Chemistry

Martin C Grossel

BSc (Lon), MA (Oxon), PhD (Lon)

Primary position:
Emeritus Fellow in Organic Chemistry

Background

The University of Southampton

Martin Grossel was an undergraduate at King’s College, London and graduated with a first class honours degree in 1970. He remained at King’s to read for a PhD in physical organic chemistry under the supervision of Professor M J Perkins. In 1973 he was appointed to a Departmental Assistantship in the Dyson Perrins Laboratory, Oxford coupled with a Teaching Lectureship at Christ Church. He joined the research group of Dr G H Whitham. In 1975 he was awarded an ICI Fellowship in the Dyson Perrins Lab to work on aspects of alicyclic chemistry. At the same time he was elected to a Research Lectureship (Junior Research Fellowship) at Christ Church.

In 1979 he was appointed Lecturer in Organic Chemistry at Bedford College, University of London (which subsequently became Royal Holloway and Bedford New College) and in 1991 moved to Southampton where he is now Reader in Organic Chemistry. Since 1979 he has continued to hold a Lectureship at Christ Church, Oxford, and in 1993 he was elected to a College Studentship (= Fellowship).

His current interests range from supramolecular chemistry to materials science and optoelectronics including: (i) the behaviour of organic molecules in the solid state; (ii) functional supramolecular assemblies for optical sensing and improving solar cell performance; and (iii) novel applications of biodegradable and thermoresponsive polymers in medicine. He has a number of successful national and international collaborations, working with Prof Peter Smith (Optoelectronics), Prof Donna Davies (School of Medicine), and Prof Tom Markvart (Engineering) in Southampton University, Dr Richard Curry (University of Surrey), Prof Brynn Hibbert (Chemistry School, University of New South Wales, Australia), Dr Dirk Aarts (Physical Chemistry) and Prof David Roberts (Medical Sciences) in the University of Oxford, and Prof. Tony Cheetham (Materials Department, University of Cambridge).

Research Keywords

Supramolecular chemistry, organic molecular and opto- electronics, crystal engineering, functional polymeric delivery systems

Dr Martin C Grossel's photo

Publications

The University of Southampton's electronic library (e-prints)

