thomas, Douglas D., Ford, Eleonora, Bartberger, Michael D., Espey, Michael G., Kass, David A., Feelisch, Martin, Fukuto, Jon M. and Wink, David A. (2003) A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system. Proceedings of the National Academy of Sciences of the United States of America, 100, (16), 9196-9201. (doi:10.1073/pnas.1430507100). (PMID:12865500).
Jourd'heuil, David, Jourd'heuil, Frances L. and Feelisch, Martin (2003) Oxidation and nitrosation of thiols at low micromolar exposure to nitric oxide. Evidence for a free radical mechanism. The Journal of Biological Chemistry, 278, (18), 15720-15726. (doi:10.1074/jbc.M300203200). (PMID:12595536).
Rassaf, Tienush, Bryan, Nathan S, Maloney, Ronald E, Specian, Vicky, Kelm, Malte, Kalyanaraman, Balaraman, Rodriguez, Juan and Feelisch, Martin (2003) NO adducts in mammalian red blood cells: too much or too little? Nature Medicine, 9, (5), 481-482. (doi:10.1038/nm0503-481). (PMID:12724738).
Feelisch, Martin (2003) Nitroxyl gets to the heart of the matter. Proceedings of the National Academy of Sciences of the United States of America, 100, (9), 4978-4980. (doi:10.1073/pnas.1031571100). (PMID:12704227).
Lauer, Thomas, Kleinbongard, Petra, Preik, Michael, Rauch, Bernhard H., Deussen, Andreas, Feelisch, Martin, Strauer, Bodo E. and Kelm, Malte (2003) Direct biochemical evidence for eNOS stimulation by bradykinin in the human forearm vasculature. Basic Research in Cardiology, 98, (2), 84-89. (doi:10.1007/s003950300000). (PMID:12607129).
Rodriguez, Juan, Maloney, Ronald E., Rassaf, Tienush, Bryan, Nathan S. and Feelisch, Martin (2003) Chemical nature of nitric oxide storage forms in rat vascular tissue. Proceedings of the National Academy of Sciences of the United States of America, 100, (1), 336-341. (doi:10.1073/pnas.0234600100). (PMID:12502793).
Miranda, Katrina M., Nims, Raymond W., Thomas, Douglas D., Espey, Michael G., Citrin, Deborah, Bartberger, Michael D., Paolocci, Nazareno, Fukuto, Jon M., Feelisch, Martin and Wink, David A. (2003) Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS. Journal of Inorganic Biochemistry, 93, (1-2), 52-60. (doi:10.1016/S0162-0134(02)00498-1). (PMID:12538052).
Pagliaro, Pasquale, Mancardi, Daniele, Rastaldo, Raffaella, Penna, Claudia, Gattullo, Donatella, Miranda, Katrina M., Feelisch, Martin, Wink, David A., Kass, David A. and Paolocci, Nazareno (2003) Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning. Free Radical Biology and Medicine, 34, (1), 33-43. (doi:10.1016/S0891-5849(02)01179-6). (PMID:12498977).
Rassaf, Tienush, Bryan, Nathan S., Kelm, Malte and Feelisch, Martin (2002) Concomitant presence of N-nitroso and S-nitroso proteins in human plasma. Free Radical Biology and Medicine, 33, (11), 1590-1596. (doi:10.1016/S0891-5849(02)01183-8). (PMID:12446216).
Feelisch, Martin, Rassaf, Tienush, Mnaimneh, Sanie, Singh, Nisha, Bryan, Nathan S., Jourd'Heuil, David and Kelm, Malte (2002) Concomitant S-, N-, and heme-nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo. The FASEB Journal, 16, (13), 1775-1785. (doi:10.1096/fj.02-0363com). (PMID:12409320).
Rassaf, Tienush, Kleinbongard, Petra, Preik, Michael, Dejam, André, Gharini, Putrika, Lauer, Thomas, Erckenbrecht, Julia, Duschin, Alexej, Schulz, Rainer, Heusch, Gerd, Feelisch, Martin and Kelm, Malte (2002) Plasma nitrosothiols contribute to the systemic vasodilator effects of intravenously applied NO: experimental and clinical Study on the fate of NO in human blood. Circulation Research, 91, (6), 470-477. (doi:10.1161/01.RES.0000035038.41739.CB). (PMID:12242264).
Joshi, Mahesh S., Ferguson, T. Bruce, Han, Tae H., Hyduke, Daniel R., Liao, James C., Rassaf, Tienush, Bryan, Nathan, Feelisch, Martin and Lancaster, Jack R. (2002) Nitric oxide is consumed, rather than conserved, by reaction with oxyhemoglobin under physiological conditions. Proceedings of the National Academy of Sciences of the United States of America, 99, (16), 10341-6. (doi:10.1073/pnas.152149699). (PMID:12124398).
