The University of Southampton
Medicine

Professor Geraldine Clough BSc, PhD

Professor of Vascular Physiology

Professor Geraldine Clough's photo
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Professor Geraldine Clough is Professor of Vascular Physiology within Medicine at the University of Southampton where her research focuses on the life course determinants of microvascular dysfunction.

Delivery to and exchange of materials within the microvasculature represents the payload of the entire cardiovascular system. We need to know when and how this goes wrong – and be able to measure this.

Geraldine Clough studied Physiology at University College London where she completed her PhD on the mechanical and transport properties of the microvasculature in 1997. She has held academic positions in the University of Oxford and at St Mary’s Hospital Medical School, Imperial College London before moving to the University of Southampton in 1996 where she was one of the first Wellcome Trust Re-entry Fellows before being appointed Professor of Vascular Physiology in 2007.

Professor Clough’s group comprises basic biomedical scientists, clinicians and engineers, and has strong links with industry. Through these links Geraldine Clough has played a leading role in developing and evaluating techniques for the assessment of tissue perfusion and nutrient delivery.

Professor Clough has held external positions within learned societies, as member of Council of the Physiological Society, Senior Editor of the Journal of Physiology, member of the Executive Committee of the Journal of Physiology, President of the British Microcirculation Society, member of the European Society of Microcirculation Executive and Awards panel and the International Liaison Committee. She has been a Visiting Professor at Southern University China (2008-2011) and is currently Visiting Professor at Kings College London..

Potential students, post-doctoral scientists or clinical scientists who are interested in joining her group are encouraged to contact Professor Clough.

Qualifications

BSc Physiology, University College London, 1973
PhD, University of London, 1977

Appointments held

Research Fellow, University Laboratory of Physiology and Lady Margaret Hall, University of Oxford 1978-1982

Lecturer in Physiology, Department of Physiology & Biophysics, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, 1984-1991

Wellcome Trust Senior Research Fellow, School of Medicine, University of Southampton, 1997-2000.

Senior Lecturer, Reader, Professor of Vascular Physiology, University of Southampton , 2000-present

Research

Responsibilities

Publications

Teaching

Contact

Research interests

Dysregulation of microvascular function in common chronic non-communicable disorders

Working with clinical colleagues within the Southampton Centre for Biomedical Research, Professor Clough is undertaking functional and therapeutic studies to investigate and model impaired microvascular function and its association with cardiovascular risk in healthy humans and in patient cohorts with metabolic syndrome and non alcoholic fatty liver disease. Her group is currently investigating the association between impaired microvascular perfusion and neurosensation in individuals at risk of tissue breakdown. Her work is currently funded by NIHR, Diabetes UK, Wellcome Trust and industry.

Priming of vascular plasticity and endothelial dysfunction

There is increasing evidence that the early life environment, of which nutrition is a key component, acts through developmental adaptations to set the capacity of cardiovascular and metabolic pathways, and ultimately the limits to physiological challenges in later life. Professor Clough’s work sets out to delineate the mechanisms underlying the developmental origins of small vessel dysfunction in cardio-metabolic disease. Her group is currently investigating the structural and functional rarefaction of the microvasculature in developmental models of cardio-metabolic disease using intravital and 3D imaging of the microvasculature. Her work is currently supported the BBSRC, BHF and Gerald Kerkut Charitable Trust.

Novel devices for the assessment of tissue health

Working with engineers and mathematicians, Professor Clough’s group have has developed and used innovative technologies with which to investigate and model impaired microvascular function. In collaboration with the University of Nottingham her group is currently developing novel sensors for the detection of vascular risk for use in free living individuals. Professor Clough’s work in the development and early testing of the clinical application of such devices is funded by the NIHR, EPSRC and industry.

Anyone interested in graduate studentships, or post-doctoral positions (non-clinical and clinical) in the group are encouraged to contact Professor Clough directly .

Confocal image of a myoendothelial gap junction co-localised with the intermediate Ca 2+-dependent K+-channel KCa3.1(IK1) from a resistance artery of the mouse
Figure 1
MicroCT images  showing 3D architecture of the microvascular bed of the soleus muscle from a mouse. Inset shows resolution of 5 µm capillary
Figure 2

Academic unit(s)

Human Development and Health Academic Units

Affiliate academic unit(s)

Human development and physiology Research group

Research project(s)

Experimental and Theoretical Investigations of Lymphatic Fluid Flows and Immunology

Sensing Skin Health

This research aims to investigate a system of skin health monitoring that is suitable for long term use by patients at risk of undetected skin damage. In particular this research will focus on problems associated with diabetic foot ulceration.

Development and evaluation of a new device for the clinical measurement of tissue blood flow and tissue oxygenation

Understanding the state of health of body tissue is essential to assessing its viability or recovery from injury. This project investigates a new non-invasive devise for detecting blood flow and oxygen delivery to superficial tissue.

Dynamic modelling of the effect of physical activity on glycaemic control in people with type 1 diabetes

Lifestyle has a significant influence on the control of blood sugars in Type 1 diabetes. Here we investigate how physical fitness and levels of activity affects blood glucose control.

Postgraduate student supervision

2001 David Voegeli PhD
2002 Paraskevi Boutsiouki PhD
2007 Joanne Rodford PhD
2009 Carolyn Gill PhD
2010 Wei Qi MPhil
2011 Miriam Avery PhD
2011 J.J. Valletta PhD
2011 M. Turzyniecka DM

Current

Stuart Armstrong PhD
Richard Bain PhD
Piia Keskivali PhD
Keith McCormick PhD
Katy Gould PhD
Kasia Kuliga PhD
Berit Plumhoff PhD

Faculty of Medicine

Athena SWAN charter group (co-chair)
MMedSc Steering Committee
Research Management Committee

University of Southampton

Past Chair Women in Science Engineering and Technology

National and International

Deputy Editor in Chief Microcirculation
Editor Journal of Vascular Research
Senior Editor Journal of Physiology (2000-2007)
Editorial Board F1000 Research

Executive Committee European Society for Microcirculation; Member President and Committee Chair, British Microcirculation Society (2004-2008)

Articles

Book Chapter

Conferences

Personal Tutor
Postgraduate Mentor
Pastoral tutor

BM5 and BM4 Delivers lectures and facilitates small group teaching in years 1, 2 and 3 that introduce cardiovascular physiology and disease, the scientific basis of medicine, and tissue homeostasis.

BMedSc and MMedSc Offers laboratory and clinical research projects that investigate vascular mechanisms in health and disease.

Professor Geraldine Clough
Institute of Developmental Sciences Building Room D08, MP 887 Southampton General Hospital Tremona Road Southampton SO16 6YD Email: G.F.Clough@southampton.ac.uk

Room Number:SGH/IDS-D08

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