Article

Leriche, Emma-Dune, Afonso, Carlos, Lange, Catherine M., Grossel, Martin C., Truong, Lina, Coadou, Gael, Oulyadi, Hassan and Loutelier-Bourhis, Corinne (2014) Glycine-modified polyamidoamine dendrimers: synthesis and structural characterization using nuclear magnetic resonance, ion-mobility mass spectrometry and capillary electrophoresis. RSC Advances, 4, 1744-1753. (doi:10.1039/c3ra43939a).
Parker, Richard Mark, Wales, Dominic J., Gates, James C., Frey, J.G., Smith, Peter G.R. and Grossel, Martin Christopher (2014) Monolayer detection of ion binding at a crown ether-functionalised supramolecular surface via an integrated optical Bragg grating. Analyst, 139, 2774-2782. (doi:10.1039/C4AN00283K).
Wales, Dominic J., Parker, Richard M., Gates, James C., Grossel, Martin C. and Smith, Peter G.R. (2013) An investigation into relative humidity measurement using an aluminosilicate sol–gel thin film as the active layer in an integrated optical Bragg grating refractometer. Sensors and Actuators B: Chemical, 188, 857-866. (doi:10.1016/j.snb.2013.07.089).
Pitt, Darren William, Treharne, Andrew John, Thomson, Heather A., Scott, Jennifer A., Lotery, Andrew John and Grossel, Martin Christopher (2013) Improving cellular adhesion on scaffolds for transplantation: synthesising a poly(MMA-co-PEGM) network. Journal of Materials Chemistry B, n/a (doi:10.1039/C3TB21248C).
Alderman, Nicholas, Adib Ibrahim, Mohd, Danos, Lefteris, Grossel, Martin C. and Markvart, Tom (2013) Determination of surface recombination velocities of organic monolayers on silicon through Kelvin probe. Applied Physics Letters, 103, (8), 081603-[5pp]. (doi:10.1063/1.4818768).
Parker, Richard M., Gates, James C., Wales, D, Smith, Peter G. R. and Grossel, Martin C. (2013) An investigation into dispersion upon switching between solvents within a microfluidic system using a chemically resistant integrated optical refractive index sensor. Lab on a Chip, 13, (3), 377-385. (doi:10.1039/C2LC41124E).
Treharne, Andrew John, Thomson, Heather A.J., Grossel, Martin C. and Lotery, Andrew J. (2012) Developing methacrylate-based copolymers as an artificial Bruch's membrane substitute. Journal of Biomedical Materials Research Part A (doi:10.1002/jbm.a.34178). (PMID:22528296). (In Press).
Thomson, Heather Anne Jane, Treharne, Andrew John, Walker, Paul, Grossel, Martin Christopher and Lotery, Andrew John (2011) Optimisation of polymer scaffolds for retinal pigment epithelium (RPE) cell transplantation. British Journal of Ophthalmology, 95, (4), 563-568. (doi:10.1136/bjo.2009.166728).
Thomson, H.A., Treharne, A.J., Backholer, L.S., Cuda, F., Grossel, M.C. and Lotery, A.J. (2010) Biodegradable poly(alpha-hydroxy ester) blended microspheres as suitable carriers for retinal pigment epithelium cell transplantation. Journal of Biomedical Materials Research Part A, 95, (4), 1233-1243. (doi:10.1002/jbm.a.32940). (PMID:20939049).
Treharne, Andrew J, Grossel, Martin C, Lotery, Andrew J and Thomson, Heather A (2010) Review: The chemistry of retinal transplantation: the influence of polymer scaffold properties on retinal cell adhesion and control. British Journal of Ophthalmology (doi:10.1136/bjo.2010.184002). (PMID:20807710).
Fant, Kristina, Esbjörner, Elin, Jenkins, Alan, Grossel, Martin C., Lincoln, Per and Nordén, Bengt (2010) Effects of PEGylation and acetylation of PAMAM dendrimers on DNA Binding, cytotoxicity and in vitro transfection efficiency. Molecular Pharmaceutics, 7, (5), 1734-1746. (doi:10.1021/mp1001312). (PMID:20695423).
Thomson , Heather Anne Jane, Treharne, Andrew John, Grossel, Martin Christopher and Lotery, Andrew John (2010) Attachment and viability of arpe-19 cells on biodegradable polymer microspheres. ARVO Meeting Abstracts, 51, (5), 5243.
Parker, R.M., Gates, J.C., Grossel, M.C and Smith, P.G.R. (2010) Athermal planar Bragg grating device for integrated photonic networks. Electronics Letters, 46, (5), 358-359. (doi:10.1049/el.2010.3424 ).
