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Work Developing Ex Vivo Model of Human Bone Regeneration Published

Published: 26 January 2017
Cylinder of human bone tissue
Cylinder of human bone tissue on the chorioallantoic membrane

Work from the Bone and Joint Research Group in the CHDSCR has been published in Scientific Reports, demonstrating the potential of using the membrane of a chick embryo to study human bone regeneration.

The study conducted by Dr Ines Moreno Jimenez and supervised by Professor Richard Oreffo, Dr Nicholas Evans and Dr Janos Kanczler showed how the chorioallantoic membrane (CAM) of eggs can be used to culture human bone tissue in a model that represents a number of clinically relevant variables in bone healing. The findings describe capillary growth from the CAM into the bone, as well as the beginnings of new bone tissue formation in defects induced within the introduced bone samples.

The CAM assay developed by the Bone and Joint Research Group has been shown to reduce the number of animals required for in vivo testing, with the potential to use it to test and screen the suitability of new materials and scaffolds developed to promote tissue regeneration.

Dr Moreno Jimenez was supported during this work by NC3Rs funding and additional information on this study can be found on their website.


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