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The University of Southampton

Research project: Effect of inflammatory proteins on age-related hearing loss - Dormant

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Chronic inflammation is common in older adults, and can lead to a number of diseases. We aim to determine the role of inflammation in the development and acceleration of age-related hearing loss, and also to investigate its role in affecting auditory performance outcomes in cochlear implant users.

Work to date in collaboration with the MRC Lifecourse Epidemiology Unit, funded by the Royal National Institute for the Deaf, has shown a clear independent relationship between markers of inflammation and hearing level in a large cohort of over 700 older inviduals on whom data on physiological status, hearing and lifestyle factors were collected. We are now planning to extend this work by evaluating the role of inflammatory processes in determining hearing loss in older adults via a longitudinal study, and also plan to develop the work by looking at the possible role of chronic inflammation on cochlear implant outcomes.

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