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The University of Southampton
Biological Sciences

Cell division: how do cells ensure that 92 divided by 2 = 46? Event

13:00 - 14:00
11 November 2014

For more information regarding this event, please telephone Kim Lipscombe on 02380 59 7747 or email .

Event details

Professor Jon Pines is at the forefront of his research field, investigating the fundamental processes that control cell division and finding out how these can go out of control, leading to cancer. He is based at the Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology in Cambridge, and has been funded by Cancer Research UK for more than 15 years.

  • Mitosis is controlled by the Anaphase Promoting Complex/Cyclosome (APC/C) that targets specific proteins for degradation at specific times
  • The APC/C itself is inhibited by the Spindle Assembly Checkpoint that detects any unattached chromosomes
  • The checkpoint is both potent - one unattached chromosome delays a cell in mitosis, and responsive - the APC/C is very quickly activated after the checkpoint turns off
  • Our recent work has shed light on both these properties of the checkpoint

Speaker information

Dr Jon Pines,Department of Biochemistry, University of Cambridge,Director of Research, The Wellcome Trust/CR UK Gurdon Institute

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