The University of Southampton

HLTH6173 Fundamental Science in Major Trauma

Module Overview

This module is designed to enable you to understand the impact of improved clinical scientific knowledge of trauma-altered physiology and its resultant aggressive management. It will enable you to build a platform of clinical scientific data and understanding for working clinical environments where major trauma care is provided. This module of learning will also focus on altered physiology in major trauma and how trauma is affected by variables such as age, co-morbidity and mechanism of injury.

Aims and Objectives

Module Aims

This module will enable you to: 1. Critically evaluate current knowledge and understanding of the key clinical scientific principles which underpin optimal trauma care 2. With reference to life science, identify and critically evaluate the contribution of historical scientific landmarks in the development of trauma care, 3. Demonstrate an in-depth understanding of altered physiology (including infection) in trauma and its aggressive management 4. Critically review the evidence on physiological and psychological responses to trauma and how this is affected by variables such as age, co-morbidity and the mechanism of injury


• Context of the scientific understanding in the development of care trauma outcomes • Key applied anatomy and physiology • Pathophysiology in trauma across the lifespan • Human physiological response to stress and injury • The psychological impact major trauma • Inflammation and sepsis • Neurological trauma • Trauma and co-morbidity • Acute coagulopathy of trauma and haemostatic resuscitations • Fluid resuscitation in trauma • Acute resuscitation • Metabolism and nutrition in trauma • Tissue healing and regeneration

Learning and Teaching

Teaching and learning methods

This module will enable you to advance your understanding and application of relevant underpinning life science in trauma by focusing on trauma scenarios, be they in clinical practice, simulation or filmed events. You will study the underpinning life sciences in-depth and with coaching and facilitation will explore in relation to practice vignettes, patient assessment, interpretation of data, diagnostic and clinical reasoning, and alternative options for intervention and therapy.

Follow-up work20
Wider reading or practice10
Completion of assessment task1.5
Preparation for scheduled sessions100
Total study time250

Resources & Reading list


Skinner DV (2013). ABC of major trauma, Skinner DV and Driscoll PA (Eds).. 

Bailitz J (2011). Emergent management of trauma. 

Bhangu AA (2010). Emergencies in trauma. Bhangu AA, Lee C and Porter K (Eds). 

Smith J (2011). Oxford desk reference: major trauma, Smith J, Greaves I, Porter KM (Eds).. 



Online journals. • The Journal of Trauma • The Journal of Trauma Practice • Trauma Quarterly • Journal of Emergency Medicine, Trauma and Acute Care • The Journal of Literature and Trauma Studies





MethodPercentage contribution
Exam  (1.5 hours) 100%


MethodPercentage contribution
Exam  (1.5 hours) 100%

Repeat Information

Repeat type: Internal & External

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