Medicine

Mark Hanson

MA, DPhil, CertEd, FRCOG

Primary position:
Director, Academic Unit of Human Development and Health
Other positions:
Director, Institute of Developmental Sciences, British Heart Foundation Professor of Cardiovascular Science

Background

The University of Southampton

Professor Mark Hanson is one of the UK’s leading researchers on developmental pathways to disease. He is current President of the International Society for the Developmental Origins of Health and Disease and was a founder member and former secretary of the Society. He has served on a range of committees in government, charitable and NGOs focusing on the importance of adopting lifecourse perspective to new ways of reducing the burden of non-communicable disease globally. In the UK he directs the University of Southampton Academic Unit of Human Development and Health in the Faculty of Medicine and overseas he holds visiting appointments in Auckland, Singapore, Dublin, Jamaica and Suzhou.

Mark has published more than 200 original papers, 125 reviews and 13 books. His research concerns several aspects of development and health, ranging from how the environment before and after birth affects the risk of chronic disease – such as cardiovascular and chronic lung disease, diabetes and obesity – to population studies aimed at the early identification of risk, so that timely preventative interventions can be made. The group are exploring the epigenetic processes which relate to such risks, and which may serve as valuable early life biomarkers. His Academic Unit works on these problems in both developed and developing countries in many parts of the world. Mark is particularly interested in the links between medical science and society and was a founder member of the Wellcome Trust’s Sci-Art panel. He is much involved in educational projects to promote health literacy in school students – LifeLab – in the public understanding of science and how evolutionary thinking applies to human biology and medicine. His recent popular science books include Mismatch – the lifestyle diseases timebomb (2006) which is translated into Mandarin, Portuguese and German, and Principles of Evolutionary Medicine (2009) ans Fat, Fate & Disease (2012), all published by OUP.

Qualifications

BA Hons Animal Physiology, St John's College, Oxford (1971)
CertEd, University of Leeds (1974)
DPhil in Physiology, St John’s College, Oxford (1979)

Appointments held

Sept 1974 - July 1976 - Lecturer in Biological Sciences, Waverley College of Further Education, Nottingham

Oct 1976 - Sept 1979 - Departmental Demonstrator and Research Assistant (MRC salaried) in University Laboratory of Physiology, Oxford

Oct 1979 -Sept 1989 - Lecturer in Biochemistry and Physiology, University of Reading

Oct 1986 -Sept 1990 - Wellcome Trust Senior Lecturer, University of Reading

Oct 1989 -Sept 1990 - Reader, University of Reading

Oct 1990 - Sept 1993 - Reader in Fetal and Neonatal Physiology and Wellcome Trust Senior Lecturer, University College London (the latter until 1997)

Oct 1993 - Dec 1999 - Professor of Fetal and Neonatal Physiology, University College London

Professor Mark Hanson's photo

Publications

The University of Southampton's electronic library (e-prints)