Rassaf, Tienush, Preik, Michael, Kleinbongard, Petra, Lauer, Thomas, Heiß, Christian, Strauer, Bodo-Eckehard, Feelisch, Martin and Kelm, Malte (2002) Evidence for in vivo transport of bioactive nitric oxide in human plasma. The Journal of Clinical Investigation, 109, (9), 1241-1248. (doi:10.1172/JCI14995). (PMID:11994413).
Cerwinka, Wolfgang H., Cooper, Dianne, Krieglstein, Christian F., Feelisch, Martin and Granger, D. Neil (2002) Nitric oxide modulates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules. American Journal of Physiology. Heart and Circulatory Physiology, 282, (3), H1111-H1117. (doi:10.1152/ajpheart.00391.2001). (PMID:11834510).
Thomas, Douglas D., Miranda, Katrina M., Espey, Michael Graham, Citrin, Deborah, Jourd'heuil, David, Paolocci, Nazareno, Hewett, Sandra J., Colton, Carol A., Grisham, Matthew B., Feelisch, Martin and Wink, David A. (2002) Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems. Methods in Enzymology, 359, 84-105. (doi:10.1016/S0076-6879(02)59174-6). (PMID:12481562).
Lauer, Thomas, Preik, Michael, Rassaf, Tienush, Strauer, Bodo E., Deussen, Andreas, Feelisch, Martin and Kelm, Malte (2001) Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action. Proceedings of the National Academy of Sciences of the United States of America, 98, (22), 12814-12819. (doi:10.1073/pnas.221381098). (PMID:11606734).
Paolocci, Nazareno, Saavedra, Walter F., Miranda, Katrina M., Martignani, Cristian, Isoda, Takayoshi, Hare, Joshua M., Espey, Michael G., Fukuto, Jon M., Feelisch, Martin, Wink, David A. and Kass, David A. (2001) Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling. Proceedings of the National Academy of Sciences of the United States of America, 98, (18), 10463-10468. (doi:10.1073/pnas.181191198). (PMID:11517312).
Reif, Andreas, Zecca, Luigi, Riederer, Peter, Feelisch, Martin and Schmidt, Harald H.H.W. (2001) Nitroxyl oxidizes NADPH in a superoxide dismutase inhibitable manner. Free Radical Biology and Medicine, 30, (7), 803-8. (doi:10.1016/S0891-5849(01)00477-4). (PMID:11275480).
Wink, David A., Miranda, Katrina M., Espey, Michael G., Pluta, Ryzard M., Hewett, Sandra J., Colton, Carol, Vitek, Michael, Feelisch, Martin and Grisham, Mathew B. (2001) Mechanisms of the antioxidant effects of nitric oxide. Antioxidants and Redox Signaling, 3, (2), 203-213. (doi:10.1089/152308601300185179). (PMID:11396476).
Miranda, Katarina M., Espey, Michael G., Yamada, Kenichi, Krishna, Murali, Ludwick, Natalie, Kim, SungMee, Jourd'heuil, David, Grisham, Matthew B., Feelisch, Martin, Fukuto, Jon M. and Wink, David A. (2001) Unique oxidative mechanisms for the reactive nitrogen oxide species, nitroxyl anion. The Journal of Biological Chemistry, 276, (3), 1720-1727. (doi:10.1074/jbc.M006174200). (PMID:11042174).
Zampolli, Antonella, Basta, Giuseppina, Lazzerini, Guido, Feelisch, Martin and De Caterina, Raffaele (2000) Inhibition of endothelial cell activation by nitric oxide donors. The Journal of Pharmacology and Experimental Therapeutics, 295, (2), 818-823. (PMID:11046123).
Orsi, Antonia, Beltrán, Belén, Clementi, Emilio, Hallén, Katarina, Feelisch, Martin and Moncada, Salvador (2000) Continuous exposure to high concentrations of nitric oxide leads to persistent inhibition of oxygen consumption by J774 cells as well as extraction of oxygen by the extracellular medium. Biochemical Journal, 346, 407-412. (PMID:10677360).
Jourd'heuil, David, Hallén, Katarina, Feelisch, Martin and Grisham, Matthew B. (2000) Dynamic state of S-nitrosothiols in human plasma and whole blood. Free Radical Biology and Medicine, 28, (3), 409-417. (doi:10.1016/S0891-5849(99)00257-9). (PMID:10699753).
Marley, Richard, Feelisch, Martin, Holt, Stephen and Moore, Kevin (2000) A chemiluminescense-based assay for S-nitrosoalbumin and other plasma S-nitrosothiols. Free Radical Research, 32, (1), 1-9. (doi:10.1080/10715760000300011). (PMID:10625212).
