Skip to main navigation Skip to main content
The University of Southampton
Southampton Neuroscience Group

Dr Ayodeji A Asuni BSc, PhD

Teaching/Senior Research Fellow

Dr Ayodeji A Asuni's photo

Dr Ayodeji A Asuni is Teaching/Senior Research Fellow within the Centre for Biological Sciences at the University of Southampton.

Research interests

Diabetes and the intersection with neurodegenerative diseases.
The mechanisms through which diabetes increases the risk of dementia and AD are still a matter of intense debate; and include insulin resistance, impairment in CNS insulin signalling, glucose toxicity, systemic or local oxidative stress, inflammatory cytokines, formation of advanced glycation endproducts (AGEs) and mediation of their pathological cellular responses via AGE receptors. Both AD and type 2 diabetes are chronic conditions that usually cannot be cured; hence a better understanding of how these mechanisms interact is prudent and necessary for advancement of AD and diabetes prevention strategies.

Our research has two focuses; one is to ascertain the contribution of hyperglycemia, abnormally conformed proteins and aberrant oxidant pathways to disease progression and the other is to understand how functional deficits in non-neuronal cells may underpin dysfunction and neurodegeneration.

Research projects

Astrocytes and Aβ metabolism
Specifically examine the impact of monomeric, oligomeric and fibrillar Aβ on primary cultures of astrocytes from different brain areas, animal age, and at different culture times which may provide novel insights into the roles of astrocytes in Aβ metabolism.

Effects of hyperglycemia on macrophage gene and protein expression
Determine whether hyperglycemia and advanced glycation end products (AGEs) mediates alteration of macrophage gene expression in the context of cognitive neurodegenerative diseases.

Research group

Biomedical Sciences

Affiliate research groups

Molecular and Cellular Biosciences, Southampton Neuroscience Group (SoNG) , Institute for Life Sciences (IfLS)

Sort via: Type or Year



Module Code Module Name Semester #Lectures Lecture Topic(s)
Biol2014 Neuroscience 1 Tutoring
Biol3020 Systems Neuroscience 2 4 Structure and function of neural cell populations
Biol3022 Cell signalling in health and disease 2 4 Innate and acquired immune mechanisms in the
central nervous system
Biol3048 Neurodegenerative diseases 2 8 Stroke, Traumatic Brain Injury, Cell Transplant Therapies, Regeneration, Prion diseases
UOSM-2016 Human Brain and Society 2 1 The basics of remembering and forgetting

BMedSc Project Group (CfBS co-ordinator).

Local Group Representative (Hampshire) of British Neuroscience Association.

Reviewer: Alzheimer’s Association, Parkinson’s UK

Dr Ayodeji A Asuni
Faculty of Medicine University of Southampton Southampton General Hospital Mailpoint 801 South Academic Block Tremona Road Southampton SO16 6YD

Share Share this on Facebook Share this on Twitter Share this on Weibo
Privacy Settings