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Research project

B Linclau - IB Catalyst - BB/M028941/1

Staff

Other researchers

Dr Seung Lee

Associate Professor

Research interests

  • Chemical biology
  • Antimicrobial resistance
  • Glycan processing enzymes

Collaborating research institutes, centres and groups

Organic Chemistry, Synthesis, Catalysis

We develop environmentally sustainable approaches to chemical manufacture that minimise chemical waste, improve product velocity and reduce the need to isolate intermediates.

Research outputs

Obtaining pure 1H NMR spectra of individual pyranose and furanose anomers of reducing deoxyfluorinated sugars
Gabija Poškaitė,
David E. Wheatley,
Neil Wells,
Bruno Linclau,
& Davy Sinnaeve
, 2023 , Journal of Organic Chemistry , 88 (19) , 13908--13925
DOI: 10.1021/acs.joc.3c01503
Type: article
Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manβ1,4GlcNAc library
Tessa Keenan,
Natasha E. Hatton,
Jack Porter,
Jean-Baptiste Vendeville,
David Wheatley,
Mattia Ghirardello,
Alice. J.C. Wahart,
Sanaz Ahmadipour,
Julia Walton,
M. Carmen Galan,
Bruno Linclau,
Gavin J. Miller,
& Martin A. Fascione
, 2023 , Chemical Science , 14 (42) , 11638--11646
DOI: 10.1039/d3sc04169g
Type: article
Synthesis and structural characteristics of all mono- and difluorinated 4,6-dideoxy-d-xylo-hexopyranoses
David Wheatley,
Clement Q Fontenelle,
Rama krishna K Kuppala,
Robert Szpera,
Edward L. Briggs,
Jean B Vendeville,
Neil J. Wells,
Mark Light,
& Bruno Linclau
, 2021 , Journal of Organic Chemistry , 86 (11) , 7725–7756
DOI: 10.1021/acs.joc.1c00796
Type: article
Profiling substrate promiscuity of wild-type sugar kinases for multifluorinated monosaccharides
Tessa Keenan,
Fabio Parmeggiani,
Julien GJ Malassis,
Clement Q Fontenelle,
Jean B Vendeville,
Wendy Offen,
Peter Both,
Kun Huang,
Andrea Marchesi,
Alex Heyam,
Carl Young,
Simon J. Charnock,
Gideon J. Davies,
Bruno Linclau,
Sabine L. Flitsch,
& Martin A. Fascione
, 2020 , Cell Chemical Biology , 27 (9) , 1199--1206.e5
DOI: 10.1016/j.chembiol.2020.06.005
Type: article
Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands
Sarah-Jane Richards,
Tessa Keenan,
Jean-Baptiste Vendeville,
David Wheatley,
Harriet Chidwick,
Darshita Budhadev,
Claire Council,
Claire S. Webster,
Helene Ledru,
Alexander Baker,
Marc Walker,
M. Carmen Galan,
Bruno Linclau,
Martin A. Fascione,
& Matthew I. Gibson
, 2020 , Chemical Science , 12 (3) , 905--910
DOI: 10.1039/D0SC05360K
Type: article
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