Medicine

Robert Charles Read

Primary position:
Head of Academic Unit - Clinical and Experimental Sciences
Other positions:
Professor of Infectious Diseases, Honorary Consultant Physician to Southampton University Hospitals

Background

The University of Southampton

Professor Robert Read undertook clinical and research training in Sheffield, Leeds, Bristol, London, Nottingham and San Francisco. He was appointed as an academic infectious disease physician at the University of Sheffield in 1995 and served as Professor of Infectious Diseases there from 2002-2012, prior to moving to Southampton in September 2012.

Professor Read has research interests in the pathogenesis and prevention of rapidly lethal infectious diseases, especially meningococcal and pneumococcal disease, and influenza.

He is the chairman of the Infectious Diseases and Microbiology Specialty Group for the NIHR clinical research network, and Chairs the postdoctoral awards panel for the NIHR Personal Training Fellowships scheme. He was chairman of the 2013 Annual Meeting Program Committee of the Infectious Disease Society of America.

He was appointed as member of the Joint Committee on Vaccine Implementation (JCVI) in September 2013.

He is Editor in Chief of the Journal of Infection and Current Opinion in Infectious Diseases, and is author and co-author of 200 publications mainly in the field of infectious diseases.

Qualifications
  • B.Med.Sci.(Physiology), University of Sheffield
  • M.B. Ch.B, University of Sheffield
  • M.R.C.P., UK 1985
  • M.D., Sheffield 1992
  • F.R.C.P. London 1997
  • FRCP Glasgow 2006
Appointments

Professor of Infectious Diseases University of Sheffield (1995-2012)
Peel Medical Research Trust Travelling Fellow San Francisco General Hospital (1994-1995)
Senior Registrar in Medicine and Infectious Diseases to the Nottingham and Sheffield Hospitals UK (1991-1994)
Research Fellow, Hon. Registrar, National Heart and Lung Institute, Royal Brompton Hospital, London, (1988-1991)
Registrar in Medicine and Infectious Diseases, Northwick Park Hospital and Clinical Research Centre, Harrow, (1986-1988)
Registrar in Medicine Bristol Royal Infirmary (1983-1985)
Senior House Officer in Medicine, Leeds Teaching Hospitals (1983-1985)
Pre-Registration House Officer, Royal Hallamshire Hospital Sheffield (1982-1983)

Professor Robert Charles Read's photo

Publications

The University of Southampton's electronic library (e-prints)

