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The University of Southampton
Genomic Informatics


The Genomic Informatics group undertake NGS studies to identify mutations which may predispose to, or occur during, cancer development.

Dividing cancer cells
Dividing cancer cells

The group has extensive, long-running collaborations with local researchers investigating the genetics of blood cancers. We have examined genomic data from germline and tumour DNA samples from patients with chronic lymphocytic leukemia and splenic marginal zone lymphoma in collaboration with Prof Jon Strefford and Dr Matthew Rose-Zerilli. Genomic studies have also been undertaken with with Dr Surinder Sahota to understand the pathogenesis and clonal evolution of multiple myeloma through analysis of genome sequence data.

A body of work has been undertaken in conjunction with Prof Nick Cross of the Wessex Regional Genetics Laboratory to investigate genetics and genomics of myeloid malignancies, including performing GWAS and RNA-seq studies.

Research in collaboration with Prof Diana Eccles is underway to identify genes underlying risk and survival in early onset breast cancer and methods for meta-analysis in breast cancer association data. We are also looking at the genetic progression of skin lesions, in collaboration with Prof Eugene Healy.


Some key publications from the group relating to cancer are listed below.



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