Article

Pantichob, N., Widdows, K.L., Crocker, I.P., Hanson, Mark A., Johnstone, E.D., Please, C.P., Sibley, C.P., Glazier, J.D., Lewis, R.M. and Sengers, Bram G. (2015) Computational modelling of amino acid exchange and facilitated transport in placental membrane vesicles. Journal of Theoretical Biology, 365, 352-364. (doi:10.1016/j.jtbi.2014.10.042).
Tennant, I.A., Barnett, A.T., Thompson, D.S., Kips, J., Boyne, M.S., Chung, E.E., Chung, A.P., Osmond, Clive, Hanson, M.A., Gluckman, P.D., Segers, P., Cruickshank, J.K. and Forrester, T.E. (2014) Impaired cardiovascular structure and function in adult services of severe acute malnutrition. Hypertension, 64, (3), 664-671. (doi:10.1161/HYPERTENSIONAHA.114.03230.). (PMID:24980666).
Black, D.E., Bryant, J., Peebles, Charles R., Godfrey, Keith M., Hanson, Mark A. and Vettukattil, Joseph J. (2014) Tissue motion annular displacement of the mitral valve using two-dimensional speckle tracking echocardiology predicts the left ventricular ejection fraction in normal children. Cardiology in the Young, 24, (4), 640-648. (doi:10.1017/S1047951113000863.). (PMID:23803408).
Black, D.E., Bryant, Jen, Peebles, Charles, Godfrey, K.M., Hanson, Mark and Vettukattil, J.J. (2014) Tissue motion annular displacement of the mitral valve using two-dimensional speckle tracking echocardiography predicts the left ventricular ejection fraction in normal children. Cardiology in the Young, 24, (4), 640-648. (doi:10.1017/S1047951113000863). (PMID:23803408).
Bateson, P., Gluckman, Peter D. and Hanson, M.A. (2014) The biology of developmental plasticity and the predictive adaptive response hypothesis. The Journal of Physiology, 592, part 11, 2357-2368. (doi:10.1113/jphysiol.2014.271460). (PMID:24882817).
Francis-Emmanuel, P.M., Thompson, D.S., Barnett, A.T., Osmond, C., Byrne, C.D., Hanson, M.A., Gluckman, P.D., Forrester, T.E. and Boyne, M.S. (2014) Glucose metabolism in adult survivors of severe acute malnutrition. Journal of Clinical Endocrinology & Metabolism, 99, (6), 2233-2240. (doi:10.1210/jc.2013-3511). (PMID:24517147).
Norris, S., Anuar, H., Matzen, P., Cheah, J., Jensen, B. and Hanson, Mark A. (2014) The life and health challenges of young Malaysian couples: results from a stakeholder consensus and engagement study to support non-communicable disease prevention. BMC Public Health, 14, (S2), supplement Responsive Health Systems: Working with the Community on Control of Non-Communicable Diseases (NCDs), S6. (doi:10.1186/1471-2458-14-S2-S6). (PMID:25080995).
Poore, Kirsten R., Hollis, Lisa J., Murray, Robert J.S., Warlow, Anna, Brewin, Andrew, Fulford, Laurence, Cleal, Jane K., Lillycrop, Karen A., Burdge, Graham C., Hanson, Mark A. and Green, Lucy R. (2014) Differential pathways to adult metabolic dysfunction following poor nutrition at two critical developmental periods in sheep. PLoS ONE, 9, (3), 1-13. (doi:10.1371/journal.pone.0090994). (PMID:24603546).
Briley, A.L., Barr, S., Badger, S., Bell, R., Croker, H., Godfrey, K.M., Holmes, B., Kinnunen, T.I., Nelson, S.M., Oteng-Ntim, E., Patel, N., Robson, S.C., Sandall, J., Sanders, T., Sattar, N., Seed, P.T., Wardle, J. and Poston, L. (2014) A complex intervention to improve pregnancy outcome in obese women; the UPBEAT randomised controlled trial. BMC Pregnancy and Childbirth, 14, (1), 74. (doi:10.1186/1471-2393-14-74.). (PMID:24533897).
Hanson, Mark A. (2014) Understanding the origins of diabetes. JAMA The Journal of the American Medical Association, 311, (6), 575-576. (doi:10.1001/jama.2014.2).
Black, D., Bryant, J., Peebles, C., Davies, L., Inskip, H., Godfrey, K., Vettukattil, Joseph J. and Hanson, M. (2014) Increased regional deformation of the left ventricle in normal children with increased body mass index: implications for future cardiovascular health. Pediatric Cardiology, 35, (2), 315-322. (doi:10.1007/s00246-013-0778-1.). (PMID:23989614).
Sellayah, Dyan, Dib, Lea, Anthony, Frederick W., Watkins, Adam J., Fleming, Tom P., Hanson, Mark A. and Cagampang, Felino R. (2014) Effect of maternal protein restriction during pregnancy and postweaning high-fat feeding on diet-induced thermogenesis in adult mouse offspring. European Journal of Nutrition, 1-9. (doi:10.1007/s00394-014-0657-4). (PMID:24481689).
Day, P.E.L., Cleal, J.K., Lofthouse, E.M., Goss, V., Koster, G., Postle, A., Jackson, J.M., Hanson, M.A., Jackson, A.A. and Lewis, R.M. (2013) Partitioning of glutamine synthesised by the isolated perfused human placenta between the maternal and fetal circulations. Placenta, 34, (12), 1223-1231. (doi:10.1016/j.placenta.2013.10.003). (PMID:24183194).
Day, P.E.L., Cleal, J.K., Lofthouse, E.M., Goss, V., Koster, G., Postle, A., Jackson, J.M., Hanson, M.A., Jackson, A.A. and Lewis, R.M. (2013) Partitioning of glutamine synthesized by the isolated perfused human placenta between the maternal and fetal circulations. Placenta, 34, (12), 1223-1231. (doi:10.1016/j.placenta.2013.10.003). (PMID:24183194).
Day, P.E., Cleal, J.K., Lofthouse, E.M., Hanson, M.A. and Lewis, R.M. (2013) What factors determine placental glucose transfer kinetics? Placenta, 34, (10), 953-958. (doi:10.1016/j.placenta.2013.07.001). (PMID:23886770).
Krause, B., Costello, P.M., Munoz-Urrutia, E., Lillycrop, Karen A., Hanson, Mark A. and Casanello, P. (2013) Role of DNA methyltransferase 1 on the altered eNOS expression in human umbilical endothelium from intrauterine growth restricted fetuses. Epigenetics, 8, (9), 944-952. (doi:10.4161/epi.25579). (PMID:23867713).
Ma, R., Chan, J., Tam, W., Hanson, Mark A. and Gluckman, P. (2013) Gestational diabetes, maternal obesity and the NCD burden. Clinical Obstetrics and Gynecology, 56, (3), 633-641. (doi:10.1097/GRF.0b013e31829e5bb0). (PMID:23820121).
Harvey, N.C., Sheppard, A., Godfrey, K.M., McLean, C., Garratt, Emma, Ntani, G., Davies, L., Murray, R., Inskip, H.M., Gluckman, P.D., Hanson, M.A., Lillycrop, K.A. and Cooper, C. (2013) Childhood bone mineral content is associated with methylation status of the RXRA promoter at birth. Journal of Bone and Mineral Research (doi:10.1002/jbmr.2056). (PMID:23907847).
Ward, L.C., Poston, L., Godfrey, K.M. and Koletzko, B. (2013) Assessing early growth and adiposity: report from an early nutrition academy workshop. Annals of Nutrition and Metabolism, 63, (1-2), 120-130. (doi:10.1159/000350702). (PMID:23969405).
Hoile, Samuel P., Irvine, Nicola A., Kelsall, Christopher J., Sibbons, Charlene, Feunteun, Aurelie, Collister, Alex, Torrens, Christopher, Calder, P.C., Hanson, Mark A., Lillycrop, Karen A. and Burdge, Graham C. (2013) Maternal fat intake in rats alters 20:4n-6 and 22:6n-3 status and the epigenetic regulation of Fads2 in offspring liver. Journal of Nutritional Biochemistry, 24, (7), 1213-1220. (doi:10.1016/j.jnutbio.2012.09.005). (PMID:23107313).
Garratt, Emma, Vickers, Mark H., Gluckman, Peter D., Hanson, Mark A., Burdge, Graham C. and Lillycrop, Karen A. (2013) Tissue-specific 5' heterogeneity of PPARa transcripts and their differential regulation by leptin. PLoS ONE, 8, (6), part E67483 (doi:10.1371/journal.pone.0067483). (PMID:23825665).
Grace, Marcus, Woods-Townsend, Kathryn, Byrne, Jenny, Christodoulou, Andri, Griffiths, Janice, Hanson, Mark A., Inskip, Hazel M. and Godfrey, Keith M. (2013) Science for health literacy: it’s never been so important. Education in Science, 252, 16-17.
Elahi, M. M., Cagampang, F. R., Ohri, Sunil K. and Hanson, Mark A. (2013) Long-term statin administration to dams on high-fat diet protects not only them but also their offspring from cardiovascular risk. Annals of Nutrition & Metabolism, 62, (3), 248-254. (doi:10.1159/000346037). (PMID:23594919).
Veenendal, M.V.E., Painter, R.C., De Rooji, S.R., Bossuyt, P.M.M., Van Der Post, J.A.M., Gluckman, Peter D., Hanson, Mark A. and Roseboom, T.J. (2013) Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine. British Journal of Obstetrics and Gynaecology, 120, (5), 548-554. (doi:10.1111/1471-0528.12136). (PMID:23346894).
Lewis, R.M., Brooks, S., Crocker, I.P., Glazier, J., Hanson, M.A., Johnstone, E.D., Panitchob, N., Please, C.P., Sibley, C.P., Widdows, K.L. and Sengers, B.G. (2013) Review: Modelling placental amino acid transfer − from transporters to placental function. Placenta, 34, S46-S51. (doi:10.1016/j.placenta.2012.10.010).
Balbus, J.M., Barouki, R., Birnbaum, L.S., Etzel, R.A., Gluckman, Peter D., Grandjean, P., Hancock, C., Hanson, Mark A., Heindel, J.J., Hoffman, K., Jensen, G.K., Keeling, A., Neira, M., Rabadan-Diehl, C., Ralston, J. and Tang, K.-C. (2013) Early-life prevention of non-communicable diseases. The Lancet, 381, (9860), 3-4.
Hanson, Mark A. (2013) Developmental origins of obesity and non-communicable disease. Endocrinologia and Nutricion, 60, (S1), 10-11. (In Press).
Godfrey, K.M., Lillycrop, K.A., Burdge, G.C., Gluckman, P.D. and Hanson, M.A. (2013) Non-imprinted epigenetics in fetal and postnatal development and growth. Nutrition Institute Workshop Series, 71, 57-63. (doi:10.1159/000342552). (PMID:23502139).
Veenendaal, M.V.E., Costello, P.M., Lillycrop, Karen A., Rooij, S.R., Van Der Post, J.A.M., Bossuyt, P.M., Hanson, Mark A., Painter, R.C. and Roseboom, T.J. (2012) Prenatal famine exposure, health in later life and promoter methylation of four candidate genes. Journal of Developmental Origins of Health and Disease, 3, (6), 450-457. (doi:10.1017/S2040174412000396).
Low, F.M., Gluckman, Peter D. and Hanson, Mark A. (2012) Developmental plasticity, epigenetics and human health. Evolutionary Biology, 39, (4), 650-665. (doi:10.1007/s11692-011-9157-0).
Lewis, R.M., Cleal, J.K. and Hanson, Mark A. (2012) Placenta, evolution and lifelong health. Placenta, 33, supplement Placenta: Predicting Future Health, S28-S32. (doi:10.1016/j.placenta.2011.12.003).
Drake, Amanda J., McPherson, Rhoanne C., Godfrey, Keith M., Cooper, Cyrus, Lillycrop, Karen A., Hanson, Mark A., Meehan, Richard R., Seckl, Jonathan R. and Reynolds, Rebecca M. (2012) An unbalanced maternal diet in pregnancy associates with offspring epigenetic changes in genes controlling glucocorticoid action and fetal growth. Clinical Endocrinology, 77, (6), 808-815.
Drake, A.J., McPherson, R.C., Godfrey, K.M., Cooper, C., Lillycrop, K.A., Hanson, M.A., Meehan, R.R., Seckl, J and Reynolds, R.M. (2012) An unbalanced diet in pregnancy associates with offspring epigenetic changes in genes controlling glucocorticoid action and fetal growth. Clinical Endocrinology, 77, (6), 808-815. (doi:10.1111/j.1365-2265.2012.04453.x). (PMID:22642564).
Torrens, Christopher, Ethirajan , P., Bruce, K.D., Cagampang , F.R., Siow , R.C., Hanson, Mark A., Byrne, Christopher D., Mann, G.E. and Clough, G.F. (2012) Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice. PLoS ONE, 7, (12), e0050671. (doi:10.1371/journal.pone.0050671). (PMID:23227196).
Hanson, Mark A., Gluckman, Peter D., Ma, Ronald C.W., Matzen, Priya and Biesma, Regien (2012) Early life opportunities for prevention of diabetes in low and middle income countries. BMC Public Health, 12, 1025-1025. (doi:10.1186/1471-248-12-1025).
O'Tierney, P.F., Lewis, R.M., McWeeney, S.K., Hanson, M.A., Inskip, H.M., Morgan, T.K., Barker, D.J., Bagby, G., Cooper, C., Godfrey, K.M. and Thornburg, K.L. (2012) Immune response gene profiles in the term placenta depend upon maternal muscle mass. Reproductive Sciences, 19, (10 ), 1041-1056. (doi:10.1177/1933719112440051 ). (PMID:22534332).
Schug, T.T., Barouki, R., Gluckman, Peter D., Grandjean, P., Hanson, Mark A. and Heindel, J.J. (2012) PPTOXIII: Environmental stressors in the developmental origins of disease: evidence and mechanisms. Toxicological Sciences, 131, (2), 343-350. (doi:10.1093/toxsci/kfs267).
Hoile, Samuel P., Lillycrop, Karen A., Grenfell, Leonie R., Hanson, Mark A. and Burdge, Graham C. (2012) Increasing the folic acid content of maternal or post-weaning diets induces differential changes in phospheonolypyruvate carboxykinase mRNA expression and promoter methylation in rats. British Journal of Nutrition, 108, (05), 852-857. (doi:10.1017/S0007114511006155 ).
Holroyd, C., Harvey, N.C., Crozier, S.R., Winder, N.R., Mahon, P.A., Ntani, G., Godfrey, K.M., Inskip, H.M., Cooper, C., Taylor, P., Greenaway, L.J., Nisbet, C.E., Robinson, S.M., Swaminathan, R., Wickramasinghe, S., Dennison, E.M., Hanson, Mark A., Cameron, Iain T., Law, C.M., Osmond, Clive, Fall, C.H. and Barker, D.J. (2012) Placental size at 19 weeks predicts offspring bone mass at birth: findings from the Southampton Women's Survey. Placenta, 33, 623-629. (doi:10.1016/j.placenta.2012.04.007). (PMID:22640438).
Cagampang, F.R., Torrens, Christopher, Anthony, F.W. and Hanson, Mark A. (2012) Developmental exposure to bisphenol A leads to cardiometabolic dysfunction in adult mouse offspring. Journal of Developmental Origins of Health and Disease, 3, (4), 287-292.
Godfrey, Keith M., Haugen, G., Kiserud, T., Inskip, H.M., Cooper, C., Harvey, N.C., Crozier, S.R., Robinson, S.M., Davies, L. and Hanson, M.A. (2012) Fetal liver blood flow distribution: role in human developmental strategy to prioritize fat deposition versus brain development. PLoS ONE, 7, (8), e41759. (doi:10.1371/journal.pone.0041759). (PMID:22927915).
Stunkel, W., Pan, H., Chew, S.B., Tng, E., Tan, J.H., Chen, L., Joseph, R., Cheong, C.Y., Ong, M.L., Lee, Y.S., Chong, Y.S., Saw, S.M., Meaney, M.J., Kwek, K., Sheppard, A.M., Gluckman, P.D., Holbrook, J.D., Bier, D., Biswas, A., Shirong, C., Chan, H., Chan, J., Chan, Y.H., Chee, C., Chia, A., Chin, C.W., Chinnadurai, A., Kiat, C.C., Chong, M., Chee, C.S., Chien, C.M., Cutfield, W., Daniel, M., Ming, D.C., Godfrey, K.M., Ferguson-Smith, A., Finkelstein, E.A., Fortier, M., Fok, D., Goh, A., Goh, D., Gooley, J.J., Meng, H.W., Hanson, M., Hartman, M., Heymann, M., Chin-Ying, S.H., Inskip, H., Kapur, J., Wah, L.B., Seng, L.Y., Leutscher-Broekman, B.F., Bee, L.S., Feei, L.S., Ling, L.Y., Magiati, I., Morton, S., Krishnamoorthy, N., Ngo, C., Wei, P.W., Agarwal, P., Anqi, Q., Long, Q.B., Rajadurai, V.S., Richmond, J., Rifkin-Graboi, A., Sheppard, A., Shek, L.P., Shuter, B., Singh, L., Wing Chee, S., Soh Shu, E., Lin, S.L., Hian, T.K., Hui, T.S., Hoe, T.O., Tong, T.Y., Tint, M.T., Van Bever, H., Van Dam, R., Venkatesh, S., Verkooijen, H.M., Wong, I.B., Wong, P.C., Yap, F. and Yeo, G.S. (2012) Transcriptome changes affecting Hedgehog and cytokine signalling in the umbilical cord: implications for disease risk. PLoS ONE, 7, (7), e39744. (doi:10.1371/journal.pone.0039744). (PMID:22808055).
Barouki, R., Gluckman, Peter D., Grandjean, P., Hanson, Mark A. and Heindel, J.J. (2012) Developmental origins of non-communicable disease: implications for research and public health. Environmental Health, 11, 42-42. (doi:10.1186/1476-069X-11-42).
de Rooij, Susanne R., Costello, Paula M., Veenendaal, Marjolein V.E., Lillycrop, Karen A., Gluckman, Peter D., Hanson, Mark A., Painter, Rebecca C. and Roseboom, Tessa J. (2012) Associations between DNA methylation of a glucocorticoid receptor promoter and acute stress responses in a large healthy adult population are largely explained by lifestyle and educational differences. Psychoneuroendocrinology, 37, (6), 782-788. (doi:10.1016/j.psyneuen.2011.09.010). (PMID:21978868).
Forrester, Terrence E., Badaloo, Asha V., Boyne, Michael S., Osmond, Clive, Thompson, Debbie, Green, Curtis, Taylor-Bryan, Carolyn, Barnett, Alan, Soares-Wynter, Suzanne, Hanson, Mark A., Beedle, Alan S. and Gluckman, Peter D. (2012) Prenatal factors contribute to the emergenece of kwoshiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model. PLoS ONE, 7, (4), e35907-[4pp]. (doi:10.1371/journal.pone.0035907). (PMID:22558267).
Kelsall, Christopher J., Hoile, Samuel P., Irvine, Nicola A., Masoodi, Mojgan, Torrens, Christopher, Lillycrop, Karen A., Calder, Philip C., Clough, Geraldine F., Hanson, Mark A. and Burdge, Graham C. (2012) Vascular dysfunction induced in offspring by maternal dietary fat involves altered arterial polyunsaturated fatty acid biosynthesis. PLoS ONE, 7, (4), e34492. (doi:10.1371/journal.pone.0034492). (PMID:22509311).
Saito, Tomomi, Musha, Yuka, Miyakawa , Miho, Itoh, Shigeru, Ohtsuji, Mareki, Hanson, Mark A. and Takeda, Satoru (2012) Angiotensin II receptor antagonist reduces subsequent uterine arterial dysfunction in pregnant offspring of protein-restricted rat dams. Journal of Obstetrics and Gynaecology Research, 38, (3), 483-489. (doi:10.1111/j.1447-0756.2011.01737.x). (PMID:22381101).
Harvey, Nicholas C., Lillycrop, Karen A., Garratt, Emma, Sheppard, Allan, McLean, Cameron, Burdge, Graham C., Slater-Jefferies, Jo, Rodford, Joanne, Crozier, Sarah, Inskip, Hazel, Emerald, B.S., Gale, C.R., Hanson, M., Gluckman, P., Godfrey, K. and Cooper, C. (2012) Evaluation of methylation status of the eNOS promoter at birth in relation to childhood bone mineral content. Calcified Tissue International, 90, (2), 120-127. (doi:10.1007/s00223-011-9554-5). (PMID:22159788).
