Centre for Biological Sciences

Tom P. Fleming

BSc, PhD

Primary position:
Professor of Developmental Biology
Other positions:
Head of Developmental Biology Group

Background

The University of Southampton

BSc Zoology, University of Wales (Swansea);
PhD in Cell Biology at University of London, CNAA (South Bank Polytechnic);
Demonstrator at University of Keele;
Senior Research Associate at University of Cambridge, Anatomy Department;
Professor of Developmental Biology, University of Southampton

Professor Tom P. Fleming's photo

Publications

The University of Southampton's electronic library (e-prints)

Article

Sun, C., Velazquez, M.A., Marfy-Smith, S., Sheth, B., Cox, A., Johnston, D.A., Smyth, N. and Fleming, T.P. (2014) Mouse early extra-embryonic lineages activate compensatory endocytosis in response to poor maternal nutrition. Development, 141, (5), 1140-1150. (doi:10.1242/dev.103952). (PMID:24504338).
Sellayah, Dyan, Dib, Lea, Anthony, Frederick W., Watkins, Adam J., Fleming, Tom P., Hanson, Mark A. and Cagampang, Felino R. (2014) Effect of maternal protein restriction during pregnancy and postweaning high-fat feeding on diet-induced thermogenesis in adult mouse offspring. European Journal of Nutrition, 1-9. (doi:10.1007/s00394-014-0657-4). (PMID:24481689).
Barker, D.J., Barker, M., Fleming, T. and Lampl, M. (2013) Developmental biology: support mothers to secure future public health. Nature, 504, 209-211. (doi:10.1038/504209a). (PMID:24350368).
Fleming, T.P., Velazquez, M.A., Eckert, J.J., Lucas, E.S. and Watkins, A.J. (2012) Nutrition of females during the peri-conceptional period and effects on foetal programming and health of offspring. [in special issue: Reproductive Health Management of Sheep and Goats] Animal Reproduction Science, 130, (3-4), 193-197. (doi:10.1016/j.anireprosci.2012.01.015). (PMID:22341375).
Kimura, Tomomi E., Merritt, Anita J., Lock, Francesca R., Eckert, Judith J., Fleming, Tom P. and Garrod, David R. (2012) Desmosomal adhesiveness is developmentally regulated in the mouse embryo and modulated during trophectoderm migration. Developmental Biology, 369, (2), 286-297. (doi:10.1016/j.ydbio.2012.06.025).
Fleming, Tom P., Lucas, Emma S., Watkins, Adam J. and Eckert, Judith J. (2011) Adaptive responses of the embryo to maternal diet and consequences for post-implantation development. Reproduction, Fertility and Development, 24, (1), 35-44. (doi:10.1071/RD11905). (PMID:22394716).
Lucas, E.S., Watkins, A.J., Cox, A.L., Marfy-Smith, S.J., Smyth, N. and Fleming, T.P. (2011) Tissue-specific selection of reference genes is required for expression studies in the mouse model of maternal protein undernutrition. Theriogenology, 76, (3), 558-569. (doi:10.1016/j.theriogenology.2011.03.008). (PMID:21550104).
Eckert, Judith J. and Fleming, Tom P. (2011) The effect of nutrition and environment on the preimplantation embryo. The Obstetrician & Gynaecologist, 13, (1), 43-48. (doi:10.1576/toag.13.1.43.27640).
Watkins, Adam J., Lucas, Emma S., Wilkins, Adrian, Cagampang, Felino R.A. and Fleming, Tom P. (2011) Maternal periconceptional and gestational low protein diet affects mouse offspring growth, cardiovascular and adipose phenotype at 1 year of age. PLoS ONE, 6, (12), e28745. (doi:10.1371/journal.pone.0028745). (PMID:22194901).
