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The University of Southampton

11th Bioengineering Sciences Seminar: cells, cell sheets and insect embryos: modelling the role of mechanics in tissue development Event

21 September 2012
Building 85 Seminar room 2207

Event details

Event from the Computational and Modelling Group

Cells, cell sheets and insect embryos: modelling the role of mechanics in tissue development

It is becoming increasingly clear that mechanical interactions play a crucial role in controlling cellular behaviours in development and morphogenesis. However, it is often unclear how we can use these observations at the cell-level to understand the development of entire tissues. In particular inferring cellular behaviour from tissue-level experimental observations is complicated due to the multiple interactions and feedbacks that are dynamically occurring between cells and their microenvironments I will here demonstrate two different approaches. In the first, individual based simulations are used to tackle the problem from the bottom-up by postulating individual cell behaviours before ‘growing' the tissue in silico. The second adopts a top-down approach using a continuum description of the whole tissue which is integrated with mechanical models for individual cellular behaviour. These models are used to explain cellular self-organization in the paradigm developmental system of Drosophila melanogaster and to infer individual cellular force generation from traction force assays.

An event from our Computational Modelling Group

Bringing together Southampton university researchers using applied Computational Modelling to support the understanding and advancement of physical and natural sciences, engineering, medicine, economy, society, psychology.

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Speaker information

Dr Carina Dunlop,, University of Surrey,Lecturer

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