Research project

Dr C McCormick: 'Temporal and co-ordinated processing of the hepatitis C virus polyprotein as an important determinant of viral fitness.'

Lead researcher:

Dr Chris McCormick
Research funder:

Medical Research Council
Status:

Not active

Staff

Lead researcher

Dr Chris McCormick BSc, DPhil, PGCert

Associate Professor

Research interests

Positive strand RNA virus replication
Viral proteases
Viral host pathogen interactions

Email: cjm@soton.ac.uk

Research outputs

Positive strand RNA viruses differ in the constraints they place on the folding of their negative strand

Morgan R. Herod,

Joseph C. Ward,

Andrew Tupin,

Mark Harris,

Nicola J. Stonehouse,

& Christopher J. Mccormick

, 2022 , RNA , 28 (10) , 1359--1376

DOI: 10.1261/rna.079125.122

Type: article

Polyprotein driven formation of two independent sets of complexes supporting hepatitis C virus genome replication

Rafael Gomes,

Olaf Isken,

Norbert Tautz,

John McLauchlan,

& Christoper J. McCormick

, 2015 , Journal of Virology , 1--53

DOI: 10.1128/JVI.01931-15

Type: article

The predominant species of nonstructural protein 4B in hepatitis C virus-replicating cells is not palmitoylated

David Paul,

Ralf Bartenschlager,

& Christopher J. McCormick

, 2015 , Journal of General Virology , 96 (7) , 1696--1701

DOI: 10.1099/vir.0.000111

Type: article

Genetic Complementation of Hepatitis C Virus Nonstructural Protein Functions Associated with Replication Exhibits Requirements That Differ from Those for Virion Assembly

Morgan R. Herod,

Vera Shregel,

Christopher Hinds,

Mengya Liu,

John McLauchlan,

& Christopher J. McCormick

, 2014 , Journal of Virology , 88 , 2748--2762

DOI: 10.1128/JVI.03588-13

Type: article

Increasing the rate of cleavage at the boundary between non-structural protein 4B and 5A inhibits replication of hepatitis C virus

Morgan R. Herod,

Daniel M. Jones,

John McLauchlan,

& Christopher J. McCormick

, 2011 , The Journal of Biological Chemistry , 287 , 568--580

DOI: 10.1074/jbc.M111.311407

Type: article