Article

Cowling, Benjamin J., Semple, Malcolm G., Myles, Puja R., Nicholson, Karl G., Lim, Wei Shen, Read, Robert C., Taylor, Bruce L., Brett, Stephen J., Openshaw, Peter J.M., Enstone, Joanne E., McMenamin, James, Bannister, Barbara and Nguyen-Van-Tam, Jonathan S. (2013) An evaluation of community assessment tools (CATs) in predicting use of clinical interventions and severe outcomes during the A(H1N1)pdm09 pandemic. PLoS ONE, 8, (9), e75384. (doi:10.1371/journal.pone.0075384). (PMID:24069409).
Gordon, Stephen B., Jagoe, R. Thomas, Jarman, Elizabeth R., North, James C., Pridmore, Alison, Musaya, Janelisa, French, Neil, Zijlstra, Eduard E., Molyneux, Malcolm E. and Read, Robert C. (2013) The alveolar microenvironment of patients infected with human immunodeficiency virus does not modify alveolar macrophage interactions with Streptococcus pneumoniae. Clinical and Vaccine Immunology, 20, (6), 882-891. (doi:10.1128/CVI.00582-12). (PMID:23576675).
Dale, Adam P. and Read, Robert C. (2013) Genetic susceptibility to meningococcal infection. Expert Review of Anti-infective Therapy, 11, (2), 187-199. (doi:10.1586/eri.12.161). (PMID:23409824).
Laver, Jay R., McLean, Samantha, Bowman, Lesley A.H., Harrison, Laura J., Read, Robert C. and Poole, Robert K. (2013) Nitrosothiols in bacterial pathogens and pathogenesis. Antioxidants & Redox Signaling, 18, (3), 309-322. (doi:10.1089/ars.2012.4767). (PMID:22768799).
Thwaites, Guy, Auckland, Cressida, Barlow, Gavin, Cunningham, Richard, Davies, Gerry, Edgeworth, Jonathan, Greig, Julia, Hopkins, Susan, Jeyaratnam, Dakshika, Jenkins, Neil, Llewelyn, Martin, Meisner, Sarah, Nsutebu, Emmanuel, Planche, Tim, Read, Robert C., Scarborough, Matthew, Soares, Marta, Tilley, Robert, Török, M. Estée, Williams, John, Wilson, Peter, Wyllie, Sarah and Walker, A. Sarah (2012) Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia (ARREST): study protocol for a randomised controlled trial. Trials, 13, (1), 241. (doi:10.1186/1745-6215-13-241). (PMID:23249501).
Pollard, Andrew J., Savulescu, Julian, Oxford, John, Hill, Adrian V.S., Levine, Myron M., Lewis, David J.M., Read, Robert C., Graham, David Y., Sun, Wellington, Openshaw, Peter and Gordon, Stephen B. (2012) Human microbial challenge: the ultimate animal model. The Lancet Infectious Diseases, 12, (12), 903-905. (doi:10.1016/S1473-3099(12)70292-X). (PMID:23174372).
Cozens, Daniel and Read, Robert C. (2012) Anti-adhesion methods as novel therapeutics for bacterial infections. Expert Review of Anti-infective Therapy, 10, (12), 1457-1468. (doi:10.1586/eri.12.145). (PMID:23253323).
Myles, Puja, Nguyen-Van-Tam, Jonathan S., Semple, Malcolm G., Brett, Stephen J., Bannister, Barbara, Read, Robert C., Taylor, Bruce L., McMenamin, Jim, Enstone, Joanne E., Nicholson, Karl G., Openshaw, Peter J., Lim, Wei Shen and Influenza Clinical Information Network (FLU‐CIN) (2012) Differences between asthmatics and non-asthmatics hospitalised with influenza A infection. European Respiratory Journal (doi:10.1183/09031936.00015512). (PMID:22903963).
Dolan, Gayle P., Myles, Puja R., Brett, Stephen J., Enstone, Joanne E., Read, Robert C., Openshaw, Peter J.M., Semple, Malcolm G., Lim, Wei Shen, Taylor, Bruce L., McMenamin, James, Nicholson, Karl G., Bannister, Barbara, Nguyen-Van-Tam, Jonathan S. and Influenza Clinical Information Network (FLU-CIN) (2012) The comparative clinical course of pregnant and non-pregnant women hospitalised with influenza A(H1N1)pdm09 infection. PLoS ONE, 7, (8), e41638. (doi:10.1371/journal.pone.0041638). (PMID:22870239).