Bailey, Andrew, Horton, Peter Neil and Grossel, Martin Christopher (2010) Self-assembly into infinite tapes by 2,7-disubstituted-1,8-naphthyridines in the solid state. CrystEngComm, 12, (12), 4074-4079. (doi:10.1039/C0CE00243G).
Parker, Richard M., Gates, James C., Rogers, Helen L., Smith, Peter G.R. and Grossel, Martin C. (2010) Using the photoinduced reversible refractive-index change of an azobenzene co-polymer to reconfigure an optical Bragg grating. Journal of Materials Chemistry, 20, (41), 9118-9125. (doi:10.1039/c0jm01334j).
Parker, R.M., Gates, J.C., Grossel, M.C. and Smith, P.G.R. (2010) A temperature insensitive Bragg grating sensor – using orthogonal polar polarisation modes for in situ temperature compensation. Sensors and Actuators, 145, (1), 428-432. (doi:10.1016/j.snb.2009.12.059).
Parker, Richard M., Gates, James C., Grossel, Martin C. and Smith, Peter G.R. (2009) In vacuo measurement of the sensitivity limit of planar Bragg grating sensors for monolayer detection. Applied Physics Letters, 95, (17), 173306-[3pp]. (doi:10.1063/1.3257727).
Thomson, Heather Anne Jane, Treharne, Andrew John, Walker , Paul, Grossel , Martin Christopher and Lotery, Andrew John (2009) Optimisation of polymer scaffolds for ocular cell transplantation. ARVO Meeting Abstracts, 50, (5), 6230.
Mamone, S., Ge, Min, Hüvonen, D., Nagel, U., Danquigny, A., Cuda, F., Grossel, M.C., Murata, Y., Komatsu, K., Levitt, M.H., Rõõm, T. and Carravetta, M. (2009) Rotor in a cage: infrared spectroscopy of an endohedral hydrogen-fullerene complex. Journal of Chemical Physics, 130, (8), 081103-[4pp]. (doi:10.1063/1.3080163). (PMID:19256588).
Horsewill, A.J., Panesar, K.S., Rols, S., Johnson, M.R., Murata, Y., Komatsu, K., Mamone, S., Danquigny, A., Cuda, F., Maltsev, S., Grossel, M.C., Carravetta, M. and Levitt, M.H. (2009) Quantum translator-rotator: Inelastic neutron scattering of dihydrogen molecules trapped inside anisotropic fullerene cages. Physical Review Letters, 102, (1), 013001. (doi:10.1103/PhysRevLett.102.013001).
Bailey, Andrew, Lee, Clare, Feller, Russel K., Orton, James B., Mellot-Draznieks, Caroline, Slater, Ben, Harrison, William T.A., Simoncic, P., Navrotsky, A., Grossel, Martin C. and Cheetham, Anthony K. (2008) Comparison of chiral and racemic forms of zinc cyclohexane trans-1,2 dicarboxylate frameworks; a structural, computational and calorimetric study. Angewandte Chemie International Edition, 47, (45), 8634-8637. (doi:10.1002/anie.200802564). (PMID:18833555).
Panesar, K.S., Horsewill, A.J., Cuda, F., Carravetta, M., Mamone, S., Danquigny, A., Grossel, M.C. and Levitt, M.H. (2008) Thermal history effects and methyl tunneling dynamics in a supramolecular complex of calixarene and para-xylene. Journal of Chemical Physics, 128, (14), 144512-[8pp]. (doi:10.1063/1.2889003).
Carravetta, M., Danquigny, A., Mamone, S., Cuda, F., Johannessen, O.G., Heinmaa, I., Panesar, K., Stern, R., Grossel, M.C., Horsewill, A.J., Samoson, A., Murata, M., Murata, Y., Komatsu, K. and Levitt, M.H. (2007) Solid-state NMR of endohedral hydrogen-fullerene complexes. Physical Chemistry Chemical Physics, 9, (35), 4879-4894. (doi:10.1039/b707075f).
Grossel, Martin C., Dwyer, Andrew N., Hursthouse, Michael B. and Orton, James B. (2007) Solid-state assemblies from pyridine-2,6-dicarboxylates: “changing the instruction set through hydration”. CrystEngComm, 9, (9), 207-210. (doi:10.1039/b617051j).
Grossel, M.C., Dwyer, A.N., Hursthouse, M.B. and Orton, J.B. (2007) Solid-state assemblies from pyridine-2,6-dicarboxylates: "changing the instruction set through hydration''. Crystengcomm, 9, (3), 207-210. (doi:10.1039/b617051j).
Araya, K., Dunmur, D.A., Grossel, M.C., Luckhurst, G.R., Marchant-Lane, S.E. and Sugimura, A. (2006) Flexible dimers as dopants for liquid crystal display mixtures with faster relaxation times. Journal of Materials Chemistry, 16, (48), 4675-4689. (doi:10.1039/b610598j).