Grace, Marcus, Woods-Townsend, Kathryn, Griffiths, Janice, Godfrey, Keith M., Hanson, Mark A., Galloway, Ian, Azaola, Marta Cristina, Harman, Kerry, Byrne, Jenny and Inskip, Hazel M. (2012) Developing teenagers' views on their health and the health of their future children. Health Education, 112, (6), 543-559. (doi:10.1108/09654281211275890).
Hoile, Samuel P., Lillycrop, Karen A., Grenfell, Leonie R., Hanson, Mark A. and Burdge, Graham C. (2011) Short communication. Increasing the folic acid content of maternal or post-weaning diets induces differential changes in phosphoenolpyruvate carboxykinase mRNA expression and promoter methylation in rats. British Journal Of Nutrition (doi:10.1017/S0007114511006155). (PMID:22136740).
Hanson, Mark and Gluckman, Peter (2011) Developmental origins of non communicable disease: population and public health implications. American Journal of Clinical Nutrition, 94, supplement 6, 1754s-1758s. (doi:10.3945/ajcn.110.001206). (PMID:21525196).
Hanson, Mark and Gluckman, Peter (2011) Developmental origins of noncommunicable disease: population and public health implications. American Journal of Clinical Nutrition, 94, supplement 6, 1754s-1758s. (doi:10.3945/​ajcn.110.001206 ). (PMID:21525196).
Bruce, Kimberley D., Stokes, Aaron, Patel, Nikesh R., Hyde, Kerry, Sadek, Khaled H., Hanson, Mark A., Byrne, Christopher D. and Cagampang, Felino R. (2011) Identification of robust cardiac reference genes in a mouse model of cardiometabolic disease. Journal of Clinical and Experimental Cardiology, 10, (2) (doi:10.4172/2155-9880.1000161).
Krause, B.J., Hanson, Mark A. and Casanello, P. (2011) Role of nitric oxide in placental vascular development and function. Placenta, 32, (11), 797-805. (doi:10.1016/j.placenta.2011.06.025).
Hanson, Mark A. and Gluckman, Peter D. (2011) Developmental origins of health and disease: moving from biological concepts to interventions and policy. International Journal of Gynecology & Obstetrics, 115, supplement 1, s3-s5. (doi:10.1016/S0020-7292(11)60003-9). (PMID:22099437).
Burdge, Graham C., Hoile, Samuel P., Uller, Tobias, Thomas, Nicola A., Gluckman, Peter D., Hanson, Mark A. and Lillycrop, Karen A. (2011) Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition. PLoS ONE, 6, (11), e28282. (doi:10.1371/journal.pone.0028282). (PMID:22140567).
Hanson, Mark, Gluckman, Peter, Nutbeam, Don and Hearn, John (2011) Priority actions for the non-communicable disease crisis. The Lancet, 378, (9791), 566-567. (doi:10.1016/S0140-6736(11)61286-5). (PMID:21840453).
Slater-Jefferies, J.L., Lillycrop, K.A., Townsend, P.A., Torrens, C., Hoile, S.P., Hanson, M.A. and Burdge, G.C. (2011) Feeding a protein-restricted diet during pregnancy induces altered epigenetic regulation of peroxisomal proliferator-activated receptor-α in the heart of the offspring. Journal of Developmental Origins of Health and Disease, 2, (04), 250-255. (doi:10.1017/S2040174410000425).
Hanson, Mark A., Low, Felicia M. and Gluckman, Peter D. (2011) Epigenetic epidemiology: the rebirth of soft inheritance. Annals of Nutrition and Metabolism, 58, supplement 2, 8-15. (doi:10.1159/000328033).
Lewis, Rohan M., Hanson, Mark A. and Burdge, Graham C. (2011) Umbilical venous-arterial plasma composition differences suggest differential incorporation of fatty acids in NEFA and cholesteryl ester pools. British Journal of Nutrition, 106, (04), 463-467. (doi:10.1017/S0007114511000377). (PMID:21521544).
Hoile, Samuel P., Lillycrop, Karen A., Thomas, Nicola A., Hanson, Mark A. and Burdge, Graham C. (2011) Dietary protein restriction during F(0) pregnancy in rats induces transgenerational changes in the hepatic transcriptome in female offspring. PLoS ONE, 6, (7), e21668-[14pp]. (doi:10.1371/journal.pone.0021668). (PMID:21750721).
Hanson, Mark, Godfrey, Keith M., Lillycrop, Karen A., Burdge, Graham C. and Gluckman, Peter D. (2011) Deveopmental plasticity and development origns of non-communicable disease: Theorectical considerations and epigenetic mechanisms. Progress in Biophysics and Molecular Biology, 106, (1), 272-280. (doi:10.1016/j.pbiomolbio.2010.12.008 ). (PMID:21219925 ).
Godfrey, Keith M., Lillycrop, Karen A., Burdge, Graham C., Gluckman, Peter D. and Hanson, Mark A. (2011) Developmental plasticity and developmental origins of non-communicable disease: theoretical considerations and epigenetic mechanisms. Progress in Biophysics and Molecular Biology, 106, (1), 272-280. (doi:10.1016/j.pbiomolbio.2010.12.008).
Low, F.M., Gluckman, Peter D. and Hanson, Mark A. (2011) Developmental plasticity and epigenetic mechanisms underpinning metabolic and cardiovascular diseases. Epigenomics, 3, (3), 279-294. (doi:10.2217/epi.11.17).
Low, Felicia M., Gluckman, Peter D. and Hanson, Mark A. (2011) Development plasticity and epigenetic mechanisms underpinning meteabolic and cardiovascular diseases. Epigenomics, 3, (3), 279-294. (doi:10.2217/epi.11.17). (PMID:22122338).
Godfrey, Keith M., Inskip, Hazel M. and Hanson, Mark A. (2011) The long-term effects of prenatal development on growth and metabolism. Seminars in Reproductive Medicine, 29, (3), 257-265. (doi:10.1055/s-0031-1275518). (PMID:21769765).
Kessler, Jörg, Rasmussen , Svein, Godfrey, Keith M., Hanson, Mark A. and Kiserud, Torvid (2011) Venous liver blood flow and regulation of human fetal growth: evidence from macrosomic fetuses. American Journal of Obstetrics and Gynecology, 204, (5), 429-437. (doi:10.1016/j.ajog.2010.12.038). (PMID:21354546).
Godfrey, Keith M., Sheppard, Alan, Gluckman, Peter D., Lillycrop, Karen A., Burdge, Graham C., McClean, Cameron, Rodford, Joanne, Slater-Jefferies, Joanne L., Garratt, Emma, Crozier, Sarah R., Emerald, B. Starling, Gale, Catharine R., Inskip, Hazel M., Cooper, Cyrus and Hanson, Mark A. (2011) Epigenetic gene promoter methylation at birth is associated with childrens later adiposity. Diabetes, 60, (5), 1528-1534. (doi:10.2337/db10-0979). (PMID:21471513).
Godfrey, Keith M., Inskip, Hazel M. and Hanson, Mark A. (2011) The long-term effects of prenatal development on growth and metabolism. Seminars in Reproductive Medicine, 29, (3), 257-265. (doi:10.1055/s-0031-1275518). (PMID:21769765).
Musha, Yuka, Itoh, Shigeru, Miyakawa, Miho, Ohtsuji, Mareki, Hanson, Mark A., Kinoshita, Katsuyuki and Takeda, Satoru (2011) Vascular, renal and placental effects on pregnant offspring of protein-restricted rat dams. Journal of Obstetrics and Gynaecology Research, 37, (4), 343-351. (doi:10.1111/j.1447-0756.2010.01351.x). (PMID:21272146).
Gluckman, Peter D., Hanson, Mark A. and Low, Felicia M. (2011) The role of developmental plasticity and epigenetics in human health. Birth Defects Research Part C: Embryo Today: Reviews, 93, (1), 12-18. (doi:10.1002/bdrc.20198). (PMID:21425438).
Gluckman, Peter D., Low, Felicia M., Buklijas, Tatjana, Hanson, Mark A. and Beedle, Alan S. (2011) How evolutionary principles improve the understanding of human health and disease. [in special issue: In the light of evolution: interdisciplinary challenges in food, health, and the environment] Evolutionary Applications, 4, (2), 249-263. (doi:10.1111/j.1752-4571.2010.00164.x).
Cleal, J.K., Glazier, J., Ntani, G., Crozier, S.R., Day, P.E., Harvey, N.C., Robinson, S.M., Cooper, C., Godfrey, Keith M., Hanson, Mark A. and Lewis, R.M. (2011) Facilitated transporters mediate net efflux of animo acids to the fetus across the basal membrane of the placental syncytiotrophoblast. The Journal of Physiology, 589, (4), 987-997. (doi:10.1113/jphysiol.2010.198549).
Cagampang, F., Poore, K.R. and Hanson, Mark A. (2011) Developmental origins of the metabolic syndrome: body clocks and stress responses. Brain, Behavior, and Immunity, 25, (2), 214-220. (doi:10.1016/j.bbi.2010.09.005). (PMID:20851177).
Cleal, J. K., Glazier, J. D., Ntani, G., Crozier, S. R., Day, P. E., Harvey, N. C., Robinson, S. M., Cooper, C., Godfrey, K. M., Hanson, M. A. and Lewis, R. M. (2011) Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblast. The Journal of Physiology, 589, (4), 987-997. (doi:10.1113/jphysiol.2010.198549). (PMID:21224231).
Gluckman, Peter D., Hanson, Mark A., Zimmet, P. and Forrester, T.E. (2011) Losing the war against obesity: the need for a developmental perspective. Science Translational Medicine, 3, (93), 1-4. (.1126/scitranslmed.3002554 ).
Godfrey, Keith M., Inskip, Hazel M. and Hanson, Mark A. (2011) The long term effects of prenatal development on growth and metabolism. Seminars in Reproductive Medicine, 29, (3), 257-265. (doi:10.1055/s-0031-1275518).
Asopa, S., Cagampang, F.R., Anthony, F.W., Lanham, S.A., Schneider, J., Ohri, Sunil K. and Hanson, Mark A. (2010) Effect of a low-protein diet during pregnancy on expression of genes involved in cardiac hypertrophy in fetal and adult mouse offspring. Journal of Developmental Origins of Health and Disease, 1, (6), 371-375. (doi:10.1017/S2040174410000541).
Slater-Jefferies, Joanne L., Hoile, Samuel P., Lillycrop, Karen A., Townsend, Paul A., Hanson, Mark A. and Burdge, Graham C. (2010) Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart. Prostaglandins, Leukotrienes and Essential Fatty Acids, 83, (4-6), 219-223. (doi:10.1016/j.plefa.2010.07.006). (PMID:20719489).
Lanham, S.A., Roberts, C., Hollingsworth, T., Sreekumar, R., Elahi, M., Cagampang, F.R., Hanson, Mark A. and Oreffo, Richard O.C. (2010) Maternal high fat diet: effects on offspring bone structure. Osteoporosis International, 21, (10), 1703-1714. (doi:10.1007/s00198-009-1118-4). (PMID:19936867).
Poore, K.R., Boullin, J.P., Cleal, J.K., Newman, J.P., Noakes, D.E., Hanson, M.A. and Green, L.R. (2010) Sex- and age-specific effects of nutrition in early gestation and early postnatal life on hypothalamo-pituitary-adrenal axis and sympathoadrenal function in adult sheep. Journal of Physiology, 588, (12), 2219-2237. (doi:10.1113/jphysiol.2010.187682). (PMID:20421287).
Cleal, J.K., Day, P.L., Hanson, M.A. and Lewis, R.M. (2010) Sex differences in the mRNA levels of housekeeping genes in human placenta. Placenta, 31, (6), 556-557. (doi:10.1016/j.placenta.2010.03.006). (PMID:20398937).
Lewis, R.M., Greenwood, S.L., Cleal, J.K., Crozier, S.R., Verrall, L., Inskip, H.M., Cameron, I.T., Cooper, C, Sibley, C.P., Hanson, M.A. and Godfrey, K.M. (2010) Maternal muscle mass may influence system A activity in human placenta. Placenta, 31, (5) (doi:10.1016/j.placenta.2010.02.001).
Cleal, J.K., Thomas, M., Hanson, M.A., Paterson-Brown, S., Gardiner, H.M. and Green, L.R. (2010) Non-invasive fetal electrocardiography following intermittent umbilical cord occlusion in the preterm ovine fetus. BJOG, 117, (4), 438-444. (doi:10.1111/j.1471-0528.2009.02471.x).
Cleal, J.K., Thomas, M., Hanson, M.A., Paterson-Brown, S., Gardiner, H.M. and Green, L.R. (2010) Noninvasive fetal electrocardiography following intermittent umbilical cord occlusion in the preterm ovine fetus. BJOG: British Journal of Obstetrics and Gynaecology, 117, (4), 438-444. (doi:10.1111/j.1471-0528.2009.02471.x).
Bruce, KD and Hanson, Mark A. (2010) The developmental origins, mechanisms, and implications of metabolic syndrome. Journal of Nutrition, 140, (3), 648-652. (doi:10.3945/​jn.109.111179). (PMID:20107145).
Gluckman, Peter D., Hanson, Mark A. and Mitchell, Murray D. (2010) Developmental origins of health and disease: reducing the burden of chronic disease in the next generation. Genome Medicine, 2, (14), 14-14. (doi:10.1186/gm135).
Watkins, Adam J., Lucas, Emma S., Torrens, Christopher, Cleal, Jane K., Green, Lauren, Osmond, Clive, Eckert, Judith J., Gray, William P., Hanson, M.A. and Fleming, Tom P. (2010) Maternal low-protein diet during mouse pre-implantation development induces vascular dysfunction and altered renin-angiotensin-system homeostasis in the offspring. British Journal of Nutrition, 103, (12), 1762-1770. (doi:10.1017/S0007114509993783). (PMID:20128937).
Gluckman, P. D., Hanson, M. A. and Buklijas, T. (2010) a conceptual framework for the developmental origins of health and disease. Journal of Developmental Origins of Health and Disease, 1, (1), 6-18. (doi:10.1017/S2040174409990171).
Bruce, K.D. and Hanson, Mark A. (2010) the Developmental Origins, mechanisms and implications of metaboli syndrome. Journal of Nutrition, 140, (3), 648-652.
Gluckman, Peter D. and Hanson, Mark A. (2010) The plastic human. Infant and Child Development, 19, 21-26. (doi:10.1002/icd.650 ).
Cleal, J.K., Bagby, S, Hanson, Mark A., Gardiner, H. and Green, L (2010) The effect of late gestation fetal hypoglycaemia on cardiovascular and endocrine function in sheep. Journal of Developmental Origins of Health and Disease, 1, (1), 42-49. (doi:10.1017/S204017440999016X).
Godfrey, Keith M., Gluckman, Peter D. and Hanson, Mark A. (2010) Developmental origins of metabolic disease: life course and intergenerational perspectives. Trends in Endocrinology and Metabolism, 1-7. (doi:10.1016/j.tem.2009.12.008).
Poston, L., Harthoorn, L., Van der Beek, E. and Hanson, Mark A. (2010) Obesity in pregnancy; implications for the mother and lifelong health of the child. A consensus statement. Pediatric Research, 69, (2), 175-180. (doi:10.1203/PDR.0b013e3182055ede).
Bruce, K.D., Cagampang, F.R., Argenton, M., Zhang, J., Ethirajan, P., Burdge, Graham C., Bateman, A.C., Clough, G.F., Poston, L., Hanson, M.A., McConnell, J. and Byrne, Christopher D. (2009) Maternal high fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. Hepatology, 50, (6), 1796-1808. (doi:10.1002/hep.23205).
Bruce, Kimberley D., Cagampang, Felino R., Argenton, Marco, Zhang, Junlong, Ethirajan, Priya L., Burdge, Graham C., Bateman, Adrian C., Clough, Geraldine F., Poston, Lucilla, Hanson, Mark A., McConnell, Josie M. and Byrne, Christopher D. (2009) Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. Hepatology, 50, (6), 1796-1808. (doi:10.1002/hep.23205).
Lanham, S.A., Roberts, C., Hollingworth, T., Sreekumar, R., Elahi, M.M., Cagampang, F.R., Hanson, M.A. and Oreffo, R.O.C. (2009) Maternal high-fat diet: effects on offspring bone structure. Osteoporosis International, 1-12. (doi:10.1007/s00198-009-1118-4).
Cleal, J.K., Day, P.I., Hanson, M.A. and Lewis, R.M. (2009) Measurement of housekeeping genes in human placenta. Placenta, 30, (11), 1002-1003. (doi:10.1016/j.placenta.2009.09.002).
Zhang, Junlong, Zhang, Fang, Didelot, Xavier, Bruce, Kimberley D., Cagampang, Felino R., Vatish, Manu, Hanson, Mark, Lehnert, Hedrik, Ceriello, Antonio and Byrne, Christopher D. (2009) Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring. BMC Genomics, 10, (478), 1-12. (doi:10.1186/1471-2164-10-478).
Godfrey, Keith M., Gluckman, Peter D., Lillycrop, Karen A., Burdge, Graham C., Rodford, J.L., Slater-Jefferies, J.L., McLean, C, Sheppard, A, Crozier, S.R., Emerald, B.S., Gale, Catharine R., Cooper, C. and Hanson, Mark A. (2009) Abstract. Epigenetic marks at birth predict childhood body composition at age 9 years. Journal of Developmental Origins of Health and Disease, 1, supplement Programme and Abstracts of the 6th World Congress on Developmental Origins of Heath and Disease, 19-22 November 2009, Santiago, Chile, S44-S44. (doi:10.1017/S2040174409990018 ).
Torrens, Christopher, Snelling, Tristram H., Chau, Ryan, Shanmuganathan, Meena, Cleal, Jane K., Poore, Kirsten R., Noakes, David E., Poston, Lucilla, Hanson, Mark A. and Green, Lucy R. (2009) Effects of pre- and periconceptional undernutrition on arterial function in adult female sheep are vascular bed dependent. Experimental Physiology, 94, (9), 1024-1033. (doi:10.1113/expphysiol.2009.047340).
Gluckman, Peter D., Hanson, Mark A., Buklijas, Tatjana, Low, Felicia M. and Beedle, Alan S. (2009) Epigenetic mechanisms that underpin metabolic and cardiovascular diseases. Nature Reviews Endocrinology, 5, (7), 401-408. (doi:10.1038/nrendo.2009.102).
Burdge, Graham C., Lillycrop, Karen A., Phillips, Emma S., Slater-Jefferies, Joanne L., Jackson, Alan A. and Hanson, Mark A. (2009) Folic acid supplementation during the juvenile-pubertal period in rats modifies the phenotype and epigenotype induced by prenatal nutrition. Journal of Nutrition, 139, (6), 1054-1060. (doi:10.3945/jn.109.104653).
Gluckman, Peter D., Hanson, Mark A., Bateson, Patrick, Beedle, Alan S., Law, .Catherine Mm, Bhutta, Zulfiqar A., Anokhin, Konstantin V., Bougneres, Pierre, Chandak, Giriraj Ratan, Dasgupta, Partha, Davey Smith, George, Ellison, Peter T., Forrester, Terrence E., Gilbert, Scott F., Jablonka, Eva, Kaplan, Hillard, Prentice, Aandrew M., Simpson, Stephen J., Uauy, Ricardo and West-Eberhard, Mary Jane (2009) Towards a new developmental synthesis: adaptive developmental plasticity and human disease. Lancet, 373, (9675), 1654-1657. (doi:10.1016/S0140-6736(09)60234-8). (PMID:19427960).
Torrens, Christopher, Kelsall, Christopher J., Hopkins, Laura A., Anthony, Frederick W., Curzen, Nick P. and Hanson, Mark A. (2009) Atorvastatin restores endothelial function in offspring of protein restricted rats in a cholesterol-independent manner. Hypertension, 53, (4), 661-667. (doi:10.1161/HYPERTENSIONAHA.108.122820).