Williams, Charlotte L, Teeling, Jessica L, Perry, V. Hugh and Fleming, Tom P. (2011) Mouse maternal systemic inflammation at the zygote stage causes blunted cytokine responsiveness in lipopolysaccharide-challenged adult offspring. BMC Biology, 9, 49-61. (doi:10.1186/1741-7007-9-49). (PMID:21771319).
Igosheva, Natalia, Abramov, Andrey Y., Poston, Lucilla, Eckert, Judith J., Fleming, Tom P., Duchen, Michael R. and McConnell, Josie (2010) Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes. PloS one, 5, (4), e10074. (doi:10.1371/journal.pone.0010074).
Watkins, Adam J., Lucas, Emma S., Torrens, Christopher, Cleal, Jane K., Green, Lauren, Osmond, Clive, Eckert, Judith J., Gray, William P., Hanson, M.A. and Fleming, Tom P. (2010) Maternal low-protein diet during mouse pre-implantation development induces vascular dysfunction and altered renin-angiotensin-system homeostasis in the offspring. British Journal of Nutrition, 103, (12), 1762-1770. (doi:10.1017/S0007114509993783). (PMID:20128937).
Sellayah, D., Anthony, F.W., Watkins, A.J., Fleming, T.P., Hanson, M.A. and Cagampang, F.R. (2009) A mismatched pre- and post-weaning diet has window of exposure- and sex-specific effects on energy homeostasis; adiposity and cardiovascular function in mice. Proceedings of the Physiological Society, 12, (C10 and PC20)
Lucas, Emma S. and Fleming, Tom P. (2009) Developmental programming and epigenetics: DNA methylation makes its mark. Cell &Tissue Biology Research, 1, (1), 15-23.
Sheth, Bhavwanti, Nowak, Rachael L., Anderson, Rebecca, Kwong, Wing Yee, Papenbrock, Thomas and Fleming, Tom P. (2008) Tight junction protein ZO-2 expression and relative function of ZO-1 and ZO-2 during mouse blastocyst formation. Experimental Cell Research, 314, (18), 3356-68. (doi:10.1016/j.yexcr.2008.08.021).
Sellayah, D., Sek, K., Anthony, F. W., Watkins, A. J., Osmond, C., Fleming, T. P., Hanson, M. A. and Cagampang, F. R. (2008) Appetite regulatory mechanisms and food intake in mice are sensitive to mismatch in diets between pregnancy and postnatal periods. Brain Research, 1237, 146-152. (doi:10.1016/j.brainres.2008.07.126).
Williams, Charlotte L., Watkins, Adam J., Eckert, Judith Joana and Fleming, Tom P. (2008) Maternal immune challenge during early embryo development affects blastocyst cell lineage ration and postnatal phenotype. [in special issue: Meeting Abstracts] Biology of Reproduction, 78, (63. 47)
Watkins, Adam J., Wilkins, Adrian, Cunningham, Colm, Perry, V.Hugh, Seet, Meei J., Osmond, Clive, Eckert, Judith J., Torrens, Christopher, Cagampang, Felino R.A., Cleal, Jane, Gray, William P., Hanson, Mark A. and Fleming, Tom P. (2008) Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring. Journal of Physiology, 586, (8), 2231-2244. (doi:10.1113/jphysiol.2007.149229 ).
Watkins, Adam J., Papenbrock, Tom and Fleming, Tom P. (2008) The preimplantation embryo: handle with care. Seminars in Reproductive Medicine, 26, (2), 175-85. (doi:10.1055/s-2008-1042956).
Eckert, Judith J. and Fleming, Tom P. (2008) Tight junction biogenesis during early development. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1778, (3), Spring Issue, 717-728. (doi:10.1016/j.bbamem.2007.09.031). (PMID:18339299).
Watkins, Adam J., Ursell, Elizabeth, Panton, Rose, Papenbrock, Thomas, Hollis, Lisa, Cunningham, Colm, Wilkins, Adrian, Perry, V.Hugh, Sheth, Bhavwanti, Kwong, Wing Yee, Eckert, Judith Joana, Wild, Arthur E., Hanson, Mark A., Osmond, Clive and Fleming, Tom P. (2008) Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease. Biology of Reproduction, 78, (2), 299-306. (doi:10.1095/biolreprod.107.064220). (PMID:17989357).
