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The University of Southampton
Biological Sciences

Regulation of endocytosis and autophagy by distinct cargo adaptors Event

13:00 - 14:00
21 October 2014

For more information regarding this event, please telephone Kim Lipscombe on 02380 59 7747 or email .

Event details

David's research focuses on understanding the regulatory mechanisms and molecular machinery required for the subcellular trafficking of receptors and subsequently how this influences cell signalling, cytoskeletal reorganisation and cell morphogenesis.

How cells coordinate the sorting, transfer, and movement of various intracellular cargoes relies on a complex set of machinery. In particular, intracellular pathways such as endocytosis and autophagy are managed by numerous scaffold, adaptor, and signalling proteins which identify and sort cargo as well as regulate signal transduction. The endocytic pathway targets extracellular and membrane associated proteins while the autophagy pathway targets cytosolic proteins and organelles, both destined for degradation and recycling by lysosomal proteases. We have characterised various proteins within these pathways and suggest that these pathways do not remain separate, but rather intersect and overlap, mediated by distinct cargo adaptors. Determining the interacting partners of these adaptors, their mechanism of action, and how they function along these pathways is crucial to understanding the relationship between endocytosis and autophagy.

Speaker information

David Tumbarello

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