Myles, Puja R., Semple, Malcolm G., Lim, Wei Shen, Openshaw, Peter J.M., Gadd, Elaine M., Read, Robert C., Taylor, Bruce L., Brett, Stephen J., McMenamin, James, Enstone, Joanne E., Armstrong, Colin, Bannister, Barbara, Nicholson, Karl G. and Nguyen-Van-Tam, Jonathan S. (2012) Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009-2010 in the UK. Thorax, 67, (8), 709-717. (doi:10.1136/thoraxjnl-2011-200266 ). (PMID:19815859).
Read, Robert C. and Carson, Gail (2012) Using the NIHR comprehensive clinical research network for infectious diseases and microbiology research. Journal of Infection, 65, (2), 99-101. (doi:10.1016/j.jinf.2012.05.003). (PMID:22584114).
Daigneault, Marc, De Silva, Thushan I, Bewley, Martin A., Preston, Julie A., Marriott, Helen M., Mitchell, Andrea M., Mitchell, Timothy J., Read, Robert C., Whyte, Moira K. B. and Dockrell, David H. (2012) Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. PLoS Pathogens, 8, (7), e1002814. (doi:10.1371/journal.ppat.1002814). (PMID:22829769).
Dexter, Laura J., Teare, M. Dawn, Dexter, Matthew, Siriwardena, A. Niroshan and Read, Robert C. (2012) Strategies to increase influenza vaccination rates: outcomes of a nationwide cross-sectional survey of UK general practice. BMJ Open, 2, (3) (doi:10.1136/bmjopen-2011-000851 ).
Myles, Puja R., Nguyen-Van-Tam, Jonathan S., Lim, Wei Shen, Nicholson, Karl G., Brett, Stephen J., Enstone, Joanne E., McMenamin, James, Openshaw, Peter J.M., Read, Robert C., Taylor, Bruce L., Bannister, Barbara and Semple, Malcolm G. (2012) Comparison of CATs, CURB-65 and PMEWS as triage tools in pandemic influenza admissions to UK hospitals: case control analysis using retrospective data. PLoS ONE, 7, (4), e34428. (doi:10.1371/journal.pone.0034428). (PMID:22509303).
Wing, James B., Smart, Lynne, Borrow, Ray, Findlow, Jamie, Findlow, Helen, Lees, Andrew, Read, Robert C. and Heath, Andrew W. (2012) Correlation of group C meningococcal conjugate vaccine response with B- and T-lymphocyte activity. PLoS ONE, 7, (2), e31160. (doi:10.1371/journal.pone.0031160). (PMID:22347446).
Gowers, Isobel R., Walters, Kevin, Kiss-Toth, Endre, Read, Robert C., Duff, Gordon W. and Wilson, Anthony G. (2011) Age-related loss of CpG methylation in the tumour necrosis factor promoter. Cytokine, 56, (3), 792-797. (doi:10.1016/j.cyto.2011.09.009). (PMID:22004920).
Darton, Tom C., Guiver, Malcolm, Naylor, Simone, Kaczmarski, Edward B., Borrow, Raymond and Read, Robert C. (2011) Bacterial genomic detection within cerebrospinal fluid of patients with meningococcal disease is influenced by microbial and host characteristics. Clinical Infectious Diseases, 53, (5), 463-467. (doi:10.1093/cid/cir433). (PMID:21798855).
Wing, James B., Smart, Lynne, Borrow, Ray, Findlow, Jamie, Findlow, Helen, Heath, Andrew W. and Read, Robert C. (2011) Kinetics of immune responses to nasal challenge with meningococcal polysaccharide one year after serogroup-C glycoconjugate vaccination. Clinical Infectious Diseases, 52, (11), 1317-1323. (doi:10.1093/cid/cir198). (PMID:21596673).
Bewley, Martin A., Pham, Trong K., Marriott, Helen M., Noirel, Josselin, Chu, Hseuh-Ping, Ow, Saw Y., Ryazanov, Alexey G., Read, Robert C., Whyte, Moira K.B., Chain, Benny, Wright, Phillip C. and Dockrell, David H. (2011) Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae. Molecular & Cellular Proteomics, 10, (6), M111.008193. (doi:10.1074/mcp.M111.008193). (PMID:21474794).