Espey, Michael Graham, Miranda, Katrina M., Feelisch, Martin, Fukuto, Jon, Grisham, Mathew B., Vitek, Michael P. and Wink, David A. (2000) Mechanisms of cell death governed by the balance between nitrosative and oxidative stress. Annals of the New York Academy of Sciences, 899, 209-221. (doi:10.1111/j.1749-6632.2000.tb06188.x). (PMID:10863541).
Ma, Xin L., Gao, Feng, Liu, Gao-Lin, Lopez, Bernard L., Christopher, Theodore A., Fukuto, Jon M. , Wink, David A. and Feelisch, Martin (1999) Opposite effects of nitric oxide and nitroxyl on postischemic myocardial injury. Proceedings of the National Academy of Sciences of the United States of America, 96, (25), 14617-14622. (doi:10.1073/pnas.96.25.14617). (PMID:10588754).
Wolzt, Michael, MacAllister, Raymond J., Davis, Dana, Feelisch, Martin, Moncada, Salvador, Vallance, Patrick and Hobbs, Adrian J. (1999) Biochemical characterization of S-nitrosohemoglobin. Mechanisms underlying synthesis, no release, and biological activity. The Journal of Biological Chemistry, 274, (41), 28983-28990. (doi:10.1074/jbc.274.41.28983). (PMID:10506146).
Feelisch, Martin, Kotsonis, Peter, Siebe, Jan, Clement, Bernd and Schmidt, Harald H.HW (1999) The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3,-a] quinoxalin-1-one is a nonselective heme protein inhibitor of nitric oxide synthase and other cytochrome P-450 enzymes involved in nitric oxide donor bioactivation. Molecular Pharmacology, 56, (2), 243-253. (PMID:10419542).
Kotsonis, Peter, Frey, Armin, Fröhlich, Lothar G., Hofmann, Heinrich, Reif, Andreas, Wink, David A., Feelisch, Martin and Schmidt, Harald H.H.W. (1999) Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity. Biochemical Journal, 340, 745-752. (PMID:10359660).
Ji, G.J., Fleischmann, B.K., Bloch, W., Feelisch, M., Andressen, C., Addicks, K. and Hescheler, J. (1999) Regulation of the L-type Ca2+ channel during cardiomyogenesis: switch from NO to adenylyl cyclase-mediated inhibition. The FASEB Journal : the Journal of the Federation of American Societies for Experimental Biology, 13, (2), 313-324. (PMID:9973319).
Liu, Gao-Lin, Christopher, Theodore A., Lopez, Bernard L., Gao, Feng, Guo, Yaping, Gao, Erhe, Knuettel, Karlheinz, Feelisch, Martin and Ma, Xin L. (1998) SP/W-5186, A cysteine-containing nitric oxide donor, attenuates postischemic myocardial injury. The Journal of Pharmacology and Experimental Therapeutics, 287, (2), 527-537. (PMID:9808677).
Mitchell, James B., DeGraff, William, Kim, Sungmee, Cook, John A., Gamson, Janet, Christodoulou, Danae, Feelisch, Martin and Wink, David A. (1998) Redox generation of nitric oxide to radiosensitize hypoxic cells. International Journal of Radiation Oncology*Biology*Physics, 42, (4), 795-798. (doi:10.1016/S0360-3016(98)00327-7). (PMID:9845098).
Feelisch, Martin (1998) The use of nitric oxide donors in pharmacological studies. Naunyn-Schmiedeberg's Archives of Pharmacology, 358, (1), 113-122. (doi:10.1007/PL00005231). (PMID:9721012).
Clementi, Emilio, Brown, Guy Charles, Feelisch, Martin and Moncada, Salvador (1998) Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proceedings of the National Academy of Sciences of the United States of America, 95, (13), 7631-7636. (PMID:9636201).
Wink, David A., Feelisch, Martin, Fukuto, Jon, Chistodoulou, Danae, Jourd'heuil, David, Grisham, Matthew B., Vodovotz, Yoram, Cook, John A., Krishna, Murali, DeGraff, William G., Kim, SungMee, Gamson, Janet and Mitchell, James B. (1998) The cytotoxicity of nitroxyl: possible implications for the pathophysiological role of NO. Archives of Biochemistry and Biophysics, 351, (1), 66-74. (doi:10.1006/abbi.1997.0565). (PMID:9501920).
Kelm, Malte, Dahmann, Rüdiger, Wink, David and Feelisch, Martin (1997) The nitric oxide/superoxide assay. Insights into the biological chemistry of the NO/O-2 interaction. The Journal of Biological Chemistry, 272, 9922-9932. (PMID:9092531).
