About the project
The project explores the development of microfluidics-based sensors or diagnostic devices that are affordable, user-friendly and provide and effective testing strategy (widely-adopted during COVID-19 for informed decision-making) for rapid testing at the point-of-care which could include a hospital bedside or a care/nursing home, or in an ambulance or at home.
The wider aim of the project is to use a laser-based direct-write technique developed and patented by our group to pattern microfluidic devices in paper for the creation of the diagnostic sensors or tests.
Our innovative laser-based manufacturing technique allows the creation of custom-designed fluid flow paths within porous materials such as paper, and when used in combination with bio-chemical assays provides a route to producing sensors with much desired functionalities, including multiplexing, semi-quantification, and enhanced sensitivity.
This research which will happen in collaboration with clinical researcher is highly multi-disciplinary, which not only draws upon expertise in laser physics/engineering and microfluidics, but also vital knowledge of biochemistry and medicine.
The objective of the PhD is the development of paper-based tests such as lateral flow tests (such as those widely used during the COVID-19 pandemic) for simultaneous detection of multiple disease-specific biomarkers which help early-stage detection of the targeted diseases or conditions – examples of these include tuberculosis, sepsis, cytokine storm and urinary tract infections.
The project is mainly experimentally oriented and will provide opportunities to train across disciplines through working within different laboratories (laser- and bio-labs with different systems and instrumentation and procedures) and locations (universities, central governmental labs or NHS hospitals) within UK and outside.
It will also provide valuable learning opportunities relating to impact awareness and outreach to lay audience.
We are seeking to enrol individuals enthusiastic about learning across the diversely different disciplines and contributing as an effective team player.
The School of Optoelectronics (ORC) is committed to promoting equality, diversity inclusivity as demonstrated by our Athena SWAN award. We welcome all applicants regardless of their gender, ethnicity, disability, sexual orientation or age, and will give full consideration to applicants seeking flexible working patterns and those who have taken a career break. The University has a generous maternity policy, onsite childcare facilities, and offers a range of benefits to help ensure employees’ well-being and work-life balance. The University of Southampton is committed to sustainability and has been awarded the Platinum EcoAward.