Green, Luke R., Monk, Peter N., Partridge, Lynda J., Morris, Paul, Gorringe, Andrew R. and Read, Robert C. (2011) Cooperative role for tetraspanins in adhesin-mediated attachment of bacterial species to human epithelial cells. Infection and Immunity, 79, (6), 2241-2249. (doi:10.1128/​IAI.01354-10 ). (PMID:21464080).
Read, Robert C., Cornaglia, Giuseppe and Kahlmeter, Gunnar (2011) Professional challenges and opportunities in clinical microbiology and infectious diseases in Europe. The Lancet Infectious Diseases, 11, (5), 408-415. (doi:10.1016/S1473-3099(10)70294-2). (PMID:21530895).
Darton, Tom C., Wing, James B., Lees, Andrew, Heath, Andrew W. and Read, Robert C. (2011) Adult survivors of invasive pneumococcal disease exhibit defective B cell function. Clinical Infectious Diseases, 52, (9), 1133-1136. (doi:10.1093/cid/cir126). (PMID:21467018).
Enstone, Joanne E., Myles, Puja R., Openshaw, Peter J.M., Gadd, Elaine M., Lim, Wei Shen, Semple, Malcolm G., Read, Robert C., Taylor, Bruce L., McMenamin, James, Armstrong, Colin, Bannister, Barbara, Nicholson, Karl G. and Nguyen-Van-Tam, Jonathan S. (2011) Nosocomial pandemic (H1N1) 2009, United Kingdom, 2009-2010. Emerging Infectious Diseases, 17, (4), 592-8. (doi:10.3201/eid1704.101679). (PMID:10493343).
Deasy, Alice and Read, Robert C. (2011) Challenges for development of meningococcal vaccines in infants and children. Expert Review of Vaccines, 10, (3), 335-343. (doi:10.1586/erv.11.3 ). (PMID:21434801).
Bewick, Thomas, Myles, Puja, Greenwood, Sonia, Nguyen-Van-Tam, Jonathan S., Brett, Stephen J., Semple, Malcolm G., Openshaw, Peter J., Bannister, Barbara, Read, Robert C., Taylor, Bruce L., McMenamin, Jim, Enstone, Joanne E., Nicholson, Karl G. and Lim, Wei Shen (2011) Clinical and laboratory features distinguishing pandemic H1N1 influenza-related pneumonia from interpandemic community-acquired pneumonia in adults. Thorax, 66, (3), 247-252. (doi:10.1136/thx.2010.151522 ). (PMID:21252388).
Nicholson, Karl G., Abrams, Keith R., Batham, Sally, Clark, Tristan W, Hoschler, Katja, Lim, Wei Shen, Medina, Marie-Jo, Nguyen-Van-Tam, Jonathan S., Read, Robert C., Warren, Fiona C. and Zambon, Maria (2011) Immunogenicity and safety of a two-dose schedule of whole-virion and AS03A-adjuvanted 2009 influenza A (H1N1) vaccines: a randomised, multicentre, age-stratified, head-to-head trial. The Lancet Infectious Diseases, 11, (2), 91-101. (doi:10.1016/S1473-3099(10)70296-6).
Findlow, H., Borrow, R., Hardelid, P., Newton, E., Frankland, S., Naylor, S., Miller, E., Kaczmarski, E. and Read, R.C. (2011) Serum antibody kinetics following nasal or parenteral challenge with meningococcal polysaccharide in healthy adults. Clinical and Vaccine Immunology, 18, (3), 424-429. (doi:10.1128/CVI.00503-10).
Jackson, Rachel J., Cooper, Katy L., Tappenden, Paul, Rees, Angie, Simpson, Emma L., Read, Robert C. and Nicholson, Karl G. (2011) Oseltamivir, zanamivir and amantadine in the prevention of influenza: a systematic review. Journal of Infection , 62, (1), 14-25. (doi:10.1016/j.jinf.2010.10.003). (PMID:20950645).
Bewley, Martin A., Marriott, Helen M., Tulone, Calogero, Francis, Sheila E., Mitchell, Timothy J., Read, Robert C., Chain, Benny, Kroemer, Guido, Whyte, Moira K.B. and Dockrell, David H. (2011) A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci. PLoS Pathogens, 7, (1), e1001262. (doi:10.1371/journal.ppat.1001262).
