Project overview
This application aims to determine: early biomarkers of cardiovascular disease (CVD) risk at birth/during childhood; the window(s) when early life interventions to reduce the risk of obesity and CVD are most effective; and the nature of potentially effective intervention(s). In the Southampton Women's Survey (SWS) prospective preconception cohort, we have discovered perinatal epigenetic biomarkers of later CVD risk in mechanistically relevant genes, now confirmed in our other cohorts. We will determine how these biomarkers relate to the trajectory of adiposity, cardiovascular structure, function and fitness in SWS children to age 12yrs. Using SWS samples collected at birth and age 12yrs we will extend our panel of epigenetic biomarkers and investigate interactions with fixed genetic variants in relation to CVD risk. Then we will relate the resulting biomarker panel to CVD risk in children from ongoing cohorts in which pre- or post-natal interventions to modify risk factors are being made.
Staff
Lead researchers
Other researchers
Collaborating research institutes, centres and groups
Research outputs
Ai-Ru Chia, Mya Thway Tint, Chad Y Han, Ling-Wei Chen, Marjorelee T. Colega, Izzuddin M. Aris, Mei Chien Chua, Kok Hian Tan, Fabian Yap, Lynette Pei-Chi Shek , Yap-Seng Chong, Keith Godfrey, Marielle V. Fortier, Yung Seng Lee & Mary Foong-Fong Chong,
2018, American Journal of Clinical Nutrition, 107(1), 71-79
DOI: 10.1093/ajcn/nqx003
Type: article
I.M. Aris, J.Y. Bernard, L.W. Chen, M.T. Tint, W.W. Pang, S.E. Soh, S.M. Saw, L.P.C. Shek, K.M. Godfrey, P.D. Gluckman, Y.S. Chong, F. Yap, M.S. Kramer & Y. S. Lee,
2018, International Journal of Obesity, 42(1), 44-51
DOI: 10.1038/ijo.2017.178
Type: article
Dilip K. Yadav, Smeeta Shrestha, Karen A. Lillycrop, Charu V. Joglekar, Hong Pan, Joanna D. Holbrook, Caroline H.D. Fall, Chittaranjan S. Yajnik & Giriraj R. Chandak,
2018, Epigenomics, 10(1), 71-90
Type: article
Nashita Patel, Christian Hellmuth, Olaf Uhl, Keith Godfrey, Annette Briley, Paul Welsh, Dharmintra Pauupathy, Paul T. Seed, Berthold Koletzko & Lucilla Poston,
2018, Journal of Clinical Endocrinology & Metabolism, 103(1), 346-355
Type: article
Alex Ireland, Sarah Crozier, Alexander E.P. Heazell, Kathryn Ward, Keith Godfrey, Hazel Inskip, Cyrus Cooper & Nicholas Harvey,
2018, Osteoporosis International, 1-7
Type: article
M. Penkler, M. Hanson, R. Biesma & R. Müller,
2018, Journal of Developmental Origins of Health and Disease, 1-6
Type: article