Burrage, Deborah M., Braddick, Lucy, Cleal, Jane K., Costello, Paula, Noakes, David E., Hanson, Mark A. and Green, Lucy R. (2009) The late gestation fetal cardiovascular response to hypoglycaemia is modified by prior peri-implantation undernutrition in sheep. Journal of Physiology, 587, (3), 611-624. (doi:10.1113/jphysiol.2008.165944).
Elahi, Maqsood M., Cagampang, Felino R., Mukhtar, Dhea, Anthony, Frederick W., Ohri, Sunil K. and Hanson, Mark A. (2009) Long-term maternal high fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice. British Journal of Nutrition, 102, (4), 514-519. (doi:10.1017/S000711450820749X).
Sellayah, D., Anthony, F.W., Watkins, A.J., Fleming, T.P., Hanson, M.A. and Cagampang, F.R. (2009) A mismatched pre- and post-weaning diet has window of exposure- and sex-specific effects on energy homeostasis; adiposity and cardiovascular function in mice. Proceedings of the Physiological Society, 12, (C10 and PC20)
Brand, A.P., Greenwood, S.L., Bennett, E.J., Godfrey, K.M., Sibley, C.P., Hanson, M.A. and Lewis, R.M. (2009) Comparison of L-serine uptake by human placental microvillous membrane vesicles and placental villous fragments. Placenta, 31, (5), 456-459. (doi:10.1016/j.placenta.2010.01.016).
Elahi, Maqsood M., Cagampang, Felino R., Mukhtar, Dhea, Anthony, Frederick W., Ohri, Sunil K. and Hanson, Mark A. (2009) Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice. British Journal of Nutrition, 102, 514-519. (doi:10.1017/S000711450820749X).
Ebbing, Cathrine, Rasmussen, Svein, Godfrey, Keith M., Hanson, Mark A. and Kiserud, Torvid (2009) Redistribution pattern of fetal liver circulation in intrauterine growth restriction. Acta Obstetricia et Gynecologica Scandinavica, 88, (10), 1118-1123. (doi:10.1080/00016340903214924 ).
Gluckman, P.D. and Hanson, M.A. (2008) Developmental and epigenetic pathways to obesity: an evolutionary-developmental perspective. International Journal of Obesity, 32, (Supp.7), S62-S71. (doi:10.1038/ijo.2008.240).
Phillips, D.I.W., Syddall, Holly E., Cooper, Cyrus and Hanson, Mark A. (2008) Association of adult height and leg length with fasting plasma cortisol concentrations: evidence for an effect of normal variation in adrenocortical activity on growth. American Journal of Human Biology, 20, (6), 712-715. (doi:10.1002/ajhb.20803).
Sellayah, D., Sek, K., Anthony, F. W., Watkins, A. J., Osmond, C., Fleming, T. P., Hanson, M. A. and Cagampang, F. R. (2008) Appetite regulatory mechanisms and food intake in mice are sensitive to mismatch in diets between pregnancy and postnatal periods. Brain Research, 1237, 146-152. (doi:10.1016/j.brainres.2008.07.126).
Ethirajan, P., Torrens, C., Bruce, K., Cagampang, F., Hanson, M.A., Byrne, C.D. and Clough, G.F. (2008) A potential mechanism for impaired vasorelaxation in a dietary model of metabolic syndrome. Journal of Vascular Research, 45, (Supplement 2), 167. (doi:10.1159/000144991).
Lillycrop, Karen A., Phillips, Emma S., Torrens, Christopher, Hanson, Mark A., Jackson, Alan A. and Burdge, Graham C. (2008) Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the promotor of the offspring. British Journal of Nutrition, 100, (2), 278-282. (doi:10.1017/S0007114507894438). (PMID:18186951).
Rodford, J.L., Torrens, Christopher, Siow, R., Mann, G., Hanson, Mark A. and Clough, G.F. (2008) Endothelial dysfunction and antioxidant protection in an animal model of the developmental origins of cardiovascular disease. Journal of Physiology, 586, (19), 4709-4720. (doi:10.1113/jphysiol.2008.156976). (PMID:18669533).
Costello, Paula M., Rowlerson, Anthea, Astaman, Nur Aida, Anthony, Fred Erick W., Sayer, Avan Aihie, Cooper, Cyrus, Hanson, Mark A.. and Green, Lucy R. (2008) Peri-implantation and late gestation maternal undernutrition differentially affect fetal sheep skeletal muscle development. Journal of Physiology, 586, (9), 2371-2379. (doi:10.1113/jphysiol.2008.150987).
Boullin, J.P., Poore, K.R., Cleal, J.K., Newman, J.P., Noakes, D., Hanson, M.A. and Green, L.R. (2008) Early-life undernutrition induces sex-specific effects on the sympatho-adrenal response to stress in sheep. Proceedings of the Nutrition Society, 67, (OCE9), E429-E429. (doi:10.1017/S0029665108009658).
Gluckman, Peter D., Hanson, Mark A., Beedle, Alan S. and Spencer, Hamish G. (2008) Predictive adaptive responses in perspective. Trends in Endocrinology & Metabolism, 19, (4), 109-110. (doi:10.1016/j.tem.2008.02.002). (PMID:18328727).
Watkins, Adam J., Wilkins, Adrian, Cunningham, Colm, Perry, V.Hugh, Seet, Meei J., Osmond, Clive, Eckert, Judith J., Torrens, Christopher, Cagampang, Felino R.A., Cleal, Jane, Gray, William P., Hanson, Mark A. and Fleming, Tom P. (2008) Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring. Journal of Physiology, 586, (8), 2231-2244. (doi:10.1113/jphysiol.2007.149229 ).
Burdge, Graham C., Lillycrop, Karen A., Jackson, Alan A., Gluckman, Peter D. and Hanson, Mark A. (2008) The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumption. British Journal of Nutrition, 99, (3), 540-549. (doi:10.1017/S0007114507815819).
Kessler, Jorg, Rasmussen, Svein, Godfrey, Keith, Hanson, Mark and Kiserud, Torvid (2008) Longitudinal study of umbilical and portal venous blood flow to the fetal liver: low pregnancy weight gain is associated with preferential supply to the fetal left liver lobe. Pediatric Research, 63, (3), 315-320.
Watkins, Adam J., Ursell, Elizabeth, Panton, Rose, Papenbrock, Thomas, Hollis, Lisa, Cunningham, Colm, Wilkins, Adrian, Perry, V.Hugh, Sheth, Bhavwanti, Kwong, Wing Yee, Eckert, Judith Joana, Wild, Arthur E., Hanson, Mark A., Osmond, Clive and Fleming, Tom P. (2008) Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease. Biology of Reproduction, 78, (2), 299-306. (doi:10.1095/biolreprod.107.064220). (PMID:17989357).
Ebbing, Cathrine, Rasmmussen, Svein, Godfrey, Keith M., Hanson, Mark A. and Kiserud, Torvid (2008) Hepatic artery hemodynamics suggest operation of a buffer response in the human fetus. Reproductive Sciences, 15, (2), 166-178. (doi:10.1177/1933719107310307).
Pike, K.C., Hanson, M.A. and Godfrey, K.M. (2008) Developmental mismatch: consequences for later cardiorespiratory health. British Journal of Obstetrics and Gynaecology: An International Journal of Obstetrics and Gynaecology, 115, (2), 149-157. (doi:10.1111/j.1471-0528.2007.01603.x).
Burdge, G.C., Slater-Jefferies, J.L., Grant, R.A., Chung, W.S., West, A.L., Lillycrop, K.A., Hanson, M.A. and Calder, P.C. (2008) Sex, but not maternal protein or folic acid intake, determines the fatty acid composition of hepatic phospholipids, but not of triacylglycerol, in adult rats. Prostaglandins, Leukotrienes and Essential Fatty Acids, 78, (1), 73-79. (doi:10.1016/j.plefa.2007.10.028).
Ebbing, C., Rasmussen, S., Godfrey, K. M., Hanson, M. A. and Kiserud, T. (2008) Fetal celiac and splenic artery flow velocity and pulsatility index: longitudinal reference ranges and evidence for vasodilation at a low portocaval pressure gradient. Ultrasound in Obstetrics and Gynecology, 32, (5), 663-672. (doi:10.1002/uog.6145).
Burrage, D., Green, L.R., Moss, T.J., Sloboda, D.M., Nitsos, I., Newnham, J.P. and Hanson, M.A. (2008) The carotid bodies influence growth responses to moderate maternal undernutrition in late-gestation fetal sheep. BJOG: An International Journal of Obstetrics & Gynaecology, 115, (2), 261-268. (doi:10.1111/j.1471-0528.2007.01607.x).
Sellayah, Dyan, Sek, Kathleen, Anthony, Frederick W., Hanson, Mark A. and Cagampang, Felino R. (2008) Sensitivity of housekeeping genes in the hypothalamus to mismatch in diets between pre- and postnatal periods in mice. Neuroscience Letters, 447, (1), 54-57. (doi:10.1016/j.neulet.2008.09.060).
Painter, R.C., Osmond, C., Gluckman, P., Hanson, M., Phillips, D.I.W. and Roseboom, T.J. (2008) Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life. BJOG: An International Journal of Obstetrics & Gynaecology, 115, (10), 1243-1249. (doi:10.1111/j.1471-0528.2008.01822.x).
Bruce, K.D., Argenton, M., Cagampang, F., McConnell, J., Poston, L., Hanson, M. and Byrne, C. (2008) Exposure to a high fat, and low carbohydrate diet in utero and during lactation modulates hepatic mitochondrial complex activity. Proceedings of the Physiological Society, 11, (C108)
Herrera, Emilio A., Reyes, Roberto V., Giussani, Dino A., Riquelme, Raquel A., Sanhueza, Emilia M., Ebensperger, German, Casnello, Paola, Mendez, Natalia, Ebensperger, Renato, Sepulveda-Kattan, Esteban, Pulgar, Victor M., Cabello, Gertrudis, Blanco, Carlos E., Hanson, Mark A., Parer, Julian T. and Llanos, Anibal J. (2008) Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano. Cardiovascular Research, 77, (1), 197-201. (doi:10.1093/cvr/cvm013).
Gluckman, P.D., Hanson, M.A., Beedle, A.S. and Raubenheimer, D. (2008) Fetal and neonatal pathways to obesity. Frontiers of Hormone Research, 36, 61-72. (doi:10.1159/000115337). (PMID:18230894).
Torrens, Christopher, Hanson, Mark A., Gluckman, Peter D. and Vickers, Mark H. (2008) Maternal undernutrition leads to endothelial dysfunction in adult male rat offspring independent of postnatal diet. British Journal Of Nutrition, 101, (1), 27-33. (doi:10.1017/S0007114508988760). (PMID:18492297).
Johnstone, J.F., Crozier, S. R., Lewis, R. M., Hanson, M.A., Challis, J.R.G., Inskip, H. and Godfrey, K.M. (2008) Relationships between maternal body composition prior to conception and duration of gestation. Reproductive Sciences, 15, (Supplement 1), p.585.
Cooper, Cyrus, Harvey, Nicholas, Javaid, Kassim, Hanson, Mark and Dennison, Elaine (2008) Growth and bone development. Nestlé Nutrition Workshop Series Paediatric Programme, 61, 53-68. (doi:10.1159/000113170). (PMID:18196944).
Slater-Jeffries, Joanne L., Phillips, Emma, Lillycrop, Karen, Legg, Gemma, Townsend, Paul, Hanson, Mark and Burdge, Graham (2008) Maternal diet alters expression of specific PPAR alpha transcripts in the hearts of their female offspring. Proceedings of the Nutrition Society, 67, (E355) (doi:10.1017/S0029665108000293).
Hanson, Mark A. and Godfrey, Keith M. (2008) Commentary: maternal constraint is a pre-eminent regulator of fetal growth. International Journal of Epidemiology, 37, (2), 252-254. (doi:10.1093/ije/dyn015).
Johnsen, S.L., Wilsgaard, T., Rasmussen, S., Hanson, M.A., Godfrey, K.M. and Kiserud, T. (2008) Fetal size in the second trimester is associated with the duration of pregnancy, small fetuses having longer pregnancies. BMC Pregnancy & Childbirth, 8, (1) (doi:10.1186/1471-2393-8-25).
Gluckman, P.D., Beedle, A.S., Hanson, M.A. and Yap, E.P. (2008) Developmental perspectives on individual variation: implications for understanding nutritional needs. Nestlé Nutrition workshop series. Paediatric programme, 62, 1-9. (doi:10.1159/000146243).
Rodford, Joanne L., Torrens, Christopher, Siow, Richard C.M., Mann, Giovanni E., Hanson, Mark A. and Clough, Geraldine F. (2008) Endothelial dysfunction and reduced antioxidant protection in an animal model of the developmental origins of cardiovascular disease. The Journal of Physiology, 586, (19), 4709-4720. (doi:10.1113/jphysiol.2008.156976).
Costello, P.M., Cripps, R.L., Bearpark, N., Rowlerson, A., Hollis, L., Patel, H., Aihie Sayer, A., Hanson, M.A., Ozanne, S.E. and Green, L.R. (2008) Effect of maternal diet and body condition on glucose metabolism and skeletal muscle structure in mature adult sheep offspring. Procedings of the Physiological Society, 11, (C32)
Cripps, R.L., Green, L.R., Thompson, J., Martin-Gronert, M.S., Monk, M., Sheldon, I.M., Hanson, M.A., Hales, C.N. and Ozanne, S.E. (2008) The effect of maternal body condition score before and during pregnancy on the glucose tolerance of adult sheep offspring. Reproductive Sciences, 15, (5), 448-456. (doi:10.1177/1933719107312161).
Elahi, Maqsood M., Cagampang, Felino R., Anthony, Frederick W., Curzen, Nick, Ohri, Sunil K. and Hanson, Mark A. (2008) Statin treatment in hypercholesterolemic pregnant mice reduces cardiovascular risk factors in their offspring. Hypertension, 51, (4), 939-944. (doi:10.1161/HYPERTENSIONAHA.107.100982).
Gluckman, Peter D., Hanson, Mark A., Cooper, Cyrus and Thornburg, Kent L. (2008) Effect of in utero and early-life conditions on adult health and disease. New England Journal of Medicine, 359, (1), 61-73.
Grandjean, P., Bellinger, D., Bergman, A., Cordier, S., Vey-Smith, G., Eskenazi, B., Gee, D., Gray, K., Hanson, M., Van den Hazel, P., Heindel, J.J., Heinzow, B., Hertz-Picciotto, I., Hu, H., Huang, T.T., Jensen, T.K., Landrigan, P.J., McMillen, I.C., Murata, K., Ritz, B., Schoeters, G., Skakkebaek, N.E., Skerfving, S. and Weihe, P. (2008) The faroes statement: human health effects of developmental exposure to chemicals in our environment. Basic & Clinical Pharmacology & Toxicology, 102, (2), 73-75. (doi:10.1111/j.1742-7843.2007.00114.x).
Hanson, M.A. and Gluckman, P.D. (2008) Developmental origins of health and disease: new insights. Basic & Clinical Pharmacology & Toxicology, 102, (2), 90-93. (doi:10.1111/j.1742-7843.2007.00186.x).
Bertram, Caroline, Khan, Omar, Ohri, Sunil, Phillips, David I., Matthews, Stephen G. and Hanson, Mark A. (2008) Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function. Journal of Physiology, 586, (8), 2217-2229. (doi:10.1113/jphysiol.2007.147967).
Cleal, Jane K., Poore, Kirsten R., Newman, James P., Noakes, David E., Hanson, Mark A. and Green, Lucy R. (2007) The effect of maternal undernutrition in early gestation on gestation length and fetal and postnatal growth in sheep. Pediatric Research, 62, (4), 422-427.
Llanos, Aníbal J., Riquelme, Raquel A., Herrera, Emilio A., Ebensperger, Germán, Krause, Bernardo, Reyes, Roberto V., Sanhueza, Emilia M.E. M., Pulgar, Víctor M., Behn, Claus, Cabello, Gertrudis, Parer, Julian T., Giussani, Dino A., Blanco, Carlos E. and Hanson, Mark A. (2007) Evolving in thin air: lessons from the llama fetus in the altiplano. Respiratory Physiology & Neurobiology, 158, (2-3), 298-306. (doi:10.1016/j.resp.2007.04.012).
Johnstone, J.F., Inskip, H., Crozier, S., Lewis, R.M., Hanson, M., Challis, J.R.G. and Godfrey, K.M. (2007) Maternal parity and stress prior to conception: relationships with preterm delivery. Early Human Development, 83, (Supplement 1), pp.S172. (doi:10.1016/S0378-3782(07)70484-X).
Phillips, E S., Lillycrop, K.A., Vickers, M., Gluckman, P.D., Hanson, M.A. and Burdge, G.C. (2007) Neonatal leptin exposure alters PPAR alpha promoter use in adipose tissue. Early Human Development, 83, (Supplement 1), pp.S98. (doi:10.1016/S0378-3782(07)70228-1).
Torrens, C., Anthony, F.W., Kelsall, C.J., Curzen, N. and Hanson, M.A. (2007) Statin treatment corrects endothelial dysfunction but not markers of inflammation in offspring of protein restricted dams. Early Human Development, 83, (Supplement 1), p.S60. (doi:10.1016/S0378-3782(07)70099-3).
Watkins, A.J., Wilkins, A., Cunningham, C., Papenbrock, T., Warner, C.M., Torrens, C., Hanson, M.A. and Fleming, T.P. (2007) Cardiovascular health is compromised in mouse offspring following environmental or genetic manipulations on the preimplantation embryo. Early Human Development, 83, (Supplement 1), S146-S147. (doi:10.1016/S0378-3782(07)70396-1).
Hanson, M. (2007) Mechanistic aspects of intergenerational influences on risk of disease. Early Human Development, 83, (Supplement 1), S33-S34. (doi:10.1016/S0378-3782(07)70007-5).
Patel, A., Anthony, F.W., Cagampang, F., Ohri, S.K. and Hanson, M.A. (2007) Brain natriuretic peptide expression is significantly elevated during rapid myocardial regeneration in MRL mice undergoing cryo-injury to the heart. Early Human Development, 83, (Supplement 1), p.S93.
Costello, P.M., Astaman, N.A., Anthony, F.W., Sayer, A. Aihie, Cooper, C., Hanson, M.A. and Green, L.R. (2007) Peri-implantation and late gestation maternal undernutrition differentially alter pathways of insulin and IGF-1 action in fetal sheep skeletal muscle. Early Human Development, 83, (Supplement 1), pp.S135. (doi:10.1016/S0378-3782(07)70356-0).
Elahi, M., Mukhtar, D., Kahraman, N., Cagampang, F., Ohri, S. and Hanson, M. (2007) Statin therapy improves blood presssure and lipid profiles in hypercholesterolemic mothers but not C-reactive proteins levels or endothelian progenitor cell expression. Early Human Development, 83, (Supplement 1), S60-S61. (doi:10.1016/S0378-3782(07)70099-3).
Cleal, J.K., Godfrey, K.M., Hanson, M.A. and Lewis, R.M. (2007) Characterisation of amino acid efflux across the human placental syncytiotrophoblast basal membrane. Early Human Development, 83, (Supplement 1), S143-S144. (doi:10.1016/S0378-3782(07)70386-9).
Hollingworth, T., Lanham, S.A., Roberts, C., Hanson, M., Elahi, M., Cagampang, F., Cooper, C. and Oreffo, R.O.C. (2007) Effects of maternal-dietary cholesterol on offspring bone development. Early Human Development, 83, (Supplement 1), S155-S156. (doi:10.1016/S0378-3782(07)70428-0).
