About
Dr. Denise Boulanger is a Senior Research Fellow working with Prof. Edd James on antigen processing and presentation with a focus on tapasin function. She completed her PhD in Biochemistry at the University of Liege (Belgium) in 1994 working on the neutralisation mechanisms of Bovine viral diarrhoea virus. She developed her expertise in virology and vaccinology in the poxvirus field at the University of Liege (Belgium), at the Compton Animal Health Institute (UK) and at the GSF/TU University in Munich (Germany) where her interest was to develop avipoxviruses as vectors for cancer immunotherapy. Her work since she joined Southampton University in 2002 has been focused on antigen processing and presentation and how modulation of this process impacts CD8 T cell responses.
You can update this in Pure (opens in a new tab). Select ‘Edit profile’. Under the heading and then ‘Curriculum and research description’, select ‘Add profile information’. In the dropdown menu, select - ‘About’.
Write about yourself in the third person. Aim for 100 to 150 words covering the main points about who you are and what you currently do. Clear, simple language is best. You can include specialist or technical terms.
You’ll be able to add details about your research, publications, career and academic history to other sections of your staff profile.
Research
Research interests
- Antigen processing and presentation
- Tapasin function and downregulation
- CD8 T cell response
- Immune evasion in cancer
Current research
Loss of MHC I surface expression is a common immune escape mechanism in cancer and correlates with poorer prognosis and reduced efficacy of immunotherapy treatments. Downregulation of tapasin, a protein involved in the optimisation of peptide selection for MHC I binding, can result in reduced MHC I surface expression. Dr. Denise Boulanger is investigating the role of tapasin in antigen presentation using quantitative flow cytometry assays, the interaction of tapasin with other chaperones at the cellular level, and how downregulation of tapasin contributes to immune evasion in cancer. Research outcome aims at laying the ground for the development of new therapeutic targets against immune escape tumours variants.
You can update the information for this section in Pure (opens in a new tab).
Research groups
Any research groups you belong to will automatically appear on your profile. Speak to your line manager if these are incorrect. Please do not raise a ticket in Ask HR.
Research interests
Add up to 5 research interests. The first 3 will appear in your staff profile next to your name. The full list will appear on your research page. Keep these brief and focus on the keywords people may use when searching for your work. Use a different line for each one.
In Pure (opens in a new tab), select ‘Edit profile’. Under the heading 'Curriculum and research description', select 'Add profile information'. In the dropdown menu, select 'Research interests: use separate lines'.
Current research
Update this in Pure (opens in a new tab). Select ‘Edit profile’ and then ‘Curriculum and research description - Current research’.
Describe your current research in 100 to 200 words. Write in the third person. Include broad key terms to help people discover your work, for example, “sustainability” or “fashion textiles”.
Research projects
Research Council funded projects will automatically appear here. The active project name is taken from the finance system.
Publications
Pagination
- 1
- 2
- 3
-
Next page
Next
Public outputs that list you as an author will appear here, once they’re validated by the ePrints Team. If you’re missing any outputs that you’ve added to Pure, they may be waiting for validation.
Supervision
A list of your current and past PhD students.
This section will only display on your public profile if content has been added.
Contact your Faculty Operating Service team to update PhD students you supervise and any you’ve previously supervised. Making this information available will help potential PhD applicants to find you.
Teaching
BM6 Y0 HSF1 deputy module lead 2022-2023.
Supervision of under-graduate students, co-supervision of PhD students.
You can update your teaching description in Pure (opens in a new tab). Select ‘Edit profile’. Under the heading and then ‘Curriculum and research description’ , select ‘Add profile information’. In the dropdown menu, select – ‘Teaching Interests’. Describe your teaching interests and your current responsibilities. Aim for 200 words maximum.
Courses and modules
Contact the Curriculum and Quality Assurance (CQA) team for your faculty to update this section.
External roles and responsibilities
You can update your external roles and responsibilities in Pure (opens in a new tab). Select ‘+ Add content’ and then ‘Activity’, your ‘Personal’ tab and then ‘Activities’. Choose which activities you want to show on your public profile.
You can hide activities from your public profile. Set the visibility as 'Backend' to only show this information within Pure, or 'Confidential' to make it visible only to you.
Biography
A chance to go into more detail about your work and interests.
This section will only display on your public profile if you’ve added content.
You can update your biography section in Pure (opens in a new tab). Select your ‘Personal’ tab then ‘Edit profile’. Under the heading, and ‘Curriculum and research description’, select ‘Add profile information’. In the dropdown menu, select - ‘Biography’. Aim for no more than 400 words.
This section will only appear if you enter the information into Pure (opens in a new tab).
Prizes
You can update this section in Pure (opens in a new tab). Select ‘+Add content’ and then ‘Prize’. using the ‘Prizes’ section.
You can choose to hide prizes from your public profile. Set the visibility as ‘Backend’ to only show this information within Pure, or ‘Confidential’ to make it visible only to you.