Project overview
This project will investigate the enzymatic glycosylation of modified carbohydrate monosaccharides to achieve larger, biologically relevant glycan structures. This will be achieved by extensive screening of glycosyltransferase enzymes (enzymes that catalyse the addition of a new monosaccharide to a growing sugar 'acceptor'), that are able to use modified sugars as the 'acceptor', but also as 'donor'. The biological relevance of the synthesised new type of glycan structures will be validated by investigating their binding profile to a range of proteins that are known to be of relevance in the health sciences, with the immediate aim to develop new diagnostics applications. However, depending on the array results, further applications in other areas in the health sciences are envisaged.
Staff
Other researchers
Collaborating research institutes, centres and groups
Research outputs
Kristian Hollingsworth, Antonio Di Maio, Sarah Jane Richards, Jean Baptiste Vendeville, David E. Wheatley, Claire E. Council, Tessa Keenan, Hélène Ledru, Harriet Chidwick, Kun Huang, Fabio Parmeggiani, Andrea Marchesi, Wengang Chai, Ryan McBerney, Tomasz P. Kamiński, Matthew R. Balmforth, Alexandra Tamasanu, James D. Finnigan, Carl Young, Stuart L. Warriner, Michael E. Webb, Martin A. Fascione, Sabine Flitsch, M. Carmen Galan, Ten Feizi, Matthew I. Gibson, Yan Liu, W. Bruce Turnbull & Bruno Linclau,
2024, Nature Communications, 15(1)
Type: article
Gabija Poškaitė, David E. Wheatley, Neil Wells, Bruno Linclau & Davy Sinnaeve,
2023, Journal of Organic Chemistry, 88(19), 13908-13925
Type: article
David Wheatley, Clement Q Fontenelle, Rama krishna K Kuppala, Robert Szpera, Edward L. Briggs, Jean B Vendeville, Neil J. Wells, Mark Light & Bruno Linclau,
2021, Journal of Organic Chemistry, 86(11), 7725–7756
Type: article
Sarah-Jane Richards, Tessa Keenan, Jean-Baptiste Vendeville, David Wheatley, Harriet Chidwick, Darshita Budhadev, Claire Council, Claire S. Webster, Helene Ledru, Alexander Baker, Marc Walker, M. Carmen Galan, Bruno Linclau, Martin A. Fascione & Matthew I. Gibson,
2020, Chemical Science, 12(3), 905-910
DOI: 10.1039/D0SC05360K
Type: article