Schmidt, Harald H.H.W., Hofmann, Heinrich, Schindler, Ursula, Shutenko, Zhanna S., Cunningham, David D. and Feelisch, Martin (1996) No ·NO from NO synthase. Proceedings of the National Academy of Sciences of the United States of America, 93, (25), 14492-14497.
Preik, Michael, Kelm, Malte, Feelisch, Martin and Strauer, Bodo E. (1996) Impaired effectiveness of nitric oxide-donors in resistance arteries of patients with arterial hypertension. Journal of Hypertension, 14, (7), 903-908. (PMID:8818930).
Wang, Steven Y., Feelisch, Martin, Harrison, David G. and Sellke, Frank W. (1996) Preferential dilation of large coronary microvessels by the mononitrates SPM-4744 and SPM-5185. Journal of Cardiovascular Pharmacology, 27, (4), 587-593. (PMID:8847878).
Zamora, R., Grzesiok, A., Weber, H. and Feelisch, M. (1995) Oxidative release of nitric oxide accounts for guanylyl cyclase stimulating, vasodilator and anti-platelet activity of Piloty's acid: a comparison with Angeli's salt. The Biochemical Journal, 312 (Pt 2), 333-339. (PMID:8526840).
Feelisch, Martin and Martin, John F. (1995) The early role of nitric oxide in evolution. Trends in Ecology & Evolution, 10, (12), 496-499. (doi:10.1016/S0169-5347(00)89206-X). (PMID:21237124).
Edling, Oliver, Bao, Gang, Feelisch, Martin, Unger, Thomas and Gohlke, Peter (1995) Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: pharmacological characterization and comparison with enalapril. The Journal of Pharmacology and Experimental Therapeutics, 275, (2), 854-863. (PMID:7473177).
Feelisch, M., Brands, F. and Kelm, M. (1995) Human endothelial cells bioactivate organic nitrates to nitric oxide: implications for the reinforcement of endothelial defence mechanisms. European Journal of Clinical Investigation, 25, (10), 737-745. (doi:10.1111/j.1365-2362.1995.tb01952.x). (PMID:8557060).
De Meyer, Guido R., Bult, Hidde, Ustünes, Levent, Kockx, Mark M., Feelisch, Martin and Herman, Arnold G. (1995) Effect of nitric oxide donors on neointima formation and vascular reactivity in the collared carotid artery of rabbits. Journal of Cardiovascular Pharmacology, 26, (2), 272-279. (PMID:7475052).
Ney, P. and Feelisch, M. (1995) Vasodilator effects of PGE1 in the coronary and systemic circulation of the rat are mediated by ATP-sensitive potassium (K+) channels. Agents and Actions. Supplements, 45, 71-76. (PMID:7536384).
Kelm, Malte, Feelisch, Martin, Krebber, Thomas, Deußen, Andreas, Motz, Wolfgang and Strauer, Bodo E. (1995) Role of nitric oxide in the regulation of coronary vascular tone in hearts from hypertensive rats. Maintenance of nitric oxide-forming capacity and increased basal production of nitric oxide. Hypertension, 25, (2), 186-93. (doi:10.1161/01.HYP.25.2.186). (PMID:7843768).
Addicks, K., Bloch, W. and Feelisch, Martin (1994) Nitric oxide modulates sympathetic neurotransmission at the prejunctional level. Microscopy Research and Technique, 29, (2), 161-168. (doi:10.1002/jemt.1070290214). (PMID:7529070).
Moro, María Ángeles, Darley-Usmar, Victor M., Goodwin, David A., Read, Nicholas G., Zamora-Pino, Rubén, Feelisch, Martin, Radomski, Marek W. and Moncada, Salvador (1994) Paradoxical fate and biological action of peroxynitrite on human platelets. Proceedings of the National Academy of Sciences of the United States of America, 91, (14), 6702-6706. (PMID:1346070).
Pino, R.Z. and Feelisch, M. (1994) Bioassay discrimination between nitric oxide (NO) and nitroxyl (NO-) using L-cysteine. Biochemical and Biophysical Research Communications, 201, (1), 54-62. (doi:10.1006/bbrc.1994.1668). (PMID:8198612).
Zanzinger, Johannes, Feelisch, Martin and Bassenge, Eberhard (1994) Novel organic nitrates are potent dilators of large coronary arteries with reduced development of tolerance during long-term infusion in dogs: role of the sulfhydryl moiety. Journal of Cardiovascular Pharmacology, 23, (5), 772-778. (PMID:7521460).
