Professor Christian Ottensmeier MD, PhD, FRCP
Professor of Experimental Medicine
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Professor Christian Ottensmeier is Professor of Experimental Medicine within Medicine at the University of Southampton.
Christian Ottensmeier is Professor in Experimental Cancer Medicine. He graduated in Münster, Germany and began his specialist training there. After a 3 year training fellowship in the Dana Farber Cancer Institute in Boston, Massachusetts, he moved to Southampton. He completed his oncology training and also undertook his PhD here. He has been a consultant in medical oncology since 2000.
Clinically his interests are thoracic malignancies and melanoma, and he has co-developed a number of national NCRI studies in lung cancer. He manages a broad and active clinical trials portfolio in both lung cancer and melanoma.
Christian leads the Experimental Cancer Medicine Centre in Southampton (http://www.ecmcnetwork.org.uk/) and the early translation of immunotherapeutic strategies into the clinic is his core academic interest. The portfolio of his own trials includes single centre and multicentre studies with both immunotherapeutics developed in house as well as collaborative work with industry. Together with Dr. Katy Rezvani at the Hammersmith Hospital he was successful in obtaining the first cancer trial grant in the UK from the Efficacy and Mechanisms Evaluation board (http://www.eme.ac.uk/) of the National Institute for Health Research in the UK for a vaccine study in haematological malignancies. A parallel strand of investigation examines the effect of chemo-immunotherapy on both anticancer as well as bystander immunity in small cell lung cancer with an anti-CTLA4 antibody. This multicenter study recruits collaboratively with the Barts (Dr. Peter Slozarek), Cambridge (Prof. Tim Eisen), Leeds (Dr. Clive Mulatero) and Sheffield (Dr. Sarah Danson) ECMCs as well as with Poole (Dr. Tom Geldart) and Brighton (Prof. Michael Schmidt).
Christian also contributes to early phase industry sponsored immunotherapy studies, utilizing a wide range of strategies including viral and cellular delivery strategies.
He has served on a number of industry advisory boards and DSMBs for industry led studies and is also a member of the Clinical Development partnership between Cancer Research UK and Astra Zeneca (http://www.clinicalpartnerships.com/team/sab).
He is a member of a number of national peer reviewed funding committees for Cancer Research UK (http://science.cancerresearchuk.org/) and Leukemia and Lymphoma Research (http://beatbloodcancers.org/research).
The overarching aim of his laboratory group is the preclinical development and early phase clinical testing of strategies to induce anti-tumour immune responses in patients. (After an initial focus on B cell malignancies the majority of the work is now in solid tumours. This has led to three linked but distinct areas of investigation: Detailed immunological evaluation of the effect of immunological intervention in patients, assay development and validation, and finally mechanistic studies in murine models as well as human modelling of immune responses to vaccination for further preclinical cancer vaccine development. The aim is to complete the loop back into the clinic.
Christian holds programmatic funding from Leukemia and Lymphoma Research and Cancer Research UK.
Key academic collaborative links of the group are:
Prf. Freda Stevenson
Prof. Martin Glennie
Prof. Tim Elliott
Prof. Aymen Al-Shamkhani
CIMT and CIP:
Dr. Cedrik Britten, Mainz
Prof. Sjoerd van der Burg, Leiden
Dr. Cecile Gouttefangeas, Tübingen
Dr. Steffen Walter, Immatics, Tübingen
MD Westfälische Wilhelmsuniversität Münster", Germany (1989)
PhD, University of Southampton (1999)
1986-1989 1986-1989 Institute of Pathology of "Von Bodelschwinghsche, Krankenanstalten" Bielefeld, Germany
1989-1991 Department of Medicine (Oncology and Haematology), Westfälische Wilhelmsuniversität Münster, Germany
1991- 1993 Postdoctoral Research Fellow, Division of Tumour Immunology, Dana-Farber Cancer Institute, Boston, USA
1994 –1999 Senior Registrar in Medical Oncology, Dept of Medical Oncology, University of Southampton, UK
1997 Certificate of Completion of Specialist Training in Medical, Oncology, Conferred by the Medical Royal Colleges, United Kingdom
1995- to date Department of Molecular Immunology/Cancer Sciences Division, University of Southampton, UK