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The University of Southampton
Haemoglobin After inTraCranial Haemorrhage (HATCH) Consortium

Output

Peer-reviewed original research articles and reviews.

HATCH CONSORTIUM

Haptoglobin genotype and aneurysmal subarachnoid haemorrhage: individual patient data analysis. Gaastra B, Ren D, Alexander S, Bennett ER, Bielawski DM, Blackburn SL, Borsody MK, Doré S, Galea J, Garland P, He T, Iihara K, Kawamura Y, Leclerc JL, Meschia JF, Pizzi MA, Tamargo RJ,  Yang W, Nyquist PA, Bulters DO, Galea I. Neurology. In press.

Haemoglobin scavenging in intracranial bleeding: biology and clinical implications. Bulters D, Gaastra B, Zolnourian A, Alexander S, Ren D, Blackburn SL, Borsody M, Doré S, Galea J, Iihara K, Nyquist P, Galea I. Nat Rev Neurol. 2018 Jul;14(7):416-432.

HATCH CONSORTIUM MEMBERS (best five)

Ian Galea, University of Southampton, UK

Pace A, Mitchell S, Casselden E, Zolnourian A, Glazier J, Foulkes L, Bulters D, Galea I. A subarachnoid haemorrhage-specific outcome tool. Brain 2018 Apr 1;141(4):1111-1121.

Gaastra B, Glazier J, Bulters D, Galea I. Haptoglobin Genotype and Outcome after Subarachnoid Haemorrhage: New Insights from a Meta-Analysis. Oxid Med Cell Longev 2017;2017:6747940.

Garland P, Durnford AJ, Okemefuna AI, Dunbar J, Nicoll JAR, Galea J, Boche D, Bulters DO, Galea I. The heme-hemopexin scavenging system is active in the brain, and associates with outcome after subarachnoid haemorrhage. Stroke 2016;47:872-6.

Durnford A, Dunbar J, Galea J, Bulters D, Nicoll JA, Boche D, Galea I. Haemoglobin scavenging after subarachnoid haemorrhage. Acta Neurochir Suppl 2015;120:51-4.

Galea J, Cruickshank G, Teeling JL, Boche D, Garland P, Perry VH, Galea I. The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhage. J Neurochem 2012;12:785-92.

 

Diederik Bulters, University of Southampton, UK

Pace A, Mitchell S, Casselden E, Zolnourian A, Glazier J, Foulkes L, Bulters D, Galea I. A subarachnoid haemorrhage-specific outcome tool. Brain 2018 Apr 1;141(4):1111-1121.

Gaastra B, Glazier J, Bulters D, Galea I. Haptoglobin Genotype and Outcome after Subarachnoid Haemorrhage: New Insights from a Meta-Analysis. Oxid Med Cell Longev 2017;2017:6747940.

Garland P, Durnford AJ, Okemefuna AI, Dunbar J, Nicoll JAR, Galea J, Boche D, Bulters DO, Galea I. The heme-hemopexin scavenging system is active in the brain, and associates with outcome after subarachnoid haemorrhage. Stroke 2016;47:872-6.

Durnford A, Dunbar J, Galea J, Bulters D, Nicoll JA, Boche D, Galea I. Haemoglobin scavenging after subarachnoid haemorrhage. Acta Neurochir Suppl 2015;120:51-4.

Galea J, Cruickshank G, Teeling JL, Boche D, Garland P, Perry VH, Galea I. The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhage. J Neurochem 2012;12:785-92.

 

Ben Gaastra, University of Southampton, UK

Haptoglobin genotype and aneurysmal subarachnoid haemorrhage: individual patient data analysis. Gaastra B, Ren D, Alexander S, Bennett ER, Bielawski DM, Blackburn SL, Borsody MK, Doré S, Galea J, Garland P, He T, Iihara K, Kawamura Y, Leclerc JL, Meschia JF, Pizzi MA, Tamargo RJ,  Yang W, Nyquist PA, Bulters DO, Galea I. Neurology. In press.

Haemoglobin scavenging in intracranial bleeding: biology and clinical implications. Bulters D, Gaastra B, Zolnourian A, Alexander S, Ren D, Blackburn SL, Borsody M, Doré S, Galea J, Iihara K, Nyquist P, Galea I. Nat Rev Neurol. 2018 Jul;14(7):416-432.

Gaastra B, Glazier J, Bulters D, Galea I. Haptoglobin Genotype and Outcome after Subarachnoid Haemorrhage: New Insights from a Meta-Analysis. Oxid Med Cell Longev 2017;2017:6747940.