Feelisch, Martin, te Poel, Marc, Zamora, Rubén, Deussen, Andreas and Moncada, Salvador (1994) Understanding the controversy over the identity of EDRF. Nature, 368, (6466), 62-65. (doi:10.1038/368062a0). (PMID:8107883).
Feelisch, M. (1993) Biotransformation to nitric oxide of organic nitrates in comparison to other nitrovasodilators. European Heart Journal, 14, supplement 1, 123-132. (doi:10.1093/eurheartj/14.suppl.1). (PMID:8293763).
Feelisch, M. (1993) [Nitrogen monoxide (NO)- the active principle of organic nitrates]. Schweizerische Rundschau für Medizin Praxis , 82, (42), 1167-1171. (PMID:8248688).
Kelm, Malte, Feelisch, Martin, Krebber, Thomas, Motz, Wolfgang and Strauer, Bodo E. (1993) Mechanisms of histamine-induced coronary vasodilatation: H1-receptor-mediated release of endothelium-derived nitric oxide. Journal of Vascular Research, 30, (3), 132-138. (doi:10.1159/000158987). (PMID:8518330).
Feelisch, Martin, Schönafingeri, Karl and Noack, Eike (1992) Thiol-mediated generation of nitric oxide accounts for the vasodilator action of furoxans. Biochemical Pharmacology, 44, (6), 1149-1157. (doi:10.1016/0006-2952(92)90379-w). (PMID:1358072).
Kelm, Malte, Feelisch, Martin, Krebber, Thomas, Motz, Wolfgang and Strauer, Bodo E. (1992) The role of nitric oxide in the regulation of coronary vascular resistance in arterial hypertension: comparison of normotensive and spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 20 , supplement 12, S183-S186. (PMID:1282963).
Feelisch, Martin and Kelm, Malte (1991) Biotransformation of organic nitrates to nitric oxide by vascular smooth muscle and endothelial cells. Biochemical and Biophysical Research Communications, 180, (1), 286-293. (doi:10.1016/S0006-291X(05)81290-2). (PMID:1656970).
Kelm, Malte, Feelisch, M, Deussen, Andreas, Strauer, Bodo E. and Schrader, Jürgen (1991) Release of endothelium derived nitric oxide in relation to pressure and flow. Cardiovascular Research, 25, (10), 831-836. (doi:10.1093/cvr/25.10.831). (PMID:1747876).
McCall, T. B., Feelisch, M., Palmer, R. M. and Moncada, S. (1991) Identification of N-iminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells. British Journal of Pharmacology, 102, (1), 234-238. (PMID:1710525).
Noack, E. and Feelisch, Martin (1991) Molecular mechanisms of nitrovasodilator bioactivation. Basic Research in Cardiology, 86 , supplement 2, 37-50. (PMID:1683227).
Noack, Eike and Feelisch, Martin (1989) Molecular aspects underlying the vasodilator action of molsidomine. Journal of Cardiovascular Pharmacology, 14, supplement 11, S1-S5. (PMID:2484685).
Feelisch, Martin, Ostrowski, J. and Noack, E. (1989) On the mechanism of NO release from sydnonimines. Journal of Cardiovascular Pharmacology, 14 , supplement 11, S13-S22. (PMID:2484692).
Kelm, M., Feelisch, Martin and Schrader, J. (1989) Release of the free nitric oxide radical (NO) and EDRF from endothelial cells. Zeitschrift für Kardiologie, 78, supplement 6, 70-74. (PMID:2618132).
Kelm, Malte, Feelisch, Martin, Spahr, Rolf, Piper, Hans-Michael, Noack, Eike and Schrader, Jürgen (1988) Quantitative and kinetic characterization of nitric oxide and EDRF released from cultured endothelial cells. Biochemical and Biophysical Research Communications, 154, (1), 236-244. (doi:10.1016/0006-291X(88)90675-4). (PMID:3260776).
Feelisch, Martin, Noack, E. and Schröder, H. (1988) Explanation of the discrepancy between the degree of organic nitrate decomposition, nitrite formation and guanylate cyclase stimulation. European Heart Journal, 9 , supplement A, 57-62. (doi:10.1093/eurheartj/9.suppl_A.57 ). (PMID:2900766).
Feelisch, Martin and Noack, Eike (1987) Nitric oxide (NO) formation from nitrovasodilators occurs independently of hemoglobin or non-heme iron. European Journal of Pharmacology, 142, (3), 465-469. (doi:10.1016/0014-2999(87)90090-2). (PMID:3123257).
Feelisch, Martin and Noack, Eike A. (1987) Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase. European Journal of Pharmacology, 139, (1), 19-30. (doi:10.1016/0014-2999(87)90493-6). (PMID:2888663).

