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The University of Southampton

Dr Chris Grainge MBBS PhD MRCP Royal Navy

Honorary Consultant Physician and Senior Lecturer

Dr Chris Grainge's photo

Dr Chris Grainge is Honorary Consultant Physician and Senior Lecturer within Medicine at the University of Southampton.

Degree Qualifications

BSc, Neuroscience, Imperial College, University of London (1995)
MBBS, Medicine and Surgery, Imperial College, University of London (1998)
MRCP, Royal Colleges of Physicians of the United Kingdom (2003)
PhD, University of Southampton (2011)

Appointments held

Honorary Consultant Physician in Respiratory, Sleep and General (Internal) Medicine, Senior Lecturer in Medicine.

Research interests

Role of mechanical forces in the pathophysiology of asthma

Dr Grainge recently demonstrated that mechanical forces may play an important role in determining long term changes in human airways, that research was published in the New England Journal of Medicine in 2011. Following the award of £110,000 from the Gerald Kerkut Trust and a University of Southampton Doctoral Training Award his team are investigating how the mechanical forces that are associated with airway narrowing in asthma influence the airway using novel techniques only available at the University of Southampton.

The role of environmental dusts in pathogenesis of lung disease

Recent clinical evidence has suggested that some individuals exposed to high levels of inhaled dusts develop the usually rare lung disease, constrictive bronchiolitis. Following the award of over £220,000 from the British Lung Foundation, the Institute of Life Sciences and the Southampton Marine and Maritime Institution Dr Grainge and his team are investigating the mechanisms underling the development of lung disease including constrictive bronchiolitis following environmental exposure to inhaled particles, and are attempting to identify potential therapies. This project is a collaboration between the National Oceanography Centre and the University of Southampton Faculty of Medicine.

The effect of platelet antagonists on allergen challenge in asthma

Platelet activation in the lungs occurs following many stimuli including allergen challenge and chemical injury to the lung. Dr Grainge and his group hypothesise that inhibiting platelet activation will decrease the lung injury associated with these stimuli and may provide an additional therapeutic pathway for asthma which has yet to be investigated. The project involves a double blind randomized controlled trial of Clopidogrel, an oral platelet antagonist, and its effects on inhaled allergen challenge.

Postgraduate Student Supervision

Currently supervising 3 PhD students and 1 MD student on a variety of projects investigating the responses of the lungs to various environmental stimuli

Faculty of Medicine

Year 3 assignment coordinator
Year 3 assessment group member

Personal tutor

BM4 and BM5. Delivers lectures and small group teaching on a variety of general medicine and respiratory medicine topics including respiratory physiology and pathophysiology. Provides clinical teaching on the wards and in clinic to medical students at various points in their undergraduate training.

4 year PhD program. Delivers small group tutorials and lectures on respiratory medicine to the 4 year PhD program to enable non medically trained scientists understand the context in which their research and activities relate to clinical disease processes.

Allergy MSc. Teaches on the MSc Allergy course to doctors, nurses and other medical professionals to improve their understanding of this growing subject area.

IMPACT. Was one of the first instructors on the Ill Medical Patient Acute Care and Treatment (IMPACT) courses which are run for doctors in their first few years of postgraduate training. Continues to teach and direct the courses at various centers around the country.

Dr Chris Grainge
Faculty of Medicine, University of Southampton, Building 85, Life Sciences Building, Highfield Campus, Southampton, SO171BJ

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