Sproviero W, Shatunov A, Stahl D, Shoai M, van Rheenen W, Jones AR, Al-Sarraj S, Andersen PM, Bonini NM, Conforti FL, Van Damme P, Daoud H, Del Mar Amador M, Fogh I, Forzan M, Gaastra B, Gellera C, Gitler AD, Hardy J, Fratta P, La Bella V, Le Ber I, Van Langenhove T, Lattante S, Lee YC, Malaspina A, Meininger V, Millecamps S, Orrell R, Rademakers R, Robberecht W, Rouleau G, Ross OA, Salachas F, Sidle K, Smith BN, Soong BW, Sorarù G, Stevanin G, Kabashi E, Troakes C, van Broeckhoven C, Veldink JH, van den Berg LH, Shaw CE, Powell JF, Al-Chalabi A. ATXN2 trinucleotide repeat length correlates with risk of ALS. Neurobiol Aging. 2017 Mar;51:178.e1-178.e9.

Gaastra B, Shatunov A, Pulit S, Jones AR, Sproviero W, Gillett A, Chen Z, Kirby J, Fogh I, Powell JF, Leigh PN, Morrison KE, Shaw PJ, Shaw CE, van den Berg LH, Veldink JH, Lewis CM, Al-Chalabi A. Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2016 Oct - Nov;17(7-8):593-599.

 

William Tapper, University of Southampton, UK

Copson ER, Maishman TC, Tapper WJ, Cutress RI, Greville-Heygate S, Altman DG,  Eccles B, Gerty S, Durcan LT, Jones L, Evans DG, Thompson AM, Pharoah P, Easton DF, Dunning AM, Hanby A, Lakhani S, Eeles R, Gilbert FJ, Hamed H, Hodgson S, Simmonds P, Stanton L, Eccles DM. Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study. Lancet Oncol. 2018  Feb;19(2):169-180.

Kadalayil L, Khan S, Nevanlinna H, Fasching PA, Couch FJ, Hopper JL, Liu J, Maishman T, Durcan L, Gerty S, Blomqvist C, Rack B, Janni W, Collins A, Eccles D, Tapper W. Germline variation in ADAMTSL1 is associated with prognosis following breast cancer treatment in young women. Nat Commun. 2017 Nov 21;8(1):1632.

Tapper W, Jones AV, Kralovics R, Harutyunyan AS, Zoi K, Leung W, Godfrey AL, Guglielmelli P, Callaway A, Ward D, Aranaz P, White HE, Waghorn K, Lin F, Chase A, Baxter EJ, Maclean C, Nangalia J, Chen E, Evans P, Short M, Jack A, Wallis L, Oscier D, Duncombe AS, Schuh A, Mead AJ, Griffiths M, Ewing J, Gale RE, Schnittger S, Haferlach T, Stegelmann F, Döhner K, Grallert H, Strauch K, Tanaka T, Bandinelli S, Giannopoulos A, Pieri L, Mannarelli C, Gisslinger H, Barosi G, Cazzola M, Reiter A, Harrison C, Campbell P, Green AR, Vannucchi A, Cross NC. Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms. Nat Commun. 2015 Apr 7;6:6691.

Tapper W, Collins A, Gibson J, Maniatis N, Ennis S, Morton NE. A map of the human genome in linkage disequilibrium units. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11835-9.

 

Paul Nyquist, John Hopkins University, Baltimore, US

Murthy SB, Caplan J, Levy AP, Pradilla G, Moradiya Y, Schneider EB, Shalom H,  Ziai WC, Tamargo RJ, Nyquist PA. Haptoglobin 2-2 Genotype Is Associated With Cerebral Salt Wasting Syndrome in Aneurysmal Subarachnoid Hemorrhage. Neurosurgery. 2016 Jan;78(1):71-6.

Rivera-Lara L, Kowalski RG, Schneider EB, Tamargo RJ, Nyquist P. Elevated relative risk of aneurysmal subarachnoid hemorrhage with colder weather in the mid-Atlantic region. J Clin Neurosci. 2015 Oct;22(10):1582-7.

Murthy SB, Levy AP, Duckworth J, Schneider EB, Shalom H, Hanley DF, Tamargo RJ, Nyquist PA. Presence of haptoglobin-2 allele is associated with worse functional outcomes after spontaneous intracerebral hemorrhage. World Neurosurg. 2015 Apr;83(4):583-7.

Nyquist PA, Wang H, Suffredini AF. Protein biomarkers in patients with subarachnoid hemorrhage, vasospasm, and delayed ischemic neurological deficits. Acta Neurochir Suppl. 2013;115:23-5.

