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Research project

Bioengineering to combat the tuberculosis pandemic

Project overview

We will combine engineering and biological approaches to investigate the host-pathogen interaction and identify new therapeutic targets.

Staff

Lead researcher

Professor Paul Elkington

Director of Inst. for Medical Innovation

Research interests

  • tuberculosis
  • immunopathology
  • diagnosis
Other researchers

Professor Xunli Zhang PhD, DIC, FRSC, CChem, CEng

Head of Department-Chemical Engineerg

Research interests

  • Xunli’s key expertise lies in the area of microfluidics technology from design and fabrication of microfluidic devices, through the development of in-situ monitoring methods for bio/chemical processes, to microfluidic modelling, microsystems integration and automation. The application is largely associated with biomedical challenges like patient specific design of microfluidic devices for cancer treatment, rapid diagnosis, and tackling antimicrobial resistance (AMR). The continuous flow reactors have been used for the synthesis of a range of nanoparticles, both organic and inorganic, for application in drug delivery and energy saving. The technologies developed in his research have also found great potential for industrial applications through a variety of industrial collaborations. 

Research outputs

Comprehensive plasma proteomic profiling reveals biomarkers for active tuberculosis
Diana J. Garay-Baquero,
Cory H. White,
Naomi F. Walker,
Marc Tebruegge,
Hannah F. Schiff,
Cesar Ugarte-Gil,
Stephen Morris-Jones,
Ben G. Marshall,
Antigoni Manousopoulou,
John Adamson,
Andres F. Vallejo,
Magdalena K. Bielecka,
Robert J. Wilkinson,
Liku B. Tezera,
Christopher H. Woelk,
Spiros D. Garbis,
& Paul Elkington
, 2020 , JCI Insight , 5 (18) , 1--21
DOI: 10.1172/jci.insight.137427
Type: article
Personal respirators for population level control of the COVID19 pandemic
Paul Elkington,
& Hywel Morgan
, 2020 , Journal of Infection , 81 (2) , 318--356
DOI: 10.1016/j.jinf.2020.04.025
Type: letterEditorial
In vitro granuloma models of tuberculosis
Paul Elkington,
Maria Lerm,
Nidhi Kapoor,
Robert Mahon,
Elsje Pienaar,
Dongeun Huh,
Deepak Kaushal,
& Larry Schlesinger
, 2019 , The Journal of Infectious Diseases , 219 (12) , 1858–1866
DOI: 10.1093/infdis/jiz020
Type: review
Reconsidering the optimal immune response to Mycobacterium tuberculosis
Liku Bekele Tezera,
Salah Mansour,
& Paul Elkington
, 2019 , American Journal of Respiratory and Critical Care Medicine , 201 (4)
DOI: 10.1164/rccm.201908-1506PP
Type: review
Cytokine diagnosis of pleural TB
Marc Tebruegge,
& Paul Elkington
, 2018 , Thorax , 73 (3) , 206--207
DOI: 10.1136/thoraxjnl-2017-210918
Type: letterEditorial