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The University of Southampton
Biological Sciences

Segregating chromosomes during early mammalian development Seminar

13:00 - 14:00
29 October 2013
Building 85 Room 2207

For more information regarding this seminar, please telephone Maria Hilliard on 02380 598148 or email .

Event details

Greg is interested in understanding the mechanistic differences in chromosome segregation between oocytes and other cells and thus expects to uncover clues as the reasons for the extreme susceptibility of the mammalian oocyte to aneuploidy.

Errors in chromosome segregation in oocytes and early embryos lead to embryo aneuploidy, which contributes to early pregnancy loss. At the heart of chromosome segregation is the spindle, a dynamic biomechanical machine fashioned from microtubules, which is tasked with gathering and sorting chromosomes and dispatching them to the daughter cells at the time of cell division. Understanding the causes of segregation error in the oocyte and early embryo will undoubtedly hinge on a thorough understanding of the mechanism of spindle assembly and function in these highly specialized cellular environments. Here I will describe recent work from our lab that highlights idiosyncrasies of chromosome segregation in the mammalian oocyte and early embryo, and discuss possible mechanisms by which chromosome segregation might go awry in these cells.

Speaker information

Dr Greg Fitzharris, Institute for Women's Health. University College London

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