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The University of Southampton
SAFA study

See if the study is suitable for you

  Question Answer Explanation
 Are you a woman aged 18 years or older?  Yes We are looking for adult women with mild, moderate or severe facial acne that has lasted for 6 months or more to take part in the study.
 Have you had acne on your face for 6 months or longer?  Yes
 How would you describe the acne on your face at the moment?  Some blackheads or whiteheads with a few or more red bumps, or your skin is worse than this.
 Are you lactose intolerant?  No  

Patients with rare hereditary problems of galactose intolerance, lactase deficiency or glucose-galactose malabsorption should not take Spironolactone-ratiopharm® tablets.

 Are you pregnant, breastfeeding or planning to become pregnant in the next 6 months?  No  

There is a very small chance the study drug could affect the way the baby develops. But risk of harm to a foetus is low and is likely to be lower than for other treatments taken by mouth for acne.

Women who are pregnant, breast-feeding or planning to become pregnant should not take part in SAFA.

 Are you taking Roaccutane (by mouth), or have you taken it in the last 6 months?  No*  

*The medicines described can improve acne and may mask the effect of the study tablet.

If you answered ‘Yes’ to either of these questions, please wait until you have stopped taking the medicine (for the length of time described) before contacting your local study team.

 Are you taking antibiotics (by mouth) for your acne, or have you taken any in the last month?  No*
 Have you started, stopped or changed hormonal contraception/treatment in the last 3 months?  No*  

*Hormonal contraception/treatment can improve acne and may mask the effect of the study tablet.

If you answered ‘Yes’, please wait for 3 months after starting, stopping or changing your treatment before contacting your local study team.

 Have you ever taken Spironolactone?  No*  * The mechanism of Spironolactone and its duration of effect is unknown. If you answered 'yes', the study is not suitable for you.


If you answered the questions as shown, the study may be suitable for you.


Please contact your local study team for more information or to book your first clinic visit.

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