Evans, C.M., Pratt, C.B., Matheson, M., Vaughan, T.E., Findlow, J., Borrow, R., Gorringe, A.R. and Read, R.C. (2011) Nasopharyngeal colonization by neisseria lactamica and induction of protective immunity against neisseria meningitidis. Clinical Infectious Diseases, 52, (1), 70-77. (doi:10.1093/cid/ciq065). (PMID:21148522).
Brett, Stephen J., Myles, Puja, Lim, Wei Shen, Enstone, Joanne E., Bannister, Barbara, Semple, Malcolm G., Read, Robert C., Taylor, Bruce L., McMenamin, Jim, Nicholson, Karl G., Nguyen-Van-Tam, Jonathan S. and Openshaw, Peter J. M. (2011) Pre-admission statin use and in-hospital severity of 2009 pandemic influenza A(H1N1) disease. PLoS ONE, 6, (4), e18120. (doi:10.1371/journal.pone.0018120).
Nicholson, K.G., Abrams, K.R., Batham, S., Clark, T.W., Hoschler, K., Lim, W.S., Medina, M., Nguyen-Van-Tam, J.S., Read, R C, Warren, F.C. and Zambon, M. (2010) A randomised, partially observer blind, multicentre, head-to-head comparison of a two-dose regimen of Baxter and GlaxoSmithKline H1N1 pandemic vaccines, administered 21 days apart. Health Technology Assessment, 14, (55), 193-334. (doi:10.3310/hta14550-04). (PMID:21208550).
Killingley, B., Greatorex, J., Cauchemez, S., Enstone, J. E., Curran, M., Read, R. C., Lim, W. S., Hayward, A., Nicholson, K. G. and Nguyen-Van-Tam, J. S. (2010) Virus shedding and environmental deposition of novel A (H1N1) pandemic influenza virus: interim findings. Health Technology Assessment, 14, (46), 237-354. (PMID:20923613).
Webster, Steve J., Daigneault, Marc, Bewley, Martin A., Preston, Julie A., Marriott, Helen M., Walmsley, Sarah R., Read, Robert C., Whyte, Moira K.B. and Dockrell, David H. (2010) Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease. The Journal of Immunology, 185, (5), 2968-2979. (doi:10.4049/jimmunol.1000805). (PMID:20656927).
Garau, J., Fritsch, A., Arvis, P. and Read, R.C. (2010) Clinical efficacy of moxifloxacin versus comparator therapies for community-acquired pneumonia caused by Legionella spp. Journal of Chemotherapy , 22, (4), 264-266. (PMID:20685631).
Nguyen-Van-Tam, J.S., Openshaw, P.J.M., Hashim, A, Gadd, E.M., Lim, W.S., Semple, M.G., Read, R.C., Taylor, B.L., Brett, S .J., McMenamin, J., Enstone, J.E., Armstrong, C. and Nicholson, K.G. (2010) Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009). Thorax, 65, (7), 645-651. (doi:10.1136/thx.2010.135210 ). (PMID:20627925).
Foster, Rachel A., Carlring, Jennifer, Lees, Andrew, Borrow, Ray, Ramsay, Mary, Kacsmarski, Ed, Miller, Elizabeth, McKendrick, Michael W., Heath, Andrew W. and Read, Robert C. (2010) Functional T-cell deficiency in adolescents who experience serogroup C meningococcal disease despite receiving the meningococcal serogroup C conjugate vaccine. Clinical and Vaccine Immunology, 17, (7), 1104-1110. (doi:10.1128/CVI.00481-09). (PMID:20463106).
McLean, Samantha, Bowman, Lesley A.H., Sanguinetti, Guido, Read, Robert C. and Poole, Robert K. (2010) Peroxynitrite toxicity in Escherichia coli K12 elicits expression of oxidative stress responses and protein nitration and nitrosylation. The Journal of Biological Chemistry, 285, (27), 20724-20731. (doi:10.1074/jbc.M109.085506). (PMID:20427277).
Deasy, Alice and Read, Robert C. (2010) Genetic variation in pro-inflammatory cytokines and meningococcal sepsis. Current Opinion in Infectious Diseases, 23, (3), 255-258. (doi:10.1097/QCO.0b013e32833939de). (PMID:20419848).