Book

Feelisch, Martin and Stamler, Jonathan (eds.) (1996) Methods in nitric oxide research, Chichester, GB, Wiley-Blackwell, 732pp.

Book Section

Whitlock , David and Feelisch, Martin (2009) Soil bacteria, nitrite and the skin. In, Rook, Graham A.W. (ed.) The Hygiene Hypothesis and Darwinian Medicine. , Springer, 103-115. (doi:10.1007/978-3-7643-8903-1_6).
 

Research

Research Interests

Martin has a long-standing interest in analytical chemistry, cardiovascular pharmacology, nutrition and metabolism, disease mechanisms, and the chemical biology of nitric oxide (NO) and nitroxyl (HNO), and has received several awards/honors in recognition of his research achievements in these areas. His more recent interests focus on the physiological significance of nitros(yl)ation reactions and the role of NO storage forms in blood and tissues; photobiology; biomarkers of cardiovascular disease and adaptation to hypoxia; hypoxic signalling and altitude physiology; regulation of mitochondrial function and redox signalling; and systems-based approaches to assessing the role of sulfide as well as nitrite, nitrate and other NO-related products in vivo. Work in his laboratory is both hypothesis- and curiosity-driven and includes basic as well as translational research projects in all of the above areas.

Primary research group:  Clinical and Experimental Sciences

Responsibilities

Postgraduate Supervision
  • Supervision of 3 Masters, 2 MD, and 8 PhD students (Germany, USA, UK)
External Assessor/Examiner/Opponent
  • 2002 Neesha Suvarna (University of Tennessee)
  • 2007 Eliza Tsou (University of Buffalo)
  • 2008 Sarah Fox (University of Edinburgh)
  • 2008 Megan Mowbray (University of Edinburgh)
  • 2012 Rasmus Aamand Olesen (Aarhus University)
  • 2014  Johanna van Langen (Antwerp University)
Honours and Service
  • 1990 Fritz-Külz-Prize (German Society for Exp & Clin Pharmacology and Toxicology)
  • 1990-today ad hoc reviewer for >20 scientific journals
  • 1992-today Organization, co-organisation and member of Scientific Advisory Boards of >10
    international scientific meetings and workshops (30-650 participants)
  • 1993-97 Editorial Board, Endothelium
  • 1995- Co-Founder and Director of the "Nitric Oxide Society"
  • 1995-today Editorial Board, Nitric Oxide Chemistry and Biology
  • 1999-today Reviewer for national and international grant funding bodies (incl NIH, Wellcome
    Trust, MRC, DFG, and FWF)
  • 2005-09 Associate Editor, British Journal of Pharmacology
  • 2009 External Reviewer and Member of Site-Visit Team, Trinity College School of Pharmacy, Dublin, Ireland
  • 2011 Chair, Gordon Research Conference on Nitric Oxide
  • 2011-today Member, Xtreme Everest Scientific Strategy Group
  • 2013-today Member, NIHR Wellcome Trust Early Phase Safety Committee
  • 2014-today Member, Scientific Advisory Board, AOBiome, Cambridge, MA

Contact

Professor Martin Feelisch
Faculty of Medicine
University of Southampton
Southampton General Hospital
Mailpoint 801
South Academic Block
Tremona Road
Southampton
SO16 6YD
or
Faculty of Medicine
University of Southampton
Building 85
Life Sciences Building
Highfield Campus
Southampton
SO171BJ

Room Number: SGH/LF80/MP810

Telephone: (023) 8120 6891
Email: M.Feelisch@soton.ac.uk