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The University of Southampton

New study to see if different types of milk feed help protect premature babies from life-threatening bowel condition NEC

Published: 27 March 2017
necrotising enterocolitis study
Which milk protects premature babies from necrotising enterocolitis?

Researchers at the University of Southampton and the University of Oxford are to study which milk feeds could help protect premature babies from a life-threatening bowel condition called necrotising enterocolitis (NEC).

The year-long study has been made possible with a grant of £26,262 from children’s charity Action Medical Research. The research will involve analysing data on the feeding patterns and type of milk given to more than 400 premature babies.

More than 61,000 babies are born prematurely in the UK each year and, sadly, NEC is a significant cause of suffering and death in babies who are born too soon. Up to one in 20 babies in neonatal units develops this devastating condition.

NEC happens when the lining of a baby’s intestines becomes inflamed and starts to die. This can lead to a hole developing, which allows the contents of the intestine to leak into the abdomen. This can cause a very dangerous infection. NEC can be difficult to diagnose but symptoms tend to include general signs of illness, problems feeding or vomiting, and a swollen and tender tummy.

Premature babies, those with a very low birth weight and babies who are already poorly are the most susceptible to developing NEC.

Babies with NEC need urgent treatment. This often involves emergency surgery to remove damaged parts of their bowel. In fact, NEC is the most common reason for emergency surgery in newborn babies.

Tragically, many babies with NEC do lose their lives and some of those who survive suffer long-term complications, such as persistent bowel problems, poor growth and learning difficulties.

Associate Professor Nigel Hall, from the Unviersity of Southampton is overseeing the research alongside Associate Professor Ed Juszczak of the University of Oxford.

Associate Professor Juszczak said: “We are investigating how different milk feeds and food supplements affect babies’ chances of developing NEC, in the hope of better understanding why so many babies still develop this devastating condition.”

Babies who are at high risk of developing NEC tend to be given breast milk first, because evidence suggests breast milk is protective against the condition. Breast milk contains growth factors, antibodies and immune cells which may help prevent the problem. But it does not always provide all of the nutrients premature babies need to support growth and development – so it is often fortified or supplemented with formula. The team is investigating whether babies’ chances of developing NEC increase if breast milk is fortified or if they are given formula milk.

Researchers will analyse data from a previous study known as the ADEPT trial. This study, which was also funded by Action Medical Research, captured detailed ‘feeding logs’ of 404 premature babies in their first few days of life.

Associate Professor Hall explains: “We hope that the data from ADEPT will enable us to find out whether the type of milk babies are fed affects their chances of getting NEC – whether babies are more likely to develop NEC if they’re given breast milk, fortified breast milk or cow’s milk formula. We are also studying the relationship between the timing of any changes in the type of milk babies were given and the onset of NEC."

Associate Professor Hall adds: “If certain types of milk feeds in these babies seem to protect against NEC, or put babies at increased risk of developing NEC, we plan to set up a clinical trial to investigate this further.”

Director of Research at Action Medical Research Dr Tracy Swinfield says: “We are so pleased to be able to support this important new project. The earlier ADEPT study, also funded by Action Medical Research, was the largest of its kind and produced a large amount of high quality data. Now, by analysing these results in more detail, the researchers will, we hope, find out more about how to protect tiny, vulnerable babies from necrotising enterocolitis.”

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