Nyquist PA, Brown RD Jr, Wiebers DO, Crowson CS, O'Fallon WM. Circadian and seasonal occurrence of subarachnoid and intracerebral hemorrhage. Neurology. 2001 Jan 23;56(2):190-3.

 

Sheila Alexander, University of Pittsburgh, US

Heinsberg LW, Turi E, Ren D, Crago E, Alexander S, Stanfill AG, Conley YP. Evaluation of APOE Genotype and Ability to Perform Activities of Daily Living Following Aneurysmal Subarachnoid Hemorrhage. Biol Res Nurs. 2018 Mar;20(2):177-182.

Gallek MJ, Alexander SA, Crago E, Sherwood PR, Klamerus M, Horowitz MB, Poloyac SM, Conley Y. Endothelin-1 gene polymorphisms influence cerebrospinal fluid endothelin-1 levels following aneurysmal subarachnoid hemorrhage. Biol Res Nurs. 2015 Mar;17(2):185-90.

Kantor E, Bayır H, Ren D, Provencio JJ, Watkins L, Crago E, Horowitz MB, Ferrell RE, Conley YP, Alexander SA. Haptoglobin genotype and functional outcome after aneurysmal subarachnoid hemorrhage. J Neurosurg. 2014 Feb;120(2):386-90.

Gallek M, Alexander S, Crago E, Sherwood P, Horowitz M, Poloyac S, Conley Y. Endothelin-1 and endothelin receptor gene variants and their association with negative outcomes following aneurysmal subarachnoid hemorrhage. Biol Res Nurs. 2013 Oct;15(4):390-7.

Alexander S, Poloyac S, Hoffman L, Gallek M, Dianxu Ren, Balzer J, Kassam A, Conley Y. Endothelial nitric oxide synthase tagging single nucleotide polymorphisms and recovery from aneurysmal subarachnoid hemorrhage. Biol Res Nurs. 2009 Jul;11(1):42-52.

 

Dianxu Ren, University of Pittsburgh, US

Heinsberg LW, Turi E, Ren D, Crago E, Alexander S, Stanfill AG, Conley YP. Evaluation of APOE Genotype and Ability to Perform Activities of Daily Living Following Aneurysmal Subarachnoid Hemorrhage. Biol Res Nurs. 2018 Mar;20(2):177-182.

Ren D, Fan J, Puccio AM, Okonkwo DO, Beers SR, Conley Y. Group-Based Trajectory Analysis of Emotional Symptoms Among Survivors After Severe Traumatic Brain Injury. J Head Trauma Rehabil. 2017 Nov/Dec;32(6):E29-E37.

Osier ND, Pham L, Pugh BJ, Puccio A, Ren D, Conley YP, Alexander S, Dixon CE. Brain injury results in lower levels of melatonin receptors subtypes MT1 and MT2. Neurosci Lett. 2017 May 22;650:18-24. doi: 10.1016/j.neulet.2017.03.053.

Kantor E, Bayır H, Ren D, Provencio JJ, Watkins L, Crago E, Horowitz MB, Ferrell RE, Conley YP, Alexander SA. Haptoglobin genotype and functional outcome after aneurysmal subarachnoid hemorrhage. J Neurosurg. 2014 Feb;120(2):386-90.

Alexander SA, Ren D, Gunn SR, Kochanek PM, Tate J, Ikonomovic M, Conley YP. Interleukin 6 and apolipoprotein E as predictors of acute brain dysfunction and survival in critical care patients. Am J Crit Care. 2014 Jan;23(1):49-57.

 

Spiros Blackburn, University of Texas, Houston, US

Peeyush Kumar T, McBride DW, Dash PK, Matsumura K, Rubi A, Blackburn SL. Endothelial Cell Dysfunction and Injury in Subarachnoid Hemorrhage. Mol Neurobiol. 2018 Jul 7.

Blackburn SL, Swisher CB, Grande AW, Rubi A, Verbick LZ, McCabe A, Lad SP. Novel Dual Lumen Catheter and Filtration Device for Removal of Subarachnoid hemorrhage: First Case Report. Oper Neurosurg (Hagerstown). 2018 Jun 5.

Blackburn SL, Kumar PT, McBride D, Zeineddine HA, Leclerc J, Choi HA, Dash PK, Grotta J, Aronowski J, Cardenas JC, Doré S. Unique Contribution of Haptoglobin and Haptoglobin Genotype in Aneurysmal Subarachnoid Hemorrhage. Front Physiol. 2018 May 31;9:592.

McBride DW, Blackburn SL, Peeyush KT, Matsumura K, Zhang JH. The Role of Thromboinflammation in Delayed Cerebral Ischemia after Subarachnoid Hemorrhage. Front Neurol. 2017 Oct 23;8:555.