Fleming, Tom P., Torrens, Christopher, Cleal, Jane, Lauren Green, Lauren Green, Clive Osmond, Clive Osmond, Judith J. Eckert, Judith J. Eckert, Gray, William P., Mark A. Hanson, Mark A. Hanson and Adam J. Watkins, Adam J. Watkins (2008) Maternal protein restriction during mouse preimplanatation development induces vascular dysfunction and altered renin-angiotensin-system homeostasis in the offspring. Biology of Reproduction, 78, (Meeting Abstrac), p.64.
Watkins, A.J., Wilkins, A., Cunningham, C., Papenbrock, T., Warner, C.M., Torrens, C., Hanson, M.A. and Fleming, T.P. (2007) Cardiovascular health is compromised in mouse offspring following environmental or genetic manipulations on the preimplantation embryo. Early Human Development, 83, (Supplement 1), S146-S147. (doi:10.1016/S0378-3782(07)70396-1).
Eckert, Judith J., Houghton, Franchesca D., Hawkhead, Judith A., Balen, Adam H., Leese, Henry J., Picton, Helen M., Cameron, Iain T. and Fleming, Tom P. (2007) Human embryos developing in vitro are susceptible to impaired epithelial junction biogenesis correlating with abnormal metabolic activity. Human reproduction, 22, (8), 2214-24. (doi:10.1093/humrep/dem147).
Watkins, Adam, Torrens, Christopher, Cunningham, Colm, Wilkins, Adrian, Gray, Liam, Perry, Hugh, Hanson, Mark and Fleming, Tom (2007) Maternal low protein diet during oocyte maturation causes increased systolic blood pressure and abnormal behaviour in the mouse [In abstracts special issue]. Biology of Reproduction, 77, p.516.
Watkins, Adam J., Platt, Duncan, Papenbrock, Tom, Wilkins, Adrian, Eckert, Judith J., Kwong, Wing Yee, Osmond, Clive, Hanson, Mark and Fleming, Tom P. (2007) Mouse embryo culture induces changes in postnatal phenotype including raised systolic blood pressure. Proceedings of the National Academy of Sciences of the United States of America, 104, (13), 5449-5454. (doi:10.1073/pnas.0610317104).
Fleming, T.P. (2007) Influence of maternal diet on the developmental potential of the preimplantation embryo. The Journal of Nutrition, 137, 276S-277S.
Kwong, Wing Yee, Miller, Daniel J., Wilkins, Adrian P., Dear, Mark S., Wright, J. Neville, Osmond, Clive, Zhang, Junlong and Fleming, Tom P. (2007) Maternal low protein diet restricted to the preimplantation period induces a gender-specific change on hepatic gene expression in rat fetuses. Molecular Reproduction and Development, 74, (1), 52-60. (doi:10.1002/mrd.20606).
Watkins, A.J., Torrens, C., Wilkins, A., Cunningham, C., Perry, H.V., Gray, L., Hanson, M.A. and Fleming, T.P. (2007) The influence of maternal diet on postnatal growth, development and physiology. Proceedings of Life Sciences
Watkins, Adam, Wilkins, Adrian, Osmond, Clive, Warner, Carol M., Comiskey, Martina, Hanson, Mark and Fleming, Tom P. (2006) The influence of mouse Ped gene expression on postnatal development. Journal of Physiology, 571, (1), 211-220. (doi:10.1113/jphysiol.2005.099192).
Kwong, Wing Yee, Miller, Daniel J, Ursell, Elizabeth, Wild, Arthur E., Wilkins, Adrian P., Osmond, Clive, Anthony, Fred W. and Fleming, Tom P. (2006) Imprinted gene expression in the rat embryo–fetal axis is altered in response to periconceptional maternal low protein diet. Reproduction, 132, (2), 265-277. (doi:10.1530/rep.1.01038).
