Current research degree projects
Explore our current postgraduate research degree and PhD opportunities.
Explore our current postgraduate research degree and PhD opportunities.
We are seekign an outstanding chemistry student with an interest in chemical biology to work on a project to develop cyclic peptide inhibitors of a protein-protein interaction that is heavily implicated in the development and growth of tumours.Mutant RAS proteins drive numerous cancers, with their inhibtion shown to have therapeutic potential in several tumour types. The majority of RAS inhibitors currently in development target the G12C KRAS mutant through a covalent inhibition mechanism, which limits their use to a small subset of cancers. The Tavassoli lab has used an in-house genetically-encoded library of cyclic peptides to identify several cyclic peptides that inhibit the interaction of RAS proteins with their affectors, and therefore inhibit downstream signalling in cancer cells.
Endofullerenes are a new class of materials in which small molecules or atoms are completely enclosed in carbon cages. The encapsulated atoms or molecules behave like “particles in a box” which have their own set of quantum energy levels. In this project, you will be trained in the theory and practice of inelastic neutron scattering (INS), in order to study the quantum properties of these remarkable new materials.
MXenes are a new class of two-dimensional materials that have been recently discovered and have already shown great promise for a range of applications, including electrochemical energy storage, electromagnetic shielding, and energy conversion. MXenes can be made modified to possess porosity, which is a feature that can prove extremely beneficial for applications in various areas, including electrochemical energy storage, catalysis and gas adsorption. MXenes have already shown promise for gas separations, as they showed outstanding performance for CO2 capture in mixtures relevant for post-combustion carbon capture.