Watkins, A.J., Wilkins, A., Cunningham, C., Torrens, C., Hanson, M.A. and Fleming, T.P. (2007) Maternal low protein diet during oocyte maturation causes increased systolic blood pressure and abnormal behaviour in the mouse. Early Human Development, 83, (Supplement 1), p.S50. (doi:10.1016/S0378-3782(07)70065-8).
Cagampang, F., Anthony, F. and Hanson, M. (2007) Developmental exposure to bishpenol-A leads to obesity and cardiovascular dysfunction in adult mouse offspring. Early Human Development, 83, (Supplement 1), S132-S133. (doi:10.1016/S0378-3782(07)70347-X).
Cleal, J.K., Hanson, M.A., Gardiner, H.M. and Green, L.R. (2007) The effect of acute maternal hypoglycaemia on fetal cardiovascular control. Early Human Development, 83, (supplement 1), p.S88. (doi:10.1016/S0378-3782(07)70191-3).
Burdge, G.C., Slater-Jefferies, J.L., Hanson, M.A. and Lillycrop, K.A. (2007) Differences in protein and folic acid intake in pregnant rats induce sex-specific changes to the epigenetic regulation of hepatic genes in the adult offspring. Early Human Development, 83, (Supplement 1), pp.S97. (doi:10.1016/S0378-3782(07)70222-0).
Asopa, S., Anthony, F.W., Cagampang, F.R.A., Terroni, P.L., Bhattacharya, S., Ohri, S.K. and Hanson, M.A. (2007) Impact on the developmental profile of the murine heart by maternal protein restriction during preganancy. Early Human Development, 83, (Supplement1), p.S87. (doi:10.1016/S0378-3782(07)70186-X).
Costello, P.M., Braddick, L., Burrage, D., Hanson, M.A. and Green, L.R. (2007) Circulating glucose affects vascular reactivity in late gestation sheep fetuses. Early Human Development, 82, (8), 518-519. (doi:10.1016/j.earlhumdev.2006.06.003).
Watkins, Adam, Torrens, Christopher, Cunningham, Colm, Wilkins, Adrian, Gray, Liam, Perry, Hugh, Hanson, Mark and Fleming, Tom (2007) Maternal low protein diet during oocyte maturation causes increased systolic blood pressure and abnormal behaviour in the mouse [In abstracts special issue]. Biology of Reproduction, 77, p.516.
Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., Burdge, Graham C. and Hanson, Mark A. (2007) Metabolic plasticity during mammalian development is directionally dependent on early nutritional status. Proceedings of the National Academy of Sciences of the United States of America, 104, (31), 12796-12800. (doi:10.1073/pnas.0705667104).
Herrera, Emilio A., Pulgar, Victor M., Riquelme, Raquel A., Sanhueza, Emilia M., Reyes, Roberto V., Ebensperger, German, Parer, Julian T., Valdez, Enrique A., Giussani, Dino A., Blanco, Carlos E., Hanson, Mark A. and Llanos, Anibal J. (2007) High-altitude chronic hypoxia during gestation and after birth modifies cardiovascular responses in newborn sheep. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 292, (6), R2234-R2240. (doi:10.1152/ajpregu.00909.2006).
Cleal, Jane K., Poore, Kirsten R., Boullin, Julian P., Khan, Omar, Chau, Ryan, Hambidge, Oliver, Torrens, Christopher, Newman, James P., Poston, Lucilla, Noakes, David E., Hanson, Mark A. and Green, Lucy R. (2007) Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood. Proceedings of the National Academy of Sciences of the United States of America, 104, (22), 9529-9533. (doi:10.1073/pnas.0610373104).
Cleal, Jane K., Brownbill, Paul, Godfrey, Keith M., Jackson, John M., Jackson, Alan A., Sibley, Colin P., Hanson, Mark A. and Lewis, Rohan M. (2007) Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro. The Journal of Physiology, 582, (2), 871-882. (doi:10.1113/jphysiol.2007.130690).
Hanson, M. and Gluckman, P.D. (2007) Animal models of the metabolic syndrome: cardiovascular effects (In special issue: 47th Annual Meeting Issue). Birth Defects Research Part A: Clinical and Molecular Teratology, 79, (5), pp.387. (doi:10.1002/bdra.20373).
Lewis, R.M., Glazier, J., Greenwood, S.L., Bennett, E.J., Godfrey, K.M., Jackson, A.A., Sibley, C.P., Cameron, I.T. and Hanson, M.A. (2007) L-serine uptake by human placental microvillous membrane vesicles. Placenta, 28, (5-6), 445-452. (doi:10.1016/j.placenta.2006.06.014).
Gluckman, P.D. and Hanson, M.A. (2007) Developmental plasticity and human disease: research directions. Journal of Internal Medicine, 261, (5), 461-471. (doi:10.1111/j.1365-2796.2007.01802.x).
Martin, R., Harvey, N.C., Crozier, S.R., Javaid, M.K., Dennison, E.M., Inskip, H.M., Hanson, M., Godfrey, K.M., Cooper, C. and Lewis, R.M. SWS Study Group (2007) Placental calcium transporter (PMCA3) gene expression predicts intrauterine bone mineral accrual. Bone, 40, (5), 1203-1208. (doi:10.1016/j.bone.2006.12.060).
Gillman, Matthew W., Barker, David, Bier, Dennis, Cagampang, Felino, Challis, John, Fall, Caroline, Godfrey, Keith, Gluckman, Peter, Hanson, Mark, Kuh, Diana, Nathanielsz, Peter, Nestel, Penelope and Thornburg, Kent L. (2007) Meeting report on the 3rd International Congress on Developmental Origins of Health and Disease (DOHaD). Pediatric Research, 61, (5, Part 1), 625-629.
Godfrey, Keith M., Lillycrop, Karen A., Burdge, Graham C., Gluckman, Peter D. and Hanson, Mark A. (2007) Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pediatric Research, 61, (5), part 2, 5R-10R.
Burdge, G.C., Hanson, M.A., Slater-Jefferies, J.L. and Lillycrop, K.A. (2007) Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life? British Journal of Nutrition, 97, (6), 1036-1046. (doi:10.1017/S0007114507682920).
Burdge, Graham C., Slater-Jefferies, Jo, Torrens, Christopher, Phillips, Emma S., Hanson, Mark A. and Lillycrop, Karen A. (2007) Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations. British Journal of Nutrition, 97, (3), 435-439. (doi:10.1017/S0007114507352392).
Gluckman, Peter D., Beedle, Alan S., Hanson, Mark A. and Vickers, Mark H. (2007) Leptin reversal of the metabolic phenotype: evidence for the role of developmental plasticity in the development of the metabolic syndrome. Hormone Research, 67, (Supplement 1), 115-120. (doi:10.1159/000097566).
Watkins, A.J., Torrens, C., Wilkins, A., Cunningham, C., Perry, H.V., Gray, L., Hanson, M.A. and Fleming, T.P. (2007) The influence of maternal diet on postnatal growth, development and physiology. Proceedings of Life Sciences
Poore, Kirsten R., Cleal, Jane K., Newman, James P., Boullin, Julian P., Noakes, David E., Hanson, Mark A. and Green, Lucy R. (2007) Nutritional challenges during development induce sex-specific changes in glucose homeostasis in the adult sheep. American Journal of Physiology: Endocrinology and Metabolism, 292, (1), E32-E39. (doi:10.1152/ajpendo.00253.2006).
Braddick, L., Burrage, D., Cleal, J., Noakes, D., Hanson, M.A. and Green, L.R. (2007) The effect of moderate early gestation undernutrition on kidney glomerular number in fetal sheep. Proceedings of the Physiological Society, 6, (PC3)
Gluckman, Peter D., Seng, Chong Y., Fukuoka, Hideoki, Beedle, Alan S. and Hanson, Mark A. (2007) Low birthweight and subsequent obesity in Japan. Lancet, 369, (9567), 1081-1082. (doi:10.1016/S0140-6736(07)60524-8).
Hollis, L., Anthony, F.W., Hanson, M.A. and Green, L.R. (2007) Hepatic glucocorticoid receptor expression in adult sheep following early gestational and / or postnatal undernutrition. Proceedings of the Physiological Society, 6, (PC4)
Hopkins, L.A., Rodford, J.L., Anthony, F.W., Curzen, N., Hanson, M.A. and Torrens, C. (2007) Statin treatment for endothelial dysfunction in thoracic aortae following maternal protein restriction in pregnancy. Proceedings of the Physiological Society, (PC386)
Gluckman, P.D., Hanson, M.A. and Beedle, A.S. (2007) Early life events and their consequences for later disease: a life history and evolutionary perspective. American Journal of Human Biology, 19, (1), 1-19. (doi:10.1002/ajhb.20590).
Costello, P., Rowlerson, A., Braddick, L., Burrage, D., Cooper, C., Ahie Sayer, A., Hanson, M.A. and Green, L.R. (2007) Fetal skeletal muscle capillary density is reduced by both early and late gestation maternal undernutrition in sheep. Proceedings of the Physiological Society, 6, PC2-PC2.
Gluckman, P.D., Hanson, M.A. and Beedle, A.S. (2007) Non-genomic transgenerational inheritance of disease risk. Bioessays, 29, (2), 145-154. (doi:10.1002/bies.20522).
Barker, David J.P., Bagby, Susan P. and Hanson, Mark A. (2006) Mechanisms of disease: in utero programming in the pathogenesis of hypertension. Nature Clinical Practice Nephrology, 2, (12), 700-707. (doi:10.1038/ncpneph0344).
Kessler, J., Rasmussen, S., Hanson, M. and Kiserud, T. (2006) Longitudinal reference ranges for ductus venosus flow velocities and waveform indices. Ultrasound in Obstetrics and Gynecology, 28, (7), 890-898. (doi:10.1002/uog.3857).
Cleal, J.K., Brownbill, P., Godfrey, K.M., Cameron, I.T., Sibley, C.P., Hanson, M.A. and Lewis, R.M. (2006) Placental materno-fetal transfer of serine by amino acid exchangers. Placenta, 27, (9-10), p.34. (doi:10.1016/j.placenta.2006.07.004).
Godfrey, K. M., Cameron, I. T. and Hanson, M. (2006) Long-term consequences of foetal restriction. Current Obstetrics & Gynaecology, 16, (5), 267-272. (doi:10.1016/j.curobgyn.2006.07.004).
Burdge, G.C., Slater-Jefferies, J.L., Torrens, C., Phillips, E.S., Hanson, M.A. and Lillycrop, K.A. (2006) Feeding a protein-restricted diet during pregnancy in the rat induces altered gene promoter methylation in the liver of the F1 and F2 offspring [In special abstracts issue]. Early Human Development, 82, (8), p.495. (doi:10.1016/j.earlhumdev.2006.06.003).
Poore, K.R., Cleal, J.K., Newman, J.P., Boullin, J., Noakes, D., Hanson, M.A. and Green, L.R. (2006) Hypothalamo-pituitary-adrenal axis responsiveness in adult sheep following early life nutrient restriction. Early Human Development, 82, (8), pp.537. (doi:10.1016/j.earlhumdev.2006.06.003).
Cleal, J.K., Poore, K.R., Newman, J.P., Noakes, D., Hanson, M.A. and Green, L.R. (2006) Sex and twinning influence early gestation undernutrition effects on sheep offspring growth. Early Human Development, 82, (8), p.550. (doi:10.1016/j.earlhumdev.2006.06.003).
Asopa, S., Anthony, F.W., Cagampang, F.R.A., Terroni, P.L., Ohri, S.K. and Hanson, M.A. (2006) Elevated BNP expression in mouse offspring left ventricles after protein restriction in utero. Early Human Development, 82, (8), 516-517. (doi:10.1016/j.earlhumdev.2006.06.003).
Torrens, C., Hanson, M.A., Gluckman, P.D. and Vickers, M.H. (2006) Endothelial dysfunction in aged rats following nutrient restriction in utero [In special abstracts issue]. Early Human Development, 82, (8), 523-524. (doi:10.1016/j.earlhumdev.2006.06.003).
Lillycrop, K.A., Phillips, E.S., Vickers, M.H., Gluckman, P.D., Hanson, M.A. and Burdge, G.C. (2006) The effect of prenatal under-nutrition, neonatal leptin exposure, and post-weaning fat intake on the expression of genes associated with lipid-metabolism in adipose tissue in female rats. Early Human Development, 82, (8), pp.496. (doi:10.1016/j.earlhumdev.2006.06.003).
Khan, O.A., Chau, R., Torrens, C., Cleal, J., Anthony, F., Ohri, S.K., Hanson, M.A. and Green, L.R. (2006) Early gestation undernutrition causes increased expression of myosin light chain kinase in adult sheep coronary arteries [In special abstracts issue]. Early Human Development, 82, (8), p.499. (doi:10.1016/j.earlhumdev.2006.06.003).
Sellayah, D., Bruce, K.D., Wang, C., Anthony, F.W., Hanson, M.A., Byrne, C.D. and Cagampang, F.R. (2006) High fat and protein diet during pregnancy and lactation alters hypothalamic adiponectin receptor gene expression in adult mouse offspring. Early Human Development, 82, (8), pp.503. (doi:10.1016/j.earlhumdev.2006.06.003).
Spencer, Hamish G., Hanson, Mark A. and Gluckman, Peter D. (2006) Response to Wells: phenotypic responses to early environmental cues can be adaptive in adults. Trends in Ecology and Evolution, 21, (8), 425-426. (doi:10.1016/j.tree.2006.05.005).
Chau, R., Torrens, C., Ohri, S.K., Noakes, D.E., Poston, L., Hanson, M.A. and Green, L.R. (2006) Pre- and periconceptional nutrient restriction affect coronary vascular reactivity in sheep offspring [In special abstracts issue]. Early Human Development, 82, (8), p.524. (doi:10.1016/j.earlhumdev.2006.06.003).
Bruce, K.D., Sellayah, D., Barnet-Lamb, E., Anthony, F.W., Wang, C., Hanson, M.A., Cagampang, F.R.A. and Byrne, C.D. (2006) A high unsaturated fat, high protein, and low carbohydrate diet during pregnancy and lactation modulates peripheral adipokine receptor gene expression in adult mouse offspring. Early Human Development, 82, (8), 494-495. (doi:10.1016/j.earlhumdev.2006.06.003).
Lillycrop, K.A., Slater-Jefferies, J.L., Phillips, E.S., Jackson, A.A., Hanson, M.A. and Burdge, G.C. (2006) The effect of prenatal under-nutrition on the expression of DNA methyltransferases and methyl CPG binding protein 2 in the liver after weaning. Early Human Development, 82, (8(A08)), 495-496. (doi:10.1016/j.earlhumdev.2006.06.003).
Elahi, M., Cagampang, F.R., Anthony, F.W., Curzen, N., Ohri, S. and Hanson, M.A. (2006) Statins during pregnancy and lactation in mice on hypercholesterolaemic diet prevents obesity, hypertension, and sedentary behaviour in adult offspring. Early Human Development, 82, (8), pp.559. (doi:10.1016/j.earlhumdev.2006.06.003).
Gluckman, P.D. and Hanson, M.A. (2006) Changing times: the evolution of puberty. Molecular and Cellular Endocrinology, 254-255, 26-31. (doi:10.1016/j.mce.2006.04.005).
Mukherjee, K., Hanson, M., Poole, J., Crozier, S., Inskip, H. and Godfrey, K. (2006) Maternal thinness is associated with altered fetal kidney size and shape in late gestation. Bjog: An International Journal of Obstetrics and Gynaecology, 113, (7), 866-866. (doi:10.1111/j.1471-0528.2006.00939.x).
Musha, Yuka, Itoh, Shigeru, Hanson, Mark A. and Kinoshita, Katsuyuki (2006) Does estrogen affect the development of abnormal vascular function in offspring of rats fed a low-protein diet in pregnancy? Pediatric Research, 59, (6), 784-789.
Torrens, Christopher, Brawley, Lee, Anthony, Frederick W., Dance, Caroline S., Dunn, Rebecca, Jackson, Alan A., Poston, Lucilla and Hanson, Mark A. (2006) Folate supplementation during pregnancy improves offspring cardiovascular dysfunction Induced by protein restriction. Hypertension, 47, (5), 982-987. (doi:10.1161/01.HYP.0000215580.43711.d1).
Lillycrop, K.A., Jackson, A.A., Hanson, M.A. and Burdge, G.C. (2006) The effect of dietary protein restriction in pregnant rats on the expression of DNA methyltransferases and methyl CpG binding protein 2 in the liver after weaning. Proceedings of the Nutrition Society, 65, (OCA-B), p.87A. (doi:10.1017/S002966510600526X).
Harvey, N.C., Martin, R., Crozier, S.R., Javaid, M.K., Dennison, E.M., Inskip, H.M., Hanson, M., Godfrey, K.M., Cooper, C. and Lewis, R.M. (2006) Placental calcium transport gene (PMCA3) expression predicts intra-uterine bone mineral accrual. Rheumatology, 45, (Supplement 1), i23-i24.
Watkins, Adam, Wilkins, Adrian, Osmond, Clive, Warner, Carol M., Comiskey, Martina, Hanson, Mark and Fleming, Tom P. (2006) The influence of mouse Ped gene expression on postnatal development. Journal of Physiology, 571, (1), 211-220. (doi:10.1113/jphysiol.2005.099192).
Burdge, G.C., Slater-Jefferies, J.L., Torrens, C., Hanson, M.A. and Lillycrop, K.A. (2006) Feeding a protein-restricted diet during pregnancy in the rat induces changes to DNA methylation in the liver of the F-1 and F-2 offspring after weaning. Proceedings of the Nutritional Society, 65, (OCA-B), p.70A. (doi:10.1017/S002966510600526X).
Gluckman, Peter D. and Hanson, Mark A. (2006) Evolution, development and timing of puberty. Trends in Endocrinology & Metabolism, 17, (1), 7-12. (doi:10.1016/j.tem.2005.11.006).
Gluckman, Peter D. and Hanson, Mark A. (2006) Evolution, development and timing of puberty. Trends in Endocrinology & Metabolism, 17, (1), 7-12. (doi:10.1016/j.tem.2005.11.006).
Braddick, L., Burrage, D., Cleal, J., Noakes, D., Hanson, M.A. and Green, L.R. (2006) Moderate early gestation undernutrition has no effect on kidney size and function in late gestation. Journal of the Society for Gynecologic Investigation, 13, (2)
Godfrey, K. and Hanson, M.A. (2006) The developmental origins of health and disease. Society, Biology & Human Affairs, 71, (1), 7-8.
Rodford, J.L., Li, F.Y., Siow, R.C.M., Mann, G.E., Hanson, M.A. and Clough, G.F. (2006) Down-regulation of heme oxygenase-1 in adult male offspring of in utero protein restricted rats. Journal of Vascular Research, 43, (S1), 18. (doi:10.1159/000094938).
Gluckman, P.D. and Hanson, M.A. (2006) The consequences of being born small - an adaptive perspective. Hormone Research, 65, (3), 5-14. (doi:10.1159/000091500).
Rodford, Joanne, Li, Francois Y., Siow, Richard C.M., Hanson, Mark A., Mann, Giovanni E. and Clough, Geraldine F. (2006) In utero protein restriction leads to a down-regulation of antioxidant gene expression in adult male offspring. Proceedings of the Physiological Society
