The cytoskeleton supports many cellular functions. An understanding of bio-membranes is essential as compartmentalisation and cell organelles work to spatially separate different functions, while organelle contact sites allow functional integration of cellular metabolism. Mechanisms of phospho-inositol signalling and control of cellular function are discussed. Finally, the module studies how organisation of cells into tissues requires integration of structure and signalling. The module contains lectures in form of a “journal club” to teach the reading of original literature.