Brouwer, Matthijs C., Read, Robert C. and van de Beek, Diederik (2010) Host genetics and outcome in meningococcal disease: a systematic review and meta-analysis. The Lancet Infectious Diseases, 10, (4), 262-274. (doi:10.1016/S1473-3099(10)70045-1). (PMID:20334849).
Rezaei, Nima, Wing, James B., Aghamohammadi, Asghar, Carlring, Jennifer, Lees, Andrew, Asgarian-Omran, Hossein, Pourpak, Zahra, Sarrafnejad, Abdolfattah, Kardar, Gholam A, Shahrestani, Tahereh, Masoumi, Farimah, Zare, Ahad, Saghafi, Shiva, Sarrafzadeh, Shokouh, Foster, Rachel A., Heath, Andrew W. and Read, Robert C. (2010) B-cell-T-cell activation and interaction in common variable immunodeficiency. Human Immunology, 71, (4), 355-362. (doi:10.1016/j.humimm.2010.01.019). (PMID:20097245).
Rezaei, Nima, Siadat, Seyed Davar, Aghamohammadi, Asghar, Moin, Mostafa, Pourpak, Zahra, Norouzian, Dariush, Mobarakeh, Jalal Izadi, Aghasadeghi, Mohammad Reza, Nejati, Mehdi and Read, Robert C. (2010) Serum bactericidal antibody response 1 year after meningococcal polysaccharide vaccination of patients with common variable immunodeficiency. Clinical and Vaccine Immunology, 17, (4), 524-528. (doi:10.1128/​CVI.00389-09 ). (PMID:20106999).
Jeans, A.R., Moore, J., Nicol, C., Bates, C. and Read, R.C. (2010) Wristwatch use and hospital-acquired infection. The Journal of Hospital Infection, 74, (1), 16-21. (doi:10.1016/j.jhin.2009.06.032). (PMID:19751955).
Laver, J.R., Stevanin, T.M., Messenger, S.L., Lunn, A.D., Lee, M.E., Moir, J.W.B., Poole, R.K. and Read, R.C. (2010) Bacterial nitric oxide detoxification prevents host cell S-nitrosothiol formation: a novel mechanism of bacterial pathogenesis. The FASEB Journal, 24, (1), 286-295. (doi:10.1096/fj.08-128330). (PMID:19720623).
Rezaei, N., Aghamohammadi, A., Nourizadeh, M., Kardar, G.A., Pourpak, Z., Zare, A. and Read, R.C. (2010) Cytokine production by activated T cells in common variable immunodeficiency. Journal of Investigational Allergology and Clinical Immunology, 20, (3), 244-251. (PMID:20635790).
Read, R.C. (2009) Still difficult; clinical practice guidelines for Clostridium difficile infection. Clinical Microbiology and Infection, 15, (12), 1051-2. (doi:10.1111/j.1469-0691.2009.03100.x). (PMID:19929971).
Lim, W.S., Baudouin, S.V., George, R.C., Hill, A.T., Jamieson, C., Le Jeune, I., Macfarlane, J.T., Read, R.C., Roberts, H.J., Levy, M.L., Wani, M. and Woodhead, M.A. (2009) BTS guidelines for the management of community acquired pneumonia in adults: update 2009. Thorax, 64 , supplement 3, iii1-iii55. (doi:10.1136/thx.2009.121434 ).
Wing, J.B., Jack, D.L., Lee, M.E., Pacey, A.A., Kinghorn, G.R. and Read, R.C. (2009) Mannose-binding lectin is present in human semen and modulates cellular adhesion of Neisseria gonorrhoeae in vitro. Clinical and Experimental Immunology, 157, (3), 408-414. (doi:10.1111/j.1365-2249.2009.03984.x). (PMID:19664150).
Gorringe, Andrew R., Taylor, Stephen, Brookes, Charlotte, Matheson, Mary, Finney, Michelle, Kerr, Moyra, Hudson, Michael, Findlow, Jamie, Borrow, Ray, Andrews, Nick, Kafatos, George, Evans, Cariad M. and Read, Robert C. (2009) Phase I safety and immunogenicity study of a candidate meningococcal disease vaccine based on Neisseria lactamica outer membrane vesicles. Clinical and Vaccine Immunology, 16, (8), 1113-1120. (doi:10.1128/​CVI.00118-09 ).