George, Michael R., Golden, Christopher A., Grossel, Martin C. and Curry, Richard J. (2006) Modified dipicolinic acid ligands for sensitization of europium(III) luminescence. Inorganic Chemistry, 45, (4), 1739-1744. (doi:10.1021/ic051461u).
Grossel, Martin C., Dwyer, Andrew N., Hursthouse, Michael B. and Orton, James B. (2006) Polymorphism in pyridine-2,6-dicarboxylic acid: Competition between “robust” synthons. CrystEngComm, 8, (2), 123-128. (doi:10.1039/B516387K).
Finlayson, C.E., Amezcua, A., Sazio, P.J.A., Walker, P.S., Grossel, M.C., Curry, R.J., Smith, D.C. and Baumberg, J.J. (2005) Infrared emitting PbSe nanocrystals for telecommunications window applications. Journal of Modern Optics, 52, (7), 955-964. (doi:10.1080/09500340512331327589).
Dwyer, A , Grossel, Martin C. and Horton, Peter N. (2004) Binding of Co3+ and CoCl42- within a pyridine-cored molecular cleft. Supramolecular Chemistry, 16, (6), 405-410. (doi: 10.1080/10610270410001713312).
Walker, Paul S., Bergin, Paul M., Grossel, Martin C. and Horton, Peter N. (2004) Modeling novel radiopharmaceuticals: mono-C6-substituted PnAO ligands (PnAO=3,3,9,9-tetramethyl-4,8-diazaundecane-2,10-dione dioxime). Inorganic Chemistry, 43, (14), 4145-4153. (doi: 10.1021/ic0497634).
Koo, Jae-Sun, Smith, Peter G.R., Williams, Richard B., Riziotis, Christos and Grossel, Martin C. (2003) UV written waveguides using crosslinkable PMMA-based copolymers. Optical Materials, 23, (3-4), 583-592. (doi:10.1016/S0925-3467(03)00025-9).
Le Gall, Thierry, Reiman, Kenneth H., Grossel, Martin C. and Owen, John R. (2003) Poly(2,5-dihydroxy-1,4-benzoquinone-3,6-methylene): a new organic polymer as positive electrode material for rechargeable lithium batteries. Journal of Power Sources, 119, 316-320. (doi: 10.1016/S0378-7753(03)00167-8).
Grossel, Martin C., Merckel, Daniel A.S. and Hutchings, Michael G. (2003) The effect of preorganisation on the solid state behaviour of simple 'aromatic-cored' bis(guanidinium) sulfates. CrystEngComm, 5, (5), 77-81. (doi: 10.1039/b207803a).
Koo, J.-S., Williams, R.B., Gawith, C.B.E., Watts, S.P., Emmerson, G.D., Albanis, V., Smith, P.G.R. and Grossel, M.C. (2003) UV written waveguide devices using crosslinkable PMMA-based copolymers. Electronics Letters, 39, (4), 394-395. (doi:10.1049/el:20030274).
Frey, J.G., Grossel, M.C., Timson, A.J., Golden, C., Macey, C., Ouick, D.W. and Rousay, E.R. (2002) Influence of cation binding on the structure of adsorbed layers of crown ethers and amino acid derivatives at the air water interface. Abstracts of Papers of the American Chemical Society, 224, U435-U436.
Koo, Jae-Sun, Smith, Peter G.R., Williams, Richard B., Grossel, Martin C. and Whitcombe, Michael J. (2002) Synthesis and characterization of methacrylate-based copolymers for integrated optical applications. Chemistry of Materials, 14, (12), 5030-5036. (doi:10.1021/cm0212010).
Boardman, Frederick H., Dunmur, David A., Grossel, Martin C. and Luckhurst, Geoffrey R. (2002) Synthesis and liquid crystal phase behaviour of 2-(4-cyanophenyl)-7-n-alkylfluorenes: luminescent mesogens. Chemistry Letters, 31, (1), 60-61. (doi:10.1246/cl.2002.60).
Hutchings, Michael G., Grossel, Martin C., Merckel, Daniel A.S., Chippendale, A. Margaret, Kenworthy, Mark and McGeorge, Gary (2001) The structure of m-xylylenediguanidinium sulfate: a putative molecular tweezer ligand for anion chelation. Crystal Growth & Design, 1, (4), 339-342. (doi: 10.1021/cg0155144).
Grossel, Martin C., Golden, Christopher A., Gomm, John R., Horton, Peter N., Merckel, Daniel A.S., Oszer, Mustafa E. and Parker, Robert A. (2001) Solid-state behaviour of pyridine-2,6-dicarboxylate esters: supramolecular assembly into infinite tapes. CrystEngComm, 3, 170-173. (doi:10.1039/b107221h).
Bartlett, P. N., Grossel, M. C. and Barrios, E. M. (2000) Electrochemistry and contact angle measurements on polymer films of omega-(3-pyrrolyl)-alkanoic acids in aqueous solution. Journal of Electroanalytical Chemistry, 487, (2), 142-148. (doi:10.1016/S0022-0728(00)00183-2).

