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The University of Southampton

DNA origami nanopores: design, developments and challenges Seminar

29 April 2015
Building 27, Room 2003 Chemistry University of Southampton Southampton SO17 1BJ

For more information regarding this seminar, please email Eugen Stulz at .

Event details

Dr Ulrich Keyser (Cavendish Laboratory, University of Cambridge) is working on DNA nano-pores in membranes and membrane transport in general, and the topic should be of interest to all working in biological, medicinal and physical chemistry alike.

DNA nanotechnology has enabled the construction of DNA origami nanopores [1]. These synthetic designer nanopores promise improved capabilities for improved single molecule detection. Here, we will review the recent developments of DNA origami nanopores both in lipid [2] and solid-state membranes [3]. These structures have extraordinary versatility and are a new and powerful tool in nanobiotechnology for a wide range of important applications beyond molecular sensing. We discuss the current challenges and possible solutions that would enhance the sensing capabilities of DNA origami nanopores [4]. Finally, we anticipate novel avenues for future research and highlight a range of exciting ideas and applications that could be explored in the near future. These include using these designer nanopores as model systems for protein channels [5].

[1] N. A. W. Bell, C. R. Engst, M. Ablay, G. Divitini, C. Ducati, T. Liedl, and U. F. Keyser. DNA origami nanopores. Nano Letters, 12(1):512-517, 2012

[2] J. R. Burns, K. Goepfrich, J. W. Wood, V. V. Thacker, E. Stulz, U. F. Keyser, and S. Howorka. Lipid-Bilayer-Spanning DNA Nanopores with a Bifunctional Porphyrin Anchor, Angewandte Chemie International Edition, 52(46):12069-12072, 2013.

[3] S. Hernandez-Ainsa, N. A. W. Bell, V. V. Thacker, K. Goepfrich, K. Misiunas, M. Fuentes-Perez, F. Moreno-Herrero, and U. F. Keyser. DNA origami nanopores for controlling DNA translocation. ACS nano, 7(7):6024-6030, 2013.

[4] N. A. W. Bell and U. F. Keyser. Specific Protein Detection using Designed DNA Carriers and Nanopores. JACS, 137(5):2035-2041, 2015.

[5] K. Goepfrich, T. Zettl, A. E. C. Meijering, S. Hernandez-Ainsa, S. Kocabey, T. Liedl, and U. F. Keyser. DNA-Tile Structures Induce Ionic Currents through Lipid Membranes. Nano Letters, ASAP, 2015.


Speaker information

Ulrich Keyser, University of Cambridge. Cavendish Laboratory

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