Leclerc JL, Blackburn S, Neal D, Mendez NV, Wharton JA, Waters MF, Doré S. Haptoglobin phenotype predicts the development of focal and global cerebral vasospasm and may influence outcomes after aneurysmal subarachnoid hemorrhage. Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1155-60.

 

Sylvain Dore, University of Florida, Gainesville, US

Mohan S, Koller EJ, Fazal JA, De Oliveria G, Pawlowicz AI, Doré S. Genetic Deletion of PGF(2α)-FP Receptor Exacerbates Brain Injury Following Experimental Intracerebral Hemorrhage. Front Neurosci. 2018 Sep 5;12:556.

Leclerc JL, Santiago-Moreno J, Dang A, Lampert AS, Cruz PE, Rosario AM, Golde TE, Doré S. Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage. J Cereb Blood Flow Metab. 2018 Jun;38(6):1032-1046.

Leclerc JL, Garcia JM, Diller MA, Carpenter AM, Kamat PK, Hoh BL, Doré S. A Comparison of Pathophysiology in Humans and Rodent Models of Subarachnoid Hemorrhage. Front Mol Neurosci. 2018 Mar 22;11:71.

Leclerc JL, Lampert AS, Loyola Amador C, Schlakman B, Vasilopoulos T, Svendsen P, Moestrup SK, Doré S. The absence of the CD163 receptor has distinct temporal influences on intracerebral hemorrhage outcomes. J Cereb Blood Flow Metab. 2018 Feb;38(2):262-273.

Wang J, Doré S. Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage. Brain. 2007 Jun;130(Pt 6):1643-52.

 

James Galea, University of Manchester, UK

Galea J, Ogungbenro K, Hulme S, Patel H, Scarth S, Hoadley M, Illingworth K, McMahon CJ, Tzerakis N, King AT, Vail A, Hopkins SJ, Rothwell N, Tyrrell P. Reduction of inflammation after administration of interleukin-1 receptor antagonist following aneurysmal subarachnoid hemorrhage: results of the Subcutaneous Interleukin-1Ra in SAH (SCIL-SAH) study. J Neurosurg. 2018 Feb;128(2):515-523.

Galea JP, Dulhanty L, Patel HC; UK and Ireland Subarachnoid Hemorrhage Database Collaborators. Predictors of Outcome in Aneurysmal Subarachnoid Hemorrhage Patients: Observations From a Multicenter Data Set. Stroke. 2017 Nov;48(11):2958-2963.

Daniels MJ, Rivers-Auty J, Schilling T, Spencer NG, Watremez W, Fasolino V, Booth SJ, White CS, Baldwin AG, Freeman S, Wong R, Latta C, Yu S, Jackson J, Fischer N, Koziel V, Pillot T, Bagnall J, Allan SM, Paszek P, Galea J, Harte MK, Eder C, Lawrence CB, Brough D. Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models. Nat Commun. 2016 Aug 11;7:12504.

Garland P, Durnford AJ, Okemefuna AI, Dunbar J, Nicoll JA, Galea J, Boche D, Bulters DO, Galea I. Heme-Hemopexin Scavenging Is Active in the Brain and Associates With Outcome After Subarachnoid Hemorrhage. Stroke. 2016 Mar;47(3):872-6.

Ogungbenro K, Hulme S, Rothwell N, Hopkins S, Tyrrell P, Galea J. Study design and population pharmacokinetic analysis of a phase II dose-ranging study of interleukin-1 receptor antagonist. J Pharmacokinet Pharmacodyn. 2016 Feb;43(1):1-12.

 

Koji Iihara, Kjushu University, Japan

Kurogi R, Kada A, Nishimura K, Kamitani S, Nishimura A, Sayama T, Nakagawara J, Toyoda K, Ogasawara K, Ono J, Shiokawa Y, Aruga T, Miyachi S, Nagata I, Matsuda S, Yoshimura S, Okuchi K, Suzuki A, Nakamura F, Onozuka D, Hagihara A, Iihara K; J-ASPECT Study Collaborators. Effect of treatment modality on in-hospital outcome in patients with subarachnoid hemorrhage: a nationwide study in Japan (J-ASPECT Study). J Neurosurg. 2018 May;128(5):1318-1326.

