Dr Andy van Hateren is a senior post-doctoral research fellow working with Prof Edd James (University of Southampton) and Prof Tim Elliott (University of Oxford), investigating the mechanisms of Major Histocompatibility Complex class I peptide selection.
- MHC I peptide selection
- Antigen presentation
The binding of peptides by Major Histocompatibility Complex class I molecules (MHC I), and their presentation to cytotoxic T cells is an integral component of the adaptive immune system, providing protection from intracellular pathogens and cancer.
MHC I molecules are highly polymorphic, with each MHC I allotype binding a different cohort of peptides. MHC I molecules become loaded with peptides in the endoplasmic reticulum of a cell, in a process that is assisted by a macromolecular peptide loading complex. A key constituent of this peptide loading complex is the molecule tapasin, which quantitatively and qualitatively enhances the intrinsic ability of MHC I molecules to select those peptides that form optimal interactions with the MHC I molecule. This peptide editing function results in the preferential selection of peptides that bind with high affinity, allowing the most effective antigen presentation.
Current PhD Students
Supervision of BMedSci undergraduates undertaking lab research projects, summer students and interns.