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Research project

CCP4: Advanced integrated approaches to macromolecular structure determination

Staff

Lead researcher

Dr Ivo Tews

Associate Professor

Research interests

  • Natural products biosynthesis: a complex cascade of catalytic steps in vitamin B6 biosynthesis is characterised by structures or reaction intermediates in the large PLP syntase complexEdit
  • Bacterial biofilms: understanding of RedOx regulated phosphodiesterase activity in dispersal of biofilms to address chronic infections
  • Cancer immunology: together with Cancer Immunology at Southampton we use a structure based apporach in developing novel cancer therapie

Collaborating research institutes, centres and groups

Research outputs

Eugene Krissinel,
Andrey A Lebedev,
Ville Uski,
Charles B Ballard,
Ronan M Keegan,
Oleg Kovalevskiy,
Navraj S Pannu,
Pavol Skubák,
John Berrisford,
Maria Fando,
Bernhard Lohkamp,
Marcin Wojdyr,
Adam J Simpkin,
Jens M H Thomas,
Christopher Oliver,
Clemens Vonrhein,
Grzegorz Chojnowski,
Arnaud Basle,
Andrew Purkiss,
Michail N Isupov,
Stuart McNicholas,
Edward Lowe,
Josep Triviño,
Kevin Cowtan,
Jon Agirre,
Daniel J Rigden,
Isabel Uson,
Victor Lamzin,
Gerard Bricogne,
Andrew G W Leslie,
& David G Brown
, 2022 , Acta Crystallographica Section D: Structural Biology , 78 (Pt 9) , 1079--1089
Type: article
Tadeo Moreno-Chicano,
Leiah M. Carey,
Danny Axford,
John H. Beale,
R. Bruce Doak,
Helen M.E. Duyvesteyn,
Ali Ebrahim,
Robert W. Henning,
Diana C.F. Monteiro,
Dean A. Myles,
Shigeki Owada,
Darren A. Sherrell,
Megan L. Straw,
Vukica Šrajjer,
Hiroshi Sugimoto,
Kensuke Tono,
Takehiko Tosha,
Martin Trebbin,
Richard W. Strange,
Kelvin L. Weiss,
Jonathan A.R. Worrall,
Flora Meilleur,
Robin L. Owen,
Reza A. Ghiladi,
& Michael A. Hough
, 2022 , IUCrJ , 9 (Part 5) , 610--624
Type: article
Sam Horrell,
Danny Axford,
Nicholas E. Devenish,
Ali Ebrahim,
Michael A. Hough,
Darren A. Sherrell,
Selina L.S. Storm,
Jonathan A.R. Worrall,
& Robin L. Owen
, 2021 , JoVE Journal , 2021 (168) , 1
Type: article
Marina Lučić,
Dimitri A. Svistunenko ,
Michael T. Wilson,
Amanda K. Chaplin,
Bradley Davy,
Ali Ebrahim,
Danny Axford,
Takehiko Tosha,
Hiroshi Sugimoto,
Shigeki Owada,
Florian S. N Dworkowski,
Robin L. Owen,
Michael A. Hough,
& Jonathan A. R. Worrall
, 2020 , Angewandte Chemie International Edition , 59 (48) , 21656–21662
Type: article
Selina L S Storm,
Adam D Crawshaw,
Nicholas E Devenish,
Rachel Bolton,
David R Hall,
& Gwyndaf Evans
, 2020 , IUCrJ , 7 (Part 1) , 129--135
Type: article
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