Onozuka D, Hagihara A, Nishimura K, Kada A, Nakagawara J, Ogasawara K, Ono J, Shiokawa Y, Aruga T, Miyachi S, Nagata I, Toyoda K, Matsuda S, Suzuki A, Kataoka H, Nakamura F, Kamitani S, Nishimura A, Kurogi R, Sayama T, Iihara K; J-ASPECT Study Collaborators. Prehospital antiplatelet use and functional status on admission of patients with non-haemorrhagic moyamoya disease: a nationwide retrospective cohort study (J-ASPECT study). BMJ Open. 2016 Mar 15;6(3):e009942.

Iihara K. Comprehensive Stroke Care Capabilities in Japan: A Neurovascular Surgeon's Perspective. Neurosurgery. 2015 Aug;62 Suppl 1:107-16.

Iihara K, Nishimura K, Kada A, Nakagawara J, Ogasawara K, Ono J, Shiokawa Y, Aruga T, Miyachi S, Nagata I, Toyoda K, Matsuda S, Miyamoto Y, Suzuki A, Ishikawa KB, Kataoka H, Nakamura F, Kamitani S. Effects of comprehensive stroke care capabilities on in-hospital mortality of patients with ischemic and hemorrhagic stroke: J-ASPECT study. PLoS One. 2014 May 14;9(5):e96819.

Ohnishi H, Iihara K, Kaku Y, Yamauchi K, Fukuda K, Nishimura K, Nakai M, Satow T, Nakajima N, Ikegawa M. Haptoglobin phenotype predicts cerebral vasospasm and clinical deterioration after aneurysmal subarachnoid hemorrhage. J Stroke Cerebrovasc Dis. 2013 May;22(4):520-6.

 

Jin Pyeong Jeon, Hallym University College of Medicine, South Korea

Hong EP, Kim BJ, Kim C, Choi HJ, Jeon JP. Association of SOX17 Gene Polymorphisms and Intracranial Aneurysm: A Case-Control Study and Meta-Analysis. World Neurosurg. 2018 Feb;110:e823-e829.

Jeon JP, Cho YD, Rhim JK, Yoo DH, Kang HS, Kim JE, Cho WS, Han MH. Extended monitoring of coiled aneurysms completely occluded at 6-month follow-up: late recanalization rate and related risk factors. Eur Radiol. 2016 Oct;26(10):3319-26.

Jeon JP, Kim JE, Ahn JH, Cho WS, Cho YD, Son YJ, Bang JS, Kang HS, Sohn CH, Chung HT, Oh CW, Kim DG. Long-term treatment outcome of venous-predominant arteriovenous malformation. J Neurosurg. 2016 Apr;124(4):1100-6.

Jeon JS, Ahn JH, Moon YJ, Cho WS, Son YJ, Kim SK, Wang KC, Bang JS, Kang HS, Kim JE, Oh CW. Expression of cellular retinoic acid-binding protein-I (CRABP-I) in the cerebrospinal fluid of adult onset moyamoya disease and its association with clinical presentation and postoperative haemodynamic change. J Neurol Neurosurg Psychiatry. 2014 Jul;85(7):726-31.

Jeon JS, Ahn JH, Huh W, Son YJ, Bang JS, Kang HS, Sohn CH, Oh CW, Kwon OK, Kim JE. A retrospective analysis on the natural history of incidental small paraclinoid unruptured aneurysm. J Neurol Neurosurg Psychiatry. 2014 Mar;85(3):289-94.

 

Mark Borsody, NeuroSpring, US

Borsody MK, Yamada C, Bielawski D, Heaton T, Castro Prado F, Garcia A, Azpiroz J, Sacristan E. Effects of noninvasive facial nerve stimulation in the dog middle cerebral artery occlusion model of ischemic stroke. Stroke. 2014 Apr;45(4):1102-7.

Borsody M, Burke A, Coplin W, Miller-Lotan R, Levy A. Haptoglobin and the development of cerebral artery vasospasm after subarachnoid hemorrhage. Neurology. 2006 Mar 14;66(5):634-40.

Komuro T, Borsody MK, Ono S, Marton LS, Weir BK, Zhang ZD, Paik E, Macdonald RL. The vasorelaxation of cerebral arteries by carbon monoxide. Exp Biol Med (Maywood). 2001 Oct;226(9):860-5.

Macdonald RL, Weir BK, Marton LS, Zhang ZD, Sajdak M, Johns LM, Kowalczuk A, Borsody M. Role of adenosine 5'-triphosphate in vasospasm after subarachnoid hemorrhage: human investigations. Neurosurgery. 2001 Apr;48(4):854-62

Borsody MK, DeGiovanni GM, Marton LS, Macdonald RL, Weir B. Thrombin reduces cerebral arterial contractions caused by cerebrospinal fluid from patients with subarachnoid hemorrhage. Stroke. 2000 Sep;31(9):2149-56.

 

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