Costello, P., Rowlerson, A., Braddick, L., Burrage, D., Cooper, C., Hanson, M.A., Ahie Sayer, A. and Green, L.R. (2006) Fetal skeletal muscle fibre number and type are altered by early and late gestation matetrnal undernutrition in sheep. Procedings of the Physiological Society, 3, (C116)
Johnstone, F., Lewis, R.M., Crozier, S., Inskip, H., Hanson, M., Challis, J.R.G. and Godfrey, K.M. (2006) Maternal dieting behaviour before pregnancy and its relation to the incidence of preterm delivery. Journal of the Society for Gynecologic Investigation, 13, (2), p.176A.
Gluckman, P.D. and Hanson, M.A. (2006) Adult disease: echoes of the past. European Journal of Endocrinology, 155, (1), 47-50. (doi:10.1530/eje.1.02233).
Cooper, Cyrus, Westlake, Sarah, Harvey, Nicholas, Javaid, Kassim, Dennison, Elaine and Hanson, Mark (2006) Review: developmental origins of osteoporotic fracture. Osteoporosis International, 17, (3), 337-347. (doi:10.1007/s00198-005-2039-5).
Torrens, Christopher, Rodford, Joanne L., Wheeler, Timothy, Hanson, Mark A. and Clough, Geraldine F. (2006) Impaired endothelial-dependent vasodilation in old but not young female offspring of rats fed a protein restricted diet during pregnancy. Procedings of the Physiological Society, 3, (C111)
Johnstone, J.F., Lewis, R.M., Crozier, S., Zelsman, M., Inskip, H., Hanson, M., Challis, J.R.G. and Godfrey, K.M. (2006) The effect of parity on the duration of gestation in term pregnancies and its association with 11 beta HSD-1, COC-2 and PGDH protein levels in the placenta and fetal membranes. Journal of the Society for Gynecologic Investigation, 13, (2), 97A-98A.
Khan, Omar A., Torrens, Christopher, Noakes, David E., Poston, Lucilla, Hanson, Mark A., Green, Lucy R. and Ohri, Sunil K. (2005) Effects of pre-natal and early post-natal undernutrition on adult internal thoracic artery function. European Journal of Cardio-Thoracic Surgery, 28, (6), 811-815. (doi:10.1016/j.ejcts.2005.08.021).
Gluckman, Peter D., Hanson, Mark A. and Spencer, Hamish G. (2005) Predictive adaptive responses and human evolution. Trends in Ecology & Evolution, 20, (10), 527-533. (doi:10.1016/j.tree.2005.08.001).
Sanhueza, Emilia M., Riquelme, Raquel A., Herrera, Emilio A., Giussani, Dino A., Blanco, Carlos E., Hanson, Mark A. and Llanos, Aníbal (2005) Vasodilator tone in the llama fetus: the role of nitric oxide during normoxemia and hypoxemia. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 289, (3), R776-R783. (doi:10.1152/ajpregu.00071.2005). (PMID:15905225).
Lillycrop, Karen A., Phillips, Emma S., Jackson, Alan A., Hanson, Mark A. and Burdge, Graham C. (2005) Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. Journal of Nutrition, 135, (6), 1382-1386.
Lewis, Rohan M., Godfrey, Keith M., Jackson, Alan A., Cameron, Iain T. and Hanson, Mark A. (2005) Low serine hydroxymethyltransferase activity in the human placenta has important implications for fetal glycine supply. Journal of Clinical Endocrinology and Metabolism, 90, (3), 1594-1598. (doi:10.1210/jc.2004-0317).
Khan, I. Y., Dekou, V., Douglas, G., Jensen, R., Hanson, M. A., Poston, L. and Taylor, P. D. (2005) A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring. American Journal of Physiology.Regulatory, Integrative and Comparative Physiology, 288, (1), R127-R133. (doi:10.1152/ajpregu.00354.2004).
Elmes, M., Green, L.R., Poore, K., Newman, J., Burrage, D., Abayasekara, D.R.E., Cheng, Z., Hanson, M.A. and Wathes, D.C. (2005) Raised dietary n-6 polyunsaturated fatty acid intake increases 2-series prostaglandin production during labour in the ewe. Journal of Physiology, 562, (2), 583-592. (doi:10.1113/jphysiol.2004.071969).
Taylor, P.D., McConnell, J., Khan, I.Y., Holemans, K., Lawrence, K.M., Sare-Anane, H., Persaud, S.J., Jones, P.M., Petrie, L., Hanson, M.A. and Poston, L. (2005) Impaired glucose homeostasis and mitochondrial abnormalities in offspring of rats fed a fat-rich diet in pregnancy. American Journal of Physiology.Regulatory, Integrative and Comparative Physiology, 288, (1), R134-R139. (doi:10.1152/ajpregu.00355.2004).
Gluckman, Peter D., Cutfield, Wayne, Hofman, Paul and Hanson, Mark A. (2005) The fetal, neonatal, and infant environments: the long-term consequences for disease risk. Early Human Development, 81, (1), 51-59. (doi:10.1016/j.earlhumdev.2004.10.003).
Zhang, Junlong, Wang, Chunli, Terroni, Paul L., Cagampang, Felino R.A., Hanson, Mark and Byrne, Christopher D. (2005) High-unsaturated-fat, high-protein, and low-carbohydrate diet during pregnancy and lactation modulates hepatic lipid metabolism in female adult offspring. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 288, (1), R112-R118. (doi:10.1152/ajpregu.00351.2004).
Hanson, Mark A. and Gluckman, Peter D. (2005) Developmental processes and the induction of cardiovascular function: conceptual aspects. Journal of Physiology, 565, (1), 27-34. (doi:10.1113/jphysiol.2004.082339).
Gluckman, Peter D., Hanson, Mark A. and Pinal, Catherine (2005) The developmental origins of adult disease. Maternal and Child Nutrition, 1, (3), 130-141. (doi:10.1111/j.1740-8709.2005.00020.x).
Khan, Omar A., Chau, Ryan, Bertram, Caroline E., Hanson, Mark A. and Ohri, Sunil K. (2005) Fetal origins of coronary heart disease-implications for cardiothoracic surgery? European Journal of Cardio-Thoracic Surgery, 27, (6), 1036-1042. (doi:10.1016/j.ejcts.2005.01.032).
Gallagher, E.A.L., Newman, J.P., Green, L.R. and Hanson, M.A. (2005) The effect of low protein diet in pregnancy on the development of brain metabolism in rat offspring. Journal of Physiology, 568, (2), 553-558. (doi:10.1113/jphysiol.2005.092825).
Gluckman, Peter D., Hanson, Mark A., Morton, Susan M. and Pinal, Catherine S. (2005) Life-long echoes: a critical analysis of the developmental origins of adult disease model. Biology of the Neonate, 87, (2), 127-139. (doi:10.1159/000082311).
Haugen, Guttorm, Hanson, Mark, Kiserud, Torvid, Crozier, Sarah, Inskip, Hazel and Godfrey, Keith M. (2005) Fetal liver-sparing cardiovascular adaptations linked to mother's slimness and diet. Circulation Research, 96, (1), 12-14. (doi:10.1161/01.RES.0000152391.45273.A2).
Gluckman, Peter D., Hanson, Mark A., Spencer, Hamish G. and Bateson, Patrick (2005) Environmental influences during development and their later consequences for health and disease: implications for the interpretation of empirical studies. Proceedings of the Royal Society B: Biological Sciences, 272, (1564), 671-677. (doi:10.1098/rspb.2004.3001).
Gluckman, Peter D. and Hanson, Mark A. (2004) Developmental origins of disease paradigm: a mechanistic and evolutionary perspective. Pediatric Research, 56, (3), 311-317. (doi:10.1203/01.PDR.0000135998.08025.FB).
Gluckman, Peter D. and Hanson, Mark A. (2004) Living with the past: evolution, development, and patterns of disease. Science, 305, (5691), 1733-1736. (doi:10.1126/science.1095292).
Khan, Imran, Dekou, Vasia, Hanson, Mark A., Poston, Lucilla and Taylor, Paul (2004) Predictive adaptive responses to maternal high-fat diet prevent endothelial dysfunction but not hypertension in adult rat offspring. Circulation, 110, (9), 1097-1102. (doi:10.1161/01.CIR.0000139843.05436.A0).
Elmes, M., Tew, P., Cheng, Z., Kirkup, S.E., Abayasekara, D.R., Calder, P.C., Hanson, M.A., Wathes, D.C. and Burdge, G.C. (2004) The effect of dietary supplementation with linoleic acid to late gestation ewes on the fatty acid composition of maternal and fetal plasma and tissues and the synthetic capacity of the placenta for 2-series prostaglandins. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1686, (1-2), 139-147. (doi:10.1016/j.bbalip.2004.09.004).
Haugen, G., Kiserud, T., Godfrey, K., Crozier, S. and Hanson, M. (2004) Portal and umbilical venous blood supply to the liver in the human fetus near term. Ultrasound in Obstetrics and Gynecology, 24, (6), 599-605. (doi:10.1002/uog.1744).
Haugen, G., Godfrey, K., Crozier, S. and Hanson, M. (2004) Doppler blood flow velocity waveforms in the fetal renal arteries: variability at proximal and distal sites in the right and left arteries. Ultrasound in Obstetrics and Gynecology, 23, (6), 590-593. (doi:10.1002/uog.976).
Smith, R.P., Miller, S.L., Igosheva, N., Peebles, D.M., Glover, V., Jenkin, G., Hanson, M.A. and Fisk, N.M. (2004) Cardiovascular and endocrine responses to cutaneous electrical stimulation after fentanyl in the ovine fetus. American Journal of Obstetrics and Gynecology, 190, (3), 836-842. (doi:10.1016/j.ajog.2003.09.064).
Gluckman, Peter D. and Hanson, Mark A. (2004) Maternal constraint of fetal growth and its consequences. Seminars in fetal and neonatal medicine, 9, (5), 419-425. (doi:10.1016/j.siny.2004.03.001).
Taylor, P.D., Khan, I.Y., Hanson, M.A. and Poston, L. (2004) Impaired EDHF-mediated vasodilatation in adult offspring of rats exposed to a fat-rich diet in pregnancy. Journal of Physiology, 558, (3), 943-951. (doi:10.1113/jphysiol.2002.018879).
Hanson, Mark, Gluckman, Peter, Bier, Dennis, Challis, John, Fleming, Tom, Forrester, Terrence, Godfrey, Keith, Nestel, Penelope and Yajnik, Chittaranjan (2004) Report on the 2nd World Congress on Fetal Origins of Adult Disease, Brighton, U.K., June 7-10, 2003. Pediatric Research, 55, (5), 894-897. (doi:10.1203/01.PDR.0000115682.23617.03).
Gluckman, Peter D. and Hanson, Mark A. (2004) Echoes of the past: evolution, development, health and disease. Discovery Medicine, 4, (24), 401-407.
Brawley, L., Torrens, C., Anthony, F.W., Itoh, S., Wheeler, T., Jackson, A.A., Clough, G.F., Poston, L. and Hanson, M.A. (2004) Glycine rectifies vascular dysfunction induced by dietary protein imbalance during pregnancy. Journal of Physiology, 554, (2), 497-504. (doi:10.1113/jphysiol.2003.052068).
Barker, D. J. P. and Hanson, M. A. (2004) Altered regional blood flow in the fetus: the origins of cardiovascular disease? Acta Paediatrica, 93, (12), 1559-1560. (doi:10.1080/08035250410024772).
Gluckman, Peter D. and Hanson, Mark A. (2004) The developmental origins of the metabolic syndrome. Trends in Endocrinology and Metabolism, 15, (4), 183-187. (doi:10.1016/j.tem.2004.03.002).
Llanos, Anibal J., Riquelme, Raquel A., Sanhueza, Emilia M., Hanson, Mark A., Blanco, Carlos E., Parer, Julian T., Herrera, Emilio A., Pulgar, Victor M., Reyes, Roberto V., Cabello, Gertrudis and Giussani, Dino A. (2003) The fetal llama versus the fetal sheep: different strategies to withstand hypoxia. High Altitude Medicine and Biology, 4, (2), 193-202.
Torrens, Christopher, Brawley, Lee, Barker, Alison C., Itoh, Shigeru, Poston, Lucilla and Hanson, Mark A. (2003) Maternal protein restriction in the rat impairs resistance artery but not conduit artery function in pregnant offspring. Journal of Physiology, 547, (Pt 1), 77-84. (doi:10.1113/jphysiol.2002.026120).
Brawley, L., Poston, L. and Hanson, M. A. (2003) Mechanisms underlying the programming of small artery dysfunction: review of the model using low protein diet in pregnancy in the rat. Archives of Physiology and Biochemistry, 111, (1), 23-35. (doi:10.1076/apab.111.1.23.15138).
Brawley, Lee, Itoh, Shigeru, Torrens, Christopher, Barker, Alison, Bertram, Caroline, Poston, Lucilla and Hanson, Mark (2003) Dietary protein restriction in pregnancy induces hypertension and vascular defects in rat male offspring. Pediatric Research, 54, (1), 83-90. (doi:10.1203/01.PDR.0000065731.00639.02).
Khan, Imran Y., Taylor, Paul D., Dekou, Vasia, Seed, Paul T., Lakasing, Lorin, Graham, Delyth, Dominiczak, Anna F., Hanson, Mark A. and Poston, Lucilla (2003) Gender-linked hypertension in offspring of lard-fed pregnant rats. Hypertension, 41, (1), 168-175. (doi:10.1161/01.HYP.0000047511.97879.FC).
Taylor, P.D., Khan, I.Y., Lakasing, L., Dekou, V. O'Brien-Coker. I., Mallet, A.I., Hanson, M.A. and Poston, L. (2003) Uterine artery function in pregnant rats fed a diet supplemented with animal lard. Experimental Physiology, 88, (3), 389-398. (doi:10.1113/eph8802495).
Nishina, Hidenori, Green, Lucy R., McGarrigle, Hugh H.G., Noakes, David E., Poston, Lucilla and Hanson, Mark A. (2003) Effect of nutritional restriction in early pregnancy on isolated femoral artery function in mid-gestation fetal sheep. Journal of Physiology, 553, (2), 637-647. (doi:10.1113/jphysiol.2003.045278).
Burdge, G.C., Delange, E., Dubois, L., Dunn, R.L., Hanson, M.A., Jackson, A.A. and Calder, P.C. (2003) Effect of reduced maternal protein intake in pregnancy in the rat on the fatty acid composition of brain, liver, plasma, heart and lung phospholipids of the offspring after weaning. British Journal of Nutrition, 90, (2), 345-352. (doi:10.1079/BJN2003909).
Hanson, Mark and Gluckman, Peter (2003) The human camel: the concept of predictive adaptive responses and the obesity epidemic. Practical Diabetes International, 20, (8), 267-268. (doi:10.1002/pdi.525).
Peebles, Donald M., Miller, Suzanne, Newman, James P., Scott, Rosemary and Hanson, Mark A. (2003) The effect of systemic administration of lipopolysaccharide on cerebral haemodynamics and oxygenation in the 0.65 gestation ovine fetus in utero. BJOG: An International Journal of Obstetrics and Gynaecology, 110, (8), 735-743. (doi:10.1111/j.1471-0528.2003.02152.x).
Riquelme, Raquel A., Sánchez, Gina, Liberona, Leonal, Sanhueza, Emilia M., Giussani, Dino A., Blanco, Carlos E., Hanson, Mark A. and Llanos, Aníbal J. (2002) Nitric oxide plays a role in the regulation of adrenal blood flow and adrenocorticomedullary functions in the llama fetus. Journal of Physiology, 544, (1), 267-276. (doi:10.1113/jphysiol.2002.018325).
Miller, Suzanne L., Green, Lucy R., Peebles, Donald M., Hanson, Mark A. and Blanco, Carlos E. (2002) Effects of chronic hypoxia and protein malnutrition on growth in the developing chick. American Journal of Obstetrics and Gynecology, 186, (2), 261-267. (doi:10.1067/mob.2002.119629).
Itoh, Shigeru, Brawley, Lee, Wheeler, Timothy, Anthony, Frederick W., Poston, Lucilla and Hanson, Mark A. (2002) Vasodilation to vascular endothelial growth factor in the uterine artery of the pregnant rat is blunted by low dietary protein intake. Pediatric Research, 51, (4), 485-491.
Bertram, Caroline E. and Hanson, Mark A. (2002) Prenatal programming of postnatal endocrine responses by glucocorticoids. Reproduction, 124, (4), 459-467.
Kiserud, Torvid, Jauniaux, Eric, West, Daniel, Ozturk, Ozkan and Hanson, Mark A. (2001) Circulatory responses to maternal hyperoxaemia and hypoxaemia assessed non-invasively in fetal sheep at 0.3-0.5 gestation in acute experiments. BJOG: An International Journal of Obstetrics & Gynaecology, 108, (4), 359-364. (doi:10.1111/j.1471-0528.2001.00096.x).
Deng, Jing, Birkett, Alex G., Kalache, Karim D., Hanson, Mark A., Peebles, Donald M., Linney, Alfred D., Lees, William R. and Rodeck, Charles H. (2001) Conversion of umbilical arterial Doppler waveforms to cardiac cycle triggering signals: a preparatory study for online motion-gated three-dimensional fetal echocardiography. Ultrasound in Medicine & Biology, 27, (1), 51-59. (doi:10.1016/S0301-5629(00)00315-X).
Kalache, Karim D., Nishina, Hidenori, Ojutiku, Dale and Hanson, Mark A. (2001) Visualisation and measurement of tracheal diameter in the sheep fetus: an ultrasound study with stereomicroscopic correlation. Fetal Diagnosis and Therapy, 16, (6), 342-345. (doi:10.1159/000053938).
Bertram, Caroline E. and Hanson, Mark A. (2001) Animal models and programming of the metabolic syndrome. Type 2 diabetes. British Medical Bulletin, 60, 103-121.
Deng, Jing, Yates, Robert, Birkett, Alex G., Ruff, Clifford F., Linney, Alfred D., Lees, William R., Hanson, Mark A. and Rodeck, Charles H. (2001) Online motion-gated dynamic three-dimensional echocardiography in the fetus--preliminary results. Ultrasound in Medicine & Biology, 27, (1), 43-50. (doi:10.1016/S0301-5629(00)00313-6).
Steyn, Clare, Hawkins, Paul, Saito, Tsukuru, Noakes, David E., Kingdom, John C. and Hanson, Mark A. (2001) Undernutrition during the first half of gestation increases the predominance of fetal tissue in late-gestation ovine placentomes. European Journal of Obstetrics, Gynecology and Reproductive Biology, 98, (2), 165-170. (doi:10.1016/S0301-2115(01)00321-9).
Newman, James P., Peebles, Donald M. and Hanson, Mark A. (2001) Adenosine produces changes in cerebral hemodynamics and metabolism as assessed by near-infrared spectroscopy in late-gestation fetal sheep in utero. Pediatric Research, 50, (2), 217-221.
Kalache, Karim D., Ojutiku, Dale, Nishina, Hidenori, Green, Lucy R. and Hanson, Mark A. (2001) Mild maternal undernutrition in the first half of ovine pregnancy influences placental morphology but not fetal Doppler flow velocity waveforms and fetal heart size. Journal of Perinatal Medicine, 29, (4), 286-292. (doi:10.1515/JPM.2001.041).
Ozaki, T., Nishina, H., Hanson, M.A. and Poston, L. (2001) Dietary restriction in pregnant rats causes gender-related hypertension and vascular dysfunction in offspring. Journal of Physiology, 530, (1), 141-152.