Book Section

Grossel, Martin C (2007) Supramolecular approaches to molecular machines. In, Rao, C.N.R., Műller, Achim and Cheetham, Anthony K. (eds.) Nanomaterials Chemistry. Weinheim FRG, Wiley, 319-352.

Conference or Workshop Item

Wales, D.J., Parker, R.M., Gates, J.C, Grossel, M.C. and Smith, P.G.R. (2012) Integrated Bragg grating sensors: achieving chemical sensing in liquid and gas flow systems. In, IONS-10: 10th conference of the International OSA Network of Students, Southampton, GB, 10 - 11 Aug 2011.
Wales, D.J., Parker, R.M., Gates, J.C., Grossel, M.C. and Smith, P.G.R. (2011) An integrated Bragg grating oxygen sensor using a hydrophobic sol-gel layer doped with an organic dye. In, CLEO/Europe-EQEC 2011, Munchen, GE, 22 - 26 May 2011. 1pp. (doi:10.1109/CLEOE.2011.5943057).
Parker, R.M., Gates, J.C., Grossel, M.C. and Smith, P.G.R. (2011) Optofluidic integrated Bragg grating chemical sensor: Utilising a sodium-elective receptor surface to enhance detection. In, European Conference on Lasers and Electro-Optics (CLEO/Europe-EQEC 2011), Munich, Germany, 22 - 26 May 2011. (doi:10.1109/CLEOE.2011.5943054).
Wales, D.J., Bardy, X.Y., Parker, R.M., Gates, J.C., Smith, P.G.R. and Grossel, M.C. (2011) Towards an optoelectronic nose: metal phthalocyanine modified siloxane polymers as sensing elements for volatile organic compounds. At The 6th International Symposium on Macrocyclic and Supramolecular Chemistry (6-ISMSC), Brighton, GB, 03 - 07 Jul 2011.
Wales, D., Parker, R.M., Gates, J.C., Grossel, M. and Smith, P.G.R. (2010) Integrated planar Bragg grating sensors: Towards an oxygen sensor. In, IS:CE Chem Seminar , Ouistreham, FR, 07 - 08 Dec 2010.
Parker, R.M., Gates, J.C., Holmes, C., Grossel, M.C. and Smith, P.G.R. (2010) Integrated temperature compensated Bragg grating refractometer. In, CLEO/QELS 2010: Lasers and Electro-Optics and Quantum Electronics and Laser Science Conference , San Jose , US, 16 - 21 May 2010.
Wales, D.J., Parker, R.M., Gates, J.C., Grossel, M.C. and Smith, P.G.R. (2010) Integrated planar Bragg grating oxygen sensor. In, 15th European Conference on Integrated Optics (ECIO) , Cambridge, UK, 07 - 09 Apr 2010.
Parker, R.M., Gates, J.C., Rogers, H.L., Grossel, M.C. and Smith, P.G.R. (2010) An integrated reconfigurable Bragg grating utilising a photoresponsive co-polymer. In, ECIO 2010: 15th European Conference on Integrated Optics, Cambridge, UK, 07 Apr 2010.
Parker, R.M., Gates, J.C., Grossel, M.C. and Smith, P.G.R. (2010) An integrated optofluidic Bragg grating device to measure the dynamic composition of a fluid. In, CLEO/QELS 2010: Lasers and Electro-Optics and Quantum Electronics and Laser Science Conference , San Jose , US, 16 - 21 May 2010.
Parker, R.M., Gates, J.C., Smith, P.G.R. and Grossel, M.C. (2009) A Bragg grating sensor for detection of monolayers at a surface. In, European Conference on Lasers and Electro-Optics (CLEO/Europe-EQEC), Munich, Germany, 14 - 19 Jun 2009.
Parker, R.M., Gates, J.C., Sessions, N.P., Kundys, D.O., Gawith, C.B.E., Grossel, M.C. and Smith, P.G.R. (2009) In vacuo measurement of the sensitivity limit of planar Bragg sensors. In, Conference on Lasers and Electro-optics - European Quantum Electronics Conference (CLEO/Europe-EQEC 2009), Munich, Germany, 1pp. (doi:10.1109/CLEOE-EQEC.2009.5196282).
Parker, R.M., Gates, J.C., Smith, P.G.R. and Grossel, M.C. (2009) Optofluidic Bragg grating sensor for monolayer detection. In, Conference on Lasers and Electro-Optics (CLEO/IQEC), Baltimore, USA, 31 May - 05 Jun 2009.
Koo, J.-S., Smith, P.G.R., Williams, R.B., Riziotis, C. and Grossel, M.C. (2002) UV written waveguides using crosslinkable PMMA-based copolymers. In, CLEO 2002: Conference on Lasers and Electro-Optics, Long Beach, California, USA, 19 - 24 May 2002.
 

Research

Research Interests

Research Funding

2005-2008 “Integrated microsphere planar lightwave circuits”, BBSRC/MOD, £208k. Collaborative grant with Dr. Jan Shute, Pharmacy Department, University of Portsmouth

2005-2009 “Cryogenic Magic Angle Spinning NMR” Basic Technology Grant. Collaborative grant with Prof Malcolm Levitt (principal applicant) + others, £2.8M

Primary research group:  Molecular Assembly, Function and Structure

Research projects

Grossel: New Crystal Engineering Synthons

Innovative Synthesis, Culture and Entrepreneurship in Chemistry (ISCE-Chem)

Grossel: Supramolecular Approaches to Cryogenic NMR Relaxation Agents

Grossel: Biological applications of polymers

Grossel: New materials for Optoelectronics Applications

Contact

Dr Martin C Grossel
Chemistry
University of Southampton
Highfield
Southampton
SO17 1BJ

Room Number: 30/2047

Telephone: (023) 8059 3153
Facsimile: (023) 8059 3781
Email: M.C.Grossel@soton.ac.uk