Parthasarathy, Varadarajan, Martin, Francine, Higginbottom, Adrian, Murray, Helen, Moseley, Gregory W., Read, Robert C., Mal, Gorakh, Hulme, Rachel, Monk, Peter N. and Partridge, Lynda J. (2009) Distinct roles for tetraspanins CD9, CD63 and CD81 in the formation of multinucleated giant cells. Immunology, 127, (2), 237-48. (doi:10.1111/j.1365-2567.2008.02945.x). (PMID:19489128).
Foster, Rachel A., Carlring, Jennifer, McKendrick, Michael W., Lees, Andrew, Borrow, Ray, Read, Robert C. and Heath, Andrew W. (2009) Evidence of a functional B-cell immunodeficiency in adults who experience serogroup C meningococcal disease. Clinical and Vaccine Immunology, 16, (5), 692-698. (doi:10.1128/​CVI.00485-08 ).
Read, Robert C., Teare, Dawn M., Pridmore, Alison C., Naylor, Simone C., Timms, James M., Kaczmarski, Edward B., Borrow, Raymond and Wilson, Anthony G. (2009) The tumor necrosis factor polymorphism TNF (-308) is associated with susceptibility to meningococcal sepsis, but not with lethality. Critical Care Medicine, 37, (4), 1237-1243. (PMID:19318832).
Darton, Tom, Guiver, Malcolm, Naylor, Simone, Jack, Dominic L., Kaczmarski, Edward B., Borrow, Raymond and Read, Robert C. (2009) Severity of meningococcal disease associated with genomic bacterial load. Clinical Infectious Diseases, 48, (5), 587-594. (doi:10.1086/596707). (PMID:19191644).
Exley, Rachel M., Sim, Richard, Goodwin, Linda, Winterbotham, Megan, Schneider, Muriel C., Read, Robert C. and Tang, Christoph M. (2009) Identification of meningococcal genes necessary for colonization of human upper airway tissue. Infection and Immunity, 77, (1), 45-51. (doi:10.1128/​IAI.00968-08 ). (PMID:18936183).
Rezaei, Nima, Aghamohammadi, Asghar and Read, Robert (2008) Response to polysaccharide vaccination amongst pediatric patients with common variable immunodeficiency correlates with clinical disease. Iranian Journal of Allergy, Asthma, and Immunology, 7, (4), 231-234. (PMID:19052353).
Vazquez-Torres, Andrés, Stevanin, Tania, Jones-Carson, Jessica, Castor, Margaret, Read, Robert C. and Fang, Ferric C. (2008) Analysis of nitric oxide-dependent antimicrobial actions in macrophages and mice. Methods in Enzymology, 437, (6), 521-38. (doi:10.1086/591283). (PMID:18433645).
Torres, Antoni, Garau, Javier, Arvis, Pierre, Carlet, Jean, Choudhri, Shurjeel, Kureishi, Amar, Le Berre, Marie-Aude, Lode, Hartmut, Winter, John and Read, Robert C. (2008) Moxifloxacin monotherapy is effective in hospitalized patients with community-acquired pneumonia: the MOTIV study--a randomized clinical trial. Clinical Infectious Diseases, 46, (10), 1499-1509. (doi:10.1086/587519). (PMID:18419482).
Hopkins, Philip A., Pridmore, Alison C., Ellmerich, Stephan, Fraser, John D., Russell, Hugh H., Read, Robert C. and Sriskandan, Shiranee (2008) Increased surface toll-like receptor 2 expression in superantigen shock. Critical Care Medicine, 36, (4), 1267-1276. (doi:10.1097/CCM.0b013e31816a0a78). (PMID:18379254).
Rezaei, Nima, Aghamohammadi, Asghar, Siadat, Seyed Davar, Moin, Mostafa, Pourpak, Zahra, Nejati, Mehdi, Ahmadi, Hojat, Kamali, Samineh, Norouzian, Dariush, Tabaraei, Bahman and Read, Robert C. (2008) Serum bactericidal antibody responses to meningococcal polysaccharide vaccination as a basis for clinical classification of common variable immunodeficiency. Clinical and Vaccine Immunology, 15, (4), 607-611. (doi:10.1128/CVI.00489-07). (PMID:18235041).
Laver, Jay R., Stevanin, Tânia M. and Read, Robert C. (2008) Chemiluminescence quantification of NO and its derivatives in liquid samples. Methods in Enzymology, 436, 113-127. (doi:10.1016/S0076-6879(08)36007-8). (PMID:18237630).
 