Eckert, Judith J., McCallum, Amanda, Mears, Andrew, Rumsby, Martin G., Cameron, Iain T. and Fleming, Tom P. (2005) Relative contribution of cell contact pattern, specific PKC isoforms and gap junctional communication in tight junction assembly in the mouse early embryo. Developmental Biology, 288, (1), 234-247. (doi:10.1016/j.ydbio.2005.09.037).
Eckert, Judith J., McCallum, Amanda, Mears, Andrew, Rumsby, Martin G., Cameron, Iain T. and Fleming, Tom P. (2004) Specific PKC isoforms regulate blastocoel formation during mouse preimplantation development preimplantation development. Developmental Biology, 274, (2), 384-401. (doi:10.1016/j.ydbio.2004.07.027).
Eckert, Judith J., McCallum, Amanda, Mears, Andrew, Rumsby, Martin G., Cameron, Iain T. and Fleming, Tom P. (2004) PKC signalling regulates tight junction membrane assembly in the pre-implantation mouse embryo. Reproduction, 127, (6), 653-667. (doi:10.1530/rep.1.00150).
Fleming, T.P., Wilkins, A., Mears, A., Miller, D.J., Thomas, F., Ghassemifar, M.R., Fesenko, I., Sheth, B., Kwong, W.Y. and Eckert, J.J. (2004) Society for Reproductive Biology Founders' Lecture 2003 - The making of an embryo: short-term goals and long-term implications. Reproduction, Fertility and Development, 16, (3), 325-337. (doi:10.1071/RD03070).
Thomas, F.C., Sheth, B., Eckert, J.J., Bazzoni, G., Dejana, E. and Fleming, T.P. (2004) Contribution of JAM-1 to epithelial differentiation and tight-junction biogenesis in the mouse preimplantation embryo. Journal of Cell Science, 117, (23), 5599-5608. (doi: 10.1242/jcs.01424).
Lloyd, S., Fleming, T.P. and Collins, J.E. (2003) Expression of Wnt genes during mouse preimplantation development. Gene Expression Patterns, 3, (3), 309-312. (doi:10.1016/S1567-133X(03)00046-2).
Kwong, W.Y., Miller, D.J., Wild, A.E., Osmond, C. and Fleming, T.P. (2003) Effect of maternal low protein diet on imprinted gene expression in the rat preimplantation embryo. Pediatric Research, 53, p.46A.
Miller, D.J., Eckert, J.J., Lazzari, G., Duranthon-Richoux, V., Sreenan, J., Morris, D., Galli, C., Renard, J.P. and Fleming, T.P. (2003) Tight junction messenger RNA expression levels in bovine embryos are dependent upon the ability to compact and in vitro culture methods. Biology of Reproduction, 68, 1394-1402. (doi:10.1095/biolreprod.102.009951).
Ghassemifar, M. Reza, Eckert, Judith J., Houghton, Franchesca D., Picton, Helen M., Leese, Henry J. and Fleming, Tom P. (2003) Gene expression regulating epithelial intercellular junction biogenesis during human blastocyst development in vitro. Molecular Human Reproduction, 9, (5), 245-252. (doi:10.1093/molehr/gag033).
Eckert, J.J., Houghton, F.D., Hawkhead, J.A., Leese, H.J., Picton, H., Cameron, I.T. and Fleming, T.P. (2003) Differentiation and metabolic activity are related in cultured human embryos. Pediatric Research, 53, (6), 48A-49A.
Benais-Pont, Gaelle, Punn, Anu, Flores-Maldonado, Catalina, Eckert, Judith, Raposo, Graca, Fleming, Tom P., Cereijido, Marcelino, Balda, Maria S. and Matter, Karl (2003) Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability. Journal of Cell Biology, 160, (5), 729-740. (doi:10.1083/jcb.200211047).
Ghassemifar, M. Reza, Sheth, Bhavwanti, Papenbrock, Tom, Leese, Henry J., Houghton, Franchesca D. and Fleming, Tom P. (2002) Occludin TM4(-): an isoform of the tight junction protein present in primates lacking the fourth transmembrane domain. Journal of Cell Science, 115, (15), 3171-3180.