Book

Gluckman, Peter D. and Hanson, Mark A. (2012) Fat, fate and disease: why exercise and diet are not enough, Oxford, GB, Oxford University Press
Hanson, Mark A. and Advisory Group on Non-ionising Radiation (2010) Health effects of exposure to ultrasound and infrasound: report of the independent advisory group on non-ionising radiation, Chilton, GB, Health Protection Agency, 180pp.
Lagercrantz, Hugo, Hanson, Mark A., Ment, Laura R. and Peebles, Donald M. (eds.) (2010) The newborn brain: neuroscience and clinical applications. 2nd edition, New York, USA, Cambridge University Press, 412pp.
Lagercrantz, Hugo, Hanson, Mark A., Ment, Laura R. and Peebles, Donald M. (eds.) (2010) The newborn brain. 2nd edition, Cambridge, GB, Cambridge University Press, 426pp.
Gluckman, Peter, Beedle, Alan and Hanson, Mark (2009) Principles of evolutionary medicine, Oxford, GB, Oxford University Press, 312pp.
Gluckman, Peter and Hanson, Mark (2008) Mismatch: the lifestyle diseases timebomb, Oxford, Oxford University Press, 296pp.
Gluckman, Peter and Hanson, Mark (2006) Mismatch: why our world no longer fits our bodies, Oxford, UK, Oxford University Press, 304pp.
Gluckman, Peter and Hanson, Mark (2006) Developmental origins of health and disease, Cambridge, UK, Cambridge University Press, 542pp.
Gluckman, Peter D. and Hanson, Mark A. (2004) The Fetal Matrix: Evolution, Development and Disease, Cambridge, GB, Cambridge University Press, 272pp.
Lagercrantz, Hogo, Hanson, Mark A., Evrard, P. and Rodeck, C.H. (eds.) (2002) The newborn brain, Cambridge, GB, Cambridge University Press
Brace, R.A., Hanson, Mark A. and Rodeck, C.H. (eds.) (1998) Fetus and Neonate: Physiology and Clinical Applications, Vol. 4 Kidney and Body Fluids, Cambridge, GB, Cambridge University Press, 340pp.
Hanson, Mark A., Spencer, J.A.D. and Rodeck, C.H. (eds.) (1995) Fetus and Neonate: Physiology and Clinical Applications Vol. 3 Growth, Cambridge, GB, Cambridge University Press, 365pp.
Hanson, Mark A., Spencer, J.A.D. and Rodeck, C.H. (eds.) (1994) Fetus and Neonate: Physiology and Clinical Applications, Vol. 2 Breathing, Cambridge, GB, Cambridge University Press, 414pp.
Hanson, Mark A., Spencer, J.A.D. and Rodeck, C.H. (eds.) (1993) Fetus and Neonate: Physiology and Clinical Applications, Vol. 1 The Circulation, Cambridge, GB, Cambridge University Presss, 454pp.

