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Research project: GAFRA / The impact of early adult rheumatoid arthritis on the biomechanical and functional characteristics of the foot and lower limb

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The aim of this research is to characterize the biomechanical function of lower limb in early rheumatoid arthritis (RA) and assess whether there is a relationship between lower limb biomechanical dysfunction and measures of disease impact and functional decline.

The study is based within the University of East London and is supports training of Mr Alexander Izod to complete his PhD.

It is recognized that the pathological processes associated with the onset and progression of rheumatoid arthritis (RA) account for a high incidence of personal disability in those living with this condition. Developments in the medical treatment for RA have improved the long-term prognosis for those with the condition. Nevertheless, radiological signs of joint damage and synovitis continue to be found. But current clinical evaluations appear to lack the sensitivity to detect early changes in the biomechanical function of people with RA. The specific aims of this study are to;

  1. Establish reliable protocols for the biomechanical evaluation of the foot and lower limb in subjects with early adult RA.
  2. Quantify and characterise the baseline biomechanical function of the foot and lower limb in adult patients with early RA determining if these characteristics differ from aged-matched healthy adults.
  3. Explore the relationship between foot and lower limb biomechanical function and disease impact.

Funder: Dr William M Scholl Research and Development Endowment Fund

Associated research themes

Rheumatoid arthritis

Lower limb biomechanics

3D motion analysis

Related research groups

Active Living and Rehabilitation
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