Fleming, T.P., Sheth, B. and Fesenko, I. (2001) Cell adhesion in the preimplantation mammalian embryo and its role in trophectoderm differentiation and blastocyst morphogenesis. Frontiers in Bioscience, 6, D1000-D1007.
Sheth, B., Fontaine, J.J., Ponza, E., McCallum, A., Page, A., Citi, S., Louvard, D., Zahraoui, A. and Fleming, T.P. (2000) Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction. Mechanisms of Development, 97, (1-2), 93-104. (doi:10.1016/S0925-4773(00)00416-0).
Kwong, W.Y., Wild, A.E., Roberts, P., Willis, A.C. and Fleming, T.P. (2000) Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension. Development, 127, (19), 4195-4202.
Fesenko, I., Kurth, T., Sheth, B., Fleming, T.P., Citi, S. and Hausen, P. (2000) Tight junction biogenesis in the early Xenopus embryo. Mechanisms of Development, 96, (1), 51-65. (doi:10.1016/S0925-4773(00)00368-3).
Fleming, T.P., Papenbrock, T., Fesenko, I., Hausen, P. and Sheth, B. (2000) Assembly of tight junctions during early vertebrate development. Seminars in Cell and Developmental Biology, 11, (4), 291-299. (doi: 10.1006/scdb.2000.0179).
Wallis, S., Lloyd, S., Wise, I., Ireland, G., Fleming, T.P. and Garrod, D. (2000) The alpha isoform of protein kinase C is involved in signaling the response of desmosomes to wounding in cultured epithelial cells. Molecular Biology of the Cell, 11, (3), 1077-1092.
Fleming, T.P., Ghassemifar, M.R. and Sheth, B. (2000) Junctional complexes in the early mammalian embryo. Seminars in Reproductive Medicine, 18, (2), 185-193. (doi:10.1055/s-2000-12557).
Sheth, B., Fesenko, I., Collins, J.E., Moran, B., Wild, A., Anderson, J.M. and Fleming, T.P. (1997) Tight junction assembly during mouse blastocyst formation is regulated by late expression of ZO-1 a+ isoform. Development, 124, 2027-2037. (PMID:9169849).
Marsden, Mark D., Collins, Jane E., Greenwood, Matthew D., Adams, Michael J., Fleming, Tom P., Magee, Anthony I. and Buxton, Roger S. (1997) Cloning and transcriptional analysis of the promoter of the human type 2 desmocollin gene (DSC2). Gene, 186, (2), 237-247. (doi:10.1016/S0378-1119(96)00715-9). (PMID:9074502).
Dunglison, G.F., Jane, S.D., McCaul, T.F., Chad, J.E., Fleming, T.P. and Kaye, P.L. (1995) Stimulation of endocytosis in mouse blastocysts by insulin - a quantitative morphological analysis. Reproduction, 105, 115-123. (doi:10.1530/jrf.0.1050115). (PMID:7490702).
Collins, J.E., Lorimer, J.E., Garrod, D.R., Pidsley, S.C., Buxton, R.S. and Fleming, T.P. (1995) Regulation of desmocollin transcription in mouse preimplantation embryos. Development, 121, 743-752. (PMID:7536656).
Collins, Jane and Fleming, Tom (1995) Specific mRNA detection in single lineage-marked blastomeres from preimplantation embryos. Trends in Genetics, 11, (1), 5-7. (doi:10.1016/S0168-9525(00)88975-1). (PMID:7900194).
Lorimer, J.E., Hall, L.S., Clarke, J.P., Collins, J.E., Fleming, T.P. and Garrod, D.R. (1994) Cloning, sequence and expression patterns of mouse desmocollin 2 (DSC 2): a cadherin-like adhesion molecule. Molecular Membrane Biology, 11, (4), 229-237. (PMID:7711832).
Fleming, T.P., Javed, Q., Collins, J.E. and Hay, M. (1993) Biogenesis of structural intercellular junctions during cleavage in the mouse embryo. Journal of Cell Science, 17, 119-125. (PMID:8144686).

