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Research project

Dr C McCormick: 'Temporal and co-ordinated processing of the hepatitis C virus polyprotein as an important determinant of viral fitness.'

  • Lead researcher:
    Dr Chris McCormick
  • Research funder:
    Medical Research Council
  • Status:
    Not active

Staff

Lead researcher

Dr Chris McCormick BSc, DPhil, PGCert

Associate Professor

Research interests

  • Positive strand RNA virus replication
  • Viral proteases
  • Viral host pathogen interactions

Research outputs

Positive strand RNA viruses differ in the constraints they place on the folding of their negative strand
Morgan R. Herod,
Joseph C. Ward,
Andrew Tupin,
Mark Harris,
Nicola J. Stonehouse,
& Christopher J. Mccormick
, 2022 , RNA , 28 (10) , 1359--1376
DOI: 10.1261/rna.079125.122
Type: article
Polyprotein driven formation of two independent sets of complexes supporting hepatitis C virus genome replication
Rafael Gomes,
Olaf Isken,
Norbert Tautz,
John McLauchlan,
& Christoper J. McCormick
, 2015 , Journal of Virology , 1--53
DOI: 10.1128/JVI.01931-15
Type: article
The predominant species of nonstructural protein 4B in hepatitis C virus-replicating cells is not palmitoylated
David Paul,
Ralf Bartenschlager,
& Christopher J. McCormick
, 2015 , Journal of General Virology , 96 (7) , 1696--1701
DOI: 10.1099/vir.0.000111
Type: article
Genetic Complementation of Hepatitis C Virus Nonstructural Protein Functions Associated with Replication Exhibits Requirements That Differ from Those for Virion Assembly
Morgan R. Herod,
Vera Shregel,
Christopher Hinds,
Mengya Liu,
John McLauchlan,
& Christopher J. McCormick
, 2014 , Journal of Virology , 88 , 2748--2762
DOI: 10.1128/JVI.03588-13
Type: article
Increasing the rate of cleavage at the boundary between non-structural protein 4B and 5A inhibits replication of hepatitis C virus
Morgan R. Herod,
Daniel M. Jones,
John McLauchlan,
& Christopher J. McCormick
, 2011 , The Journal of Biological Chemistry , 287 , 568--580
DOI: 10.1074/jbc.M111.311407
Type: article
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