Book Section

Hoile, S.P., Lillycrop, K.A., Grenfell, Leonie R., Hanson, M.A. and Burdge, G.C. (2014) Phenotypic and epigenetic inheritance across multiple generations in mammals through the female line. In, Tollesfsbol, Trygve O (ed.) Transgenerational Epigenetics: Evidence and Debate. Philadelphia, US, Elsevier , 269-277.
Low, F.M., Gluckman, P.D. and Hanson, Mark A. (2014) Epigenetic and developmental basis of risk of obesity and metabolic disease. In, Ulloa-Aguirre, Alfredo and Conn, Michael P. (eds.) Cellular Endocrinology in Health and Disease. Philadelphia, US, Elsevier .
Hanson, M.A., Gluckman, P.D. and Godfrey, K.M. (2014) Developmental epigenetics and risks of later non-communicable disease. In, Secki, Jonathan R. and Christen, Yves (eds.) Hormones, Intrauterine Health and Programming. New York, US, Springer, 175-183. (Research and Perspectives in Endocrine Interactions, 12).
Hanson, M.A., Gluckman, P.D. and Godfrey, K.M. (2014) Developmental epigenetics and risks of later non-communicable disease. In, Seckl, Jonathan R. and Christen, Yves (eds.) Hormones, Interauterine Health and Programming. New York, US, Springer International Publishing, 175-183. (Research and Perspectives in Endocrine Interactions, 12).
Poston, L. and Hanson, M.A. (2013) Developmental origins of health and disease. In, Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice. Philadelphia, US, Elsevier, 139-145.
Gluckman, Peter D., Beedle, A.S., Hanson, Mark A. and Low, F.M. (2013) Human growth: evolutionary and life history perspectives. In, Recent Advances in Growth Research: Nutritional, Molecular and Endocrine Perspectives. Basel, CH, Karger, 89-102. ( Nestlé Nutrition Institute Workshop Series, 71).
Gluckman, P.D., Low, F.M. and Hanson, M.A. (2013) Developmental epigenomics and metabolic disease. In, Jirtle, Randy L. (ed.) Environmental Epigenomics in Health and Disease. New York, US, Springer, 31-50.
Green, L.R. and Hanson, Mark A. (2012) Insights into pathogenesis of adult cardiovascular disease from fetal animal studies. In, Kilby, Mark D. and Johnson, Anthony (eds.) Fetal Therapy: Scientific Basis and Critical Appraisal of Clinical Benefits. Cambridge, GB, Cambridge University Press, 12-23.
Ma, R.C.W., Gluckman, Peter D. and Hanson, Mark A. (2012) Maternal obesity and developmental priming of risk of later disease. In, Mahmood, Tahir A. (ed.) Obesity - a Ticking Timebomb for Reproductive Health. London, GB, Elsevier, 193-212. (Elsevier Insights).
Laphm, A.S., Lillycrop, K.A., Burdge, G.C., Gluckman, P.D., Hanson, M.A. and Godfrey, K.M. (2012) Epigenetic approaches to control obesity. In, Tollefsbol, T. (ed.) Epigenetics in Human Disease. Kidlington, GB, Academic Press, 297-320.
Low, F.M., Gluckman, P.D. and Hanson, M.A. (2012) Fetal and early postnatal life determinatns of adiposty. In, Bray, George A. and Bouchard, Claude (eds.) Handbook of Obesity. London, GB, CRC Press, 297-320.
Alves, J.G., Godfrey, K. and Hanson, M. (2012) Developmental origins of allergic diseases. In, Allergy and Immunology in Children and Adolescents. , IMIP, 21-28. (Submitted).
Torrens, Christopher, Clough, Geraldine F. and Hanson, Mark A. (2011) Developmental origins of endothelial dysfunction: a key step in cardiometabolic disease. In, Byrne, Christopher D. and Wild, Sarah H. (eds.) The Metabolic Syndrome. 2nd Edition. Chichester, GB, Wiley-Blackwell, 45-59.
Lillycrop, Karen A., Hanson, Mark A. and Burdge, Graham C. (2011) The effect of maternal macronutrient intake on phenotype induction. In, Niculescu, Mihai and Haggarty, Paul (eds.) Nutrition in Epigenetics. Chichester, GB, Wiley , 275-285.
Gluckman, Peter D., Hanson, Mark A., Beedle, A.S., Buklijas, T. and Low, F.M. (2011) Epigenetics of human disease. In, Hallgrímsson, Benedikt and Hall, Brian K. (eds.) Epigenetics: Linking Genotype and Phenotype in Development and Evolution. Berkeley, US, University of California Press.
Gluckman, Peter D., Hanson, Mark A. and Buklijas, T. (2011) Maternal and transgenerational influences on human health. In, Gissis, Snait B. and Jablonka, Eva (eds.) Transformations of Lamarckism: From Subtle Fluids to Molecular Biology. Cambridge, US, MIT Press, 237-249.
Godfrey, K.M., Lillycrop, K.A., Hanson, M.A. and Burdge, G.C. (2011) Epigenetic mechanisms in the developmental origins of adult disease. In, Roach, Helmtrud I., Bronner, Felix and Oreffo, Richard O.C. (eds.) Epigenetic Aspects of Chronic Diseases. Heidelberg, DE, Springer.
Green, L.R. and Hanson, Mark A. (2011) Developmental effects on fetal circulation. In, Polin, Richard A., Fox, William W. and Abman, Steven H. (eds.) Fetal and Neonatal Physiology. 4th Edition. Philadelphia, US, Saunders, 798-806.
Cooper, C., Harvey, N., Cole, Z., Hanson, M. and Dennison, E. (2009) Developmental origins of osteoporosis: the role of maternal nutrition. In, Early Nutrition Programming and Health Outcomes in Later Life. London, GB, Springer, 31-39. (Advances in Experimental Medicine and Biology, 646). (doi:10.1007/978-1-4020-9173-5_3).
Hanson, Mark and Godfrey, Keith (2009) The developmental origins of health and disease. In, Panter-Brick, Catherine and Fuentes, Agustin (eds.) Health, Risk and Adversity. New York, US, Berghahn Books.
Poston, L and Hanson, M.A. (2008) Developmental origins of health and disease. In, Creasy, Robert and Resnik, Robert (eds.) Creasy and Resnick's Maternal-Fetal Medicine: Principles and Practice. Philadelphia, US, Elsevier.
Poston, L. and Hanson, Mark A. (2008) Developmental origins of health and disease. In, Creasy, Robert K., Resnik, Robert, Iams, Jay D., Lockwood, Charles J. and Moore, Thomas R. (eds.) Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice 6th Ed. Philadelphia, US, Saunders Elsevier.
Poore, K.R., Cleal, J.K., Newman, J.P., Boullin, J., Hanson, M.A. and Green, L.R. (2008) The effect of growth in early life on metabolic homeostasis in later life. In, Wilsher, S., Wade, J.F. and Allen, W.R. (eds.) Proceedings of a Workshop on Second Workshop Embryonic and Fetal Nutrition. Embryonic and Fetal Nutrition 2006 Newmarket, United Kingdom, R & W Communications, 81-86. (Havemeyer Foundation Monograph Series 21).
Hanson, Mark A. and Godfrey, Keith M. (2008) The developmental origins of health and disease. In, Panter-Brick, Catherine and Goodman, Alan (eds.) Health Risk and Adversity. New York, US, Berghahn Books.
Kuzawa, Christopher W., Gluckman, Peter D., Hanson, Mark A. and Beadle, Alan S. (2008) Evolution developmental plasticity and metabolic disease. In, Stearns, Stephen C. and Koella, Jacob C. (eds.) Evolution in Health and Disease. New York, USA, Oxford University Press, 253-264.
Kuzawa, Christopher W., Gluckman, Peter D., Hanson, Mark A. and Beedle, Alan S. (2007) Evolution, developmental plasticity, and metabolic disease. In, Stearns, Stephen C. and Koella, Jacob C. (eds.) Evolution in Health and Disease. Second edition. Oxford, UK, Oxford University Press, 253-264.
Kuzawa, Christopher W., Gluckman, Peter D., Hanson, Mark A. and Beedle, Alan S. (2007) Evolution, developmental plasticity and metabolic disease. In, Stearns, Stephen C. and Koella, Jacob C. (eds.) Evolution in Health and Disease. Oxted, GB, Oxford University Press, 253-264.
Kuzawa, Christopher W., Gluckman, Peter D. and Hanson, Mark A. (2007) Developmental perspectives on the origins of obesity. In, Fantuzzi, Giamila and Mazzone, Theodore (eds.) Adipose Tissue and Adipokines in Health and Disease. Totowa, USA, Humana, 207-219. (Nutrition and Health). (doi:10.1007/978-1-59745-370-7_16).
Poston, Lucilla, Torrens, Christopher, Armitage, James A. and Hanson, Mark A. (2006) The role of vascular dysfunction in developmental origins of health and disease: evidence from human and animal studies. In, Gluckman, Peter and Hanson, Mark (eds.) Developmental Origins of Health and Disease. Cambridge, UK, Cambridge University Press, 286-299.
Gluckman, Peter D. and Hanson, Mark A. (2006) The developmental origins of health and disease: an overview. In, Gluckman, Peter and Hanson, Mark (eds.) Developmental Origins of Health and Disease. Cambridge, UK, Cambridge University Press, 1-5. (doi:10.2277/0521847435).
Gluckman, Peter D. and Hanson, Mark A. (2006) The developmental origins of health and disease. In, Wintour, Marelyn E. and Owens, Julie A. (eds.) Early Life Origins of Health and Disease. London, GB, Springer, 1-7. (Advances in Experimental Medicine and Biology, 573).
Gluckman, Peter D. and Hanson, Mark A. (2006) The conceptual basis for the developmental origins of health and disease. In, Gluckman, Peter and Hanson, Mark (eds.) Developmental origins of Health and Disease. Cambridge, UK, Cambridge University Press, 33-50. (doi:10.2277/0521847435).
Gluckman, Peter D. and Hanson, Mark A. (2005) Developmental origins of health and disease: theoretical considerations, mechanisms, and implications. In, Wassarman, Paul and Neill, Jimmy (eds.) Knobil and Neill's Physiology of Reproduction. New York, USA, Elsevier, 2975-2993.
Gluckman, Peter D. and Hanson, Mark A. (2005) Metabolic disease: evolutionary, developmental and transgenerational influences. In, Hornstra, G., Uauy, R. and Yang, X. (eds.) The Impact of Maternal Nutrition on the Offspring. Basel, CH, Karger, 17-28. (Nestle Nutrition Workshop Paediatric Program, Vol 55).
Ohri, Sunil K. and Hanson, Mark A. (2004) Current therapies for heart failure. In, Ohri, Sunil K., Tang, Augustine and Stephenson, Larry W. (eds.) Key Topics in Cardiac Surgery. Oxford, GB, Taylor and Francis, 235-238.
Newman, J.P., Hanson, Mark A. and Green, L.R. (2003) Fetal adaptations to hypoxia. In, Lahiri, S., Semenza, G.L. and Prabhakar, N.R. (eds.) Oxygen Sensing: Responses and Adaptation to Hypoxia. New York, US, Marcel Dekker, 209-234. (Lung Biology in Health and Disease, 175).
Peebles, D. and Hanson, Mark A. (2002) Antepartum hypoxia and the developing fetus. In, Donn, S.M., Sinha, S.K. and Chiswick, M.L. (eds.) Current Issues in Fetal and Neonatal Asphyxial Brain Injury. New York, US, Futura Publishing, 355-376.
Blanco, C.E. and Hanson, Mark A. (2002) Fetal respiratory control and changes at birth. In, Haddad, G.G., Abman, S.H. and Chernick, V. (eds.) Basic Mechanisms of Pediatric Respiratory Disease. Hamilton, CA, Decker, 386-397.
Bertram, Caroline and Hanson, Mark A. (2001) Animal models and the programming of the metabolic syndrome. In, Barker, David (ed.) Type 2 Diabetes: The Thrifty Phenotype. Oxford, GB, Oxford University Press for the British Council, 103-121. (British Medical Bulletin, 60.1). (doi:10.1093/bmb/60.1.103).
Hanson, Mark A. (1999) Fetal and placental physiology [Section Editor]. In, Rodeck, C.H. and Whittle, M. (eds.) Fetal Medicine: Basic Science and Clinical Practice. London, GB, Churchill Livingstone, 87-241.

Conference or Workshop Item

Rodford, J.L., Garratt, Emma, Hyde, Kerry, Cooper, C., Gluckman, Peter D., Lillycrop, Karen A., Burdge, Graham C., Slater-Jefferies, J.L., McLean, C., Sheppard, A., Crozier, S.R., Hanson, Mark A. and Godfrey, Keith M. (2009) Variations in DNA methylation in a large cohort of children differs between different CpG sites within the promoters of candidate genes. UNSPECIFIED , S267-S267. (doi:10.1017/S2040174409990067).
Cleal, J.K., Thomas, M., Smith, M.J., Hanson, M.A., Gardiner, H.M. and Green, L.R. (2006) Non-invasive measures of heart rate variability following intermittent umbilical cord occlusion in the preterm ovine fetus. In, Measurement & Modelling of Autonomic Function, London, UK, 22 Mar 2006.

Monograph

Hanson, Mark A. Advisory Group on Non-ionising Radiation (2010) Health effect of exposure to ultrasound and infrasound: report of the independent advisory group on non-ionising radiation. Didcot, GB, Health Protection Agency, 196pp. (Documents of the Health Protection Agency: Radiation, Chemical and Enviromental Hazards, RCE-14).
Hanson, Mark, Fall, Caroline, Robinson, Sian, Baird, Janis and BMA Board of Science (2009) Early life nutrition and lifelong health. London, GB, British Medical Association, 122pp.

Patent

(2008) Pheontype derivatives. 2650443.
 

Research

Research Interests

Mark’s research over many years has been translated to experimental medicine and to healthcare and public health at multiple levels. Overall it concerns the Developmental Origins of Health and Disease. He was the leading proponent of the concept that the fetus responds to aspects of its environment, and that this has long-term consequences after birth.

Examples of his track record in translational medicine include:

  • Development of a method for measuring respiratory chemoreflexes in neonates, applied to preterm infants and those suffering from bronchopulmonary dysplasia.
  • Involvement over many years in the technology and analysis for measuring blood flow in the fetal circulation investigation of the factors regulating it, followed by its application to human fetuses to define longitudinal reference ranges through gestation, the effects of maternal slimness and diet and of intrauterine growth restriction or fetal macrosomia.
  • Pioneering the use of near-infra red spectroscopy for measuring fetal brain oxygenation, blood volume and oxidative state, now piloted for use for fetal monitoring in labour
  • Study of the human placenta to define processes regulating amino acid transport to the fetus in relation to maternal body composition and diet.
  • Investigation of the biology underlying transgenerational effects of prenatal exposure to undernutrition and application in the investigation of cohorts in both developed and developing societies to assess developmental contributions to health in later life
  • Development, with funding from public and private sources, of epigenetic biomarkers for use at birth in assessing the impact of maternal diet and lifestyle as predictors of later risk factors such as childhood adiposity

Academic unit:  Human Development and Health Academic Units

Affiliate academic units:  Human development and physiology Research group

Research project

Identification of perinatal epigenetic markers of later phenotype

Responsibilities

Mark has served on external review panels for departments and units conducting basic-clinical research translation, in NZ, Canada, Brazil, Jamaica, Hong Kong, China, Dundee, Aberdeen and Dublin.

Mark was senior author of an invited report for BMA on Early Life Nutrition and Lifelong Health (2009), a member of the Health Protection Agency Advisory Group on Non-Ionising Radiation Sub-Group on Ultrasound and Infrasound Safety, published as Health Effects of Exposure to Ultrasound and Infrasound – Report of the independent Advisory Group on Non-Ionising Radiation (2010) Health Protection Agency ISBN 978-0-85951-662-4.

Mark was Senior Editor for 4 books in the series The Fetus and Neonate – physiology and clinical applications on: The Circulation; Breathing; Kidney & Body Fluids; Growth (Cambridge University Press)

Mark was co-editor of The Newborn Brain – neuroscience and clinical applications (now in 2nd edition) (Cambridge University Press)

Mark has given 179 invited lectures at clinical research meetings, presenting the results of on-going research and its applications

Mark currently supervises 5 students – either as first supervisor or co-ordinating supervisor

Teaching Responsibilities

Mark has successfully supervised 28 post-graduate students

He currently lectures to BM4 and BM5 students on Developmental Origins of Health and Disease and on the BIOL3044 course.

Contact

Professor Mark Hanson
Phone: (023) 8079 5255
Fax: (023) 8079 4221
Email: m.hanson@soton.ac.uk

Room Number: SGH/IDS/MP887