Research

Read and colleagues conduct research to investigate pathogenesis, treatment and prevention of rapidly lethal infections; notably meningococcal disease and influenza.

Successful colonisation of the mucosa of the upper respiratory tract is a prerequisite for disease and transmission of pathogens between human hosts. The focus of Reads group is on host and microbial factors that permit colonisation and disease. A number of models have been developed including human tissue and cell culture systems as well as human controlled infection to enable this.

Figure 1

Human primary macrophages and respiratory mucosa are used to understand molecular pathogenesis

Figure 1

Bacterial pathogenesis is investigated using defined mutations to determine the effect of individual bacterial elements on processing by host phagocytes and epithelial cells. Hitherto this has been done in cell culture systems including human monocyte-derived primary macrophages.

Recent work has focussed on the use of controlled human infections, notably with Neisseria lactamica to determine how this organism interferes with colonisation and invasion by the pathogen Neisseria meningitidis.

Figure 2

Human controlled infections are used to investigate natural colonisation and immunity

Figure 2

Read has conducted a number of important (investigator-initiated) clinical observational studies and clinical trials. Some of these have been national and international networked studies including those which use the UK NIHR Clinical Research Network and its sub group for Infectious Disease and Clinical Microbiology, which Read chairs. Important work has included original studies on the effects of vaccination with sub capsular Neisseria meningitidis vaccines on microbial colonisation, and observational studies of influenza and its prevention.

Primary research group:  Clinical and Experimental Sciences

Responsibilities

International

  • Editor-in-Chief, Journal of Infection, 2005-current
  • Editor-in-Chief Current Opinion in Infectious Diseases, 2011-current 
  • Chair, Infectious Diseases Society of America Annual Program Commitee 2013
  • Executive Member and Working Group Co-Chair, International Severe Acute Respiratory Infection Consortium, 2012-current
  • Member, Committee for Human Medicinal Products (CHMP) Scientific Advisory Group in Anti-infectives (European Medicines Agency) 2011-current
  • Member, Joint ERS/ESCMID Guidelines Writing Committee, Hospital-Acquired Respiratory Tract infections 2013-current
  • Member, ESCMID Guidelines Committee, Treatment of Meningitis
  • Scientific Affairs Officer, Chairman Scientific Affairs Committee, Executive member, European Society for Clinical Microbiology and Infectious Diseases (ESCMID) 2009-2012
  • Professional Affairs Officer, Chairman Professional Affairs Committee, European Congress of Clinical Microbiology and Infectious Diseases (ESCMID). 2005-2009
  • Member, Programme Committee European Congress of Clinical Microbiology and Infectious Diseases 2004-2011
  • Member, WHO SARS Emergency Clinical Response Group 2003-2004 (Department of Health Representative)

National

  • Chair, National Infectious Diseases and Clinical Microbiology Specialty Group, NIHR Clinical Research Network Coordinating Centre 2009-current
  • Chairman, Personal Awards Scheme, National Institute for Health Research (NIHR) (Postdoctoral Fellowships) Trainees Coordinating Centre 2008-current
  • Member, Joint Committee on Vaccine Implementation (JCVI) 2013-current
  • Member, Scientific Pandemic Influenza Advisory Committee (SPI) 2009-2012
  • Member, Department of Health Influenza Clinical Information Network (FLU-CIN) 2009-2011
    Member , Chief Medical Officers Working Group, Pandemic Influenza, 2005-2009
  • Member, Department of Health Pandemic Influenza Contingency Plan Clinical Management Guidelines Development Group, 2005-2009
  • Member, DH Expert Advisory Group HIV and Infectious Diseases (MHRA) 2006-current
  • Member, DH Expert Advisory Group, Biologicals and Vaccines, Commission on Human Medicines, 2007-2013
  • Member, British Thoracic Society Community Acquired Pneumonia Guidelines Writing Committee, 2007-current
  • External Examiner, Cardiff MBChB (2005-2010), Swansea MBChB, 2006-current, Nottingham BMedSci, 2006-2009.
  • External Examiner PhD/MD, various
  • Clinical Lead; UK SARS Taskforce, Health Protection Agency 2003-current

 

Teaching Responsibilities

Professor Read teaches Infectious Disease and Clinical Microbiology to undergraduates and postgraduate clinicians, and supervises PhD and MSc students.

Contact

Professor Robert Charles Read
Faculty of Medicine
University of Southampton
Southampton General Hospital
Mailpoint 814
South Academic Block
Tremona Road
Southampton
SO16 6YD

PA

Cindy Phillips
Senior Faculty Administrative Officer
Room LC68, C Level, South Block
Southampton General Hospital
Tremona Road
Southampton
SO16 6YD
023 81206455
C.M.Phillips@soton.ac.uk