- Chemical biology
- Antimicrobial resistance
- Glycan processing enzymes
Current research projects are mainly focused on tackling antimicrobial resistance. An effort is being made to utilise small molecules to activate bacteria's own signalling pathways, which can reverse antimicrobial resistance. Another effort is to deliver antibacterial agents through a bacterial nutrient channel. An intrinsic mechanism of bacterial resistance to last line of antibiotic defence is also under intense study.
Current PhD Students
Dr Seung Seo Lee is a chemical biologist, and his research has been focused on the chemical biology/medicinal chemistry of proteins and enzymes involved in post-translational modification of proteins, with a long standing interest in the structure, function and mechanism of signalling pathways involving carbohydrates and carbohydrate processing enzymes. Recently he is using his expertise in chemical biology to tackle antibiotic resistant pathogens through innovative approach to bacterial signalling pathways. These research projects require highly multidisciplinary expertise of chemistry and biology.
Dr Seung Lee obtained his BSc and MSc in chemistry from Seoul National University in South Seoul, Korea. He then worked in the pharmaceutical industry before starting his doctoral study in chemistry at University of British Columbia in Vancouver, Canada. He obtained his PhD under the supervision of Professor Stephen G Withers, studying the reaction mechanism of glycan processing enzymes.
For his postdoctoral studies, he expanded his skillset to directed evolution techniques with Dr Florian Hollfelder in Department of Biochemistry at University of Cambridge and synthetic carbohydrate chemistry with Professor David R Bundle in the Department of Chemistry at University of Alberta. He then joined Professor Benjamin G Davis' group, working on various projects of chemical biology involving enzymes. In October 2012 he was appointed as a lecturer in Chemistry at University of Southampton.