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The University of Southampton
Southampton Clinical Trials Unit

WIN Trial

Trial Name

WT1 Immunity via DNA fusion Gene Vaccination in Haematological Malignancies by intramuscular injection followed by intramuscular electroporation.

Description

The WIN trisl studys the effect of DNA vaccination with two DNA vaccines, p.DOM-WT1-37 and p.DOM-WT1 in two patient groups Chronic Myeloid Leukaemia (CML) and Acute Myeloid Leukaemia (AML).

Objectives

Primary Objectives:

Secondary Objectives:

Design

Open label, single dose level, Phase II study in two patient groups (CML and AML) using genetic randomisation. Consented and eligible HLA A2+ve patients will be vaccinated with two DNA vaccines. HLA A2 –ve patients will be followed up on trial without vaccination. 

Status

Complete

Population

Contact Details

All Trial enquiries should be addressed to ctu@soton.ac.uk

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