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The University of Southampton
Animal Welfare and Ethical Review Body

Examples of the Benefits of Our Research

Examples of research performed at the University of Southampton that utilise animal models:

New bone regeneration from stem cells & biomaterials: from the laboratory to the clinic

Our skeletal regenerative work is producing candidate biomaterials that support bone stem cell growth and skeletal regeneration improving healing of fractures where major bone loss is a critical clinical problem for the patient. Here we demonstrate in vitro and pre-clinical research on stem cell/bone allograft impaction to regenerate bone and stimulate blood vessel growth (A). This work has led to the clinical translation to repair femoral head avascular necrosis and femoral neck fibrous cortical bone loss (B). Furthermore, this work informed the clinical studies using stem cells in conjunction with 3D printed hips to aid in very large hip bone repair and regeneration (C).

In vivo to human
Click or tap to zoom

The role of integrins in axonal survival and healing

Our work may contribute to better healing following injury to the central nervous system, we are trying to understand if parts of our nervous system can be modified in the hope of improving the condition of people suffering from partial or total paralysis.

Image taken using fluorescent microscope showing nerve fibre re-growth
Nerve fibres showing re-growth - click or tap to zoom

Coral fluorescents

Our in-depth studies of fluorescent coral pigments yielded proteins that can be used as molecular markers in biomedical imaging applications. The pigments can be applied to monitor the molecular workings of living cells and organisms and teach us how diseases work. One these pigments, the red fluorescent protein mRuby from a coral reef-dwelling sea anemone was licensed 2018 for integration in life science products for research purposes. We have discovered and isolated the fluorescent protein “EosFP” from the brain coral Lobophyllia hemprichii which can change its colour from green to red. This protein has subsequently helped the scientist Eric Betzig to develop a novel microscopy technique that enables to study cells with superresolution. An invention for which he was awarded the Noble Prize in Chemistry in 2015. We have used the relevance of coral pigments for medical research to educate the general public about the importance of protecting coral reefs through communicating the value of reefs as source of novel tools and drugs, using the fascinating phenomenon of coral fluorescence as vector to deliver our message. A video on the applications of our research on coral fluorescence can be watched here.

 

Fluorescence of Acropora coral
Fluorescence of Acropora coral

Solent oyster restoration project

Native European oysters (Ostrea edulis) are a keystone species in the ecology of estuaries and coastal waters and designated as a BAP (Biodiversity Action Plan) species by the UK government. The Solent oyster population, which used to be the largest self-sustaining population in the UK, has been seriously depleted by a mixture of disease, human exploitation and predation in the past 20 years. SOES is one of the partners in local initiatives, many led by the Blue Marine Foundation, to restore the Solent oyster to its former abundance. SOES research focuses on establishing the physiological and reproductive reactions of oysters to a variety of environmental influences and so establish where, ideally, oysters should be relaid to produce larvae that will settle within the Solent and form the basis for a self-sustaining population in the future. This work combines a mixture of aquarium investigations and field trials.

Understanding disease processes in crustacean aquaculture

The Marine Invertebrate Physiology and Immunology (MIPI) Lab have broad interests in how organisms respond to changing marine environments; in particular how predicted climate change scenarios and anthropogenic pollution in the marine environment might impact the health and performance of shellfish species. The group work across a range of scales within organisms, from studies of changes in gene expression in tissues and cells, to studies of metabolism and tissue biochemistry through to assays of whole organism physiology and behaviour.

In a key current project with eight other international partners, and funded through the UK Newton Global Research Partnership, we are investigating the environmental controls on the incidence of disease outbreaks in Asian shrimp and fish aquaculture (Poverty alleviation through control of disease in Asian Aquaculture (PACONDAA)). ​This project is seeking to understand the environmental controls of global disease pandemics within the shrimp farming industry; diseases which present a significant challenge to the provision of Global Food Security through aquaculture, as the world population approaches an estimated 9.3bn by 2050.

In Southampton, much of our work is based on the immune system of the European shore crab Carcinus maenas as a model species. Effectively, we take blood samples from these crabs to better understand their response to infection and disease resistance. Blood sampling is sometimes carried out after sub-lethal infection with opportunistic pathogenic marine bacteria in order to confirm our in vitro findings with in vivo infection processes.

Non-Technical Summaries:

NTS - Chorioallantoic Membrane Model for Tissue Engineering

NTS - Nervous System Injury and Repair

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