Book Section

Sheth, Bhavwanti, Eckert, Judith, Thomas, Fay and Fleming, Tom P. (2006) Tight junctions during development. In, Gonzalez-Mariscal, Lorenza (ed.) Tight Junctions. New York, USA, Springer, 164-174. (Science and Business Media). (doi:10.1007/0-387-36673-3_12).

Additional publications

Fleming TP (2006) Periconceptional events and the embryo. In Developmental Origins of Health and Disease – A Biomedical Perspective, eds PD Gluckman and MA Hanson, pp. 51-61, Cambridge Univ Press.

Fleming TP, Eckert JJ, Thomas FC and Sheth B (2005) Morphogenesis of the early mammalian embryo: cell lineage heterogeneity and developmental potential. In Implantation and Early Development, Royal College of Obstetricians and Gynaecologists.

Hanson M, Gluckman P, Bier D, Challis J, Fleming T, Forrester T, Godfrey K, Nestel P, Yajnik C. (2004). Report on the 2nd World Congress on Fetal Origins of Adult Disease, Brighton , U.K. , June 7-10, 2003 . Pediatr Res. 55: 894-7.

Fleming, T.P. (2002). Cell-Cell Interactions: A Practical Approach (editor). IRL Press at Oxford University Press.

Fleming, T.P., Eckert, J.J., Kwong, W.Y., Thomas, F.C., Miller, D., Fesenko, I., Mears, A. and Sheth, B. (2002). Cell-cell interactions in early mammalian development. In: Cell-cell interactions: a practical approach . T.P. Fleming (editor), pp. 203-228, Oxford University Press, Oxford.

Fleming, T.P., Ghassemifar, M.R., Eckert, J., Destouni, A., Thomas, F., Collins, J.E., and Sheth, B. (2001). Cell junctions and cell interactions in animal and human blastocyst development. In: Art and the Human Blastocyst . D.K.Gardner and M.Lane (editors), pp.91-102, Proceedings of Serono Symposium, USA, Springer.

Fleming, T.P., Sheth, B., Thomas, F., Fesenko, I. and Eckert, J. (2001). Developmental assembly of the tight junction. In: Tight Junctions. M. Cereijido and J. Anderson (editors), pp.285-303, CRC Press.

Fleming, T.P., Ghassemifar, M.R. and Sheth, B. (2001). Junctional complexes in the early mammalian embryo. Sem. Reprod. Med. 18 : 185-193.

 

Research

Research Interests

Embryo environment and developmental potential and health:
We are interested in how the environment of the oocyte and preimplantation embryo can influence its development and future long-term potential. We investigate how maternal diet (in vivo), maternal sickness (in vivo) or IVF-related culture conditions (in vitro) can affect blastocyst development including gene expression patterns, cell proliferation and cellular phenotype. We derive embryonic stem cell lines to further characterise environmental effects on developmental potential.

We also examine long-term consequences of rodent preimplantation environment on subsequent fetal growth and gene expression, maternal nutrient provision, postnatal growth, cardiovascular and metabolic physiology, behaviour, immune reactivity.

Our data indicate that programming of postnatal phenotype can derive from early embryonic environment which has important implications for embryo potential and fetal/postnatal health. Our studies comprise a range of molecular, epigenetic, cellular and physiological technologies on extra-embryonic and embryonic cell lineages and postnatal tissues.

Mechanisms of early mammalian development:
We are also interested in the basic mechanisms regulating early mammalian development. Following fertilization, the egg undergoes a series of cell divisions to form a blastocyst which implants into the uterus wall. The blastocyst initially contains two types of cells, one an outer epithelium (trophectoderm) which gives rise to most of the placental tissues of the conceptus, the other, (inner cell mass), which gives rise to the entire foetus after implantation. Blastocyst formation is therefore an essential first step in our development. We use the mouse embryo to tackle the fundamental questions: How do different cell types expressing different genes and proteins emerge during development? What role is played by cell-cell interactions in this process? How do cells mature and differentiate into an epithelium, the commonest tissue in our bodies?

We utilize mainly animal models for our research (principally the mouse) but also include human embryos where appropriate and under HFEA license.

