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The University of Southampton
Southampton Clinical Trials Unit


Trial Name:

FACS Trial - A randomised controlled trial to assess the cost-effectiveness of intensive versus no scheduled follow-up in patients who have undergone resection for colorectal cancer with curative intent.


The aim of this trial is to determine the best way of following up patients who have had successful treatment for colorectal cancer. Follow-up strategies for patients vary enormously from intensive monitoring to symptomatic follow-up by a General Practitioner. The cost implication to the NHS of intensive follow-up is very large. Several randomised trials of follow-up summarised in the Cochrane review show only small or no benefit of intensive follow-up.


To assess the effect of augmenting symptomatic follow-up in primary care with two intensive methods of follow-up (monitoring of tumour marker in primary care and intensive imaging in hospital) on the number of recurrences treated surgically with curative intent.

Primary objective:

Secondary objectives:


Multicentre, randomised, controlled, intention to treat, 2x2 factorial design clinical trial. The clinician must decide pre-randomisation whether the patient has a certain/uncertain need for imaging follow-up.




All patients who have undergone curative treatment for primary colorectal cancer (R0 resections, Dukes A-C).


Site and stage of colorectal cancer influence the likelihood and distribution of disease recurrence and postrecurrence survival: data from the FACS randomized controlled trial

Effect of 3 to 5 years of scheduled CEA and CT follow-up to detect recurrence of colorectal cancer: the FACS randomized clinical trial

Contact details:

All Trial enquiries should be addressed to

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