Research project

Prof Tom Fleming BBSRC Pre-implantation Embryos

Lead researchers:

Emeritus Professor Thomas Fleming
Other researchers:

Emeritus Professor Mark Hanson,

Professor Rohan Lewis
Research funder:

Biotechnology & Biological Sciences Research Council
Status:

Not active

Staff

Lead researchers

Emeritus Professor Thomas Fleming

Connect with Thomas

Email: T.P.Fleming@soton.ac.uk

Other researchers

Emeritus Professor Mark Hanson

Connect with Mark

Email: M.Hanson@soton.ac.uk

Professor Rohan Lewis PhD, FTPS

Prof of Placental&Integrative Physiology

Connect with Rohan

Email: Rohan.Lewis@soton.ac.uk

Research outputs

Insulin and branched-chain amino acid depletion during mouse preimplantation embryo culture programmes body weight gain and raised blood pressure during early postnatal life

Miguel A. Velazquez, Bhavwanti Sheth, Stephanie J. Smith, Judith J. Eckert, Clive Osmond & Tom P. Fleming, 2018, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1864(2), 590-600

DOI: 10.1016/j.bbadis.2017.11.020

Type: article

Advanced maternal age causes adverse programming of mouse blastocysts leading to altered growth and impaired cardiometabolic health in post-natal life

M.A. Velazquez, C.G.C. Smith, N.R. Smyth, C. Osmond & Thomas Fleming, 2016, Human Reproduction, 31(9), 1970-80

DOI: 10.1093/humrep/dew177

Type: article

Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation

Oleg Denisenko, Emma S. Lucas, Congshan Sun, Adam J. Watkins, Daniel Mar, Karol Bomsztyk & Tom P. Fleming, 2016, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1859(7), 906-913

DOI: 10.1016/j.bbagrm.2016.04.001

Type: article

DOHaD and the periconceptional period, a critical window in time

Congshan Sun, Miguel A. Velazquez & Tom P. Fleming, 2016

DOI: 10.1016/B978-0-12-801383-0.00003-7

Type: bookChapter

Embryos, DOHaD and David Barker

Thomas Fleming, Miguel Velazquez & Judith Eckert, 2015, Journal of Developmental Origins of Health and Disease, 6(5), 377-383

DOI: 10.1017/S2040174415001105

Type: article

Maternal nutrition modifies trophoblast giant cell phenotype and fetal growth in mice

Adam J. Watkins, Emma S. Lucas, Stephanie Marfy-Smith, Nicola Bates, Susan J. Kimber & Tom P. Fleming, 2015, Reproduction, 149(6), 563-575