Professor Paul Elkington

Professor Paul Elkington

Professor of Respiratory Medicine

Research interests

tuberculosis
immunopathology
diagnosis

Accepting applications from PhD students.

Email: p.elkington@soton.ac.uk

Address: Southampton General Hospital, Tremona Road Shirley, SO16 6YD (View in Google Maps)

ORCID

Research

Research groups

Member of:

Research interests

tuberculosis
immunopathology
diagnosis
matrix metalloproteinase

Research projects

Active projects

Investigating local determinants of outcome in human tuberculosis

Researchers:

Professor Paul Elkington

,

Professor Hywel Morgan

Sponsor: Medical Research Council

Developing a multi-omics approach to identify new therapeutic targets in tuberculosis

Researchers:

Professor Paul Elkington

Sponsor: Rosetrees Trust

Developing a multi-omics approach to identify new therapeutic targets in tuberculosis’

Researchers:

Professor Paul Elkington

Sponsor: Rosetrees Trust

Investigating CD1c lipid-antigen presentation and its role in tuberculosis

Researchers:

Doctor Salah Mansour

,

Professor Bruno Linclau ,

Doctor Ivo Tews ,

Professor Paul Elkington

Sponsor: Medical Research Council

Investigating the functional role of CD1 expression and defining protective and pathogenic CD1c-immunity in tuberculosis

Researchers:

Doctor Salah Mansour

,

Doctor Diana Garay Baquero ,

Professor Paul Elkington

An open-access Spatial Biology Platform for inter-disciplinary studies of human disease

Researchers:

Professor Mark Jones

,

Professor Delphine Boche ,

Professor Rohan Lewis ,

Professor Jane Lucas ,

Doctor Claire Jackson ,

Doctor David Johnston ,

Professor Tom Wilkinson ,

Professor Gareth Thomas ,

Professor Diego Gomez-Nicola ,

Professor Paul Elkington ,

Doctor Matthew Loxham ,

Doctor Jay Amin ,

Doctor Joseph Bell ,

Doctor Zoë Walters ,

Doctor Owen Rackham

Sponsor: Medical Research Council

Completed projects

Investigating Matrix Degradation Products in Tuberculosis Fellowship

Researchers:

Professor Paul Elkington

Sponsor: Medical Research Council

Dr P. Elkington: Investigating multi-drug resistant tuberculosis in the 3-dimensional bioelectrospray cell culture model

Researchers:

Professor Paul Elkington

Sponsor: Medical Research Council

Bioengineering to combat the tuberculosis pandemic

Researchers:

Professor Paul Elkington

,

Professor Xunli Zhang

Sponsor: Medical Research Council

Imaging TB in microspheres

Researchers:

Professor Paul Elkington

P Elkington NIH 1R21Al102239-01

Researchers:

Professor Paul Elkington

Sponsor: National Institutes of Health

Developing the 3 - dimensional cellular model of Tuberculosis by integrating co-axial bioelectrospray, technology and stem cells

Researchers:

Professor Paul Elkington

Sponsor: Wessex Medical Research

Multidimensional transcriptomic analysis of tuberculosis granulomas to define pathophysiological mechanisms

Researchers:

Professor Paul Elkington

Sponsor: The Academy of Medical Sciences

Elkington - Rosetree's Trust - Reichman Fellowship - Tuberculosis in 3 dimensionsto identify new treatment approaches, by Dr Michaela Reichman

Researchers:

Professor Paul Elkington

Sponsor: Rosetrees Trust

Analysis of gene expression in tuberculosis to identify new treatment approaches

Researchers:

Professor Paul Elkington

Sponsor: The Morriston Davies Charitable Trust

Investigating the role of B cells in immunity to tuberculosis through advanced cell culture modelling

Researchers:

Professor Paul Elkington

Sponsor: Medical Research Foundation

Investigating granuloma modifying drugs in the 3D biomimetic model

Researchers:

Professor Paul Elkington

Optically controlled fluid flow in paper-based medical diagnostic devices

Researchers:

Professor Paul Elkington

Sponsor: EPSRC

Laser-based engineering (Lab-flo)

Researchers:

Doctor Collin Sones ,

Professor Paul Elkington ,

Professor Tony Williams

Sponsor: EPSRC

Biography

Prof Elkington trained in medicine at Oxford and then worked in various London teaching hospitals, in addition to Zambia, and completed his training in respiratory and general medicine in 2007. His research into lung destruction in tuberculosis started in Jon Friedland’s group at Imperial College London with a Wellcome Trust Clinical research training fellowship (2002 – 2005), followed by a NIHR Clinician Scientist Award (2006 – 2011), and then a HEFCE Clinical Senior Lecturer Award (2011 - 2016). He moved to Southampton University in June 2012 to develop a research programme centred on the role of proteases in the pathology of pulmonary infection. With Liku Tezera, he has developed the 3D bioelectrospray model of tuberculosis, which has provided entirely novel insights into disease pathogenesis. Prof Elkington has also co-chaired the Faculty Athena SWAN committee, awarded Silver in 2015 and 2021, is lead for Organisation in the TransFoM programme, and is section head for Innate Immunity. At the start of the COVID-19 pandemic, he initiated and co-directed the PeRSo project, providing over 1,500 respirators to staff at Southampton General Hospital in wave 1, and over 3,500 in wave 2, all requested by staff. Prof Elkington is secretary to the Acid Fast Club, the national tuberculosis research association, and was awarded an MBE for services to Medicine in 2020.

Prizes

MBE for services to Medicine (2020)
Royal Academy of Engineering President's Award (2020)
Vice-Chancellor's Award (2020)
Shine a Light Award (2020)

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