We have strong links with the School of Medicine at Southampton, particularly staff within DOHaD (Developmental Origins of Health and Disease) and the early human development and stem cell consortium within the university.

Research projects

1. How do preimplantation embryos sense and respond to maternal nutrition affecting fetal development and adult health? (BBSRC). An investigation into mechanisms contributing to induction of adverse programming of adult health during preimplantation development mediated through poor maternal diet and concerned mostly with effects on the extra-embryonic lineages.
2. Maternal mechanisms induced by diet regulating embryo developmental plasticity affecting life-long health. (BBSRC). An investigation of the role of specific maternal metabolites altered by diet and their effect on induction of adverse developmental programming of early embryos using in vitro and in vivo models.
3. Linking perturbed maternal environment during periconceptional development, due to diabetes, obesity or assisted reproductive technologies, and altered health during ageing (EpiHealth; EU FP7). An investigation of the short- and long-term effects on early embryos and their offspring of different environmental conditions associated with assisted conception treatment.
4. Maternal interactions with gametes and embryos (‘Gemini’; EU COST). Contributor to European consortium and different models – see http://www.cost-gemini.eu/  

Affiliate research group: Developmental Biology

Primary research group:  Biomedical Sciences

Affiliate research group:  Institute for Life Sciences (IfLS)

Research projects

Consequences of early embryo environment

Maternal nutrient restriction exclusive to the preimplantation period has a pronounced influence on fetal and postnatal growth and organ development, as well as postnatal physiology.

Maternal mechanisms induced by diet regulating embryo developmental plasticity affecting life-long health

Discovering the maternal mechanisms induced by diet which act through embryo developmental plasticity to alter later health.

Effect of mouse maternal high fat diet during preimplantation and later stages of pregnancy on offspring development and health

An analysis of effects of maternal high fat diet on embryo developmental potential.

Linking perturbed maternal environment during periconceptional development, due to diabetes, obesity or assisted reproductive technologies, and altered health during ageing

Mechanisms by which assisted conception treatments may affect embryo development and health into adulthood.

How do preimplantation embryos sense and respond to maternal nutrition affecting fetal development and adult health

Mechanisms by which maternal diet affects embryo development and health into adulthood.

EpiHealthNet: Environment during periconceptional development, due to diabetes, obesity or assisted reproductive technologies, and altered health during ageing

Effects of assisted conception treatments on embryo development and health into adulthood.

Role of maternal diet on regulation of embryonic neural stem cells

Effect of mouse maternal diet on development and characteristics of neural stem cells.

Teaching Responsibilities

Module Coordinator: Biol 2003; Biol 3001; Biol 3006

Contribute also to: Biol 1005/6; Biol 1012/13

Contributions

  • 2008-13 Editor-in-Chief, Reproduction
  • 2000- Editorial Board: Reproduction; Biology of Reproduction (reviews); J DOHaD; Cell Tissue Biol Res
  • 2008 Member of Council: Society of Reproduction and Fertility
  • Line Manager to 6 CfBS academic staff

PhD supervision

Since 2008, completed:
Rose Panton (MRC, Main supervisor)
Charlotte Williams (BBSRC, Main SV)

Current:
Franchesca Lock (Co SV, Medicine)
Sarah Finn (Co SV, Medicine)
Andy Cox (Co SV, BBSRC)
Congshun Sun (Main SV, University + Private)
Ayat Bakheet (Co SV, Overseas)
Yi-Lung Chang (Co SV, Overseas)
Ili Raja Khalif (Main SV, Overseas)
Claire Smith (Main SV, EU)
Anan Aljahdali (Main SV, Overseas)

Contact

Professor Tom P. Fleming
Professor of Developmental Biology
Centre for Biological Sciences
University of Southampton
Mailpoint 840, Level D Lab & Path Block
Southampton General Hospital
Tremona Road
Southampton, SO16 6YD
Tel: +44 (0)2380 794145

Room number: LD62
Email:tpf@soton.ac.uk

Room Number: SGH/62A/